Figure 5

Bachyury regulates EMT via Akt/Snail pathway. (A) Western blot assay demonstrated overexpression Bachyury repressed PTEN and enhanced p-Akt, Snail, but not t-Akt expression in HepG2 cells. (B) AKT inhibitor prevented the Brachyury-mediated increase in p-AKT and Snail expression and abolished Bachyury-induced HCC EMT phenotype. (C) SiRNA against snail abolished Bachyury-induced Snail expression and HCC EMT phenotype.