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  1. Macrophages take center stage in the tumor microenvironment, a niche composed of extracellular matrix and a heterogeneous group of cells, including immune ones. They can evolve during tumor progression and acq...

    Authors: Anna Maria Lucianò, Marta Di Martile, Ana B. Pérez-Oliva, Marica Di Caprio, Maria Laura Foddai, Simonetta Buglioni, Victoriano Mulero and Donatella Del Bufalo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:178
    Content type: Research Published on:

  2. Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits ar...

    Authors: Yaxian Wang, Xinyang Zhong, Xuefeng He, Zijuan Hu, Huixia Huang, Jiayu Chen, Keji Chen, Senlin Zhao, Ping Wei and Dawei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:177
    Content type: Review Published on:

  4. The mitogen-activated protein kinase (MAPK) signaling pathway is frequently hyperactivated in malignant melanoma and its inhibition has proved to be an efficient treatment option for cases harboring BRAFV600 muta...

    Authors: Corinna Kosnopfel, Simone Wendlinger, Heike Niessner, Johannes Siewert, Tobias Sinnberg, Angelika Hofmann, Jonas Wohlfarth, David Schrama, Marion Berthold, Claudia Siedel, Birgit Sauer, Aarthi Jayanthan, Georg Lenz, Sandra E. Dunn, Bastian Schilling and Birgit Schittek
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:175
    Content type: Research Published on:

  6. Cancer is the main cause of death worldwide and metastasis is a major cause of poor prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a multiplex process, including EMT throug...

    Authors: Mohammad Ahmad, Louis-Bastien Weiswald, Laurent Poulain, Christophe Denoyelle and Matthieu Meryet-Figuiere
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:173
    Content type: Review Published on:

  7. The interplay between gut microbiota and tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC) is largely unknown. Here, we elucidated the functional role of B. adolescentis and its possible...

    Authors: Yifeng Lin, Lina Fan, Yadong Qi, Chaochao Xu, Dingjiacheng Jia, Yao Jiang, Shujie Chen and Liangjing Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:172
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:212

  8. Chemotherapy, radiotherapy, targeted therapy, and immunotherapy are established cancer treatment modalities that are widely used due to their demonstrated efficacy against tumors and favorable safety profiles ...

    Authors: Ting-Wan Kao, Geng-Hao Bai, Tian-Li Wang, Ie-Ming Shih, Chi-Mu Chuang, Chun-Liang Lo, Meng-Chen Tsai, Li-Yun Chiu, Chu-Chien Lin and Yao-An Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:171
    Content type: Review Published on:

  9. Approximately 20–50% of patients presenting with localized colorectal cancer progress to stage IV metastatic disease (mCRC) following initial treatment and this is a major prognostic determinant. Here, we have...

    Authors: Mario Cioce, Maria Rita Fumagalli, Sara Donzelli, Frauke Goeman, Valeria Canu, Daniela Rutigliano, Giulia Orlandi, Andrea Sacconi, Claudio Pulito, Alina Catalina Palcau, Maurizio Fanciulli, Aldo Morrone, Maria Grazia Diodoro, Marco Caricato, Anna Crescenzi, Martina Verri…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:170
    Content type: Research Published on:

  10. Circular RNAs (circRNAs) contribute to multiple biological functions and are also involved in pathological conditions such as cancer. However, the role of circRNAs in metabolic reprogramming, especially upon e...

    Authors: Zhifei Ma, Hao Chen, Zhijun Xia, Jing You, Chencheng Han, Siwei Wang, Wenjia Xia, Yongkang Bai, Tongyan Liu, Lin Xu, Guoren Zhou, Youtao Xu and Rong Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:169
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:180

  12. Cutaneous squamous cell carcinoma (cSCC) is the second most prevalent form of skin cancer, showing a rapid increasing incidence worldwide. Although most cSCC can be cured by surgery, a sizeable number of cases...

    Authors: Marika Quadri, Natascia Tiso, Francesco Musmeci, Maria I. Morasso, Stephen R. Brooks, Luca Reggiani Bonetti, Rossana Panini, Roberta Lotti, Alessandra Marconi, Carlo Pincelli and Elisabetta Palazzo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:167
    Content type: Research Published on:

  13. Increasing evidence suggests a vital role of the pre-metastatic niche in the formation of distant metastasis of many cancers. However, how the pre-metastatic niche is formed and promotes pulmonary metastasis o...

    Authors: Chong Zhang, Qing Li, Qi Xu, Wei Dong, Chunmei Li, Bin Deng, Jiao Gong, Li-Zhen Zhang and Junfei Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:166
    Content type: Research Published on:

  14. The majority of women with epithelial ovarian cancer (OvCa) are diagnosed with metastatic disease, resulting in a poor 5-year survival of 31%. Obesity is a recognized non-infectious pandemic that increases OvC...

    Authors: Yueying Liu, Jing Yang, Tyvette S. Hilliard, Zhikun Wang, Jeff Johnson, Wanrui Wang, Elizabeth I. Harper, Connor Ott, Caitlin O’Brien, Leigh Campbell, Brian Crowley, Stephen Grisoli, Nicholas M. Stavrou, Anna Juncker-Jensen and M. Sharon Stack
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:165
    Content type: Research Published on:

  15. The receptor for advanced glycation-end products (RAGE) and its ligands have been implicated in obesity and associated inflammatory processes as well as in metabolic alterations like diabetes. In addition, RAG...

    Authors: Marianna Talia, Francesca Cirillo, Asia Spinelli, Azzurra Zicarelli, Domenica Scordamaglia, Lucia Muglia, Salvatore De Rosis, Damiano Cosimo Rigiracciolo, Gianfranco Filippelli, Ida Daniela Perrotta, Mariano Davoli, Rosanna De Rosa, Rachele Macirella, Elvira Brunelli, Anna Maria Miglietta, Bruno Nardo…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:164
    Content type: Research Published on:

  16. Autologous tumor cell-based vaccines (ATVs) aim to prevent and treat tumor metastasis by activating patient-specific tumor antigens to induce immune memory. However, their clinical efficacy is limited. Mannan-...

    Authors: Juan Ye, Herui Wang, Rogelio Medina, Samik Chakraborty, Mitchell Sun, Alex Valenzuela, Xueyu Sang, Yaping Zhang, Ondrej Uher, Jan Zenka, Karel Pacak and Zhengping Zhuang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:163
    Content type: Research Published on:

  17. A growing body of research has revealed the connection of metabolism reprogramming and tumor progression, yet how metabolism reprogramming affects inter-patient heterogeneity and prognosis in head and neck squ...

    Authors: Jiezhong Guan, Xi Xu, Guo Qiu, Chong He, Xiaoyue Lu, Kang Wang, Xinyu Liu, Yuanyuan Li, Zihang Ling, Xuan Tang, Yujie Liang, Xiaoan Tao, Bin Cheng and Bo Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:162
    Content type: Research Published on:

  18. After diagnosis, glioblastoma (GBM) patients undertake tremendous psychological problems such as anxiety and depression, which may contribute to GBM progression. However, systematic study about the relationshi...

    Authors: Yan Wang, Xiang Wang, Kai Wang, Ji Qi, Yu Zhang, Xu Wang, Long Zhang, Yi Zhou, Linbo Gu, Rutong Yu and Xiuping Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:161
    Content type: Research Published on:

  19. Endothelial-mesenchymal transition (EndoMT) is an emerging adaptive process that modulates lymphatic endothelial function to drive aberrant lymphatic vascularization in the tumour microenvironment (TME); howev...

    Authors: Wen-Fei Wei, Hui-Ling Zhou, Pei-Yu Chen, Xiao-Lan Huang, Long Huang, Luo-Jiao Liang, Chu-Hong Guo, Chen-Fei Zhou, Lan Yu, Liang-Sheng Fan and Wei Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:160
    Content type: Research Published on:

  20. The management of advanced clear cell renal cell carcinoma (ccRCC) remains a major challenge in clinical practice, and the construction of more reliable prognostic prediction models and the further elucidation...

    Authors: Yawei Xu, Lei Li, Wuping Yang, Kenan Zhang, Zedan Zhang, Chaojian Yu, Jianhui Qiu, Lin Cai, Yanqing Gong, Zheng Zhang, Jingcheng Zhou and Kan Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:159
    Content type: Research Published on:

  21. Authors: Boxuan Zhou, Jinhua Xue, Runxin Wu, Hongyu Meng, Ruixi Li, Zhaohong Mo, Hang Zhai, Xianyu Chen, Rongqiang Liu, Guie Lai, Xiaohong Chen, Taiyuan Li and Shiyang Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:158
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2023 42:138

  24. Pancreatic ductal adenocarcinoma (PDAC) tends to undergo distant metastasis, especially liver metastasis, leading to a poor prognosis. Metabolic remodelling and epigenetic reprogramming are two important hallm...

    Authors: Jinshou Yang, Bo Ren, Jie Ren, Gang Yang, Yuan Fang, Xing Wang, Feihan Zhou, Lei You and Yupei Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:155
    Content type: Research Published on:

  25. Osteosarcoma (OS) is the most common primary bone tumor in children and adolescent. Surgery and multidrug chemotherapy are the standard of treatment achieving 60–70% of event-free survival for localized diseas...

    Authors: Caterina Cascini, Chiara Ratti, Laura Botti, Beatrice Parma, Valeria Cancila, Adriana Salvaggio, Cristina Meazza, Claudio Tripodo, Mario P. Colombo and Claudia Chiodoni
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:154
    Content type: Research Published on:

  26. Authors: Changhong Li, Kui Zhang, Guangzhao Pan, Haoyan Ji, Chongyang Li, Xiaowen Wang, Xin Hu, Ruochen Liu, Longfei Deng, Yi Wang, Liqun Yang and Hongjuan Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:153
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:125

  27. Immune checkpoint blockade (ICB) treatment of hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV) infection may activate viral-specific T cells to attack HBV infected hepatocytes and thus indu...

    Authors: Lulu Liu, Junwei Liu, Pan Li, Jijun Luo, Rui Qin, Qiao Peng, Bin Li, Xuyong Wei, Tian Wang, Hongyu Shi, Ming-Da Wang, Chao Li, Weijia Fang, Wei Chen, Xiao Xu, Tian Yang…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:152
    Content type: Research Published on:

  28. Glycolysis is the key hallmark of cancer and maintains malignant tumor initiation and progression. The role of N6-methyladenosine (m6A) modification in glycolysis is largely unknown. This study explored the bi...

    Authors: Wei Wei, Zhong-Yuan Zhang, Bin Shi, Yike Cai, Hou-Shun Zhang, Chun-Lei Sun, Yun-Fei Fei, Wen Zhong, Shuang Zhang, Chen Wang, Bing He, Guan-Min Jiang and Hao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:151
    Content type: Research Published on:

  29. The incidence of colorectal cancer and cancer death rate are increasing every year, and the affected population is becoming younger. Traditional Chinese medicine therapy has a unique effect in prolonging survi...

    Authors: Fangyuan Zhou, Haiyang Gao, Luorui Shang, Jinxiao Li, Mengqi Zhang, Shuhan Wang, Runze Li, Lin Ye and Shenglan Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:150
    Content type: Research Published on:

  30. Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA editing destabilizes endogenous dsRNAs, which are ...

    Authors: Jing Yuan, Li Xu, Hai-Juan Bao, Jie-lin Wang, Yang Zhao and Shuo Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:149
    Content type: Review Published on:

  31. AXL is a member of the TAM (TYRO3, AXL, and MERTK) receptor tyrosine kinases family (RTKs), and its abnormal expression has been linked to clinicopathological features and poor prognosis of cancer patients. Th...

    Authors: Yaoxiang Tang, Hongjing Zang, Qiuyuan Wen and Songqing Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:148
    Content type: Review Published on:

  32. The epithelial-to-mesenchymal transition (EMT) is a trans-differentiation process that endows epithelial cells with mesenchymal properties, including motility and invasion capacity; therefore, its aberrant rea...

    Authors: Laura Amicone, Alessandra Marchetti and Carla Cicchini
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:147
    Content type: Review Published on:

  33. Invasive adenocarcinoma (IAC), which is typically preceded by minimally invasive adenocarcinoma (MIA), is the dominant pathological subtype of early-stage lung adenocarcinoma (LUAD). Identifying the molecular ...

    Authors: Yanan Cui, Jun Li, Pengpeng Zhang, Dandan Yin, Ziyu Wang, Jiali Dai, Wei Wang, Erbao Zhang and Renhua Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:146
    Content type: Research Published on:

  34. Metabolic reprogramming is a well-known marker of cancer, and it represents an early event during hepatocellular carcinoma (HCC) development. The recent approval of several molecular targeted agents has revolu...

    Authors: Christian Bergamini, Ilaria Leoni, Nicola Rizzardi, Mattia Melli, Giuseppe Galvani, Camelia Alexandra Coada, Catia Giovannini, Elisa Monti, Irene Liparulo, Francesca Valenti, Manuela Ferracin, Matteo Ravaioli, Matteo Cescon, Francesco Vasuri, Fabio Piscaglia, Massimo Negrini…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:145
    Content type: Research Published on:

  36. Hypoxia-induced glycogen turnover is implicated in cancer proliferation and therapy resistance. Triple-negative breast cancers (TNBCs), characterized by a hypoxic tumor microenvironment, respond poorly to ther...

    Authors: E. C. de Heer, C. E. Zois, E. Bridges, B. van der Vegt, H. Sheldon, W. A. Veldman, M. C. Zwager, T. van der Sluis, S. Haider, T. Morita, O. Baba, C. P. Schröder, S. de Jong, A. L. Harris and M. Jalving
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:143
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:220

  37. Cuproptosis and ferroptosis are the two newly defined metal-related regulated cell death. However, the crosstalk between cuproptosis and ferroptosis is obscure.

    Authors: Weikai Wang, Kaizhong Lu, Xin Jiang, Qi Wei, Liyuan Zhu, Xian Wang, Hongchuan Jin and Lifeng Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:142
    Content type: Research Published on:

  39. The transmembrane receptor Kremen2 has been reported to participate in the tumorigenesis and metastasis of gastric cancer. However, the role of Kremen2 in non-small cell lung cancer (NSCLC) and the underlying ...

    Authors: Yuxiao Sun, Yu Gao, Mingxin Dong, Jiuzhen Li, Xin Li, Ningning He, Huijuan Song, Manman Zhang, Kaihua Ji, Jinhan Wang, Yeqing Gu, Yan Wang, Liqing Du, Yang Liu, Qin Wang, Hezheng Zhai…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:140
    Content type: Research Published on:

  41. Breast cancer (BC) negatively impacts the health of women worldwide. Circular RNAs (circRNAs) are a group of endogenous RNAs considered essential regulatory factor in BC tumorigenesis and progression. However,...

    Authors: Boxuan Zhou, Jinhua Xue, Runxin Wu, Hongyu Meng, Ruixi Li, Zhaohong Mo, Hang Zhai, Xianyu Chen, Rongqiang Liu, Guie Lai, Xiaohong Chen, Taiyuan Li and Shiyang Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:138
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:158

  42. Immune checkpoint blockade (ICB) elicits a strong and durable therapeutic response, but its application is limited by disparate responses and its associated immune-related adverse events (irAEs). Previously, i...

    Authors: Radhika Mishra, Ariunbuyan Sukhbaatar, Shiro Mori and Tetsuya Kodama
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:132
    Content type: Research Published on:

  43. Disulfidptosis, a new form of cell death triggered by disulfide stress, is characterized by the collapse of cytoskeleton proteins and F-actin due to the intracellular accumulation of disulfides. This discovery...

    Authors: Tingjin Zheng, Qingbo Liu, Feiyue Xing, Chong Zeng and Weidong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:137
    Content type: Commentary Published on:

  44. Increasing evidence indicates that the tumor microenvironment (TME) is a crucial determinant of cancer progression. However, the clinical and pathobiological significance of stromal signatures in the TME, as a...

    Authors: Jian-Zhong He, Yang Chen, Fa-Min Zeng, Qing-Feng Huang, Hai-Feng Zhang, Shao-Hong Wang, Shuai-Xia Yu, Xiao-Xiao Pang, Ye Liu, Xiu-E Xu, Jian-Yi Wu, Wen-Jun Shen, Zhan-Yu Li, En-Min Li and Li-Yan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:136
    Content type: Research Published on:

  45. Authors: Chrysostomi Gialeli, Emre Can Tuysuz, Johan Staaf, Safa Guleed, Veronika Paciorek, Matthias Mörgelin, Konstantinos S. Papadakos and Anna M. Blom
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:135
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:258

  46. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. Large-scale metabolomic data have associated metabolic alterations with the pathogenesis and progression of renal carcinoma a...

    Authors: Christofer Rupert, Carmela Dell’ Aversana, Laura Mosca, Vittorino Montanaro, Davide Arcaniolo, Marco De Sio, Antonio Bilancio, Lucia Altucci, Wulf Palinski, Roberto Pili and Filomena de Nigris
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:134
    Content type: Research Published on:

  47. Efforts to precisely assess tumor-specific T-cell immune responses still face major challenges, and the potential molecular mechanisms mediating hepatocellular carcinoma (HCC) microenvironment imbalance after ...

    Authors: Zheng-Rong Shi, Yu-Xin Duan, Fang Cui, Zhong-Jun Wu, Mao-Ping Li, Pei-Pei Song, Qi-Ling Peng, Wen-Tao Ye, Kun-Li Yin, Mei-Qing Kang, Yan-Xi Yu, Jian Yang, Wei Tang and Rui Liao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:133
    Content type: Research Published on:

  49. Hippo signaling was first identified in Drosophila as a key controller of organ size by regulating cell proliferation and anti-apoptosis. Subsequent studies have shown that this pathway is highly conserved in ...

    Authors: Juan Luo, Liang Deng, Hailin Zou, Yibo Guo, Tongyu Tong, Mingli Huang, Gengqiang Ling and Peng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:130
    Content type: Review Published on:

  50. Emerging studies have identified chronic psychological stress as an independent risk factor influencing breast cancer growth and metastasis. However, the effects of chronic psychological stress on pre-metasta...

    Authors: Yifeng Zheng, Neng Wang, Shengqi Wang, Juping Zhang, Bowen Yang and Zhiyu Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:129
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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