Table 5 The down-regulated DEGs sharing from cirrhosis to metastasis stage relating to the following GO process.

C5

complement component 5

1–2

IL4RA

interleukin 4 receptor, alpha

1–2

MBL2

mannose binding lectin 2 (protein C)

1–3

NOX4

NADPH oxidase 4

2–3

ATRN

Attractin

2–3

C1S

complement component 1, s subcomponent

1

C4BPB

complement component 4 binding protein, beta

1

AZGP1

alpha-2-glycoprotein 1, zinc

1

C6

complement component 6

1

CXCL12

chemokine (C-X-C motif) ligand 12

1

MX2

myxovirus (influenza virus) resistance 2

1

OAS1

2',5'-oligoadenylate synthetase 1, 40/46 kDa

1

RT1-S3

RT1 class Ib, locus S3

1

VIPR1

vasoactive intestinal peptide receptor 1

1

APOA2

apolipoprotein A-II

2

BCL6_predicted

B-cell leukemia/lymphoma 6 (predicted)

2

KLKB1

kallikrein B, plasma 1

2

PROC

protein C

2

PTGER3

Prostaglandin E receptor 3 (subtype EP3)

2

MEOX2

mesenchyme homeobox 2

3

CA3

carbonic anhydrase 3

3

ABCB11

ATP-binding cassette, sub-family B (MDR/TAP), member 11

3

ALAD

aminolevulinate, delta-, dehydratase

3

CYP2E1

cytochrome P450, family 2, subfamily e, polypeptide 1

3

EGFR

epidermal growth factor receptor

3

HAO1

hydroxyacid oxidase 1

3

HNF4A

Hepatocyte nuclear factor 4, alpha

3