Fig. 4

Advancing the Translation of Gastric Microbial Research: from clinic to clinic. The multicenter longitudinal cohort studies employ standardized strategies crafted to enhance the precision of data collection and analysis related to gastric microbiota. By incorporating a diverse range of genetic and non-genetic methodologies and considering potential influencing factors affecting outcomes, while recognizing inter-individual variability, the initiative aims to advance the comprehension of the intricate interplay between the microbiota and host co-evolution. Through the integration of both in vitro and in vivo studies, the research goes beyond mere identification of associations, correlations, and predictions. Instead, it delves into the exploration of mechanistic underpinnings behind causal relationships, providing profound insights at the molecular level. This concerted effort lays the foundation for personalized diagnostics and microbiota-based synergistic therapies in the intervention of gastric cancer