Skip to main content

Articles

Page 19 of 77

  1. Triple-negative breast cancer (TNBC) is the most heterogeneous and malignant subtype of breast cancer (BC). TNBC is defined by the absence of expression of estrogen, progesterone and HER2 receptors and lacks e...

    Authors: Chiara Naro, Monica De Musso, Francesca Delle Monache, Valentina Panzeri, Pierre de la Grange and Claudio Sette
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:397
    Content type: Research Published on:

  2. Breast cancer has been associated with activation of the WNT signaling pathway, although no driver mutations in WNT genes have been found yet. Instead, a high expression of the alternative WNT receptor ROR2 wa...

    Authors: Kerstin Menck, Saskia Heinrichs, Darius Wlochowitz, Maren Sitte, Helen Noeding, Andreas Janshoff, Hannes Treiber, Torben Ruhwedel, Bawarjan Schatlo, Christian von der Brelie, Stefan Wiemann, Tobias Pukrop, Tim Beißbarth, Claudia Binder and Annalen Bleckmann
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:395
    Content type: Research Published on:

  3. Authors: Jian Zhang, Xin Wen, Na Liu, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Pan-Pan Zhang, Jun Ma and Ying Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:394
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:147

  4. Alterations in metabolism are one of the emerging hallmarks of cancer cells and targeting dysregulated cancer metabolism provides a new approach to developing more selective therapeutics. However, insufficient...

    Authors: Liwei Lang, Fang Wang, Zhichun Ding, Xiangdong Zhao, Reid Loveless, Jin Xie, Chloe Shay, Peng Qiu, Yonggang Ke, Nabil F. Saba and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:393
    Content type: Research Published on:

  5. Flavonoids exhibit both chemopreventive and chemotherapeutic activity for multiple tumor types, however, their mechanisms of action are not well defined. Based on some of their functional and gene modifying ac...

    Authors: Rupesh Shrestha, Kumaravel Mohankumar, Greg Martin, Amanuel Hailemariam, Syng-ook Lee, Un-ho Jin, Robert Burghardt and Stephen Safe
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:392
    Content type: Research Published on:

  6. Squamous cell carcinoma (SCC) of the skin is a common form of nonmelanoma skin cancer. Monocyte chemotactic protein 1-induced protein 1 (MCPIP1), also called Regnase-1, is an RNase with anti-inflammatory prope...

    Authors: Weronika Szukala, Agata Lichawska-Cieslar, Roza Pietrzycka, Maria Kulecka, Izabela Rumienczyk, Michal Mikula, Iwona Chlebicka, Piotr Konieczny, Katarzyna Dziedzic, Jacek C Szepietowski, Giulia Fontemaggi, Janusz Rys and Jolanta Jura
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:391
    Content type: Research Published on:

  7. Centromere protein N (CENP-N) has been reported to be highly expressed in malignancies, but its role and mechanism in nasopharyngeal carcinoma (NPC) are unknown.

    Authors: Cheng-Lin Qi, Mao-Ling Huang, You Zou, Rui Yang, Yang Jiang, Jian-Fei Sheng, Yong-Gang Kong, Ze-Zhang Tao, Hong-Yan Feng, Qing-Quan Hua, Li-Hong Bu and Shi-Ming Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:390
    Content type: Research Published on:

  8. micro(mi)RNAs are short noncoding RNAs that through their seed sequence (pos. 2–7/8 of the guide strand) regulate cell function by targeting complementary sequences (seed matches) located mostly in the 3′ untr...

    Authors: Ashley Haluck-Kangas, Monal Patel, Bidur Paudel, Aparajitha Vaidyanathan, Andrea E. Murmann and Marcus E. Peter
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:389
    Content type: Review Published on:

  9. Emerging evidence from the numerous clinical trials involving cytokine-induced killer (CIK) cell therapy suggests that its optimization in combination with other contemporary cancer therapies in a complementar...

    Authors: Amit Sharma and Ingo G. H. Schmidt-Wolf
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:388
    Content type: Commentary Published on:

  10. Mannose, a natural hexose existing in daily food, has been demonstrated to preferentially inhibit the progression of tumors with low expression of phosphate mannose isomerase (PMI). However, its function in th...

    Authors: Sharui Ma, Na Wang, Rui Liu, Rui Zhang, Hui Dang, Yubo Wang, Simeng Wang, Zekun Zeng, Meiju Ji and Peng Hou
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:387
    Content type: Research Published on:

  12. Authors: Dongmei Zhang, Jingrong Lin, Yulin Chao, Lu Zhang, Lei Jin, Na Li, Ruiping He, Binbin Ma, Wenzhi Zhao and Chuanchun Han
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:385
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:176

  14. Short or small interfering RNAs (siRNAs) and microRNA (miRNAs) are molecules similar in size and function able to inhibit gene expression based on their complementarity with mRNA sequences, inducing the degrad...

    Authors: Rossana Cuciniello, Stefania Filosa and Stefania Crispi
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:383
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:403

  15. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is emerging as both a novel cancer hallm...

    Authors: Emilia Alors-Perez, Ricardo Blázquez-Encinas, Sonia Alcalá, Cristina Viyuela-García, Sergio Pedraza-Arevalo, Vicente Herrero-Aguayo, Juan M. Jiménez-Vacas, Andrea Mafficini, Marina E. Sánchez-Frías, María T. Cano, Fernando Abollo-Jiménez, Juan A. Marín-Sanz, Pablo Cabezas-Sainz, Rita T. Lawlor, Claudio Luchini, Laura Sánchez…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:382
    Content type: Research Published on:

  16. Synovial sarcoma (SS) is an aggressive soft tissue tumor with limited therapeutic options in advanced stage. SS18-SSX fusion oncogenes, which are the hallmarks of SS, cause epigenetic rewiring involving histone d...

    Authors: Cinzia Lanzi, Enrica Favini, Laura Dal Bo, Monica Tortoreto, Noemi Arrighetti, Nadia Zaffaroni and Giuliana Cassinelli
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:381
    Content type: Research Published on:

  17. Despite  improvements in outcome, 15-25% of newly diagnosed multiple myeloma (MM) patients have treatment resistant high-risk (HR) disease with a poor survival. The lack of a genetic basis for HR has focused a...

    Authors: Hussein Ghamlouch, Eileen M. Boyle, Patrick Blaney, Yubao Wang, Jinyoung Choi, Louis Williams, Michael Bauer, Daniel Auclair, Benedetto Bruno, Brian A. Walker, Faith E. Davies and Gareth J. Morgan
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:380
    Content type: Review Published on:

  19. The incidence of bladder urothelial carcinoma (UC), a common malignancy of the urinary tract, is approximately three times higher in men than in women. High expression of the mitotic kinase BUB1 is associated ...

    Authors: Ning Jiang, Yihao Liao, Miaomiao Wang, Youzhi Wang, Keke Wang, Jianing Guo, Peikang Wu, Boqiang Zhong, Tao Guo and Changli Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:378
    Content type: Research Published on:

  20. Authors: Weidong Li, Xuesong Dong, Changjun He, Gang Tan, Ziyi Li, Bo Zhai, Jing Feng, Xian Jiang, Chang Liu, Hongchi Jiang and Xueying Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:377
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:183

  21. Nonsense-mediated mRNA decay (NMD) is a highly conserved cellular surveillance mechanism, commonly studied for its role in mRNA quality control because of its capacity of degrading mutated mRNAs that would pro...

    Authors: Roberta Bongiorno, Mario Paolo Colombo and Daniele Lecis
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:376
    Content type: Review Published on:

  23. The critical role of phosphoinositide 3-kinase (PI3K) activation in tumor cell biology has prompted massive efforts to develop PI3K inhibitors (PI3Kis) for cancer therapy. However, recent results from clinical...

    Authors: Xin Peng, Shaolu Zhang, Wenhui Jiao, Zhenxing Zhong, Yuqi Yang, Francois X. Claret, Moshe Elkabets, Feng Wang, Ran Wang, Yuxu Zhong, Zhe-Sheng Chen and Dexin Kong
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:374
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:396

  24. Gallbladder cancer (GBC) is known for its high malignancy and multidrug resistance. Previously, we uncovered that impaired integrity and stability of the elongator complex leads to GBC chemotherapy resistance,...

    Authors: Sunwang Xu, Cen Jiang, Ruirong Lin, Xiaopeng Wang, Xiaoqiang Hu, Wei Chen, Xiangjin Chen and Tao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:373
    Content type: Research Published on:

  25. Transmembrane serine protease 4 (TMPRSS4) is a cell surface–anchored serine protease. Elevated expression of TMPRSS4 correlates with poor prognosis in colorectal cancer, gastric cancer, prostate cancer, non–sm...

    Authors: Yunhee Lee, Junghwa Yoon, Dongjoon Ko, Minyeong Yu, Soojin Lee and Semi Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:372
    Content type: Research Published on:

  26. Brain metastasis (BM) is thought to be related to the mortality and poor prognosis of non-small cell lung cancer (NSCLC). Despite promising development of NSCLC treatment, the treatment of NSCLC BM is still no...

    Authors: Ruo-Yue Fan, Jia-Qi Wu, Yu-Yang Liu, Xiang-Yu Liu, Si-Tong Qian, Chong-Yong Li, Ping Wei, Zhe Song and Ming-Fang He
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:371
    Content type: Research Published on:

  27. Breast cancer is one of the most-common female malignancies with a high risk of relapse and distant metastasis. The distant metastasis of breast cancer exhibits organotropism, including brain, lung, liver and ...

    Authors: Cenzhu Wang, Kun Xu, Runtian Wang, Xin Han, Jinhai Tang and Xiaoxiang Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:370
    Content type: Review Published on:

  29. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s13046-021-02172-6

    Authors: Jie Yuan, Fan Zhang, Dennis Hallahan, Zhen Zhang, Liming He, Ling-Gang Wu, Meng You and Qin Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:368
    Content type: Retraction Note Published on:

  30. Chimeric antigen receptor (CAR) T-cell therapy has yielded impressive outcomes and transformed treatment algorithms for hematological malignancies. To date, five CAR T-cell products have been approved by the U...

    Authors: Xinyi Xiao, Shengkang Huang, Sifei Chen, Yazhuo Wang, Qihang Sun, Xinjie Xu and Yuhua Li
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:367
    Content type: Review Published on:

  31. Authors: Shengming Deng, Guoxi Zhang, Jiajie Kuai, Peng Fan, Xuexiang Wang, Pei Zhou, Dan Yang, Xichen Zheng, Xiaomei Liu, Qunli Wu and Yuhui Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:366
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:260

  32. Authors: Pingfu Hou, Sen Meng, Minle Li, Tian Lin, Sufang Chu, Zhongwei Li, Junnian Zheng, Yuming Gu and Jin Bai
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:365
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:52

  33. Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumours worldwide. Sorafenib (SOR) is one of the most effective single-drug systemic therapy against advanced HCC, but the identifi...

    Authors: Ilaria Romito, Manuela Porru, Maria Rita Braghini, Luca Pompili, Nadia Panera, Annalisa Crudele, Daniela Gnani, Cristiano De Stefanis, Marco Scarsella, Silvia Pomella, Stefano Levi Mortera, Emmanuel de Billy, Adrian Libenzio Conti, Valeria Marzano, Lorenza Putignani, Manlio Vinciguerra…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:364
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:40

  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xuehui Wang, Changle Ji, Jiashu Hu, Xiaochong Deng, Wenfang Zheng, Yunhe Yu, Kaiyao Hua, Xiqian Zhou and Lin Fang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:363
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:29

  35. Approaches based on expression signatures of prostate cancer (PCa) have been proposed to predict patient outcomes and response to treatments. The transcription factor NF-Y participates to the progression from ...

    Authors: Silvia Belluti, Valentina Semeghini, Giovanna Rigillo, Mirko Ronzio, Daniela Benati, Federica Torricelli, Luca Reggiani Bonetti, Gianluca Carnevale, Giulia Grisendi, Alessia Ciarrocchi, Massimo Dominici, Alessandra Recchia, Diletta Dolfini and Carol Imbriano
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:362
    Content type: Research Published on:

  36. Cisplatin-based chemotherapy is a mainstay systematic therapy for advanced esophageal squamous cell carcinoma (ESCC), and cisplatin resistance, which is not uncommon, is the major barrier to improving patient ...

    Authors: Zhenchuan Liu, Shaorui Gu, Kaiqin Wu, Lei Li, Chenglai Dong, Wenli Wang and Yongxin Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:361
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:61

  37. Small nucleolar RNA host gene (SNHG) long noncoding RNAs (lncRNAs) are frequently dysregulated in human cancers and involved in tumorigenesis and progression. SNHG17 has been reported as a candidate oncogene i...

    Authors: Zehua Bian, Mingyue Zhou, Kaisa Cui, Fan Yang, Yulin Cao, Shengbai Sun, Bingxin Liu, Liang Gong, Jiuming Li, Xue Wang, Chaoqun Li, Surui Yao, Yuan Yin, Shenglin Huang, Bojian Fei and Zhaohui Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:360
    Content type: Research Published on:

  38. Highly expressed STOML2 has been reported in a variety of cancers, yet few have detailed its function and regulatory mechanism. This research aims to reveal regulatory mechanism of STOML2 and to provide eviden...

    Authors: Wenhui Ma, Yuehong Chen, Wenjun Xiong, Wenyi Li, Zhuoluo Xu, Ying Wang, Zhigang Wei, Tingyu Mou, Zhaokun Wu, Mingzhen Cheng, Yini Zou, Yu Zhu, Weijie Zhou, Feng Liu and Yan Geng
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:359
    Content type: Research Published on:

  39. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1114-2.

    Authors: Zhang Jia-Xing, He Wei-Ling, Feng Zi-Hao, Chen Dong-Liang, Gao Ying, He Ying, Qin Kai, Zheng Zhou-San, Chen Cui, Weng Hui-Wen, Yun Miao, Ye Sheng, Xu Rui-Hua and Xie Dan
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:358
    Content type: Retraction Note Published on:

  40. Diffuse large B-cell lymphoma (DLBCL) comprises at least two main biologically distinct entities: germinal center B-cell (GCB) and activated B-cell (ABC) subtype. Albeit sharing common lesions, GCB and ABC DLB...

    Authors: Giulio Sartori, Sara Napoli, Luciano Cascione, Elaine Yee Lin Chung, Valdemar Priebe, Alberto Jesus Arribas, Afua Adjeiwaa Mensah, Michela Dall’Angelo, Chiara Falzarano, Laura Barnabei, Mattia Forcato, Andrea Rinaldi, Silvio Bicciato, Margot Thome and Francesco Bertoni
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:357
    Content type: Research Published on:

  41. Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in...

    Authors: Ravi Chauhan, Ajaz A. Bhat, Tariq Masoodi, Puneet Bagga, Ravinder Reddy, Ashna Gupta, Zahoor Ahmad Sheikh, Muzafar A. Macha, Mohammad Haris and Mayank Singh
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:356
    Content type: Review Published on:

  42. The hopeful outcomes from 30 years of research in BH3-mimetics have indeed served a number of solid paradigms for targeting intermediates from the apoptosis pathway in a variety of diseased states. Not only ha...

    Authors: Paul A. Townsend, Maria V. Kozhevnikova, Olivier N. F. Cexus, Andrey A. Zamyatnin Jr and Surinder M. Soond
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:355
    Content type: Review Published on:

  43. Authors: Tao Qin, Bai Li, Xiaoyue Feng, Shujun Fan, Lei Liu, Dandan Liu, Jun Mao, Ying Lu, Jinfeng Yang, Xiaotang Yu, Qingqing Zhang, Jun Zhang, Bo Song, Man Li and Lianhong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:354
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:287

  44. Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Its therapy has not significantly improved during the past four decades despite intense research efforts. New molecularly targeted t...

    Authors: Hao Zhou, Wei Liu, Yongming Zhou, Zhenya Hong, Jian Ni, Xiaoping Zhang, Ziping Li, Mengyuan Li, Wenjuan He, Donghua Zhang, Xuexing Chen and Jianhua Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:353
    Content type: Research Published on:

  45. Angiogenesis plays an important role in the occurrence, development and metastasis of hepatocellular carcinoma (HCC). According to previous studies, miR-378a participates in tumorigenesis and tumor metastasis,...

    Authors: Bin Zhu, Jun-Jie Chen, Ying Feng, Jun-Ling Yang, Hua Huang, Wen Yuan Chung, Yi-Lin Hu and Wan-Jiang Xue
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:352
    Content type: Research Published on:

  46. Growing evidence shows that long non-coding RNAs (lncRNAs) play significant roles in cancer development. However, the functions of most lncRNAs in human gastric cancer are still not fully understood. Here, we ...

    Authors: Ziwei Ji, Tianbin Tang, Mengxia Chen, Buyuan Dong, Wenjing Sun, Nan Wu, Hao Chen, Qian Feng, Xingyi Yang, Rong Jin and Lei Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:351
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2024 43:40

  47. Progesterone receptor membrane component 1 (PGRMC1) is a heme-binding protein inducing dimerization with cytochrome P450, which mediates chemoresistance. Increased PGRMC1 expression is found in multiple types ...

    Authors: Ji Hyeon You, Jaewang Lee and Jong-Lyel Roh
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:350
    Content type: Research Published on:

  48. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Chunfeng Xie, Xu Zhou, Chunhua Liang, Xiaoting Li, Miaomiao Ge, Yue Chen, Juan Yin, Jianyun Zhu and Caiyun Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:349
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:266

  49. Resistance to oxaliplatin is a major obstacle for the management of locally advanced and metastatic colon cancer (CC). Although long noncoding RNAs (lncRNAs) play key roles in CC, the relationships between lnc...

    Authors: Qingguo Li, Huizhen Sun, Dakui Luo, Lu Gan, Shaobo Mo, Weixing Dai, Lei Liang, Yufei Yang, Midie Xu, Jing Li, Peiyong Zheng, Xinxiang Li, Yan Li and Ziliang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:348
    Content type: Research Published on:

  50. Glioblastoma (GBM; grade IV glioma) is characterized by a very short overall survival time and extremely low 5-year survival rates. We intend to promote experimental and clinical research on rationale and scie...

    Authors: Silvia Matteoni, Paola Matarrese, Barbara Ascione, Lucia Ricci-Vitiani, Roberto Pallini, Veronica Villani, Andrea Pace, Marco G. Paggi and Claudia Abbruzzese
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:347
    Content type: Research Published on:

Annual Journal Metrics

  • 2022 Citation Impact
    11.3 - 2-year Impact Factor
    11.5 - 5-year Impact Factor
    1.870 - SNIP (Source Normalized Impact per Paper)
    2.413 - SJR (SCImago Journal Rank)

    2023 Speed
    4 days submission to first editorial decision for all manuscripts (Median)
    100 days submission to accept (Median)

    2023 Usage 
    3,003,080 downloads
    3,022 Altmetric mentions

Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

Contact us