Fig. 10
NPs-mediated upregulation of circPDE5A and PDE5A-500aa inhibits ESCC proliferation in vivo. A Schematic representation of a subcutaneous xenograft tumor model treated with NPs. B Photographs of subcutaneous xenograft tumors collected from mice at the end of treatment in each group (n = 8). C Volume growth curves of subcutaneous xenograft tumors in each treatment group after starting treatment. Tumor volume was measured every 4 days after the start of treatment (n = 8, unit: mm3). D The weight of subcutaneous xenograft tumors in each treatment group measured at the end of the experiment (n = 8, unit: mg). E IHC staining for PIK3IP1, PI3K, p-AKT, p-mTOR, and Ki67 in tumor tissues after systemic treatment in subcutaneous xenograft tumor nude mice with ESCC in each group. Bar represents 50 μm