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Correction: The RNA-binding protein GRSF1 promotes hepatocarcinogenesis via competitively binding to YY1 mRNA with miR-30e-5p
Journal of Experimental & Clinical Cancer Research volume 41, Article number: 181 (2022)
The Original Article was published on 08 January 2022
Correction: J Exp Clin Cancer Res 41, 17 (2022)
https://doi.org/10.1186/s13046-021-02217-w
Following publication of the original article [1], errors were identified in Figs. 4 and 7, specifically:
The corrected figures are given here. The correction does not have any effect on the final conclusions of the paper. The original article has been corrected.
miR-30e-5p inhibited YY1 and hepatocarcinogenesis by binding to the 3’UTR of YY1. A miR-30e-5p and its putative binding sequence in the YY1 3′-UTR. B miR-30e-5p expression was decreased in HCC tissues. C miR-30e-5p expression in MHCC-97H and Hep3B cells was increased upon transfection with pre-miR-30e-5p but was not regulated by YY1 overexpression. D Luciferase reporter gene assay showing that miR-30e-5p overexpression decreased YY1 luciferase activity when combined with the wt YY1 3′-UTR. E YY1 expression was decreased, followed by increased miR-30e-5p expression, and upregulated upon transfection with the ov-YY1 vector in HCC cells. F-I Increased miR-30e-5p expression suppressed the colony formation (F), proliferation (G, H) and migration (I) ability of HCC cells, and the antitumor function of miR-30e-5p was counteracted by YY1 overexpression. Values are the mean ± SEM (n = 3). *p < 0.05, **p < 0.01
VE821 inhibits HCC by repressing the GRSF1/YY1 pathway. A Chemical structure of VE821. B Cytotoxicity analysis of VE821 in MHCC-97H and Hep3B cells. C GRSF1 and YY1 expression levels were decreased in MHCC-97H and Hep3B cells treated with VE821. D VE821 markedly inhibited the proliferation, migration, and colony formation ability of MHCC-97H and Hep3B cells and enhanced apoptosis (n = 5). Values are the mean ± SEM (n = 3); *p < 0.05, **p < 0.01
Reference
Han L, Huang C, Wang X, et al. The RNA-binding protein GRSF1 promotes hepatocarcinogenesis via competitively binding to YY1 mRNA with miR-30e-5p. J Exp Clin Cancer Res. 2022;41:17. https://doi.org/10.1186/s13046-021-02217-w.
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Han, L., Huang, C., Wang, X. et al. Correction: The RNA-binding protein GRSF1 promotes hepatocarcinogenesis via competitively binding to YY1 mRNA with miR-30e-5p. J Exp Clin Cancer Res 41, 181 (2022). https://doi.org/10.1186/s13046-022-02392-4
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DOI: https://doi.org/10.1186/s13046-022-02392-4