Subject /Sample Size | Gastric sample type | Country | Method | Gastric microbial diversity alternation in diseases | Gastric microbial composition alternation | Ref |
---|---|---|---|---|---|---|
12 GC VS 20 functional Dyspepsia | Gastric tissue | Malaysia | 16S rRNA sequencing | GC: ↑ | GC: Lactococcus, Veilonella, Fusobacteriaceae (Fusobacterium), Leptotrichia ↑ | [8] |
268 GC VS 288 control | Gastric mucosa | Korea | 16S rRNA sequencing | GC: ↓ | GC: Helicobacter, Propionibacterium acnes, Prevotella copri ↑ Control: Lactococcus lactis ↑ | [9] |
17 SG VS 10 AG VS 5 GIN VS 15 GC | Gastric mucosa | China | 16S rRNA sequencing | NS | GC: Slackia, Selenomonas, Bergeyella, Capnocytopha, Parvimonas, Eikenella, Prevotella-2, Kroppenstedtia, Lentibacillus, Oceanobacillus ↑ GIN: Romboutsia, Fusicatenibacter, Prevotellaceae-Ga6A1-group, Intestinimonas ↑ | [22] |
20 HC VS 20 Gastritis VS 40 AG VS 40 IM VS 48 GC | Gastric mucosa | Mongolia | 16S rRNA sequencing | HC > IM > GC > gastritis > AG | H. Pylori(-) GC:Lactobacilli and Enterococci ↑ H. pylori( ±) GC:Carnobacterium, Glutamicibacter, Paeniglutamicibacter, Fusobacterium, Parvimonas ↑ | [23] |
17 SG VS 16 IM (low-risk) VS 6 IM (high-risk) VS 4 EGN | Gastric antral biopsies | Singapore | 16S rRNA sequencing | NS | EGN: Proteobacteria(genus Proteus), H. pylori ↑ Bacteroidetes(S24-7 group), Bfidobacteria, Lactobacillus ↓ High-risk IM: H. pylori, Actinomyces, Moryella ↑ Low-risk IM: Phyllobacteriaceae, Enhydrobacter, Moryella ↑ Bifidobacteria, Lactobacillus ↓ | [51] |
30 HC VS 21 CG VS 27 IM VS IN VS 29 GC | Gastric mucosa | China | 16S rRNA sequencing | HC > CG > IM > GC | IM and GC: Gram-positive and anaerobic bacteria ↑ IN, IM and GC: Nitrospirae ↓ | [52] |
21 SG VS 23 AG VS 17 IM VS 20 GC from Xi an 56 SG VS 51 AG VS 19 GC from Hohhot | Gastric mucosa | China | 16S rRNA sequencing | IM and GC: ↓ | GC: Peptostreptococcus stomatis, Streptococcus anginosus, Parvimonas micra, Slackia exigua, Dialister pneumosintes ↑ | [53] |
61 SG VS 55 IM VS 64 GC | Gastric mucosa and Gastric fluid | China | 16S rRNA sequencing | GC: ↓ | GC: Lactobacillus, Veillonella, Gemella ↑ | [54] |
9 Gastritis VS 7 IM VS 11 GC | Gastric mucosa | China | 16S rRNA sequencing | / | GC: Clostridium colicanis, Fusobacterium nucleatum and Lactobacillus species ↑ H. pylroi-negative patients.: Burkholderia, Enterobacter, and Leclercia ↑ | [55] |
89 IM VS 89 matched controls | Gastric mucosa | America | Shotgun metagenomic sequencing | NS | IM: Johnsonella ignava, Actinomyces sp. oral taxon 448, Prevotella baroniae, Filifactor alocis, Veillonella sp. oral taxon 780, Leptotrichia goodfellowii ↑ | [56] |
54 GC VS 81 CG | Gastric mucosa | Portuguese, China and Mexico | 16S rRNA sequencing | GC: ↓ | GC: phylum level: Firmicutes, Actinobacteria and non-Helicobacter Proteobacteria ↑; Genus level: Citrobacter, Clostridium, Lactobacillus, Achromobacter, Rhodococcus, Phyllobacterium ↑ | [57] |
230 Normal tissues VS 247 peritumoral tissues VS 229 tumoral tissues | Gastric tissue | China | 16S rRNA sequencing | Normal > Tumor > Peritumoral tissue | Tumor: Prevotella melaninogenica, Streptococcus anginosus, Propionibacterium acnes↑ H. pylori, Prevotella copri, Bacteroides uniformis ↓ | [58] |
10 high GC risk VS 10 low GC risk | Gastric biopsy samples | Colombia | Whole metagenomic shotgun sequencing | NS | high GC risk: Staphylococus, Streptococcus, Bacillus, Aspergillus, and Siphoviridae↑ | [59] |
53 tumorous tissue VS 53 adjacent gastric tissue | Gastric mucosa | America | 16S rRNA sequencing | Tumor: ↑ | worse overall survival in GC: Fusobacterium and Prevotella ↑ | [60] |
62 cancerous tissues VS 62 neiboring non-cancerous tissues | Gastric mucosa | China | 16S rRNA sequencing | Cancerous tissues: ↑ | cancerous tissues: Fusobacterium, Streptococcus, Peptostreptococcus↑ non-cancerous tissues: Lactococcus lactis, Lactobacillus brevis ↑ | [61] |
25 H. pylori(-) SG VS 34 GC | Gastric mucosa | China | 16S rRNA sequencing | NS | CG: Lactobacillus, Streptococcus, Citrobacter, Klebsiella ↑ H. pylori(-) GC: Pseudomonadales, Betaproteobacteria, Gammaproteobacteria ↑ H. pylori( +) GC: Campylobacterales ↑ | [62] |
18 GC tumor samples VS 78 paracancerous samples VS 64 SG samples | Gastric mucosa | China | 16S rRNA sequencing | GC: ↓ | GC: Dialister spp., Helicobacter spp., Lactobacillus spp., Rhodococcus spp., Rudaea spp., Sediminibacterium spp. ↑ tumor tissue: Bradyrhizobium spp., Mesorhizobium spp.↓ | [63] |
37 tumor tissues VS 37 adjacent non-tumor tissues | Gastric mucosa | China | 16S rRNA sequencing | Tumor tissue: ↑ | tumor tissues: Lactobacillus, Streptococcus, Acinetobacter, Prevotella, Sphingomonas, Bacteroides, Fusobacterium, Comamonas, Empedobacter, Faecalibacterium ↑ non-tumor tissues: Helicobacter ↑ | [64] |
53 GC VS 30 CG | Gastric mucosa | China | 16S rRNA sequencing | GC: ↓ | GC: Oceanobacter, Methylobacterium, and Syntrophomona ↑ | [65] |
16 distal GC (normal and tumor tissue) VS 13 proximal GC (normal and tumor tissue) | Gastric tissue | China | 16S rRNA sequencing | Tumor tissue: ↑ | tumor: Helicobacter↓, Lactobacillus and Muribaculaceae ↑ proximal GC: Rikenellaceae_RC9_gut_group, Porphyromonas, Catonella, Proteus, Oribacterium, and Moraxella ↑ distal GC: Methylobacterium_ Methylorubrum ↑ | [66] |