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Retraction Note: Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis

The Original Article was published on 15 January 2019

Retraction Note: J Exp Clin Cancer Res 38, 19 (2019)

https://doi.org/10.1186/s13046-018-1010-1

The Editor in Chief has retracted this article. Although Fig. 9 was corrected in May 2019 [1] additional concerns have been raised regarding the following issues:

  • Figure 2D: the Oct4 blot looks similar to blot described as CD133 in Fig. 7D of [2], which was consideration around the same time and shares two authors with this article ;

  • Figure 4C: one of the actin controls looks very similar to the blot previously published [3] in Fig. 4B as a GAPDH control by different authors;

  • Figure 7B, the actin control appears similar to the Tubulin one in Fig. 4B in a previously-published paper by different authors [4];

  • Figure 8C, the upper actin control seems similar to the a-tubulin blot in Fig. 4B of a previously-published paper [5] by different authors.

  • Figure 8C, the lower actin control seems similar to the A549 actin control in Fig. 3A of a previously-published paper [6] by different authors.

Additionally, the tumour sizes in the corrected Fig. 9 do not appear to match the volume bar chart, and the additional tumours in FigS5A appear too large to meet ethical standards around animal welfare.

The authors sent raw photos but were unable to provide the original Western blot images and the ethics approval. The Editor in Chief, therefore, has lost confidence in the integrity of the findings of this article. All authors agree with this retraction.

References

  1. Ning Y, Feng W, Cao X, et al. Correction to: Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis. J Exp Clin Cancer Res. 2021;40:155. https://doi.org/10.1186/s13046-021-01958-y.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Wen Q, Xu C, Zhou J, et al. 8-bromo-7-methoxychrysin suppress stemness of SMMC-7721 cells induced by co-culture of liver cancer stem-like cells with hepatic stellate cells. BMC Cancer. 2019;19:224. https://doi.org/10.1186/s12885-019-5419-5.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Sui X, Xu Y, Yang J, Fang Y, Lou H, Han W, et al. Use of Metformin Alone Is Not Associated with Survival Outcomes of Colorectal Cancer Cell but AMPK Activator AICAR Sensitizes Anticancer Effect of 5-Fluorouracil through AMPK Activation. PLoS ONE. 2014;9(5):e97781. https://doi.org/10.1371/journal.pone.0097781.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. McConnell BV, Koto K, Gutierrez-Hartmann A. Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression. Mol Cancer. 2011;10:75. https://doi.org/10.1186/1476-4598-10-75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Hui W, Yuntao L, Lun L, WenSheng L, ChaoFeng L, HaiYong H, et al. MicroRNA-195 Inhibits the Proliferation of Human Glioma Cells by Directly Targeting Cyclin D1 and Cyclin E1. PLoS ONE. 2013;8(1):e54932. https://doi.org/10.1371/journal.pone.0054932.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Choi KE, Hwang CJ, Gu SM, Park MH, Kim JH, Park JH, et al. Cancer Cell Growth Inhibitory Effect of Bee Venom via Increase of Death Receptor 3 Expression and Inactivation of NF-kappa B in NSCLC Cells. Toxins. 2014;6:2210–28. https://doi.org/10.3390/toxins6082210.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Jianguo Cao, Xiang Li or Xin Luo.

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Ning, Y., Feng, W., Cao, X. et al. Retraction Note: Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis. J Exp Clin Cancer Res 42, 30 (2023). https://doi.org/10.1186/s13046-023-02603-6

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  • DOI: https://doi.org/10.1186/s13046-023-02603-6