Skip to main content

Table 2 In vitro screening in human tumor cell lines

From: 6-Nitro-2-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis

Compound Conc. (M) Breast Neuroblastoma Liver Colon Lung Prostate
   MCF-7 IMR-32 SK-N-SH Hep-2 502713 Colo-205 HCT-15 SW-620 A549 DU-145 PC-3
Growth inhibition (%)*
1d 1 × 10-6 0 32 0 - - 8 4 - 0 - -
  1 × 10-5 23 69 41 - - 64 29 - 23 - -
1i 1 × 10-6 15 71 45 5 43 26 12 34 - 34 0
  1 × 10-5 24 39 89 26 84 23 24 56 - 53 51
5-FU 1 × 10-5 30 - 66 - 45 - - 26 - - -
Paclitaxel 1 × 10-6 - 72 - - - - 76 62 62 - -
Mitomycin C 1 × 10-6 - - 50 - - 43 - 71 - 58 46
  1 × 10-5 60 - 85 49 - - 70 - - - -
Doxorubicin 1 × 10-6 37 - 51 64 - - - - - - -
  1 × 10-5 - - - - - - 47 - - - 70