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Table 1 Summary of the methods used and the types of tumor induced in zebrafish

From: A fresh look at zebrafish from the perspective of cancer research

Technology Treatment Types of induced tumor Reference
Chemical treatment DMBA hepatoma, cholangiocarcinoma and intestinal cancer [30]
DEN hepatoma, cholangiocarcinoma and pancreatic carcinoma [23]
NDMA hepatoma and cholangiocarcinoma [31]
ENU hepatoma and testicular cancer [24]
MNNG hepatoma and testicular cancer [32]
Genetic technology
Knockout: P53 malignant peripheral nerve sheath tumors [41]
APC colon adenoma [42]
NF1 gliomas and malignant peripheral nerve sheath tumors [43]
BRCA2, MYBL2, esp11 testicular cancer [44, 45]
pen/lgl2, bmyb and cds gene epidermal cancer [32, 46, 47]
GSTT1 lymphoma [48]
vhl hepatoma and intestinal cancer [33]
pten T-cell acute lymphoblastic leukemia and hemangiosarcoma [49, 50]
Overexpression: Myc T-cell leukemia and hepatoma [51, 53]
xmrk and KRAS (V12) hepatoma [52, 54, 55]
MYCN and fgf8 neuroblastoma [56]
KRAS (G12D) rhabdomyosarcoma [57]
Akt1 lipoma [58]
Scr in p53 mutant background hepatoma [59]
NRAS, BRAF in p53 mutant background melanoma [60, 41]
EWS-FIL1 in p53 mutant background Ewing's sarcoma [61]
Xenotransplantation Transplant tumor cells in zebrafish Melanoma, glioma, hepatoma, lung cancer, pancreatic cancer, ovarian carcinomas, breast cancer, prostate cancer, retinoblastoma, leukemia [6473]