Fig. 2
From: The role of extracelluar matrix in osteosarcoma progression and metastasis
Schematic of signaling pathways involved the ECM remodeling in OS. The ECM is dynamically remodeled by multiple proteases and signaling pathways. In OS, MMP-2, MMP-9, and MMP-13 function via PI3K/Akt and ERK associated signaling pathways. Heparanase also participates in ECM remodeling, as it cleaves the ECM by heparan sulfate degradation, thus promoting OS cell invasion and metastasis