Fig. 2

Shallow deletion of gene copy number contributes to the downregulation of KAT2B in CCA. (A) Analysis of the TCGA CCA dataset revealed that KAT2B gene copy number deletion was detected in 75% of CCA tumors (n = 27). (B) The co-relationship between KAT2B gene copy number and its mRNA expression from TCGA CCA cohort. (C, D) The CCA tissues from deceased patients exhibited higher proportion (89%) of shallow deletion (C) and lower level of KAT2B gene copy number (D). (E) The mRNA expression of KAT2B was lower in the CCA tissues from deceased patients than that from living patients. *P < 0.05, **P < 0.01