From: The immunoregulatory mechanisms of carcinoma for its survival and development
Carcinoma type | Antibodies for immunohistochemical staining | Distribution of total HLA class I expression loss (% of negative staining*) | References |
---|---|---|---|
Bladder | W6/32 and GRH1 | The altered of HLA class I including total losses associates with higher grade lesions and tumor recurrence | [20] |
 | A-072 | 1) 16.6% in G1, 38.5% in G2, and 57.1% in G3; 2) 5-year survival: 74% with positive versus 36% with negative staining | [21] |
Gastric | A-072 | 0% in T1 (mucosa & submucosa) versus100% in T2-3 (muscle and fat invasion) | [22] |
Esophageal | W6/32 | 0%: normal and benign versus 40.5% carcinoma lesions | [23] |
Bronchogenic | W6/32 and HC-10 | 1) 13% of Diploid versus 45% of Aneuploid; 2) 17.3% in G1-2 versus 69% in G3 | [24] |
NSCLC | W6/32 | 1) 26.8% in T1-2 versus 35% in T3; 2) 20.7% in G1-2 versus 39.3% in G3; 3) 24.1% in N0 versus 34.5% in N1-2 | [25] |
Breast | HC-10 | 0% in low-grade versus 67.6% in high-grade lesions | [26] |
 | W6/32 | 24% in primary versus 64% in corresponding LN samples | [27] |
Pancreatic | W6/32 and 246-E8.E7 | 1) 6% in primary versus 43% in metastastic tumors; 2) 0% in G1, 33% in G2 and 67% in G3 | [28] |
Prostate | A-072 | 1) 0% in Benign, 41% in primary and 66% in LN metastases; 2) 33% in low-grade versus 50% in high grade lesions | [29] |