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  1. Murine xenografts of pediatric leukemia accurately recapitulate genomic aberrations. How this translates to the functional capacity of cells remains unclear. Here, we studied global protein abundance, phosphor...

    Authors: Anuli C. Uzozie, Enes K. Ergin, Nina Rolf, Janice Tsui, Amanda Lorentzian, Samuel S. H. Weng, Lorenz Nierves, Theodore G. Smith, C. James Lim, Christopher A. Maxwell, Gregor S. D. Reid and Philipp F. Lange
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:96
  2. Ectopic insulin-like growth factor binding protein 3 (IGFBP3) expression has been shown to enhance cell migration and lymph node metastasis of oral squamous cell carcinoma (OSCC) cells. However, OSCC patients ...

    Authors: Ssu-Han Wang, Yu-Lin Chen, Jenn-Ren Hsiao, Fang-Yu Tsai, Shih Sheng Jiang, Alan Yueh-Luen Lee, Hui-Jen Tsai and Ya-Wen Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:95
  3. In the last decades, the concept of metabolic rewiring as a cancer hallmark has been expanded beyond the “Warburg effect” and the importance of other metabolic routes, including lipid metabolism, has emerged. ...

    Authors: Serena Castelli, Fabio Ciccarone, Daniela Tavian and Maria Rosa Ciriolo
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:94
  4. There is no consensus about the effective dosages of melatonin in cancer management, thus, it is imperative to fully understand the dose-dependent responsiveness of cancer cells to melatonin and the underlying...

    Authors: Liwei Lang, Yuanping Xiong, Nestor Prieto-Dominguez, Reid Loveless, Caleb Jensen, Chloe Shay and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:93
  5. Emerging evidence confirms that lncRNAs (long non-coding RNAs) are potential biomarkers that play vital roles in tumors. ZNF582-AS1 is a novel lncRNA that serves as a potential prognostic marker of cancers. Ho...

    Authors: Wuping Yang, Kenan Zhang, Lei Li, Yawei Xu, Kaifang Ma, Haibiao Xie, Jingcheng Zhou, Lin Cai, Yanqing Gong and Kan Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:92

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:167

  6. Pancreatic ductal adenocarcinoma (PDAC) is a very lethal disease, with minimal therapeutic options. Aberrant tyrosine kinase activity influences tumor growth and is regulated by phosphorylation. We investigate...

    Authors: T. Y. S. Le Large, M. F. Bijlsma, B. El Hassouni, G. Mantini, T. Lagerweij, A. A. Henneman, N. Funel, B. Kok, T. V. Pham, R. de Haas, L. Morelli, J. C. Knol, S. R. Piersma, G. Kazemier, H. W. M. van Laarhoven, E. Giovannetti…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:91
  7. FBXW7 m6A modification plays an important role in lung adenocarcinoma (LUAD) progression; however, the underlying mechanisms remain unclear.

    Authors: Yingtong Wu, Ning Chang, Yong Zhang, Xinxin Zhang, Leidi Xu, Yinggang Che, Tianyun Qiao, Bin Wu, Ying Zhou, Jun Jiang, Jie Xiong, Jian Zhang and Jian Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:90
  8. Recent developments in abscopal effect strongly support the use of radiotherapy for the treatment of metastatic disease. However, deeper understanding of the molecular mechanisms underlying the abscopal effect...

    Authors: Anna Tesei, Chiara Arienti, Gianluca Bossi, Spartaco Santi, Ilaria De Santis, Alessandro Bevilacqua, Michele Zanoni, Sara Pignatta, Michela Cortesi, Alice Zamagni, Gianluca Storci, Massimiliano Bonafè, Anna Sarnelli, Antonino Romeo, Carola Cavallo, Armando Bartolazzi…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:89
  9. WD repeat domain 3 (WDR3) is involved in a variety of cellular processes including gene regulation, cell cycle progression, signal transduction and apoptosis. However, the biological role of WDR3 in pancreatic...

    Authors: Wenjie Su, Shikai Zhu, Kai Chen, Hongji Yang, Mingwu Tian, Qiang Fu, Ganggang Shi, Shijian Feng, Dianyun Ren, Xin Jin and Chong Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:88
  10. Irradiation has emerged as a valid tool for nasopharyngeal carcinoma (NPC) in situ treatment; however, NPC derived from tissues treated with irradiation is a main cause cancer-related death. The purpose of thi...

    Authors: Weiqiang Huang, Longshan Zhang, Mi Yang, Xixi Wu, Xiaoqing Wang, Wenqi Huang, Lu Yuan, Hua Pan, Yin Wang, Zici Wang, Yuting Wu, Jihong Huang, Huazhen Liang, Shaoqun Li, Liwei Liao, Laiyu Liu…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:87

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:108

  11. Cholangiocarcinoma is a highly malignant cancer with very dismal prognosis. Perihilar cholangiocarcinoma(pCCA) accounts for more than 50% of all cholangiocarcinoma and is well-characterized for its low rate of...

    Authors: Zhipeng Li, Jialiang Liu, Tianli Chen, Rongqi Sun, Zengli Liu, Bo Qiu, Yunfei Xu and Zongli Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:86
  12. Alternative polyadenylation (APA) is an important mechanism of gene expression regulation through generation of RNA isoforms with distinct 3′ termini. Increasing evidence has revealed that APA is actively invo...

    Authors: Sheng Tan, Ming Zhang, Xinglong Shi, Keshuo Ding, Qiang Zhao, Qianying Guo, Hao Wang, Zhengsheng Wu, Yani Kang, Tao Zhu, Jielin Sun and Xiaodong Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:85
  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ping Zhou, Jiaqi Qin, Yuan Li, Guoxia Li, Yinsong Wang, Ning Zhang, Peng Chen and Chunyu Li
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:84

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:115

  14. Dedifferentiated liposarcoma (DDLPS), a tumor that lacks effective treatment strategies and is associated with poor outcomes, expresses amplified MDM2 in the presence of wild-type p53. MDM2 ubiquitination of p...

    Authors: Valentina Zuco, Sandro Pasquali, Monica Tortoreto, Silvia Brich, Stefano Percio, Gian Paolo Dagrada, Chiara Colombo, Roberta Sanfilippo, Calogero Lauricella, Mrinal Gounder, Rihan El Bezawy, Marta Barisella, Angelo Paolo Dei Tos, Paolo Giovanni Casali, Alessandro Gronchi, Silvia Stacchiotti…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:83
  15. Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic opportunities. Recently, splicing factors have gained attention as potential targets for cancer treatment...

    Authors: Esmee Koedoot, Eline van Steijn, Marjolein Vermeer, Román González-Prieto, Alfred C. O. Vertegaal, John W. M. Martens, Sylvia E. Le Dévédec and Bob van de Water
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:82
  16. Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of complex tissues at single-cell levels, can identify differential gene expression and epigenetic factors caused by mutations ...

    Authors: Yijie Zhang, Dan Wang, Miao Peng, Le Tang, Jiawei Ouyang, Fang Xiong, Can Guo, Yanyan Tang, Yujuan Zhou, Qianjin Liao, Xu Wu, Hui Wang, Jianjun Yu, Yong Li, Xiaoling Li, Guiyuan Li…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:81
  17. TMEM52B is a novel gene broadly expressed in a variety of normal human tissues. However, the biological function of TMEM52B expression in cancer is largely unknown.

    Authors: Yunhee Lee, Dongjoon Ko, Junghwa Yoon, Younghoon Lee and Semi Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:58
  18. Laryngeal cancer has the highest mortality rate among head and neck tumours. RNA N6-methyladenosine (m6A) is the most plentiful and variable in mammalian mRNA. Yet, the m6A regulatory mechanism underlying the ...

    Authors: Xin Wang, Linli Tian, Yushan Li, Jingting Wang, Bingrui Yan, Like Yang, Qiuying Li, Rui Zhao, Ming Liu, Peng Wang and Yanan Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:80
  19. A prostate cancer diagnosis is based on biopsy sampling that is an invasive, expensive procedure, and doesn’t accurately represent multifocal disease.

    Authors: Simona Giglio, Cosimo De Nunzio, Roberto Cirombella, Antonella Stoppacciaro, Omar Faruq, Stefano Volinia, Gustavo Baldassarre, Andrea Tubaro, Hideshi Ishii, Carlo M. Croce and Andrea Vecchione
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:79
  20. Long non-coding RNAs (lncRNA) are reported to influence colorectal cancer (CRC) progression. Currently, the functions of the lncRNA ZNF561 antisense RNA 1 (ZNF561-AS1) in CRC are unknown.

    Authors: Zizhen Si, Lei Yu, Haoyu Jing, Lun Wu and Xidi Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:78
  21. Claudin-2 expression is upregulated in multiple cancers and promotes cancer malignancy. Remarkably, the regulation of claudin-2 expression in kidney cell lines contrasts its reported regulation in other organs...

    Authors: Balawant Kumar, Rizwan Ahmad, Giovanna A. Giannico, Roy Zent, Geoffrey A. Talmon, Raymond C. Harris, Peter E. Clark, Vinata Lokeshwar, Punita Dhawan and Amar B. Singh
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:77
  22. Accumulating evidence has revealed that circular RNAs (circRNAs), as novel noncoding RNAs, play critical roles in carcinogenesis and tumor progression. However, the functions and molecular mechanisms of circRN...

    Authors: Qi Lv, Gangmin Wang, Yinan Zhang, Aijun Shen, Junjun Tang, Yi Sun, Chunhui Ma and Peijun Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:76
  23. The Mnk2 kinase, encoded by MKNK2 gene, plays critical roles in MAPK signaling and was involved in oncogenesis. Human MKNK2 pre-mRNA can be alternatively spliced into two splicing isoforms, the MKNK2a and MKNK2b,...

    Authors: Hongda Liu, Zheng Gong, Kangshuai Li, Qun Zhang, Zekuan Xu and Yunfei Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:75
  24. Immune checkpoint inhibitors provide considerable therapeutic benefit in a range of solid cancers as well as in a subgroup of hematological malignancies. Response rates are however suboptimal, and despite cons...

    Authors: Allan Relecom, Maysaloun Merhi, Varghese Inchakalody, Shahab Uddin, Darawan Rinchai, Davide Bedognetti and Said Dermime
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:74
  25. In hepatocellular carcinoma patients, due to the microenvironmental specificity of liver, the tumor microenvironment exhibits high immunosuppression and drug resistance, resulting in excessive or insufficient ...

    Authors: Jingyi Zhou, Weiyu Wang and Qi Li
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:73
  26. Long non-coding RNAs (lncRNAs) are widely involved in human cancers’ progression by regulating tumor cells’ various malignant behaviors. MAPKAPK5-AS1 has been recognized as an oncogene in colorectal cancer. Ho...

    Authors: Liang Wang, Liankang Sun, Runkun Liu, Huanye Mo, Yongshen Niu, Tianxiang Chen, Yufeng Wang, Shaoshan Han, Kangsheng Tu and Qingguang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:72
  27. Previous research has highlighted the ability of Homeobox A10 (HOXA10) to the promote proliferation, migration, and epithelial-mesenchymal transformation of various cancers, including lung adenocarcinoma (LAD)...

    Authors: Tiangang Ma, Bingdi Yan, Yanbing Hu and Qinghua Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:71
  28. MicroRNAs (miRs) have been shown to play an important role in tumorigenesis, including in head and neck squamous cell carcinoma (HNSCC). The miR-34 family is thought to play a role in tumor suppression, but th...

    Authors: Xun Wu, Yi-Shing Lisa Cheng, Mathew Matthen, Angela Yoon, Gary K. Schwartz, Shashi Bala, Alison M. Taylor and Fatemeh Momen-Heravi
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:70
  29. Gene amplification of MET, which encodes for the receptor tyrosine kinase c-MET, occurs in a variety of human cancers. High c-MET levels often correlate with poor cancer prognosis. Interleukin-like EMT inducer (I...

    Authors: Ulrike Schmidt, Gerwin Heller, Gerald Timelthaler, Petra Heffeter, Zsolt Somodi, Norbert Schweifer, Maria Sibilia, Walter Berger and Agnes Csiszar
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:69
  30. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Chunmei Guo, Chao Gao, Dongting Zhao, Jiahui Li, Jinxia Wang, Xujuan Sun, Qinlong Liu, Lihong Hao, Frederick T. Greenaway, Yuxiang Tian, Shuqing Liu and Ming-Zhong Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:68

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:70

  31. Currently, tRNA-derived small RNAs (tsRNAs) are recognized as a novel and potential type of non-coding RNAs (ncRNAs), which participate in various cellular processes and play an essential role in cancer progre...

    Authors: En-Wei Tao, Hao-Lian Wang, Wing Yin Cheng, Qian-Qian Liu, Ying-Xuan Chen and Qin-Yan Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:67
  32. The abnormal expression of circular RNAs (circRNAs) in uveal melanoma (UM) has been revealed, but the specific underlying molecular mechanism of their association with UM development has not been fully explored.

    Authors: Shuting Liu, Liang Chen, Hua Chen, Kangkang Xu, Xi Peng and Mingchang Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:66
  33. Bladder carcinoma is one of the most common urological cancers. ITPR3, as a ubiquitous endoplasmic reticulum calcium channel protein, was reported to be involved in the development and progression of various t...

    Authors: Mengzhao Zhang, Lu Wang, Yangyang Yue, Lu Zhang, Tianjie Liu, Minxuan Jing, Xiao Liang, Minghai Ma, Shan Xu, Ke Wang, Xinyang Wang and Jinhai Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:65
  34. Emerging evidence indicates that metabolism reprogramming and abnormal acetylation modification play an important role in lung adenocarcinoma (LUAD) progression, although the mechanism is largely unknown.

    Authors: Hui-er Zhu, Tao Li, Shengnan Shi, De-xiong Chen, Weiping Chen and Hui Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:64
  35. Ferritin receptor (CD71) is an example of a very attractive cancer target, since it is highly expressed in virtually all tumor types, including metastatic loci. However, this target can be considered to be ina...

    Authors: Elisabetta Falvo, Verena Damiani, Giamaica Conti, Federico Boschi, Katia Messana, Patrizio Giacomini, Michele Milella, Vincenzo De Laurenzi, Veronica Morea, Gianluca Sala, Giulio Fracasso and Pierpaolo Ceci
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:63
  36. Homeobox A10 (HOXA10) belongs to the HOX gene family, which plays an essential role in embryonic development and tumor progression. We previously demonstrated that HOXA10 was significantly upregulated in gastr...

    Authors: Chenlong Song and Chongzhi Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:62
  37. ONC201 is a dopamine receptor D2 (DRD2) antagonist that inhibits tumor growth in preclinical models through ClpP activation to induce integrated stress response pathway and mitochondrial events related to inhi...

    Authors: Stuart R. Pierce, Ziwei Fang, Yajie Yin, Lindsay West, Majdouline Asher, Tianran Hao, Xin Zhang, Katherine Tucker, Allison Staley, Yali Fan, Wenchuan Sun, Dominic T. Moore, Chang Xu, Yi-Hsuan Tsai, Joel Parker, Varun Vijay Prabhu…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:61
  38. Indoleamine 2,3-dioxygenase 1 (IDO1), a monomeric heme-containing enzyme, catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan metabolism, which plays an important role in immunit...

    Authors: Yu Yao, Heng Liang, Xin Fang, Shengnan Zhang, Zikang Xing, Lei Shi, Chunxiang Kuang, Barbara Seliger and Qing Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:60
  39. c-Myc, a well-established oncogene, plays an important role in the initiation and progression of various cancers, including prostate cancer. However, its mechanism in cancer cell remains largely unknown and wh...

    Authors: Jianchao Ge, Wandong Yu, Junhong Li, Hangbin Ma, Pengyu Wang, Yinghao Zhou, Yang Wang, Jun Zhang and Guowei Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:59
  40. Hepatocellular carcinoma (HCC) is a common type of malignant human cancer with high morbidity and poor prognosis, causing numerous deaths per year worldwide. Growing evidence has been demonstrated that long no...

    Authors: He Zhu, Hongwei Zhang, Youliang Pei, Zhibin Liao, Furong Liu, Chen Su, Yachong Liu, Renshun Dong, Jia Song, Xuewu Zhang, Yawei Fan, Huifang Liang, Bixiang Zhang and Xiaoping Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:57
  41. Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high proliferative activity. TNBC tumors exhibit elevated MYC expression and altered expression of MYC regulatory genes, whic...

    Authors: Yunting Jian, Xinjian Huang, Lishan Fang, Meng Wang, Qinghua Liu, Hongyi Xu, Lingzhi Kong, Xiangfu Chen, Ying Ouyang, Xi Wang, Weidong Wei and Libing Song
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:56
  42. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Junfeng Sun, Jiyi Hu, Guojun Wang, Zhen Yang, Chunlin Zhao, Xiefu Zhang and Jiaxiang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:55

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:106

  43. Accumulating evidence has highlighted the importance of negative elongation factor complex member E (NELFE) in tumorigenesis. However, the relationship between NELFE and gastric cancer (GC) remains unclear. Th...

    Authors: Shijun Yu, Li Li, Hui Cai, Bin He, Yong Gao and Yandong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:54
  44. Hepatocellular carcinoma (HCC) is one of the most common cancers with high incidence and mortality. However, the underlying mechanisms of HCC still remain unclear. Eukaryotic translation initiation factors (eI...

    Authors: Shuangshuang Li, Jiajia Shao, Guohua Lou, Chao Wu, Yanning Liu and Min Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:53
  45. Increasing studies have shown that long noncoding RNAs (lncRNAs) are pivotal regulators participating in carcinogenic progression and tumor metastasis in colorectal cancer (CRC). Although lncRNA long intergeni...

    Authors: Pingfu Hou, Sen Meng, Minle Li, Tian Lin, Sufang Chu, Zhongwei Li, Junnian Zheng, Yuming Gu and Jin Bai
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:52

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:365

  46. Occurring in over 60% of human genes, alternative polyadenylation (APA) results in numerous transcripts with differing 3’ends, thus greatly expanding the diversity of mRNAs and of proteins derived from a singl...

    Authors: Yi Zhang, Lian Liu, Qiongzi Qiu, Qing Zhou, Jinwang Ding, Yan Lu and Pengyuan Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:51
  47. Forkhead box C1 (FOXC1), as a member of the FOX family, is important for promote HCC invasion and metastasis. FOX family protein lays a pivotal role in metabolism. ROS is involved in tumor progression and is a...

    Authors: Zhuoying Lin, Wenjie Huang, Qin He, Dongxiao Li, Zhihui Wang, Yangyang Feng, Danfei Liu, Tongyue Zhang, Yijun Wang, Meng Xie, Xiaoyu Ji, Mengyu Sun, Dean Tian and Limin Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:50
  48. Myelofibrosis (MF) is a clonal disorder of hemopoietic stem/progenitor cells (HSPCs) with high prevalence in elderly patients and mutations in three driver genes (JAK2, MPL, or CALR). Around 10–15% of patients ar...

    Authors: Dorian Forte, Martina Barone, Cristina Morsiani, Giorgia Simonetti, Francesco Fabbri, Samantha Bruno, Erika Bandini, Daria Sollazzo, Salvatore Collura, Maria Chiara Deregibus, Giuseppe Auteri, Emanuela Ottaviani, Nicola Vianelli, Giovanni Camussi, Claudio Franceschi, Miriam Capri…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:49
  49. As a novel type of non-coding RNA, circular RNAs (circRNAs) play a critical role in the initiation and development of various diseases, including cancer. However, the exact function of circRNAs in human cervic...

    Authors: Mingyi Zhou, Zhuo Yang, Danbo Wang, Peng Chen and Yong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:48
  50. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jian Li, Danli Ye, Peng Shen, Xiaorong Liu, Peirong Zhou, Guifang Zhu, Yangwei Xu, Yun Fu, Xuanqi Li, Jingbo Sun, Jia Xu and Qingling Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:46

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:212

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  • Citation Impact 2023
    Journal Impact Factor: 11.4
    5-year Journal Impact Factor: 11.4
    Source Normalized Impact per Paper (SNIP): 1.770
    SCImago Journal Rank (SJR): 2.806

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    Submission to first editorial decision (median days): 5
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