Correction: circPVT1 regulates medullary thyroid cancer growth and metastasis by targeting miR-455-5p to activate CXCL12/CXCR4 signaling

Correction: J Exp Clin Cancer Res 40, 157 (2021)

https://doi.org/10.1186/s13046-021-01964-0

Following the publication of the original article [1], authors would like to correct he typographical error in the cell line under Materials and Methods, Cell Culture section.

The correct sentence should read as:

Two human MTC cell lines (TT, MZ-CRC-1), and one normal human thyrocyte cell line (NThy-ori3.1) were used for the study as TT and MZ-CRC-1 are the two of most widely used MTC-derived cell lines [23–25].

Furthermore, the figure legends for figure 1, 3, 5 and 6 are in the wrong order. The right order for these figure legends are given below:

Fig. 1 miR-455-5p was reduced in MTC and overexpression of miR-455-5p suppressed MTC cell proliferation, migration, and invasion. a Relative miR-455-5p levels in MTC tissues and adjacent non-tumor tissues. b Survival rate in patients with high miR-455-5p level and low miR-455-5p level. c Relative miR-455-5p levels in MTC cells. d Relative miR-455-5p levels in MTC cells transfected with mimics NC or miR-455-5p mimics. e & f Representative images of colonies formed in mimics NC transfected or miR-455-5p mimics transfected MTC cells. g Flow cytometry analysis of the number of transfected cells in G1, S, and G2 phases. h Flow cytometry analysis of cell apoptosis in MTC cells transfected with mimics NC or miR-455-5p mimics. i & j Transwell assay to quantify the migration and invasion abilities of transfected cells. k & l EMT-related protein levels in transfected MTC cells. *P < 0.05; ** P < 0.01;*** P < 0.001

Fig. 3 Inhibition of CXCL12/CXCR4 signaling blocked the effects of miR-455-5p inhibitor on MTC cell proliferation, migration, and invasion. a Relative CXCL12 mRNA and protein levels in MTC cells transfected shNC or shCXCL12. b & c Representative images of colonies formed in MTC cells transfected miR-455-5p mimics or shCXCL12 or treated with CXCR4 antagonist AMD3100. d Flow cytometry analysis of the number of transfected cells in G1, S, and G2 phases. e Flow cytometry analysis of cell apoptosis in MTC cells transfected miR-455-5p mimics or shCXCL12 or treated with CXCR4 antagonist AMD3100. f & g Transwell assay to analyze the migration and invasion abilities of transfected cells. h & i EMT-related protein levels in MTC cells transfected miR-455-5p mimics or shCXCL12 or treated with CXCR4 antagonist AMD3100. *P < 0.05; ** P < 0.01; *** P < 0.001

Fig. 5 Knockdown of circPVT1 suppressed MTC cell proliferation, migration, and invasion. a & b The number of colonies formed in shNC transfected or shcircPVT1 transfected MTC cells. c Flow cytometry analysis of the number of transfected cells in G1, S, and G2 phases. d Flow cytometry analysis of cell apoptosis in MTC cells transfected with shNC or shcircPVT1. e & f Transwell assay assay to analyze migration and invasion abilities of transfected cells. g & h EMT-related protein levels in MTC cells transfected with shNC or shcircPVT1. * P < 0.05; ** P < 0.01; *** P < 0.001

Fig. 6 ci rcPVT1 regulated MTC cells proliferation and apoptosis via miR-455-5p/CXCL12 axis. a Relative circPVT1 level in MTC cells transfected circPVT1 overexpressing vector. b & c The number of colonies formed in MTC cells transfected with circPVT1 overexpressing vector or miR-455-5p mimics or treated with CXCR4 antagonist AMD3100. d Flow cytometry analysis of the number of transfected cells in G1, S, and G2 phases. e Flow cytometry analysis of cell apoptosis in MTC cells transfected with circPVT1 overexpressing vector or miR-455-5p mimics or treated with CXCR4 antagonist AMD3100. * P < 0.05; ** P < 0.01; *** P < 0.001

These corrections do not affect the overall result or conclusion of the article. The original article has been corrected.