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Correction: CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis

The Original Article was published on 20 October 2022

Correction: J Exp Clin Cancer Res 41, 307 (2022)

https://doi.org/10.1186/s13046-022-02518-8

Following publication of the original article [1], author identified an error in Fig. 4k. It was caused by errors in the publishing process. The correct figure is presented below:

Fig. 4
figure 1

CircLRFN5 binds to PRRX2 protein and promotes its degradation via the ubiquitin-mediated proteasomal pathway. a CircLRFN5 binds to PRRX2 proteins via CatRAPID prediction. b-d RIP assays showed anti-PRRX2 proteins could lead to the enrichment of circLRFN5 in circLRFN5 overexpressed (b) or knockdown (c,d) GSCs. e RNA pull-down assays showed the biotinylated circLRFN5 probe pulled down PRRX2 proteins in GSC51 (left) and GSC53 (right). f Five biotinylated probes (1- 590, 590- 1085, 653- 1085, 1085- 1581 and 1148- 1581) containing different fragments of circLRFN5 were designed for RNA pull-down assay. g qPCR assays showed the mRNA expression of PRRX2 after circLRFN5 overexpression (left) or knockdown (right) in GSCs. h Western blotting showed the protein expression of PRRX2 after circLRFN5 overexpression (left) or knockdown (right) in GSCs. i, j The circLRFN5 overexpressed GSC51 (i) or knockdown GSC53 (j) were treated with cycloheximide (CHX, 100 ng/ml) and the half-life of PRRX2 protein was detected by western blotting. k The circLRFN5 overexpressed GSC51 (upper) or knockdown GSC53 (lower) was treated with or without MG-132 (50 μM) for 6 h, and PRRX2 expression was detected by western blotting. l, m In vitro ubiquitination assays showed the level of ubiquitination of PRRX2 protein after circLRFN5 overexpression (l) or knockdown (m) in GSCs. All data are expressed as the mean ±SD (three independent experiments). *p < 0.05; **p < 0.01; ***p < 0.001

The correction does not have any effect on the results or conclusions of the paper. The original article has been corrected.

Reference

  1. Jiang Y, Zhao J, Li R, et al. CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. J Exp Clin Cancer Res. 2022;41:307. https://doi.org/10.1186/s13046-022-02518-8.

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Correspondence to Liang Gao or Daming Cui.

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Jiang, Y., Zhao, J., Li, R. et al. Correction: CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. J Exp Clin Cancer Res 41, 320 (2022). https://doi.org/10.1186/s13046-022-02527-7

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