Fig. 1

Lactate metabolism was increased in glioma and positively correlated with M2-type TAM infiltration. A Different mRNA expression levels of LDHA or SLC16A1, between GBM and Normal group, or among grade of gliomas in TCGA dataset. B Kaplan–Meier survival curves revealed the correlation between LDHA or SLC16A1 mRNA expression and survival of glioma patients in the TCGA dataset. C Western blot analysis of LDHA and MCT1 protein expression in clinical samples. D Correlation analysis between the expressions of LDHA or SLC16A1 and CD68 or CD163, respectively, using bulk RNA-seq data from the TCGA dataset. E Representative pictures for immunofluorescence staining of clinical tissues for LDHA, MCT1, CD68 and CD163. Cell nuclei were counterstained with DAPI. Data are presented as the Mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001