Fig. 6

Selected Auranofin drug combination strategies. Bubble plots showing the ZIP synergy score (bubble size) and Normalized Organoid Growth Rate (NOGR, colored heatmap) for a concentration range of A IM156, B Palbociclib, C Cisplatin and D Paclitaxel in combination with 909 nM Auranofin for each organoid line. Bubble size: very small = ZIP < -10 indicating antagonism; small = -10 < ZIP < 10 indicating an additive effect; medium = 10 < ZIP < 20 indicating moderate synergism; large = ZIP > 20 indicating strong synergism. NOGR between 1 and 0 indicates a cytostatic response, NOGR < 0 indicates a cytotoxic response