Figure 2
miR-212 promoted PDAC cell proliferation and motility. (A) CCK-8 assays performed to examine PANC-1 cells proliferation. Transfection of miR-212 mimic significantly increased PANC-1 cells proliferation, while transfection of miR-212 inhibitor significantly decreased PANC-1 cells proliferation. (B) Colony formation assay showed that miR-212 mimic increased PANC-1 cells colony formation, while miR-212 inhibitor significantly inhibited cell colony formation. (C) The wound healing assays showed the migration ability of PANC-1 cells transfected with miR-212 mimic or miR-212 inhibitor, statistical analysis is shown in (D). (E) Transwell assays showed that miR-212 significantly enhanced PANC-1 cell invasion, while miR-212 inhibitor weaken cell invasion. statistical analysis is shown in (F). Three independent experiments were performed. *P < 0.05.