Table 2 In vitro screening in human tumor cell lines
Compound | Conc. (M) | Breast | Neuroblastoma | Liver | Colon | Lung | Prostate | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
MCF-7 | IMR-32 | SK-N-SH | Hep-2 | 502713 | Colo-205 | HCT-15 | SW-620 | A549 | DU-145 | PC-3 | ||
Growth inhibition (%)* | ||||||||||||
1d | 1 × 10-6 | 0 | 32 | 0 | - | - | 8 | 4 | - | 0 | - | - |
1 × 10-5 | 23 | 69 | 41 | - | - | 64 | 29 | - | 23 | - | - | |
1i | 1 × 10-6 | 15 | 71 | 45 | 5 | 43 | 26 | 12 | 34 | - | 34 | 0 |
1 × 10-5 | 24 | 39 | 89 | 26 | 84 | 23 | 24 | 56 | - | 53 | 51 | |
5-FU | 1 × 10-5 | 30 | - | 66 | - | 45 | - | - | 26 | - | - | - |
Paclitaxel | 1 × 10-6 | - | 72 | - | - | - | - | 76 | 62 | 62 | - | - |
Mitomycin C | 1 × 10-6 | - | - | 50 | - | - | 43 | - | 71 | - | 58 | 46 |
1 × 10-5 | 60 | - | 85 | 49 | - | - | 70 | - | - | - | - | |
Doxorubicin | 1 × 10-6 | 37 | - | 51 | 64 | - | - | - | - | - | - | - |
1 × 10-5 | - | - | - | - | - | - | 47 | - | - | - | 70 | |