Fig. 7

Therapy using resveratrol and anti-PD-L1 in obesity-lymphoma mice. A Protein levels of phosphorylated-SPHK1, SPHK1, phosphorylated-YAP, YAP, and CTGF in tumor invaded LN tissues from the xenograft model of resveratrol treated EL4-lymphoma mice and untreated EL4-lymphoma mice, in comparison with the lymph node from the non-lymphoma mice. B Flow Cytometry analysis to detect F4/80⁺MHCII⁺ cells and F4/80⁺CD206⁺ cells in the collected PMM from peritoneal injection model of resveratrol and IFN-γ treated EL4-lymphoma mice, in comparison with untreated EL4-lymphoma mice and the PBS injection non-tumor controls. C Schematic diagram of resveratrol and anti-PD-L1 treatment in xenograft model of EL4-lymphoma. D Gross anatomy of tumor mass, and tumor volume in 4 groups of the EL4-WSHFD mice. *, P < 0.05; **, P < 0.01. ***, P < 0.001