Table 2 Univariate and multivariate Cox-regression analysis of prognostic factors for patients with ESCC (n = 100)

Gender

 Female

12

1

 Male

88

3.179

0.764–13.238

0.112

Age

  < 65

72

1

  ≥ 65

28

1.897

0.966–3.724

0.074

BMI

  ≥ 18.5

97

1

  < 18.5

3

2.881

1.196–6.939

0.036*

1.792

0.700–4.587

0.224

Smoking history

 No

52

1

 Yes

48

1.014

0.530–1.938

0.967

Alcohol history

 No

36

1

 Yes

64

0.577

0.305–1.095

0.092

Histologic grade

 G1

14

1

 G2 + G3

86

2.493

0.755–8.234

0.134

T stage

 T1 + T2

45

1

 T3 + T4

55

1.386

0.723–2.657

0.326

N stage

 N0

45

1

 N1 + N2 + N3

55

3.274

1.568–6.837

0.002**

2.527

0.829–7.346

0.069

M stage

 M0

95

1

 M1

5

3.155

1.105–9.012

0.032*

1.580

0.327–4.376

0.687

TNM stage

 I + II

58

1

 III + IV

42

2.853

1.462–5.565

0.002**

0.799

0.280–2.578

0.929

Expression of circPDE5A

 Low

50

1

 High

50

0.274

0.126–0.599

0.001**

0.354

0.139–0.875

0.034*

Expression of PDE5A-500aa

 Low

50

1

 High

50

0.203

0.079–0.522

0.001**

0.263

0.100–0.691

0.017*