Fig. 6

Identification of the potential targets from LM.SIG. (A) Ranking of genes based on their knockout effects on anti‑tumor immunity across 17 CRISPR datasets. (B) Radar plot comparing the percentage of top‑ranked genes for LM.SIG and other predictive signatures. (C) Heatmap depicting z-scores of 19 LM.SIG genes in the 5% top‑ranked genes across different CRISPR datasets. (D) Veen plot depicting the intersection of LM.SIG genes ranked in CRISPR datasets and LM prognostic model (LMP gene). (E) The expression of LDHA across diverse cancers. (F) The representative image of IHC depicted the upregulated protein expression of LDHA in tumor samples of the cervix, kidney, lung and pancreas. (G) The expression of LDHA in immunotherapy ST dataset of HCC. (ns, not significant; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)