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  1. Cardiotoxicity is a major complication of anticancer drugs, including anthracyclines and 5-fluorouracil(5-FU) and it can have detrimental effects both in patients and workers involved in the preparation of che...

    Authors: Monica Lamberti, Stefania Porto, Monica Marra, Silvia Zappavigna, Anna Grimaldi, Daniela Feola, Delia Pesce, Silvio Naviglio, Annamaria Spina, Nicola Sannolo and Michele Caraglia
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:60
    Content type: Research Published on:

  2. Invasive ductal carcinoma is the most common type of breast malignancy, with varying molecular features and resistance to treatment. Although CD44+/CD24- cells are believed to act as breast cancer stem cells a...

    Authors: Yan Lin, Ying Zhong, Heng Guan, Xiaohui Zhang and Qiang Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:59
    Content type: Research Published on:

  4. The purpose of the current study was to determine whether a tropical ginger derived compound 1’-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wi...

    Authors: Vinita Batra, Zanobia Syed, Jennifer N Gill, Malari A Coburn, Patrick Adegboyega, John DiGiovanni, J Michael Mathis, Runhua Shi, John L Clifford and Heather E Kleiner-Hancock
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:57
    Content type: Research Published on:

  5. The progression of many solid tumors is characterized by the release of tumor-associated proteases and the detection of tumor specific proteolytic activity in serum specimens is a promising diagnostic tool in ...

    Authors: Peter Findeisen, Victor Costina, Diego Yepes, Ralf Hofheinz and Michael Neumaier
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:56
    Content type: Research Published on:

  6. It is still technically difficult to collect high purity cancer cells from tumor tissues, which contain noncancerous cells. We hypothesized that xenograft models of NOG mice expressing enhanced green fluoresce...

    Authors: Kentaro Shima, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Takaho Okada, Naoaki Sakata, Noriyuki Omura, Yo Kitamura, Fuyuhiko Motoi, Toshiki Rikiyama, Yu Katayose, Shinichi Egawa, Naoto Ishii, Akira Horii and Michiaki Unno
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:55
    Content type: Research Published on:

  7. Lung cancer is the major cause of cancer death globally, it is often diagnosed at an advanced stage and has one of the lowest survival rates of any type of cancer. The common interest in the field of lung canc...

    Authors: Peng Guan, Zhihua Yin, Xuelian Li, Wei Wu and Baosen Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:54
    Content type: Research Published on:

  9. In our previous study, we detected decreased expression of phospho-Smad1/5/8 and its upstream signaling molecule, bone morphogenetic protein receptor IB subunit (BMPR-IB), in certain glioblastoma tissues, unli...

    Authors: Shuang Liu, Feng Yin, Wenhong Fan, Shuwei Wang, Xin-ru Guo, Jian-ning Zhang, Zeng-min Tian and Ming Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:52
    Content type: Research Published on:

  11. New chemotherapic agents and new protocols in oncology have led to an increasing survival rate in patients affected by tumors. However, this increased use has been accompanied by a growth in the incidence of c...

    Authors: Gabriella Fabbrocini, Norma Cameli, Maria Concetta Romano, Maria Mariano, Luigia Panariello, Dario Bianca and Giuseppe Monfrecola
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:50
    Content type: Research Published on:

  12. Gastrokine-1 (GKN1), a secreted protein, is specifically expressed in gastric mucosa to protect and maintain the integrity of gastric epithelium. The present study investigated differential expression of GKN1 ...

    Authors: Wei Mao, Jie Chen, Tie-Li Peng, Xiao-Fei Yin, Lian-Zhou Chen and Min-Hu Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:49
    Content type: Research Published on:

  13. Baicalin, a flavone present in Scutellaria baicalensis Georgi, inhibits the growth of human leukemia and myeloma cells through induction of apoptosis.

    Authors: Yi Huang, Jianda Hu, Jing Zheng, Jing Li, Tiannan Wei, Zhihong Zheng and Yingyu Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:48
    Content type: Research Published on:

  14. Progress in recent years strengthened the concept of cellular tumor vaccinations. However, a crucial barrier to successful cancer immunotherapy is tumor-mediated immunosuppression. Tumor-derived soluble factor...

    Authors: Alexander Shimabukuro-Vornhagen, Andreas Draube, Tanja M Liebig, Achim Rothe, Matthias Kochanek and Michael S von Bergwelt-Baildon
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:47
    Content type: Research Published on:

  15. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor associated with gastric carcinogenesis. 3,3'-Diindolylmethane (DIM) is a relatively non-toxic selective AhR modulator. This study was ...

    Authors: Xiao-Fei Yin, Jie Chen, Wei Mao, Yu-Hong Wang and Min-Hu Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:46
    Content type: Research Published on:

  16. To understand the role of proteases involved in human thyroid cancer progression and tissue invasion, thyrocytes from other species could potentially be used provided their characteristics are similar. It is n...

    Authors: Eleonore Fröhlich, Elke Maier and Richard Wahl
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:45
    Content type: Research Published on:

  17. Chloride intracellular channel 1 (CLIC1) is expressed ubiquitously in human tissues and is involved in the regulation of cell cycle, cell proliferation and differentiation. Recent studies have shown that CLIC1...

    Authors: Liang Wang, Shiming He, Yanyang TU, Peigang Ji, Jianhai Zong, Jingyu Zhang, Fuqiang Feng, Jipei Zhao, Yongsheng Zhang and Guodong Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:44
    Content type: Research Published on:

  18. Recent studies have shown dysregulation in TJ structure of several cancers including breast. Claudin-5 is a protein member of the TJ structure expressed in both endothelial and epithelial cells. This study exa...

    Authors: Astrid Escudero-Esparza, Wen G Jiang and Tracey A Martin
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:43
    Content type: Research Published on:

  19. Previous studies suggested that estrogen receptor alpha (ERα) plays an important role in the chemoresistance of breast cancers. However, large random trials failed to demonstrate any benefit of the concurrent ...

    Authors: Zhinong Jiang, Junlan Guo, Jianguo Shen, Mei Jin, Shuduo Xie and Linbo Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:42
    Content type: Research Published on:

  20. Sigma-2 receptor ligands have been studied for treatment of pancreatic cancer because they are preferentially internalized by proliferating cells and induce apoptosis. This mechanism of apoptosis is poorly und...

    Authors: John R Hornick, Suwanna Vangveravong, Dirk Spitzer, Carmen Abate, Francesco Berardi, Peter Goedegebuure, Robert H Mach and William G Hawkins
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:41
    Content type: Research Published on:

  21. Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. VEGF is believed to implicate poor prognosis in various cancers. The overexpress...

    Authors: Lei Yang, Shuo You, Vikas Kumar, Chaoyue Zhang and Ya Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:40
    Content type: Research Published on:

  22. We have reported previously that overexpression of glucose-regulated protein 78 (GRP78) promotes the invasion of hepatocellular carcinoma. However, whether GRP78 knockdown affects the extracellular matrix degr...

    Authors: Hongdan Li, Huijuan Song, Junsheng Luo, Jia Liang, Song Zhao and Rongjian Su
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:39
    Content type: Research Published on:

  23. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level. The dysregulation of miRNAs has been linked to a series of diseases, including various ty...

    Authors: Ruimin Ma, Tao Jiang and Xixiong Kang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:38
    Content type: Review Published on:

  24. Vascular endothelial growth factor (VEGF) plays a critical role in tumor angiogenesis. Bevacizumab is a humanized monoclonal antibody that neutralizes VEGF. We examined the impact on radiation response by bloc...

    Authors: Tien Hoang, Shyhmin Huang, Eric Armstrong, Jens C Eickhoff and Paul M Harari
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:37
    Content type: Research Published on:

  25. RNA binding motif 5 (RBM5) is a tumor suppressor gene that modulates apoptosis through the regulation of alternative splicing of apoptosis-related genes. This study aimed to detect RBM5 expression in non-small...

    Authors: Hong Liang, Jie Zhang, Chen Shao, Lijing Zhao, Wei Xu, Leslie C Sutherland and Ke Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:36
    Content type: Research Published on:

  26. Stanniocalcin-1 (STC-1) is a potential marker of disseminated tumor cells (DTCs). The aim of this study was to examine STC-1 expression in peripheral blood (PB) and bone marrow (BM) of esophageal squamous cell...

    Authors: Haizhu Song, Biao Xu and Jun Yi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:35
    Content type: Research Published on:

  27. This study was designed to establish a biomarker risk model for predicting bone metastasis in stage III non-small cell lung cancer (NSCLC).

    Authors: Zhen Zhou, Zhi-Wei Chen, Xiao-Hua Yang, Lan Shen, Xing-Hao Ai, Shun Lu and Qing-Quan Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:34
    Content type: Research Published on:

  28. To determine whether early monitoring of the effects of bevacizumab in patients with recurrent high-grade gliomas, by a Perfusion Computed Tomography (PCT), may be a predictor of the response to treatment asse...

    Authors: Antonello Vidiri, Andrea Pace, Alessandra Fabi, Marta Maschio, Gaetano Marco Latagliata, Vincenzo Anelli, Francesca Piludu, Carmine Maria Carapella, Giuseppe Giovinazzo and Simona Marzi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:33
    Content type: Research Published on:

  29. Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknow...

    Authors: Ricardo Ribeiro, Cátia Monteiro, Virgínia Cunha, Maria José Oliveira, Mariana Freitas, Avelino Fraga, Paulo Príncipe, Carlos Lobato, Francisco Lobo, António Morais, Vítor Silva, José Sanches-Magalhães, Jorge Oliveira, Francisco Pina, Anabela Mota-Pinto, Carlos Lopes…
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:32
    Content type: Research Published on:

  30. The role of B Lymphocyte Stimulator (BLyS) in the survival of malignant B cells and the maintenance of normal B cell development and homeostasis has been intensively studied in the literature. However, the inf...

    Authors: Jing Zhu, Li Sun, Sensen Lin, Renping Zhao, Liqiang Zhou, Dongdong Fang, Liang Chen, Jin Liu, Wenting Shi, Luyong Zhang and Shengtao Yuan
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:31
    Content type: Research Published on:

  31. The mitogen-activated protein kinase (MAPK) signaling pathway participates in several steps of tumour development and is considered a prominent therapeutic target for the design of chemotherapeutic agents. We ...

    Authors: Yoshitaka Fujimori, Mikito Inokuchi, Yoko Takagi, Keiji Kato, Kazuyuki Kojima and Kenichi Sugihara
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:30
    Content type: Research Published on:

  32. Response gene to complement-32 (RGC-32) is comprehensively expressed in many kinds of tissues and has been reported to be expressed abnormally in different kinds of human tumors. However, the role of RGC-32 in...

    Authors: Liang Zhu, Hua Qin, Pei-Yuan Li, Sheng-Nan Xu, Hui-Fang Pang, Hui-Zhen Zhao, De-Min Li and Qiu Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:29
    Content type: Research Published on:

  33. The exact mechanism of the effects of hypoxia on the proliferation and apoptosis in carcinoma cells is still conflicting. This study investigated the variation of hypoxia-inducible factor-1α(HIF-1α) expression...

    Authors: Zhi-Jun Dai, Jie Gao, Xiao-Bin Ma, Kun Yan, Xiao-Xu Liu, Hua-Feng Kang, Zong-Zheng Ji, Hai-Tao Guan and Xi-Jing Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:28
    Content type: Research Published on:

  34. Pure curcumin has been reported to down-regulate the expression of WT1 in leukemic cells. However, the molecular mechanism underlying the down-regulation of WT1 by curcumin is not completely delineated. The pu...

    Authors: Shen-meng Gao, Jun-jun Yang, Chi-qi Chen, Jun-jie Chen, Li-ping Ye, Lu-yao Wang, Jian-bo Wu, Chong-yun Xing and Kang Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:27
    Content type: Research Published on:

  35. Osteopontin (OPN), also known as SPP1 (secreted phosphoprotein), is an integrin binding glyco-phosphoprotein produced by a variety of tissues. In cancer patients expression of OPN has been associated with poor...

    Authors: Farbod Shojaei, Nathan Scott, Xiaolin Kang, Patrick B Lappin, Amanda A Fitzgerald, Shannon Karlicek, Brett H Simmons, Aidong Wu, Joseph H Lee, Simon Bergqvist and Eugenia Kraynov
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:26
    Content type: Research Published on:

  36. The aim of this study was to investigate prognostic value of excision repair cross-complementing 1 (ERCC1), BCL2-associated athanogene (BAG-1), the breast and ovarian cancer susceptibility gene 1 (BRCA1), ribo...

    Authors: Xue-Feng Leng, Ming-Wu Chen, Lei Xian, Lei Dai, Guang-Yao Ma and Man-Hong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:25
    Content type: Research Published on:

  37. Xenografts have been shown to provide a suitable source of tumor tissue for molecular analysis in the absence of primary tumor material. We utilized ES xenograft series for integrated microarray analyses to id...

    Authors: Neda Mosakhani, Mohamed Guled, Gayle Leen, Silvia Calabuig-Fariñas, Tarja Niini, Isidro Machado, Suvi Savola, Katia Scotlandi, José Antonio López-Guerrero, Antonio Llombart-Bosch and Sakari Knuutila
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:24
    Content type: Research Published on:

  38. Multidrug resistance is one of the main impediments to the successful treatment of colon cancer. Glucosylceramide synthase (GCS) which is related to multidrug resistance (MDR) can reduce the level of ceramide ...

    Authors: Min Song, Weidong Zang, Baohua Zhang, Jing Cao and Guanrui Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:23
    Content type: Research Published on:

  39. The nucleosome binding protein 1 (HMGN5/NSBP1) is a member of the HMGN protein family and is highly expressed in several kinds of cancer. Nevertheless, the role of NSBP1 in clear cell renal cell carcinoma (ccR...

    Authors: Shi-Qi Ji, Lin Yao, Xiao-Yu Zhang, Xue-Song Li and Li-Qun Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:22
    Content type: Research Published on:

  40. Authors: Xiangan Tu, Jintao Zhuang, Wenwei Wang, Liang Zhao, Liangyun Zhao, Jiquan Zhao, Chunhua Deng, Shaopeng Qiu and Yuanyuan Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:21
    Content type: Retraction Note Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2011 30:105

  41. Sexual function in patients with breast cancer especially in younger patients is an important issue from clinical and psychosocial perspectives. This study aimed to assess sexual function among Iranian breast ...

    Authors: Iraj Harirchi, Ali Montazeri, Fereshteh Zamani Bidokhti, Nina Mamishi and Kazem Zendehdel
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:20
    Content type: Research Published on:

  42. Epithelial ovarian cancer (EOC) is one of the leading causes of cancer deaths in women worldwide. Adrenomedullin (AM) is a multifunctional peptide which presents in various kinds of tumors.

    Authors: Boya Deng, Siyang Zhang, Yuan Miao, Zhuang Han, Xiaoli Zhang, Fang Wen and Yi Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:19
    Content type: Research Published on:

  43. Sex determining region Y (SRY)-related high mobility groupbox 9 (SOX9) is an important transcription factor required for development, which regulates the expression of target genes in the associated pathway. T...

    Authors: Chun-Hui Zhou, Li-Ping Ye, Shi-Xing Ye, Yan Li, Xin-Yin Zhang, Xin-Yu Xu and Li-Yun Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:18
    Content type: Research Published on:

  44. Immunoglobulin D multiple myeloma (MM) is rare and has a poorer prognosis than other MM isotypes.

    Authors: Francesco Pisani, Maria Teresa Petrucci, Diana Giannarelli, Velia Bongarzoni, Marco Montanaro, Valerio De Stefano, Giacinto La Verde, Fabiana Gentilini, Anna Levi, Tommaso Za, Alessandro Moscetti, Luciana Annino and Maria Concetta Petti
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:17
    Content type: Research Published on:

  45. Antiangiogenic therapy is one of the most significant advances in anticancer treatment. The benefits of antiangiogenic therapies of late-stage cancers have been investigated but are still too limited.

    Authors: Yuan Xu, Qin Li, Xiao-Yu Li, Qiu-Ya Yang, Wei-Wei Xu and Gao-Lin Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:16
    Content type: Research Published on:

  46. SPC-c-Raf-1-BxB transgenic mice develop genetically induced disseminated lung adenocarcinoma allowing examination of carcinogenesis and evaluation of novel treatment strategies. We report on assessment of lung...

    Authors: Thomas Rodt, Christian von Falck, Sabine Dettmer, Katja Hueper, Roman Halter, Ludwig Hoy, Matthias Luepke, Juergen Borlak and Frank Wacker
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:15
    Content type: Research Published on:

  47. Ovarian cancer is the most lethal gynecologic malignancy. It appears that the vast majority of what seem to be primary epithelial ovarian and primary peritoneal carcinomas is, in fact, secondary from the fimbr...

    Authors: Ayako Kim, Yutaka Ueda, Tetsuji Naka and Takayuki Enomoto
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:14
    Content type: Review Published on:

  48. Previous therapy with anthracyclines (ANT) and conditioning regimen followed by hematopoietic stem cell transplantation (HSCT) represents a high risk for development of cardiotoxicity. The aim of this study wa...

    Authors: Lubica Roziakova, Eva Bojtarova, Martin Mistrik, Juraj Dubrava, Jozef Gergel, Nadezda Lenkova and Beata Mladosievicova
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:13
    Content type: Research Published on:

  49. Human interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies,...

    Authors: Xiao-Fen Lai, Cong-Xiang Shen, Zhong Wen, Yu-Hong Qian, Chao-Sheng Yu, Jun-Qi Wang, Ping-Neng Zhong and Hai-Li Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:12
    Content type: Research Published on:

  50. Environmental factors-induced dysfunction of esophageal squamous epithelium, including genomic DNA impairment and apoptosis, play an important role in the pathogenesis of esophageal squamous cell cancer. DNA d...

    Authors: Bao xiang Wang, Bang Liang Yin, Bin He, Chen Chen, Ming Zhao, Wei xing Zhang, Zhen Kun Xia, Yi zhi Pan, Jing qun Tang, Xin min Zhou and Ni Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:11
    Content type: Research Published on:

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  • Citation Impact 2023
    Journal Impact Factor: 11.4
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    Source Normalized Impact per Paper (SNIP): 1.770
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    Submission to first editorial decision (median days): 5
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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