LF and HPY contribute equally to this work. LF was involved in preparation of antibody-drug conjugation, some in vitro and in vivo studies related to NSCLC. SS was involved in antibody characterization, some in vitro studies related to breast cancer. HPY and YQZ produced and purified anti-RON antibody, participated in some in vitro experiment, analyzed data, and provided partial funds for this project. JWZ provided experimental design and technical support for some intro experiments. RWZ participated in experimental design for combination study. MHW designed the study, participated in data analysis, wrote the manuscript, and secured the fund for completion of this study. All authors read and approved the final manuscript.
The online version of the original article can be found under doi:10.1186/s13046-016-0347-6.