Farazi PA, DePinho RA: Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer. 2006, 6: 674-687. 10.1038/nrc1934.
Article
CAS
PubMed
Google Scholar
Mathurin P, Rixe O, Carbonell N, Bernard B, Cluzel P, Bellin MF, Khayat D, Opolon P, Poynard T: Review article: overview of medical treatments in unresectable hepatocellular carcinoma-an impossible meta-analysis?. Aliment Pharmacol Ther. 1998, 12: 111-126. 10.1046/j.1365-2036.1998.00286.x.
Article
CAS
PubMed
Google Scholar
Kawano Y, Sasaki A, Kai S, Endo Y, Iwaki K, Uchida H, Shibata K, Ohta M, Kitano S: Prognosis of patients with intrahepatic recurrence after hepatic resection for hepatocellular carcinoma: a retrospective study. European J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2009, 35: 174-179.
CAS
Google Scholar
Liotta LA: Mechanisms of cancer invasion and metastasis. Important advances in oncology 1985:28–41.,
Thiery JP, Acloque H, Huang RY, Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell. 2009, 139: 871-890. 10.1016/j.cell.2009.11.007.
Article
CAS
PubMed
Google Scholar
Larue L, Bellacosa A: Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene. 2005, 24: 7443-7454. 10.1038/sj.onc.1209091.
Article
CAS
PubMed
Google Scholar
Christofori G: New signals from the invasive front. Nature. 2006, 441: 444-450. 10.1038/nature04872.
Article
CAS
PubMed
Google Scholar
Boivin D, Bilodeau D, Beliveau R: Regulation of cytoskeletal functions by Rho small GTP-binding proteins in normal and cancer cells. Can J Physiol Pharmacol. 1996, 74: 801-810. 10.1139/y96-083.
Article
CAS
PubMed
Google Scholar
Niu RF, Zhang L, Xi GM, Wei XY, Yang Y, Shi YR, Hao XS: Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma. J Exp Clin Cancer Res CR. 2007, 26: 385-394.
CAS
PubMed
Google Scholar
Teng Y, Zeisberg M, Kalluri R: Transcriptional regulation of epithelial-mesenchymal transition. J Clin Invest. 2007, 117: 304-306. 10.1172/JCI31200.
Article
PubMed Central
CAS
PubMed
Google Scholar
Naiche LA, Harrelson Z, Kelly RG, Papaioannou VE: T-box genes in vertebrate development. Annu Rev Genet. 2005, 39: 219-239. 10.1146/annurev.genet.39.073003.105925.
Article
CAS
PubMed
Google Scholar
Zhou B, Chen H, Wei D, Kuang Y, Zhao X, Li G, Xie J, Chen P: A novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma. J Exp Clin Cancer Res. 2014, 33: 55-10.1186/1756-9966-33-55.
Article
PubMed Central
PubMed
Google Scholar
Beddington RS, Rashbass P, Wilson V: Brachyury-a gene affecting mouse gastrulation and early organogenesis. Dev Suppl 1992, 157-165.,
Schulte-Merker S, van Eeden FJ, Halpern ME, Kimmel CB, Nusslein-Volhard C: no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene. Development. 1994, 120: 1009-1015.
CAS
PubMed
Google Scholar
Wilson V, Manson L, Skarnes WC, Beddington RS: The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation. Development. 1995, 121: 877-886.
CAS
PubMed
Google Scholar
Showell C, Binder O, Conlon FL: T-box genes in early embryogenesis. Dev Dyn Off Publ Am Assoc Anat. 2004, 229: 201-218.
CAS
Google Scholar
Griffin KJP, Kimelman D: One-Eyed Pinhead and Spadetail are essential for heart and somite formation. Nat Cell Biol. 2002, 4: 821-825. 10.1038/ncb862.
Article
CAS
PubMed
Google Scholar
Kilic N, Feldhaus S, Kilic E, Tennstedt P, Wicklein D, Wasielewski R, Viebahn C, Kreipe H, Schumacher U: Brachyury expression predicts poor prognosis at early stages of colorectal cancer. Eur J Cancer. 2011, 47: 1080-1085. 10.1016/j.ejca.2010.11.015.
Article
PubMed
Google Scholar
Yang XR, Ng D, Alcorta DA, Liebsch NJ, Sheridan E, Li S, Goldstein AM, Parry DM, Kelley MJ: T (Brachyury) gene duplication confers major susceptibility to familial chordoma. Nat Genet. 2009, 41: 1176-1178. 10.1038/ng.454.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fernando RI, Litzinger M, Trono P, Hamilton DH, Schlom J, Palena C: The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells. J Clin Invest. 2010, 120: 533-544. 10.1172/JCI38379.
Article
PubMed Central
CAS
PubMed
Google Scholar
Huang B, Cohen JR, Fernando RI, Hamilton DH, Litzinger MT, Hodge JW, Palena C: The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies. Cell Death Dis. 2013, 4: e682-10.1038/cddis.2013.208.
Article
PubMed Central
CAS
PubMed
Google Scholar
Imajyo I, Sugiura T, Kobayashi Y, Shimoda M, Ishii K, Akimoto N, Yoshihama N, Kobayashi I, Mori Y: T-box transcription factor Brachyury expression is correlated with epithelial-mesenchymal transition and lymph node metastasis in oral squamous cell carcinoma. Int J Oncol. 2012, 41: 1985-1995.
PubMed Central
PubMed
Google Scholar
Wong N, Lai P, Lee SW, Fan S, Pang E, Liew CT, Sheng Z, Lau JW, Johnson PJ: Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: relationship to disease stage, tumor size, and cirrhosis. Am J Pathol. 1999, 154: 37-43. 10.1016/S0002-9440(10)65248-0.
Article
PubMed Central
CAS
PubMed
Google Scholar
Weiss-Steider B, Soto-Cruz I, Martinez-Campos CA, Mendoza-Rincon JF: Expression of MICA, MICB and NKG2D in human leukemic myelomonocytic and cervical cancer cells. J Exp Clin Cancer Res. 2011, 30: 37-10.1186/1756-9966-30-37.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chen L, Chan TH, Yuan YF, Hu L, Huang J, Ma S, Wang J, Dong SS, Tang KH, Xie D, Li Y, Guan XY: CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. J Clin Invest. 2010, 120: 1178-1191. 10.1172/JCI40665.
Article
PubMed Central
CAS
PubMed
Google Scholar
Thiery JP, Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 2006, 7: 131-142. 10.1038/nrm1835.
Article
CAS
PubMed
Google Scholar
Ning J, Liu W, Zhang J, Lang Y, Xu S: Ran GTPase Induces EMT and Enhances Invasion in Non-Small Cell Lung Cancer Cells Through Activation of PI3K-AKT Pathway. Oncol Res Featuring Preclin Clin Cancer Ther. 2014, 21: 67-72.
CAS
Google Scholar
Ginnebaugh KR, Ahmad A, Sarkar FH: The therapeutic potential of targeting the epithelial-mesenchymal transition in cancer. Expert Opin Ther Targets. 2014, 18: 731-745. 10.1517/14728222.2014.909807.
Article
CAS
PubMed
Google Scholar
Tian H, Ge C, Li H, Zhao F, Hou H, Chen T, Jiang G, Xie H, Cui Y, Yao M, Li J: Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma. Hepatology. 2014, 59: 1459-1470. 10.1002/hep.26929.
Article
CAS
PubMed
Google Scholar
Chen KC, Chen CY, Lin CJ, Yang TY, Chen TH, Wu LC, Wu CC: Luteolin attenuates TGF-beta1-induced epithelial-mesenchymal transition of lung cancer cells by interfering in the PI3K/Akt-NF-kappaB-Snail pathway. Life Sci. 2013, 93: 924-933. 10.1016/j.lfs.2013.10.004.
Article
CAS
PubMed
Google Scholar
Yang MH, Chen CL, Chau GY, Chiou SH, Su CW, Chou TY, Peng WL, Wu JC: Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology. 2009, 50: 1464-1474. 10.1002/hep.23221.
Article
CAS
PubMed
Google Scholar
Roselli M, Fernando RI, Guadagni F, Spila A, Alessandroni J, Palmirotta R, Costarelli L, Litzinger M, Hamilton D, Huang B, Tucker J, Tsang KY, Schlom J, Palena C: Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer. Clin Cancer Res. 2012, 18: 3868-3879. 10.1158/1078-0432.CCR-11-3211.
Article
PubMed Central
CAS
PubMed
Google Scholar
Haro A, Yano T, Kohno M, Yoshida T, Koga T, Okamoto T, Takenoyama M, Maehara Y: Expression of Brachyury gene is a significant prognostic factor for primary lung carcinoma. Ann Surg Oncol. 2013, 20 (Suppl 3): S509-S516. 10.1245/s10434-013-2914-9.
Article
PubMed
Google Scholar
Palena C, Roselli M, Litzinger MT, Ferroni P, Costarelli L, Spila A, Cavaliere F, Huang B, Fernando RI, Hamilton DH, Jochems C, Tsang KY, Cheng Q, Kim Lyerly H, Schlom J, Guadagni F: Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis. J Natl Cancer Inst. 2014, 9: 106(5)-
Google Scholar
Pinto F, Pértega-Gomes N, Pereira MS, Vizcaíno JR, Monteiro P, Henrique RM, Baltazar F, Andrade RP, Reis RM: T-box transcription factor brachyury is associated with prostate cancer progression and aggressiveness. Clin Cancer Res. 2014, 20: 4949-4961. 10.1158/1078-0432.CCR-14-0421.
Article
CAS
PubMed
Google Scholar
Lim J, Thiery JP: Epithelial-mesenchymal transitions: insights from development. Development. 2012, 139: 3471-3486. 10.1242/dev.071209.
Article
CAS
PubMed
Google Scholar
Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002, 2: 442-454. 10.1038/nrc822.
Article
CAS
PubMed
Google Scholar
Larocca C, Cohen JR, Fernando RI, Huang B, Hamilton DH, Palena C: An Autocrine Loop between TGF-β1 and the Transcription Factor Brachyury Controls the Transition of Human Carcinoma Cells into a Mesenchymal Phenotype. Mol Cancer Ther. 2013, 12: 1805-1815. 10.1158/1535-7163.MCT-12-1007.
Article
CAS
PubMed
Google Scholar
Leslie NR, Yang X, Downes CP, Weijer CJ: PtdIns(3,4,5)P3-Dependent and -Independent Roles for PTEN in the Control of Cell Migration. Curr Biol. 2007, 17: 115-125. 10.1016/j.cub.2006.12.026.
Article
PubMed Central
CAS
PubMed
Google Scholar