Skip to main content

Correction: Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44 + cancer stem cells to 5 azacytidine in hepatocellular carcinoma

The Original Article was published on 31 July 2018

Correction: J Exp Clin Cancer Res 37, 179 (2018)

https://doi.org/10.1186/s13046-018-0832-1

Following publication of the original article [1], errors were found in Fig. 5a due to misused of images in Hep3B-SCR/EV, -shOPN/EV, and -shOPN/DNMT1.

The correct figure is given below:

Fig. 5
figure 1

OPN modulates the properties of CD133+/CD44 + cells through regulating DNMT1. a When CD133+/CD44 + cells with shOPN were transfected with DNMT1 from Huh7 and Hep3B cells, the ability of sphere forming was rescued compared to the shOPN group, 40X. b The expression of indicated genes down regulated in CD133+/CD44 + cells from Huh7 and Hep3B transfected with shOPN compared to the control, were reversed in part by DNMT1 transfection. c The number of spheres formed by CD133+/CD44 + cells with EV, CD133+/CD44 + cells with OPN and CD133+/CD44 + cells with OPN treated by 5 Aza, **, p < 0.01, ***, p < 0.001. d The number of spheres formed by CD133+/CD44 + cells with EV/SCR, CD133+/CD44 + cells with OPN/SCR and CD133+/CD44 + cells with OPN/shDNMT1, **, p < 0.01. e CD133+/CD44 + SCR/EV, CD133+/CD44 + shOPN/EV and CD133+/CD44 + cells shOPN/DNMT1 from Huh7 were injected subcutaneously into the mice, and recorded the time of tumor initiation, tumor weight and tumor volume, **, p < 0.01, ***, p < 0.001, NS, no significance. f IHC staining of stemness-related markers, OCT4 and Nanog in the tumor tissues derived from CD133+/CD44 + cells with SCR/EV or shOPN/EV or shOPN/DNMT1

References

  1. Gao X, Sheng Y, Yang J, et al. Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44 + cancer stem cells to 5 azacytidine in hepatocellular carcinoma. J Exp Clin Cancer Res. 2018;37:179. https://doi.org/10.1186/s13046-018-0832-1.

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Qiongzhu Dong or Lunxiu Qin.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

The online version of the original article can be found at https://doi.org/10.1186/s13046-018-0832-1.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gao, X., Sheng, Y., Yang, J. et al. Correction: Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44 + cancer stem cells to 5 azacytidine in hepatocellular carcinoma. J Exp Clin Cancer Res 42, 266 (2023). https://doi.org/10.1186/s13046-023-02852-5

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/s13046-023-02852-5