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Correction: Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44 + cancer stem cells to 5 azacytidine in hepatocellular carcinoma
Journal of Experimental & Clinical Cancer Research volume 42, Article number: 266 (2023)
The Original Article was published on 31 July 2018
Correction: J Exp Clin Cancer Res 37, 179 (2018)
Following publication of the original article [1], errors were found in Fig. 5a due to misused of images in Hep3B-SCR/EV, -shOPN/EV, and -shOPN/DNMT1.
The correct figure is given below:
OPN modulates the properties of CD133+/CD44 + cells through regulating DNMT1. a When CD133+/CD44 + cells with shOPN were transfected with DNMT1 from Huh7 and Hep3B cells, the ability of sphere forming was rescued compared to the shOPN group, 40X. b The expression of indicated genes down regulated in CD133+/CD44 + cells from Huh7 and Hep3B transfected with shOPN compared to the control, were reversed in part by DNMT1 transfection. c The number of spheres formed by CD133+/CD44 + cells with EV, CD133+/CD44 + cells with OPN and CD133+/CD44 + cells with OPN treated by 5 Aza, **, p < 0.01, ***, p < 0.001. d The number of spheres formed by CD133+/CD44 + cells with EV/SCR, CD133+/CD44 + cells with OPN/SCR and CD133+/CD44 + cells with OPN/shDNMT1, **, p < 0.01. e CD133+/CD44 + SCR/EV, CD133+/CD44 + shOPN/EV and CD133+/CD44 + cells shOPN/DNMT1 from Huh7 were injected subcutaneously into the mice, and recorded the time of tumor initiation, tumor weight and tumor volume, **, p < 0.01, ***, p < 0.001, NS, no significance. f IHC staining of stemness-related markers, OCT4 and Nanog in the tumor tissues derived from CD133+/CD44 + cells with SCR/EV or shOPN/EV or shOPN/DNMT1
References
Gao X, Sheng Y, Yang J, et al. Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44 + cancer stem cells to 5 azacytidine in hepatocellular carcinoma. J Exp Clin Cancer Res. 2018;37:179. https://doi.org/10.1186/s13046-018-0832-1.
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Gao, X., Sheng, Y., Yang, J. et al. Correction: Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44 + cancer stem cells to 5 azacytidine in hepatocellular carcinoma. J Exp Clin Cancer Res 42, 266 (2023). https://doi.org/10.1186/s13046-023-02852-5
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DOI: https://doi.org/10.1186/s13046-023-02852-5