A fresh look at zebrafish from the perspective of cancer research

Table 1 Summary of the methods used and the types of tumor induced in zebrafish

Technology	Treatment	Types of induced tumor	Reference
Chemical treatment	DMBA	hepatoma, cholangiocarcinoma and intestinal cancer	[30]
	DEN	hepatoma, cholangiocarcinoma and pancreatic carcinoma	[23]
	NDMA	hepatoma and cholangiocarcinoma	[31]
	ENU	hepatoma and testicular cancer	[24]
	MNNG	hepatoma and testicular cancer	[32]
Genetic technology
Knockout:	P53	malignant peripheral nerve sheath tumors	[41]
	APC	colon adenoma	[42]
	NF1	gliomas and malignant peripheral nerve sheath tumors	[43]
	BRCA2, MYBL2, esp11	testicular cancer	[44, 45]
	pen/lgl2, bmyb and cds gene	epidermal cancer	[32, 46, 47]
	GSTT1	lymphoma	[48]
	vhl	hepatoma and intestinal cancer	[33]
	pten	T-cell acute lymphoblastic leukemia and hemangiosarcoma	[49, 50]
Overexpression:	Myc	T-cell leukemia and hepatoma	[51, 53]
	xmrk and KRAS ^(V12)	hepatoma	[52, 54, 55]
	MYCN and fgf8	neuroblastoma	[56]
	KRAS ^(G12D)	rhabdomyosarcoma	[57]
	Akt1	lipoma	[58]
	Scr in p53 mutant background	hepatoma	[59]
	NRAS, BRAF in p53 mutant background	melanoma	[60, 41]
	EWS-FIL1 in p53 mutant background	Ewing's sarcoma	[61]
Xenotransplantation	Transplant tumor cells in zebrafish	Melanoma, glioma, hepatoma, lung cancer, pancreatic cancer, ovarian carcinomas, breast cancer, prostate cancer, retinoblastoma, leukemia	[64–73]

ISSN: 1756-9966