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  1. Our previous work showed that some Rho GTPases, including Rho, Rac1 and Cdc42, play critical roles in gastric cancer (GC); however, how they are regulated in GC remains largely unknown. In this study, we aimed...

    Authors: Xiaowei Li, Mingzuo Jiang, Di Chen, Bing Xu, Rui Wang, Yi Chu, Weijie Wang, Lin Zhou, Zhijie Lei, Yongzhan Nie, Daiming Fan, Yulong Shang, Kaichun Wu and Jie Liang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:71
    Content type: Research Published on:

  2. The adipocyte remodeling, including of the morphological change, might indicate special pathological function. Our previous study found that the morphological remodeling of larger marrow adipocytes into small ...

    Authors: Wei Lu, Yun Wan, Zhiqiang Li, Bin Zhu, Chunrong Yin, Haiyan Liu, Shaoxin Yang, Yuanmei Zhai, Yehua Yu, Yanyu Wei and Jun Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:66
    Content type: Research Published on:

  3. PHD-finger domain protein 5A (PHF5A) is a highly conserved small transcriptional regulator also involved in pre-mRNA splicing; however, its biological functions and molecular mechanisms in non-small cell lung ...

    Authors: Yan Yang, Jian Zhu, Tiantian Zhang, Jing Liu, Yumei Li, Yue Zhu, Lingjie Xu, Rui Wang, Fang Su, Yurong Ou and Qiong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:65
    Content type: Research Published on:

  4. miR-141 is up-regulated and plays crucial roles in nasopharyngeal carcinoma (NPC). However, the molecular mechanism underlying the dysregulation of miR-141 is still obscure.

    Authors: Yukun Liu, Ran Zhao, Yanmei Wei, Mengna Li, Heran Wang, Weihong Niu, Yao Zhou, Yuanzheng Qiu, Songqing Fan, Yihao Zhan, Wei Xiong, Yanhong Zhou, Xiaoling Li, Zheng Li, Guiyuan Li and Ming Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:64
    Content type: Research Published on:

  5. Metformin is a commonly used drug for the treatment of diabetes. Accumulating evidence suggests that it exerts anti-tumor effects in many cancers, including multiple myeloma (MM); however, the underlying molec...

    Authors: Yan Wang, Wenbin Xu, Zixun Yan, Weili Zhao, Jianqing Mi, Junmin Li and Hua Yan
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:63
    Content type: Research Published on:

  6. The bcr-abl fusion gene is the pathological origin of chronic myeloid leukemia (CML) and plays a critical role in the resistance of imatinib. Thus, bcr-abl disruption-based novel therapeutic strategy may warra...

    Authors: Ningshu Huang, Zhenglan Huang, Miao Gao, Zhenhong Luo, Fangzhu Zhou, Lin Liu, Qing Xiao, Xin Wang and Wenli Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:62
    Content type: Research Published on:

  7. The epidermal growth factor receptor (EGFR) plays important roles in cell survival, growth, differentiation, and tumorigenesis. Dysregulation of the EGFR is a common mechanism in cancer progression especially ...

    Authors: Meng-Shih Weng, Jer-Hwa Chang, Wen-Yueh Hung, Yi-Chieh Yang and Ming-Hsien Chien
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:61
    Content type: Review Published on:

  8. In the publication of this article [1], there is an error in the Methods section at paragraph Cell culture and reagents and the Additional file2: Fig. S1 was erroneous linked.

    Authors: Mengmeng Zhang, Fei Miao, Rong Huang, Wenjie Liu, Yuechao Zhao, Tao Jiao, Yalan Lu, Fan Wu, Xiaojuan Wang, Han Wang, Hong Zhao, Hongge Ju, Shiying Miao, Linfang Wang and Wei Song
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:60
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:22

  9. CDK5RAP3 was initially isolated as a binding protein of the CDK5 activator p35. Although CDK5RAP3 has been shown to negatively regulate the Wnt/β-catenin signaling pathway in gastric cancer by repressing GSK-3...

    Authors: Chao-Hui Zheng, Jia-Bin Wang, Man-Qiang Lin, Peng-Yang Zhang, Li-Chao Liu, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Jian-Wei Xie, Ping Li and Chang-Ming Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:59
    Content type: Research Published on:

  11. Developing drugs that target KRAS, the most frequently mutated oncogene in cancer, has not been successful despite much concerted efforts dedicated towards it in the last thirty years. Considering the key role th...

    Authors: Manuela Porru, Luca Pompili, Carla Caruso, Annamaria Biroccio and Carlo Leonetti
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:57
    Content type: Research Published on:

  12. This study aims to clarify the underlying mechanism for the tumor suppressive function of lnc TUSC7 in chemotherapy resistance of esophageal squamous cell carcinoma (ESCC).

    Authors: Zhi-wei Chang, Yong-xu Jia, Wei-jie Zhang, Li-jie Song, Ming Gao, Ming-jun Li, Rui-hua Zhao, Jing Li, Ya-li Zhong, Qiao-zhi Sun and Yan-ru Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:56
    Content type: Research Published on:

  13. Precision medicine calls for an early indicator of treatment efficiency. Circulating tumor DNA (ctDNA) is a promising marker in this setting. Our prospective study explored the association between disease deve...

    Authors: C. B. Thomsen, T. F. Hansen, R. F. Andersen, J. Lindebjerg, L. H. Jensen and A. Jakobsen
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:55
    Content type: Research Published on:

  14. Diabetic patients have a higher risk factor for colorectal cancer (CRC) metastasis. Stearoyl-CoA desaturase 1 (SCD1), the main enzyme responsible for producing monounsaturated fatty acids(MUFA) from saturated fat...

    Authors: Hui Ran, Yemin Zhu, Ruyuan Deng, Qi Zhang, Xisheng Liu, Ming Feng, Jie Zhong, Shuhai Lin, Xuemei Tong and Qing Su
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:54
    Content type: Research Published on:

  15. Ovarian cancer is a deadly disease. Inhibitors of apoptosis proteins (IAPs) are key regulators of apoptosis and are frequently dysregulated in ovarian cancer. Overexpression of IAPs proteins has been correlate...

    Authors: Bao-Xia Li, Heng-Bang Wang, Miao-Zhen Qiu, Qiu-Yun Luo, Han-Jie Yi, Xiang-Lei Yan, Wen-Tao Pan, Lu-Ping Yuan, Yu-Xin Zhang, Jian-Hua Xu, Lin Zhang and Da-Jun Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:53
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:108

  16. Multidrug resistance is the main obstacle for hepatocellular carcinoma (HCC) treatment. miR-32-5p is involved in HCC progression but its function in multidrug resistance is still unclear. Here we aim to find o...

    Authors: Xiao Fu, Mengjie Liu, Shengyang Qu, Jiequn Ma, Yamin Zhang, Tingting Shi, Hongqing Wen, Yujuan Yang, Shuhong Wang, Jing Wang, Kejun Nan, Yu Yao and Tao Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:52
    Content type: Research Published on:

  17. Triptolide is a structurally unique diterpene triepoxide with potent antitumor activity. However,the effect and mechanism of triptolide on hepatocellular carcinoma (HCC) is not well studied.

    Authors: Shu-Guang Li, Qian-Wei Shi, Ling-yan Yuan, Li-ping Qin, Yan Wang, Yu-Qing Miao, Zhe Chen, Chang-Quan Ling and Wen-xing Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:51
    Content type: Research Published on:

  18. Dysregulation of eukaryotic translation elongation factor 1 delta (EEF1D) in cancers has been reported; however, the role and mechanisms of EEF1D in osteosarcoma remain poorly understood. The aim of this study...

    Authors: Dong-dong Cheng, Shi-jie Li, Bin Zhu, Shu-min Zhou and Qing-cheng Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:50
    Content type: Research Published on:

  19. Accumulating evidence confirm that aberrant microRNAs (miRNAs) expression contributes to hepatocellular carcinoma (HCC) development and progression. Previous study reported that miR-1468 showed an up-regulated...

    Authors: Zhikui Liu, Yufeng Wang, Changwei Dou, Liankang Sun, Qing Li, Liang Wang, Qiuran Xu, Wei Yang, Qingguang Liu and Kangsheng Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:49
    Content type: Research Published on:

  21. The United States Food and Drug Administration (FDA) recently approved the clinical use of two comprehensive ‘mid-size’ Next Generation Sequencing (NGS) panels calling actionable genomic aberrations in cancer....

    Authors: Matteo Allegretti, Alessandra Fabi, Simonetta Buglioni, Aline Martayan, Laura Conti, Edoardo Pescarmona, Gennaro Ciliberto and Patrizio Giacomini
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:47
    Content type: Commentary Published on:

  22. Cell adhesion molecules (CADMs) comprise of a protein family whose functions include maintenance of cell polarity and tumor suppression. Hypo-expression of CADM2 gene expression has been observed in several ca...

    Authors: Dongliang Li, Yongjian Zhang, He Zhang, Chao Zhan, Xin Li, Tu Ba, Zini Qiu, Fang E, Guixiang Lv, Chendan Zou, Chuxuan Wang, Lining Si, Chaoxia Zou, Qiang Li and Xu Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:46
    Content type: Research Published on:

  23. Castor zinc finger 1 (CASZ1) plays critical roles in various biological processes and pathologic conditions, including cancer. However, the prognostic importance and biologic functions of CASZ1 in hepatocellul...

    Authors: Ji-Long Wang, Meng-yuan Yang, Shuai Xiao, Bo Sun, Yi-Ming Li and Lian-Yue Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:45
    Content type: Research Published on:

  24. T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and plays a crucial part in tumor-induced immune suppression. However, the mechanism of TIM3 in regulating immunosuppression in head and nec...

    Authors: Jian-Feng Liu, Lei Wu, Lei-Lei Yang, Wei-Wei Deng, Liang Mao, Hao Wu, Wen-Feng Zhang and Zhi-Jun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:44
    Content type: Research Published on:

  25. Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limi...

    Authors: Jianjun Zhu, Mingpeng Jin, Jiaojiao Wang, Hui Zhang, Yousheng Wu, Deyang Li, Xiaoying Ji, Hushan Yang, Chun Yin, Tingting Ren and Jinliang Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:43
    Content type: Research Published on:

  26. Anti-CD105 mAb-conjugated immunoliposomes, loaded with secreted mouse endostatin gene, were developed for targeted tumor imaging and antiangiogenic gene therapy.

    Authors: Huiqin Zhuo, Baoshi Zheng, Jianming Liu, Yong Huang, Huiling Wang, Duo Zheng, Naiquan Mao, Jinyu Meng, Sufang Zhou, Liping Zhong and Yongxiang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:42
    Content type: Research Published on:

  27. Many types of cancers are devoid of the small leucine-rich proteoglycans: osteoglycin (OGN), but its role in tumorigenesis is poorly studied especially in colorectal cancers (CRC). Here we aim to evaluate the ...

    Authors: Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng and San-Jun Cai
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:41
    Content type: Research Published on:

  28. Wilms’ tumor 1-associating protein (WTAP) plays an important role in physiological processes and the development of tumor such as cell cycle regulation. The regulation of cell cycle is mainly dependent on cycl...

    Authors: Jingyuan Tang, Feng Wang, Gong Cheng, Shuhui Si, Xi Sun, Jie Han, Hao Yu, Wei Zhang, Qiang Lv, Ji-Fu Wei and Haiwei Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:40
    Content type: Research Published on:

  29. The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. Howev...

    Authors: Xiangrui Li, Zhijian Zhang, Yao Zhang, Yuxiang Cao, Huijun Wei and Zhihao Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:39
    Content type: Research Published on:

  30. With cancer stem cells (CSCs) became the research hotspot, emerging studies attempt to reveal the functions of these special subsets in tumorigenesis. Although various approaches have been used in CSCs researc...

    Authors: Y. T. Luo, J. Cheng, X. Feng, S. J. He, Y. W. Wang and Q. Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:38
    Content type: Review Published on:

  31. Ovarian cancer is the most leading cause of death and the third most common gynecologic malignancy in women. Traditional chemotherapy has inevitable drawbacks of nonspecific tumor targeting, high toxicity, and...

    Authors: Shu Yao, Li Li, Xuan-tao Su, Kai Wang, Zai-jun Lu, Cun-zhong Yuan, Jin-bo Feng, Shi Yan, Bei-hua Kong and Kun Song
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:29
    Content type: Research Published on:

  32. Doxorubicin is the preferred chemotherapeuticdrug for osteosarcoma treatment of which clinical efficacy is limited because of its chemo-resistance and cardiac toxicity. It is necessary to develop the combinati...

    Authors: Wanchun Wang, Ding Chen and Kewei Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:37
    Content type: Research Published on:

  33. Current treatment for acute myeloid leukemia (AML) is less than optimal, but increased understanding of disease pathobiology and genomics has led to clinical investigation of novel targeted therapies and ratio...

    Authors: Silvia Boffo, Angela Damato, Luigi Alfano and Antonio Giordano
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:36
    Content type: Review Published on:

  34. In the publication of this article [1], there is an error in the first sentence of the Acknowledgements section.

    Authors: Enrico Vizza, Giacomo Corrado, Martina De Angeli, Mariantonia Carosi, Emanuela Mancini, Ermelinda Baiocco, Benito Chiofalo, Lodovico Patrizi, Ashanti Zampa, Giulia Piaggio and Lucia Cicchillitti
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:35
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:16

  35. CLCA2 was reported as a tumor suppressor and disregulated in breast cancer. However, its function in tumor growth and metastasis in NPC has rarely been reported. In this study, we investigated the functional a...

    Authors: Yuan-Yuan Qiang, Chang-Zhi Li, Rui Sun, Li-Sheng Zheng, Li-Xia Peng, Jun-Ping Yang, Dong-Fang Meng, Yan-Hong Lang, Yan Mei, Ping Xie, Liang Xu, Yun Cao, Wen-Wen Wei, Li Cao, Hao Hu, Qin Yang…
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:34
    Content type: Research Published on:

  36. Non-small-cell lung cancer (NSCLC) is currently the leading cause of cancer-related death. Accumulating evidences suggest that overcoming the therapeutic resistance in NSCLC is a big challenge. Recently, the o...

    Authors: Xing Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:33
    Content type: Commentary Published on:

  37. Extracellular matrix (ECM) is a mediator of tumor progression. However, whether the alterations of the intraperitoneal ECM prior to tumor establishment affects the malignant progression of ovarian cancer remai...

    Authors: Huiling Lai, Xuejiao Zhao, Yu Qin, Yi Ding, Ruqi Chen, Guannan Li, Marilyne Labrie, Zhiyong Ding, Jianfeng Zhou, Junbo Hu, Ding Ma, Yong Fang and Qinglei Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:32
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:415

  38. ATP-binding cassette subfamily G member 2 (ABCG2), a member of the ABC transporter superfamily proteins, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out of cancer cells and d...

    Authors: Xiaoran Guo, Kenneth K. W. To, Zhen Chen, Xiaokun Wang, Jianye Zhang, Min Luo, Fang Wang, Shirong Yan and Liwu Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:31
    Content type: Research Published on:

  40. Identification of novel MDM2 or p53 binding proteins may reveal undefined oncogenes, tumor suppressors, signaling pathways and possible treatment targets.

    Authors: Xingwang Xie, Xueyan Wang, Weijia Liao, Ran Fei, Nan Wu, Xu Cong, Qian Chen, Lai Wei, Yu Wang and Hongsong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:28
    Content type: Research Published on:

  41. Aberrant expression of transcription Factor AP-2 Gamma (TFAP2C) has been reported to be implicated in malignant process of many cancers. The purpose of this study is to investigate the clinical significance an...

    Authors: Xu Wang, Di Sun, Jiandong Tai, Si Chen, Miao Yu, Dong Ren and Lei Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:27
    Content type: Research Published on:

  42. Since Salinomycin (Sal) emerged its ability to target breast cancer stem cells in 2009, numerous experiments have been carried out to test Sal’s anticancer effects. What deserve to be mentioned is that Sal can...

    Authors: Jiang Jiang, Hailong Li, Eskandar Qaed, Jing Zhang, Yushu Song, Rong Wu, Xinmiao Bu, Qinyan Wang and Zeyao Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:26
    Content type: Review Published on:

  43. Pancreatic cancer characterizes high recurrence and poor prognosis. In clinical practice, radiotherapy is widely used for pancreatic cancer treatment. However, the outcome remains undesirable due to tumor repo...

    Authors: Chi Fang, Chen-yun Dai, Zhu Mei, Ming-jie Jiang, Dian-na Gu, Qian Huang and Ling Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:25
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:402

  44. Estrogen receptor alpha (ER alpha) is expressed in the majority of breast cancers and promotes estrogen-dependent cancer progression. ER alpha positive breast cancer can be well controlled by ER alpha modulato...

    Authors: Huijie Yang, Na Yu, Juntao Xu, Xiaosheng Ding, Wei Deng, Guojin Wu, Xin Li, Yingxiang Hou, Zhenhua Liu, Yan Zhao, Min Xue, Sifan Yu, Beibei Wang, Xiumin Li, Gang Niu, Hui Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:24
    Content type: Research Published on:

  45. 14,15-epoxyeicosatrienoic acid (14,15-EET) is an important lipid signaling molecule involved in the regulation of tumor metastasis, however, the role and molecular mechanisms of 14,15-EET activity in breast ca...

    Authors: Jing Luo, Jian-Feng Yao, Xiao-Fei Deng, Xiao-Dan Zheng, Min Jia, Yue-Qin Wang, Yan Huang and Jian-Hua Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:23
    Content type: Research Published on:

  46. 40–50% of colorectal cancer (CRC) patients develop metastatic disease; the presence of metastasis hinders the effective treatment of cancer through surgery, chemotherapy and radiotherapy, which makes 5-year su...

    Authors: Mengmeng Zhang, Fei Miao, Rong Huang, Wenjie Liu, Yuechao Zhao, Tao Jiao, Yalan Lu, Fan Wu, Xiaojuan Wang, Han Wang, Hong Zhao, Hongge Ju, Shiying Miao, Linfang Wang and Wei Song
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:22
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2018 37:60

  47. Prohibitin 1 (PHB) is a potential target for the treatment of urothelial carcinoma of the bladder (UCB). FL3 is a newly synthesized agent that inhibits cancer cell proliferation by targeting the PHB protein; h...

    Authors: Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou and Dan Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:21
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:291

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:115

  48. Antibody-Drug Conjugates (ADCs) are a class of cancer therapeutics that combines antigen specificity and potent cytotoxicity in a single molecule as they are comprised of an engineered antibody linked chemical...

    Authors: Cécile Chalouni and Sophia Doll
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:20
    Content type: Review Published on:

  49. Metastasis is one of the main reasons for treatment failure in endometrial cancer. Notably, high mobility group AT-hook 2 (HMGA2) has been recognized as a driving factor of tumour metastasis. microRNAs (miRNAs...

    Authors: Jian Ma, Da Li, Fan-Fei Kong, Di Yang, Hui Yang and Xiao-Xin Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:19
    Content type: Research Published on:

  50. The tumour microenvironment is essential for cancer progress and metastasis. Integrin-β5 (ITGB5), a member of the integrin family, has been implicated to mediate the interactions of cells with the extracellula...

    Authors: Zhikun Lin, Ruiping He, Haifeng Luo, Chang Lu, Zhen Ning, Yuanhang Wu, Chuanchun Han, Guang Tan and Zhongyu Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:17
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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