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Retraction Note: Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma

  • The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:8

Retraction note to: J Exp Clin Cancer Res 38, 8 (2019)

https://doi.org/10.1186/s13046-018-1012-z

The Editor-in-Chief has retracted this article [1] due to overlapping images with other articles, specifically:

  • Figure 8d: the Beclin1 Vehicle and XAG (80 mg/kg) panels appear to overlap with the cleaved caspase-3 Vehicle and Exanthone (80 mg/kg/day) panels of Fig. 7c of [2].

  • Figure 8d: the p-c-Jun Vehicle panel appears to overlap with the Beclin Vehicle panel of Fig. 7c of [2].

  • Figure 3a: the Bel7402 XAG + 3-MA panel appears to be identical to the SMMC7721 Vehicle panel.

  • Figure 3c: the Bel7402 XAG + Atg5 siRNA panel appears to be identical to the SMMC7721 Vehicle panel.

  • Figure 3c: the SMMC7721 Atg5 siRNA panel appears to be similar to the SKOV3 Control and A2780 Control panels of Fig. 1e of [3], the Vehicle panel of Fig. 4b in [4] and the HT29 Control panel of Fig. 7b of [5]

  • Figure 8d: the Vehicle CHOP, GRP78 and p-JNK panels appears to be similar to the Ki-67 EX(40 mg/kg) panel, the IL-18 Vehicle panel and the IL-18 EX(20 mg/kg) panel of [6].

  • Figure 8d: the XAG(40 mg/kg) CHOP panel appears to be similar to the KI-67 EX(20 mg/kg) panel of [6].

  • Figure 8d: the XAG(80 mg/kg) CHOP and GRP78 panels appear to be similar to the KI-67 Vehicle and the IL-18 EX(40 mg/kg) panels of [6].

The data reported in this article are therefore unreliable.

Hui Gao agrees to this retraction. Zichao Li, Luying Zhang, Mingquan Gao, Mei Han, Kaili Liu, Zhuang Zhang, Zhi Gong, Lifei Xing, Xianzhou Shi, Kui Lunot have responded to any correspondence from the publisher about this retraction.

References

  1. 1.

    Li Z, Zhang L, Gao M, et al. Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2019;38:8 https://doi.org/10.1186/s13046-018-1012-z.

    Article  Google Scholar 

  2. 2.

    Zhu L, Liu X, Li D, Sun S, Wang Y, Sun X. RETRACTED: autophagy is a pro-survival mechanism in ovarian cancer against the apoptotic effects of euxanthone. Biomed Pharmacother. 2018;103:708–18. https://doi.org/10.1016/j.biopha.2018.04.090.

    CAS  Article  PubMed  Google Scholar 

  3. 3.

    Zou J, Wang Y, Liu M, et al. Euxanthone inhibits glycolysis and triggers mitochondria-mediated apoptosis by targeting hexokinase 2 in epithelial ovarian cancer. Cell Biochem Funct. 2018;36:303–11. https://doi.org/10.1002/cbf.3349.

    CAS  Article  PubMed  Google Scholar 

  4. 4.

    Yang X, Yin G, Sun H, Zhao G. Physcion 8-O-β-Glucopyranoside Alleviates Oxidized Low-Density Lipoprotein-Induced Human Umbilical Vein Endothelial Cell Injury by Inducing Autophagy Through AMPK/SIRT1 Signaling. J Cardiovasc Pharmacol. 2019;74(1):53–61. https://doi.org/10.1097/FJC.0000000000000680.

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Liu K, Gao H, Wang Q, et al. Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer. Cancer Sci. 2018 May;109(5):1369–81. https://doi.org/10.1111/cas.13575.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Chen Y-F, Qi H-Y, Wu F-L. Euxanthone exhibits anti-proliferative and anti-invasive activities in hepatocellular carcinoma by inducing pyroptosis: preliminary results. Eur Rev Med Pharmacol Sci. 2018;22(N. 23):8186–96. https://doi.org/10.26355/eurrev_201812_16511.

    Article  PubMed  Google Scholar 

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Correspondence to Kui Lu or Hui Gao.

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Li, Z., Zhang, L., Gao, M. et al. Retraction Note: Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma. J Exp Clin Cancer Res 39, 164 (2020). https://doi.org/10.1186/s13046-020-01668-x

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