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  1. Content type: Research

    Melanoma, the most aggressive form of skin cancer, is characterized by high rates of metastasis, drug resistance and mortality. Here we investigated the role of Semaphorin 5A (Sema5A) on the properties associa...

    Authors: Simona D’Aguanno, Elisabetta Valentini, Maria Grazia Tupone, Marianna Desideri, Marta Di Martile, Manuela Spagnuolo, Simonetta Buglioni, Cristiana Ercolani, Italia Falcone, Marco De Dominici, Michele Milella, Maria Giulia Rizzo, Bruno Calabretta, Carlo Cota, Andrea Anichini, Daniela Trisciuoglio…

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:278

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  2. Content type: Research

    Metastasis is the primary cause of death in renal cell carcinoma (RCC). Loss of cell-to-cell adhesion, including tight junctions (TJs) is the initial step in the process of metastasis. Claudin-7 (CLDN7) is a m...

    Authors: Yifan Li, Yanqing Gong, Xianghui Ning, Ding Peng, Libo Liu, Shiming He, Kan Gong, Cuijian Zhang, Xuesong Li and Liqun Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:276

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  3. Content type: Research

    As a type of recently discovered noncoding RNA, circular RNAs (circRNAs) exert pivot biological functions in diverse cancers. However, the role of circRNA_102171 in papillary thyroid cancer (PTC) has not been ...

    Authors: Wen Bi, Jiayu Huang, Chunlei Nie, Bo Liu, Guoqing He, Jihua Han, Rui Pang, Zhaoming Ding, Jin Xu and Jiewu Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:275

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  4. Content type: Research

    Reprogrammed energy metabolism has become an emerging hallmark of cancer in recent years. Transporters have been reported to be amino acid sensors involved in controlling mTOR recruitment and activation, which...

    Authors: Mengyu Feng, Guangbing Xiong, Zhe Cao, Gang Yang, Suli Zheng, Jiangdong Qiu, Lei You, Lianfang Zheng, Taiping Zhang and Yupei Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:274

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  5. Content type: Research

    Accumulating evidences have indicated that long non-coding RNAs (lncRNAs) are potential biomarkers that play key roles in tumor development and progression. Differentiation antagonizing non-protein noding RNA ...

    Authors: Yonghao Zhan, Zhicong Chen, Yifan Li, Anbang He, Shiming He, Yanqing Gong, Xuesong Li and Liqun Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:273

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  6. Content type: Research

    Multidrug resistance remains a major obstacle to successful treatment for patients with gastric cancer (GC). Recently, glycosylation has been demonstrated to play a vital role in the acquisition of multidrug r...

    Authors: Jian Wu, Sheng Chen, Hao Liu, Zhe Zhang, Zhen Ni, Jie Chen, Zhiping Yang, Yongzhan Nie and Daiming Fan

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:272

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  7. Content type: Research

    Bioenergetic characterisation of malignant tissues revealed that different tumour cells can catabolise multiple substrates as salvage pathways, in response to metabolic stress. Altered metabolism in gliomas ha...

    Authors: Zoltán Hujber, Gergő Horváth, Gábor Petővári, Ildikó Krencz, Titanilla Dankó, Katalin Mészáros, Hajnalka Rajnai, Norbert Szoboszlai, William P. J. Leenders, András Jeney, László Tretter and Anna Sebestyén

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:271

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  8. Content type: Correction

    In the publication of this article [1], there are two inadvertent errors.

    Authors: Wuhua Zhou, Li Gong, Qinchuan Wu, Chunyang Xing, Bajin Wei, Tianchi Chen, Yuan Zhou, Shengyong Yin, Bin Jiang, Haiyang Xie, Lin Zhou and Shusen Zheng

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:270

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:215

  9. Content type: Research

    Vitex negundo L (Verbenaceae) is an aromatic shrub that is abundant in Asian countries. A series of compounds from Vitex negundo have been used in traditional Chinese medicine for the treatment of various disease...

    Authors: Nian Liu, Kuan Song Wang, Min Qi, Ying Jun Zhou, Guang Yao Zeng, Juan Tao, Jian Da Zhou, Jiang Lin Zhang, Xiang Chen and Cong Peng

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:269

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  10. Content type: Research

    MicroRNAs (miRNAs) posttranscriptionally regulate gene expression and thereby contribute to the modulation of numerous complex and disease-relevant cellular processes, including cell proliferation, cell motili...

    Authors: Ke-ting Que, Yun Zhou, Yu You, Zhen Zhang, Xiao-ping Zhao, Jian-ping Gong and Zuo-jin Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:268

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  11. Content type: Correction

    In the publication of this article (1), there is an error in Fig. 5b. This has now been updated in the original article (1).

    Authors: Zeribe C. Nwosu, Nadia Battello, Melanie Rothley, Weronika Piorońska, Barbara Sitek, Matthias P. Ebert, Ute Hofmann, Jonathan Sleeman, Stefan Wölfl, Christoph Meyer, Dominik A. Megger and Steven Dooley

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:267

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:211

  12. Content type: Review

    Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer effect of these chemotherap...

    Authors: Haotian Yang, Rehan M Villani, Haolu Wang, Matthew J Simpson, Michael S Roberts, Min Tang and Xiaowen Liang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:266

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  13. Content type: Research

    Glioblastoma multiforme (GBM) is the common primary brain tumor classified the most malignant glioma. Long non-coding RNAs (LncRNAs) are important epigenetic regulators with critical roles in cancer initiation...

    Authors: Qi Li, Chengya Dong, Jiayue Cui, Yubo Wang and Xinyu Hong

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:265

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  14. Content type: Research

    Human carbonyl reductase 1 (CBR1) plays major roles in protecting cells against cellular damage resulting from oxidative stress. Although CBR1-mediated detoxification of oxidative materials increased by stress...

    Authors: Miyong Yun, Ae Jin Choi, Young Chan Lee, Munkyoo Kong, Ji-Youn Sung, Sung Soo Kim and Young-Gyu Eun

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:264

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  15. Content type: Research

    Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a high incidence and high mortality in East Asia. Identifying biomarkers and clarifying the regulatory mechanisms of HCC are of g...

    Authors: Cong Chen, Chao Ge, Zheng Liu, Liangyu Li, Fangyu Zhao, Hua Tian, Taoyang Chen, Hong Li, Ming Yao and Jinjun Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:263

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  16. Content type: Commentary

    This commentary wishes to highlight the 2018 Nobel Prize in Medicine awarded to two cancer immunotherapy scientists, Prof James Allison and Prof Tasuku Honjo, for their discovery on unleashing the body’s immun...

    Authors: Anand Rotte, Gabriella D’Orazi and Madhuri Bhandaru

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:262

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  17. Content type: Research

    The PD-L1/PD-1 pathway blockade-mediated immune therapy has shown promising efficacy in the treatment of multiple cancers including melanoma. The present study investigated the effects of the flavonoid apigeni...

    Authors: Lu Xu, Yang Zhang, Kang Tian, Xi Chen, Rongxin Zhang, Xindi Mu, Yueguang Wu, Duchuang Wang, Shanshan Wang, Fang Liu, Taishu Wang, Jinrui Zhang, Shuyan Liu, Yingqiu Zhang, Caixia Tu and Han Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:261

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  18. Content type: Research

    Antiangiogenic agents are commonly used in lung and colon cancer treatments, however, rapid development of drug resistance limits their efficacy.

    Authors: Shengming Deng, Guoxi Zhang, Jiajie Kuai, Peng Fan, Xuexiang Wang, Pei Zhou, Dan Yang, Xichen Zheng, Xiaomei Liu, Qunli Wu and Yuhui Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:260

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  19. Content type: Research

    Lysosome-associated agents have been implicated as possible chemo-sensitizers and immune regulators for cancer chemotherapy. We investigated the potential roles and mechanisms of hydroxychloroquine (HCQ) in co...

    Authors: Yong Li, Fengjun Cao, Mingxing Li, Pindong Li, Yuandong Yu, Longchao Xiang, Tao Xu, Jinhua Lei, Yun Yan Tai, Jianyong Zhu, Bingbing Yang, Yingpin Jiang, Xiufang Zhang, Long Duo, Ping Chen and Xiongjie Yu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:259

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  20. Content type: Research

    Neuroblastoma (NB) is the most common pediatric solid tumor that originates from neural crest-derived sympathoadrenal precursor cells that are committed to development of sympathetic nervous system. The well d...

    Authors: Yuting Gu, Fan Lv, Mingxing Xue, Kai Chen, Cheng Cheng, Xinyuan Ding, Min Jin, Guofeng Xu, Yanyun Zhang, Zhixiang Wu, Leizhen Zheng and Yeming Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:258

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  21. Content type: Research

    Breast cancer is a highly heterogeneous pathology, exhibiting a number of subtypes commonly associated with a poor outcome. Due to their high stability, microRNAs are often regarded as non-invasive cancer biom...

    Authors: Cornelia Braicu, Lajos Raduly, Gabriela Morar-Bolba, Roxana Cojocneanu, Ancuta Jurj, Laura-Ancuta Pop, Valentina Pileczki, Cristina Ciocan, Alin Moldovan, Alexandru Irimie, Alexandru Eniu, Patriciu Achimas-Cadariu, Angelo Paradiso and Ioana Berindan-Neagoe

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:257

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  22. Content type: Research

    Hypoxic tumor microenvironment and maintenance of stemness contribute to drug resistance in breast cancer. However, whether Hypoxia-inducible factor-2α (HIF-2α) in hypoxic tumor microenvironment mediates conve...

    Authors: Yuanyuan Yan, Fangxiao Liu, Li Han, Lin Zhao, Jianjun Chen, Olufunmilayo I Olopade, Miao He and Minjie Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:256

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  23. Content type: Research

    Sodium/hydrogen exchanger 1 (NHE1), encoded by the SLC9A1 gene (SoLute Carrier family 9A1) in humans, is the main H+ efflux mechanism in maintaining alkaline intracellular pH (pHi) and Warburg effects in glioma. ...

    Authors: Xiudong Guan, Lanxin Luo, Gulnaz Begum, Gary Kohanbash, Qingkun Song, Aparna Rao, Nduka Amankulor, Baoshan Sun, Dandan Sun and Wang Jia

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:255

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  24. Content type: Research

    Although tamoxifen is a highly effective drug for treating estrogen receptor–positive (ER+) breast cancer, nearly all patients with metastasis with initially responsive tumors eventually relapse, and die from acq...

    Authors: Yawei Shi, Yang Zhao, Yunjian Zhang, NiJiati AiErken, Nan Shao, Runyi Ye, Ying Lin and Shenming Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:254

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  25. Content type: Research

    Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), a long noncoding RNA, is significantly highly expressed and associated with metastasis and poor prognosis in many cancers, including nasopharyngeal...

    Authors: Yu Lian, Fang Xiong, Liting Yang, Hao Bo, Zhaojian Gong, Yumin Wang, Fang Wei, Yanyan Tang, Xiayu Li, Qianjin Liao, Hui Wang, Ming Zhou, Bo Xiang, Xu Wu, Yong Li, Xiaoling Li…

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:253

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  26. Content type: Research

    There is increasing evidence that liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) initiation and progression. MicroRNA (miRNA) plays a significant functional role by directly regul...

    Authors: Yu-Shui Ma, Zhong-Wei Lv, Fei Yu, Zheng-Yan Chang, Xian-Ling Cong, Xiao-Ming Zhong, Gai-Xia Lu, Jian Zhu and Da Fu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:252

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  27. Content type: Research

    The combination of phytochemicals with chemotherapy drugs is an emerging new strategy for cancer therapy to increase antitumor responses.

    Authors: Yang Wang, Xu Deng, Chang Yu, Guosheng Zhao, Jing Zhou, Ge Zhang, Ming Li, Dianming Jiang, Zhengxue Quan and Yuan Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:251

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  28. Content type: Research

    Temozolomide-perillyl alcohol conjugate (TMZ-POH), a novel Temozolomide (TMZ) analog developed based on the conjugation of TMZ and perillyl alcohol (POH), displayed strong anticancer potency in multiple cancer...

    Authors: Minghui Chang, Xingguo Song, Xinran Geng, Xingwu Wang, Weijun Wang, Thomas C. Chen, Li Xie and Xianrang Song

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:250

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  29. Content type: Correction

    In the publication of this article [1], there is an error in Fig. 4b. The Cyto c western blot image in Fig. 4b is misrepresented. This has now been included in this correction. The authors declare that the cor...

    Authors: Rui Yu, Bi-xia Yu, Jun-feng Chen, Xiu-yi Lv, Ze-jun Yan, Yue Cheng and Qi Ma

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:249

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:40

  30. Content type: Research

    Andrographolide (Andro), a diterpenoid lactone, has been used for treatment of various cancers with less adverse effects. However, the underlying mechanisms regarding its anti-tumor mechanism still remain uncl...

    Authors: Yulin Peng, Yan Wang, Ning Tang, Dongdong Sun, Yulong Lan, Zhenlong Yu, Xinyu Zhao, Lei Feng, Baojing Zhang, Lingling Jin, Fabiao Yu, Xiaochi Ma and Chuanzhu Lv

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:248

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  31. Content type: Research

    The Hedgehog (Hh) signaling pathway plays critical roles in modulating embryogenesis and maintaining tissue homeostasis, with glioma-associated oncogene (GLI) transcription factors being the main mediators. Ab...

    Authors: Dengliang Huang, Yiting Wang, Linlin Xu, Limin Chen, Minzhang Cheng, Wei Shi, Huanting Xiong, Detina Zalli and Shiwen Luo

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:247

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  32. Content type: Research

    The blood-brain barrier (BBB) strongly restricts the entry of anti-glioma drugs into tumor tissues and thus decreases chemotherapy efficacy. Malignant gliomas are highly invasive tumours that use the perivascu...

    Authors: Xue Leng, Jun Ma, Yunhui Liu, Shuyuan Shen, Hai Yu, Jian Zheng, Xiaobai Liu, Libo Liu, Jiajia Chen, Lini Zhao, Xuelei Ruan and Yixue Xue

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:246

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  33. Content type: Research

    Microenvironment cues involved in melanoma progression are largely unknown. Melanoma is highly influenced in its aggressive phenotype by the changes it determinates in its microenvironment, such as pH decrease...

    Authors: Zaira Boussadia, Jessica Lamberti, Fabrizio Mattei, Elisabetta Pizzi, Rossella Puglisi, Cristiana Zanetti, Luca Pasquini, Federica Fratini, Luca Fantozzi, Federica Felicetti, Katia Fecchi, Carla Raggi, Massimo Sanchez, Stefania D’Atri, Alessandra Carè, Massimo Sargiacomo…

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:245

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  34. Content type: Research

    Osteosarcoma is the most common bone cancer. Despite advances, molecular mechanisms associated with osteosarcoma have not been fully understood. Hence, an effective treatment for osteosarcoma has yet to be dev...

    Authors: Dongqing Zuo, Kristen L Shogren, Jie Zang, Donna E Jewison, Brian E Waletzki, Alan L Miller II, Scott H Okuno, Zhengdong Cai, Michael J Yaszemski and Avudaiappan Maran

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:244

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  35. Content type: Research

    Licorice is an herb extensively used for both culinary and medicinal purposes. Various constituents of licorice have been shown to exhibit anti-tumorigenic effect in diverse cancer types. However, majority of ...

    Authors: Changliang Chen, Anitha K. Shenoy, Ravi Padia, Dongdong Fang, Qing Jing, Ping Yang, Shi-Bing Su and Shuang Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:243

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  36. Content type: Research

    Cancer-associated fibroblasts (CAFs) have been widely reported to promote tumor angiogenesis. However, the underlying mechanisms of the proangiogenic switch of CAFs remain poorly understood. This study aims to...

    Authors: Xiaocheng Zhou, Tinglin Yan, Chunming Huang, Zhi Xu, Lin Wang, Erhui Jiang, Hui Wang, Yang Chen, Ke Liu, Zhe Shao and Zhengjun Shang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:242

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  37. Content type: Research

    Pancreatic cancer is a deadly disease with a very low 5-year patient survival rate of 6–8%. The major challenges of eliminating pancreatic cancer are treatment resistance and stromal barriers to optimal drug a...

    Authors: Xiang Ling, Wenjie Wu, Chuandong Fan, Chao Xu, Jianqun Liao, Laurie J. Rich, Ruea-Yea Huang, Elizabeth A. Repasky, Xinjiang Wang and Fengzhi Li

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:240

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  38. Content type: Research

    Glioblastoma (GBM) is the most common and most malignant primary brain cancer in adults. Despite multimodality treatment, the prognosis is still poor. Therefore, further work is urgently required to discover n...

    Authors: Wei Meng, Baocheng Wang, Weiwei Mao, Jiajia Wang, Yang Zhao, Qifeng Li, Chenran Zhang, Yujie Tang and Jie Ma

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:241

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  39. Content type: Review

    The mechanism by which c-Myc exerts its oncogenic functions is not completely clear and different hypotheses are still under investigation. The knowledge of the capacity of c-Myc to bind exclusively E-box sequ...

    Authors: Matteo Caforio, Cristina Sorino, Stefano Iacovelli, Maurizio Fanciulli, Franco Locatelli and Valentina Folgiero

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:239

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  40. Content type: Research

    Aberrant activation of Wnt/β-catenin signaling pathway is considered to be an important issue in progression and metastasis of various human cancers, especially in colorectal cancer (CRC). MiR-452 could activa...

    Authors: Tingting Li, Xiangyu Jian, Han He, Qiuhua Lai, Xianzheng Li, Danling Deng, Tengfei Liu, Jiehong Zhu, Hongli Jiao, Yaping Ye, Shuyang Wang, Minhui Yang, Lin Zheng, Weijie Zhou and Yanqing Ding

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:238

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  41. Content type: Research

    Long noncoding RNAs (LncRNAs) have been reported to be abnormally expressed in human ovarian cancer and associated with the proliferation and metastasis of cancer cells. The objective of this study was to inve...

    Authors: Huan Yan, Hong Li, Pengyun Li, Xia Li, Jianjian Lin, Linlin Zhu, Maria A. Silva, Xiaofang Wang, Ping Wang and Zhan Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:237

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  42. Content type: Research

    Pancreatic cancer (PC) is the fourth most common cause of cancer death. Combination therapies with classical chemotherapeutic agents improved treatment of advanced PC at the cost of a relevant toxicity, but th...

    Authors: Serena Veschi, Laura De Lellis, Rosalba Florio, Paola Lanuti, Alberto Massucci, Nicola Tinari, Michele De Tursi, Pierluigi di Sebastiano, Marco Marchisio, Clara Natoli and Alessandro Cama

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:236

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  43. Content type: Research

    We previously reported that miR-203 functions as a tumor suppressor in ovarian cancer cells by directly targeting transcription factor Snai2 and inhibiting epithelial to mesenchymal transition (EMT), whereas B...

    Authors: Baojin Wang, Xia Li, Guannan Zhao, Huan Yan, Peixin Dong, Hidemichi Watari, Michelle Sims, Wei Li, Lawrence M Pfeffer, Yuqi Guo and Junming Yue

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:235

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  44. Content type: Research

    The L-type amino acid transporter 1 (LAT1/SLC7A5) transports essential amino acids across the plasma membrane. While LAT1 is overexpressed in a variety of human neoplasms, its expression and its role in thyroid c...

    Authors: Pascal Häfliger, Julien Graff, Matthias Rubin, Amandine Stooss, Matthias S. Dettmer, Karl-Heinz Altmann, Jürg Gertsch and Roch-Philippe Charles

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:234

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  45. Content type: Research

    Patient-derived xenograft (PDX) tumor model has become a new approach in identifying druggable tumor mutations, screening and evaluating personalized cancer drugs based on the mutated targets.

    Authors: Cheng-Lung Hsu, Kar-Wai Lui, Lang-Ming Chi, Yung-Chia Kuo, Yin-Kai Chao, Chun-Nan Yeh, Li-Yu Lee, Yenlin Huang, Tung-Liang Lin, Mei-Yuan Huang, Yi-Ru Lai, Yuan-Ming Yeh, Hsien-Chi Fan, An-Chi Lin, Yen-Jung Lu, Chia-Hsun Hsieh…

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:233

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  46. Content type: Research

    Multidrug resistance (MDR) is often responsible for the failure of chemotherapy treatment, and current strategies for cancer MDR are not adequately satisfying as to their efficacy and safety. In this study, we...

    Authors: Chixiong Huang, Senlin Huang, Hairui Li, Xinzhong Li, Bing Li, Lintao Zhong, Junfeng Wang, Meishen Zou, Xiang He, Hao Zheng, Xiaoyun Si, Wangjun Liao, Yulin Liao, Li Yang and Jianping Bin

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:232

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  47. Content type: Research

    Cartilage oligomeric matrix protein (COMP) is known to promote fibrosis in skin, lung and liver. Emerging evidence shows that COMP plays critical roles in tumor development, including breast cancer, colon canc...

    Authors: Qing Li, Cong Wang, Yufeng Wang, Liankang Sun, Zhikui Liu, Liang Wang, Tao Song, Yingmin Yao, Qingguang Liu and Kangsheng Tu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:231

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  48. Content type: Research

    Non-small cell lung cancer (NSCLC) is a leading cause of death worldwide. MicroRNAs (miRNAs) have been indicated as crucial actors in cancer biology. Accumulating evidence suggests that miRNAs can be used as d...

    Authors: Xi He, Si-yuan Chen, Zhao Yang, Jie Zhang, Wei Wang, Mei-yue Liu, Yi Niu, Xiao-mei Wei, Hong-min Li, Wan-ning Hu and Guo-gui Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:230

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  49. Content type: Research

    The sperm-associated antigen 5 (SPAG5) plays a key role in controlling various cellular phenomena, including cell cycle progression and proliferation. However, the role of SPAG5 in hepatocellular carcinoma (HC...

    Authors: Hongliang Liu, Junwen Hu, Ran Wei, Longfei Zhou, Hua Pan, Hongchao Zhu, Mingwen Huang, Jun Luo and Wei Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:229

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  50. Content type: Research

    In this research, we aimed to investigate the biological functions of LIM domain only 3 (LMO3) in hepatocellular carcinoma (HCC) and uncover the underlying molecular mechanism in it.

    Authors: Yang Cheng, Tianlu Hou, Jian Ping, Tianyang Chen and Baobing Yin

    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:228

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