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  1. Gastric cancer (GC) is among the most commonly cancer occurred in Asian, especially in China. With its high heterogeneity and few of validated drug targets, GC remains to be one of the most under explored area...

    Authors: Jia-Qi Wu, Jing Zhai, Chong-Yong Li, Ai-Min Tan, Ping Wei, Li-Zong Shen and Ming-Fang He
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:160
  2. Though androgen deprivation therapy is the standard treatment for prostate cancer (PCa), most patients would inevitably progress to castration-resistant prostate cancer (CRPC) which is the main cause of PCa de...

    Authors: Zhixin Ling, Xiaoyan Wang, Tao Tao, Lei Zhang, Han Guan, Zonghao You, Kai Lu, Guangyuan Zhang, Shuqiu Chen, Jianping Wu, Jinke Qian, Hui Liu, Bin Xu and Ming Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:159
  3. MicroRNAs function as key regulators in various human cancers, including breast cancer (BC). MiR-361-5p has been proved to be a tumor suppressor in colorectal cancer and gastric cancer in our previous study. I...

    Authors: Fei Ma, Lei Zhang, Li Ma, Yiyun Zhang, Jianguo Zhang and Baoliang Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:158
  4. Claudin-6 (CLDN6), a member of CLDN family and a key component of tight junction, has been reported to function as a tumor suppressor in breast cancer. However, whether CLDN6 plays any role in breast cancer ch...

    Authors: Minlan Yang, Yanru Li, Xiangfeng Shen, Yang Ruan, Yan Lu, Xiangshu Jin, Peiye Song, Yantong Guo, Xiaoli Zhang, Huinan Qu, Yijia Shao and Chengshi Quan
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:157
  5. Transgelin-2 (TAGLN2) is a member of the calponin family of actin-bundling proteins that is involved in the regulation of cell morphology, motility, and cell transformation. Here, the clinical significance and...

    Authors: Ming-Zhi Han, Ran Xu, Yang-Yang Xu, Xin Zhang, Shi-Lei Ni, Bin Huang, An-Jing Chen, Yu-Zhen Wei, Shuai Wang, Wen-Jie Li, Qing Zhang, Gang Li, Xin-Gang Li and Jian Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:155
  6. ERBB2 is overexpressed in up to 20–30% of human breast cancers (BCs), and it is associated with aggressive disease. Trastuzumab (Tz), a humanized monoclonal antibody, improves the prognosis associated with ERB...

    Authors: Carolina D’Alesio, Grazia Bellese, Maria Cristina Gagliani, Cinzia Aiello, Elena Grasselli, Gianluca Marcocci, Angela Bisio, Sara Tavella, Tiziana Daniele, Katia Cortese and Patrizio Castagnola
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:154
  7. Clinically, breast cancer is generally classified into estrogen receptor-positive (ER+) or estrogen receptor-negative (ER−) subtypes. The phytoestrogen calycosin has been shown to inhibit the proliferation of ...

    Authors: Jing Tian, Yong Wang, Xing Zhang, Qianyao Ren, Rong Li, Yue Huang, Huiling Lu and Jian Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:153

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:184

  8. CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested t...

    Authors: Yu Zhang, Wei Liang, Peng Zhang, Jingyan Chen, Hui Qian, Xu Zhang and Wenrong Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:152
  9. The traditional treatment for cancer is lack of specificity and efficacy. Modular synthetic regulatory RNAs, such as inhibitive RNA (iRNA) and active RNA (aRNA), may overcome these limitations. Here, we synthe...

    Authors: Chengle Zhuang, Xinbo Huang, Changshui Zhuang, Xiaomin Luo, Xiaowei Zhang, Zhiming Cai and Yaoting Gui
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:151
  10. Although previous studies have shown promise for targeting Musashi RNA-binding protein 2 (MSI-2) in diverse tumors, the role and mechanism of MSI-2 for cervical cancer (CC) progression and the regulation of MS...

    Authors: Peixin Dong, Ying Xiong, Sharon J. B. Hanley, Junming Yue and Hidemichi Watari
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:150
  11. PTEN (phosphatase and tensin homolog gene on chromosome 10), a well-characterized tumor suppressor, is a key regulator of the phosphatidylinositol-3-kinase (PI3K)/AKT pathway involved in cell survival, metasta...

    Authors: Xu-Jie Zhou, Jing Wu, Liang Shi, Xiao-Xia Li, Lei Zhu, Xi Sun, Jia-Yi Qian, Ying Wang, Ji-Fu Wei and Qiang Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:149
  12. Infection with the hepatitis B virus (HBV) is closely associated with the development of hepatocellular carcinoma (HCC). The osmoregulatory transcription factor nuclear factor of activated T-cells 5 (NFAT5) ha...

    Authors: Xian Qin, Changsheng Li, Tao Guo, Jing Chen, Hai-Tao Wang, Yi-Tao Wang, Yu-Sha Xiao, Jun Li, Pengpeng Liu, Zhi-Su Liu and Quan-Yan Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:148
  13. Epigenetic abnormalities play important roles in nasopharyngeal cancer (NPC), however, the epigenetic changes associated with abnormal cell proliferation remain unclear.

    Authors: Jian Zhang, Xin Wen, Na Liu, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Pan-Pan Zhang, Jun Ma and Ying Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:147

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:394

  14. Abnormal proliferation is significantly associated with the promotion of malignant tumor. Growing evidence suggest that the signal pathways of p21cdc42/rac1-activated kinase 5 (PAK5) have been found in various tu...

    Authors: Ying-Chun Zhang, Fu-Chun Huo, Lu-Lu Wei, Chan-Chan Gong, Yao-Jie Pan, Jie Mou and Dong-Sheng Pei
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:146
  15. Accumulating evidences indicate that circular RNAs (circRNAs), a class of non-coding RNAs, play important roles in tumorigenesis. However, the function of circRNAs in triple negative breast cancer (TNBC) is la...

    Authors: Rongfang He, Peng Liu, Xiaoming Xie, Yujuan Zhou, Qianjin Liao, Wei Xiong, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng and Hailin Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:145
  16. Chemotherapy resistance remains a major challenge in cancer treatment. COX-2 (cyclooxygenase 2) is involved in drug resistance and poor prognosis of many neoplastic diseases or cancers. However, investigations...

    Authors: Wei Li, Yuanyuan Cao, Jinling Xu, Ying Wang, Weijie Li, Qian Wang, Ziwei Hu, Yaping Hao, Li Hu, Yawen Sun, Guanglin Xu and Guizhen Ao
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:144
  17. This is a retrospective cross sectional study aimed to verify whether Multiplex Ligation-dependent Probe Amplification (MLPA), a quantitative molecular assay, may represent a valuable reflex test in breast can...

    Authors: Cristiana Ercolani, Caterina Marchiò, Anna Di Benedetto, Alessandra Fabi, Letizia Perracchio, Patrizia Vici, Francesca Sperati, Simonetta Buglioni, Vincenzo Arena, Edoardo Pescarmona, Anna Sapino, Irene Terrenato and Marcella Mottolese
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:143
  18. The α-Melanocyte Stimulating Hormone (αMSH)/Melanocortin-1 receptor (MC1R) interaction promotes melanogenesis through the cAMP/PKA pathway. The direct induction of this pathway by Forskolin (FSK) is also known...

    Authors: Enrica Flori, Eleonora Rosati, Giorgia Cardinali, Daniela Kovacs, Barbara Bellei, Mauro Picardo and Vittoria Maresca
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:142
  19. Our previous studies reported that SHC SH2-domain binding protein 1 (SHCBP1) functions as an oncogene via promoting cell proliferations in synovial sarcoma (SS) cells. However, whether SHCBP1 has any effect on...

    Authors: Changliang Peng, Hui Zhao, Yan Song, Wei Chen, Xiaoying Wang, Xiaoli Liu, Cheng Zhang, Jie Zhao, Ji Li, Guanghui Cheng, Dongjin Wu, Chunzheng Gao and Xiuwen Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:141
  20. Recently, immunotherapy with anti-PD-1 antibodies has shown clinical benefit in recurrent Small Cell Lung Cancer (SCLC). Since anti-PD-1 re-activates anti-tumor Cytotoxic T Lymphocyte (CTL) responses, it is cr...

    Authors: Grazia Carbotti, Amin Reza Nikpoor, Paola Vacca, Rosaria Gangemi, Chiara Giordano, Francesco Campelli, Silvano Ferrini and Marina Fabbi
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:140
  21. Prostate cancer (PCa) is one of the most frequent tumors and leading cause of cancer deaths among males worldwide. The majority of deaths are due to recurrence and subsequent development of the metastatic canc...

    Authors: Pei-Jie Zhou, Wei Xue, Jinliang Peng, Yanqing Wang, Lianzi Wei, Ziqiang Yang, Helen He Zhu, Yu-Xiang Fang and Wei-Qiang Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:139
  22. miR-203a-3p was reported as a tumor suppressor and disregulated in many malignancies including nasopharyngeal carcinoma (NPC). However, its function in tumor growth and metastasis in NPC has rarely been reported.

    Authors: Ning Jiang, Xuesong Jiang, Zhenzhang Chen, Xue Song, Lirong Wu, Dan Zong, Dan Song, Li Yin, Dejun Wang, Cheng Chen, Xiuhua Bian and Xia He
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:138
  23. Chemo-resistance is a leading cause of tumor relapse and treatment failure in patients with ovarian cancer. The identification of effective strategies to overcome drug resistance will have a significant clinic...

    Authors: Shanyang He, Gang Niu, Jianhong Shang, Yalan Deng, Zhiyong Wan, Cai Zhang, Zeshan You and Hongwei Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:137
  24. Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression.We and others find that YAP is up-regulated in human gliomas a...

    Authors: Yan Wang, Peng Pan, Zhaohao Wang, Yu Zhang, Peng Xie, Decheng Geng, Yang Jiang, Rutong Yu and Xiuping Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:136
  25. Glioblastoma (GB) is the most malignant brain tumor in adults. It is characterized by angiogenesis and a high proliferative and invasive capacity. Standard therapy (surgery, radiotherapy and chemotherapy with ...

    Authors: Anne Clavreul, Milad Pourbaghi-Masouleh, Emilie Roger, Nolwenn Lautram, Claudia N. Montero-Menei and Philippe Menei
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:135
  26. Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC...

    Authors: Jie Lin, Wansong Lin, Yunbin Ye, Liping Wang, Xiaoyan Chen, Shengbing Zang and Aimin Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:134
  27. Extranodal NK/T cell lymphoma (NKTCL) is a highly aggressive non-Hodgkin lymphoma with poor prognosis. Resveratrol (RSV, 3,5,4′-trihydroxystilbene), a natural nontoxic phenolic compound found in the skin of gr...

    Authors: Xianxian Sui, Canjing Zhang, Jianan Zhou, Shengxuan Cao, Chen Xu, Feng Tang, Xiuling Zhi, Bobin Chen, Songmei Wang and Lianhua Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:133
  28. Malignant glioma is the most common primary brain tumor in adults and has a poor prognosis. However, there are no effective targeted therapies for glioma patients. Thus, the development of novel targeted thera...

    Authors: Chenglong Yue, Mingshan Niu, Qian Qian Shan, Ting Zhou, Yiming Tu, Peng Xie, Lei Hua, Rutong Yu and Xuejiao Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:132
  29. As a disease with extremely complex molecular mechanisms, many deregulated miRNAs have been identified in colon cancer. Few studies have been performed by using Ingenuity Pathways Analysis (IPA) to predict miR...

    Authors: Tao Jiang, Ling Ye, Zhongbo Han, Yuan Liu, Yinxue Yang, Zhihai Peng and Junwei Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:131
  30. The tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even enhances their aggressive phenotype. However, little is known about the mol...

    Authors: Zhi-hang Zhou, Jin-wen Song, Wen Li, Xue Liu, Liu Cao, Lu-ming Wan, Ying-xia Tan, Shou-ping Ji, Yu-mei Liang and Feng Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:130
  31. The purpose of this study was to elucidate the regulation of programmed death ligand 1 (PDL1), lactate dehydrogenase A (LDHA) and miR-34a in triple negative breast cancer (TNBC) and to explore the function and...

    Authors: Xiaojia Huang, Xinhua Xie, Hua Wang, Xiangsheng Xiao, Lu Yang, Zhi Tian, Xiaofang Guo, Lijuan Zhang, Hailin Tang and Xiaoming Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:129
  32. The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically t...

    Authors: Nicola Silvestris, Gennaro Ciliberto, Paolo De Paoli, Giovanni Apolone, Maria Luisa Lavitrano, Marco A. Pierotti and Giorgio Stanta
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:128
  33. The prognosis of human astrocytoma is poor, and the molecular alterations underlying its pathogenesis still needed to be elucidated. Nucleolar and spindle associated protein 1 (NUSAP1) was observed in several ...

    Authors: Xianqiu Wu, Benke Xu, Chao Yang, Wentao Wang, Dequan Zhong, Zhan Zhao, Longshuang He, Yuanjun Hu, Lili Jiang, Jun Li, Libing Song and Wei Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:127
  34. As an important cellular stress sensor phosphoprotein p53 can trigger cell cycle arrest and apoptosis and regulate autophagy. The p53 activity mainly depends on its transactivating function, however, how p53 c...

    Authors: Alessia Garufi, Giuseppa Pistritto, Silvia Baldari, Gabriele Toietta, Mara Cirone and Gabriella D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:126
  35. ICG-001, a small molecule, binds CREB-binding protein (CBP) to disrupt its interaction with β-catenin and inhibits CBP function as a co-activator of Wnt/β-catenin-mediated transcription. Given its ability to i...

    Authors: Yi Liu, Hui Chen, Peiming Zheng, Yingxia Zheng, Qin Luo, Guohua Xie, Yanhui Ma and Lisong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:125
  36. Pancreatic cancer is generally acknowledged as the most common primary malignant tumor, and it is known to be resistant to conventional chemotherapy. Novel, selective antitumor agents are pressingly needed.

    Authors: Zihang Xu, Fei Zhang, Chao Bai, Chao Yao, Hairong Zhong, Chunpu Zou and Xiao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:124

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:263

  37. Development of resistance to therapy continues to be a serious clinical problem in lung cancer management. We previously identified that Annexin A2 is significantly up-regulated in cisplatin-resistant non-smal...

    Authors: Xiaomin Feng, Hao Liu, Zhijie Zhang, Yixue Gu, Huisi Qiu and Zhimin He
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:123
  38. Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of t...

    Authors: Bernhard Englinger, Sebastian Kallus, Julia Senkiv, Daniela Heilos, Lisa Gabler, Sushilla van Schoonhoven, Alessio Terenzi, Patrick Moser, Christine Pirker, Gerald Timelthaler, Walter Jäger, Christian R. Kowol, Petra Heffeter, Michael Grusch and Walter Berger
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:122
  39. Next generation sequencing (NGS) is being increasingly applied for assisting cancer molecular diagnosis. However, it is still needed to validate NGS accuracy on detection of DNA alternations based on a large n...

    Authors: Dan Su, Dadong Zhang, Kaiyan Chen, Jing Lu, Junzhou Wu, Xinkai Cao, Lisha Ying, Qihuang Jin, Yizhou Ye, Zhenghua Xie, Lei Xiong, Weimin Mao and Fugen Li
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:121
  40. Non–small cell lung cancer (NSCLC) accounts for approximately 80–85% of all lung cancers and is usually diagnosed at an advanced stage with poor prognosis. Targeted therapy has produced unprecedented outcomes ...

    Authors: Xuanxuan Dai, Guilong Guo, Peng Zou, Ri Cui, Weiqian Chen, Xi Chen, Changtian Yin, Wei He, Rajamanickam Vinothkumar, Fan Yang, Xiaohua Zhang and Guang Liang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:120
  41. Previous clinical trials have already demonstrated that combinations of two or more drugs were more effective in the cancer treatment, especially sequential photodynamic design combing with sequential chemothe...

    Authors: Li Fan, Saisai Zhao, Qian Yang, Jiali Tan, Chaojun Song and Hong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:119
  42. Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown to enhance the efficacy of radiotherapy for certain solid tum...

    Authors: Xin Zhang, Ran Xu, Chao Zhang, Yangyang Xu, Mingzhi Han, Bin Huang, Anjing Chen, Chen Qiu, Frits Thorsen, Lars Prestegarden, Rolf Bjerkvig, Jian Wang and Xingang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:118
  43. The overall response rate of hepatocellular carcinoma (HCC) to chemotherapy is poor. In our previous study, oxaliplatin-resistant HCC is found to exhibit an enhanced stemness, and increased levels of CCN2 and ...

    Authors: Qingan Jia, Yang Bu, Zhiming Wang, Bendong Chen, Qiangbo Zhang, Songning Yu and Qingguang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:117
  44. NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response. However, the roles of NLRP3 inflammasome in the tumorigenesis and development of cancer stem cells (CS...

    Authors: Cong-Fa Huang, Lei Chen, Yi-Cun Li, Lei Wu, Guang-Tao Yu, Wen-Feng Zhang and Zhi-Jun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:116
  45. Metastatic malignant melanoma is one of the most aggressive malignancies and its treatment remains challenging. Recent studies demonstrate that the melanoma metastasis has correlations with the heightened acti...

    Authors: Ping Zhou, Jiaqi Qin, Yuan Li, Guoxia Li, Yinsong Wang, Ning Zhang, Peng Chen and Chunyu Li
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:115

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:84

  46. The potential mechanisms regarding how methylation of microRNA(miRNA) CpG Island could regulate cancer cell chemo-resistance remains unclear. This study aims to explore the epigenetic dysregulation mechanism o...

    Authors: Yixue Gu, Zhijie Zhang, Jiang Yin, Jiahui Ye, Yin Song, Hao Liu, Yan Xiong, Minying Lu, Guopei Zheng and Zhimin He
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:114
  47. Horizontal transfer of malignant traits from the primary tumor to distant organs, through blood circulating factors, has recently become a thoroughly studied metastatic pathway to explain cancer dissemination....

    Authors: Mohamed Abdouh, Dana Hamam, Zu-Hua Gao, Vincenzo Arena, Manuel Arena and Goffredo Orazio Arena
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:113
  48. Although major improvements have been made in surgical management, chemotherapeutic, and radiotherapeutic of prostate cancer, many prostate cancers remain refractory to treatment with standard agents. Therefor...

    Authors: Liwei Lang, Chloe Shay, Xiangdong Zhao and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:112
  49. Chemotherapy is one of major therapeutic regimens for neuroblastoma (NB) in children. However, recurrence and metastasis associated with poor prognosis caused by acquired multidrug resistance remains a challen...

    Authors: Yi Wang, Kai Chen, Yihong Cai, Yuanxia Cai, Xiaojun Yuan, Lifeng Wang, Zhixiang Wu and Yeming Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:111

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  • Citation Impact 2023
    Journal Impact Factor: 11.4
    5-year Journal Impact Factor: 11.4
    Source Normalized Impact per Paper (SNIP): 1.770
    SCImago Journal Rank (SJR): 2.806

    Speed 2023
    Submission to first editorial decision (median days): 5
    Submission to acceptance (median days): 100

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    Downloads: 3,003,080
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