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Articles
Page 55 of 77
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Citation: Journal of Experimental & Clinical Cancer Research 2016 35:102
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miRNA-106a directly targeting RARB associates with the expression of Na+/I− symporter in thyroid cancer by regulating MAPK signaling pathway
Serum miRNAs profiles between papillary thyroid carcinoma (PTC) patients with non-131I and 131I-avid lung metastases are differentially expressed. These miRNAs have to be further validated and the role of these m...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:101 -
RETRACTED ARTICLE: TRIM11 overexpression promotes proliferation, migration and invasion of lung cancer cells
Tripartite Motif Containing 11 (TRIM11), a member of TRIM proteins, is overexpressed in high-grade gliomas and plays an oncogenic function in glioma biology. However, little is known about the role of TRIM11 i...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:100 -
Synthetic tetracycline-controllable shRNA targeting long non-coding RNA HOXD-AS1 inhibits the progression of bladder cancer
Long non-coding RNAs (lncRNAs) have been proved to act as key molecules in cancer development and progression. Dysregulation of lncRNAs is discovered in various tumor tissues and cancer cells where they can se...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:99 -
Inhibition of SALL4 reduces tumorigenicity involving epithelial-mesenchymal transition via Wnt/β-catenin pathway in esophageal squamous cell carcinoma
Growing evidence suggests that SALL4 plays a vital role in tumor progression and metastasis. However, the molecular mechanism of SALL4 promoting esophageal squamous cell carcinoma (ESCC) remains to be elucidated.
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:98 -
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR
Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. PIK3CA, which encodes the phosphoinositide 3-kinase (PI3K) subunit p110α, is freq...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:97 -
Erratum to: Combined therapy with oncolytic adenoviruses encoding TRAIL and IL-12 genes markedly suppressed human hepatocellular carcinoma both in vitro and in an orthotopic transplanted mouse model
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:96 -
Erratum to: Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:95 -
Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs
Medulloblastoma (MB) is the most common pediatric brain tumor. Current treatment regimes consisting of primary surgery followed by radio- and chemotherapy, achieve 5-year overall survival rates of only about 6...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:94 -
MicroRNA-155-3p promotes hepatocellular carcinoma formation by suppressing FBXW7 expression
MicroRNAs (miRNAs) are small non-coding RNAs frequently dysregulated in human malignant tumors. In the present study, we analyzed the role miR-155-3p plays in Hepatocellular carcinoma (HCC), which has been rep...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:93 -
Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma
Brain-expressed X-linked (BEX) 4 is a member of BEX family. The functional role of BEX4 in oral squamous cell carcinoma (OSCC) remains unknown.
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:92 -
The role of the AMOP domain in MUC4/Y-promoted tumour angiogenesis and metastasis in pancreatic cancer
MUC4 is a high molecular weight membrane protein that is overexpressed in pancreatic cancer (PC) and is associated with the development and progression of this disease. However, the exact mechanisms through wh...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:91 -
Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a
Glioma is one of the most common and aggressive primary malignant tumor in the brain. Accumulating evidences indicated that aberrantly expressed non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNA...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:90 -
MicroRNA-655-3p functions as a tumor suppressor by regulating ADAM10 and β-catenin pathway in Hepatocellular Carcinoma
Increasing evidence suggests that microRNAs (miRNAs) play critical roles in malignant transformation, tumor progression and metastasis. Aberrant miR-655-3p expression has been associated with several cancers. ...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:89 -
RNF8 promotes epithelial-mesenchymal transition of breast cancer cells
Epithelial-mesenchymal transition (EMT) is a crucial step for solid tumor progression and plays an important role in cancer invasion and metastasis. RNF8 is an ubiquitin E3 ligase with RING domain, and plays e...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:88 -
Hepatitis B virus whole-X and X protein play distinct roles in HBV-related hepatocellular carcinoma progression
The role of HBV X protein (HBx) in the development of hepatocellular carcinoma (HCC) has been well studied. However, little is known about the molecular functions of HBV whole-X protein (HBwx), a protein fused...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:87 -
The comparison of clinical and biological characteristics between IDH1 and IDH2 mutations in gliomas
Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in low-grade gliomas and secondary glioblastomas (sGBM). Because they yield the same oncometabolite, D-2-hydroxygl...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:86 -
Elevated MTSS1 expression associated with metastasis and poor prognosis of residual hepatitis B-related hepatocellular carcinoma
Hepatectomy generally offers the best chance of long-term survival for patients with hepatocellular carcinoma (HCC). Many studies have shown that hepatectomy accelerates tumor metastasis, but the mechanism rem...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:85 -
Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication
The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous tissues compared to normal tissues and has regulatory roles in cell proliferation, cell viability, epithelial-mesenchymal tran...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:84 -
Up-regulation of long non-coding RNA PANDAR is associated with poor prognosis and promotes tumorigenesis in bladder cancer
Long non-coding RNAs (lncRNAs) have emerged as biomarkers and important regulators of tumor development and progression. PANDAR (promoter of CDKN1A antisense DNA damage activated RNA) is a novel long non-codin...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:83 -
Overexpression of CTNND1 in hepatocellular carcinoma promotes carcinous characters through activation of Wnt/β-catenin signaling
Increasing evidence supports the association of CTNND1 with tumor development and progression. However, the mechanism and clinical significance of CTNND1 deregulation in hepatocellular carcinoma (HCC) remains ...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:82 -
Erratum to: Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:81 -
Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients
It was reported that metastases might occur via transfer of biologically active blood circulating molecules from the primary tumor to distant organs rather than only migration of cancer cells. We showed in an ...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:80 -
FLIPL is critical for aerobic glycolysis in hepatocellular carcinoma
Tumor cells use aerobic glycolysis to rapidly generate ATP and growth substrate which expenses a large amount of glucose. However, how tumor cells take in enough glucose from the tumor microenvironment of insu...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:79 -
PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition
Glioblastoma multiforme is the most aggressive malignant primary brain tumor, characterized by rapid growth and extensive infiltration to neighboring normal brain parenchyma. Both PI3K/Akt and JNK pathways are...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:78 -
Erratum to: Pancreatic cancer cell-derived IGFBP-3 contributes to muscle wasting
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:77 -
MicroRNA-361-3p suppresses tumor cell proliferation and metastasis by directly targeting SH2B1 in NSCLC
Lung cancer is the most common malignancies worldwide. However, the detailed molecular mechanisms underlying lung cancer progression are still not completely clear. MicroRNAs are small noncoding RNAs which occ...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:76 -
High expression of long non-coding RNA SBF2-AS1 promotes proliferation in non-small cell lung cancer
Recent evidence has proven that long noncoding RNAs (lncRNAs) play important roles in cancer biology, while few lncRNAs have been characterized in NSCLC. Here, we characterized a novel lncRNA, SBF2 antisense R...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:75 -
Combined therapy with oncolytic adenoviruses encoding TRAIL and IL-12 genes markedly suppressed human hepatocellular carcinoma both in vitro and in an orthotopic transplanted mouse model
Gene-based virotherapy mediated by oncolytic viruses is currently experiencing a renaissance in cancer therapy. However, relatively little attention has been given to the potentiality of dual gene virotherapy ...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:74 -
Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
Chemotherapy with docetaxel (Doc) remains the standard treatment for metastatic and castration-resistance prostate cancer (CRPC). However, the clinical success of Doc is limited by its chemoresistance and side...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:73 -
TET3 inhibits TGF-β1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells
Abnormal DNA methylation/demethylation is recognized as a hallmark of cancer. TET (ten-eleven translocation) family members are novel DNA demethylation related proteins that dysregulate in multiple malignances...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:72 -
Enhancement of anti-tumor effects of 5-fluorouracil on hepatocellular carcinoma by low-intensity ultrasound
Hepatocellular carcinoma (HCC) accounts for 75 % of liver cancers and is the second most lethal cancer, associated with its multiple etiologies, poor prognosis and resistance to chemotherapy drugs. Chemotherap...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:71 -
Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer
Aberrant expression of the RON receptor tyrosine kinase, a member of the MET proto-oncogene family, in breast cancer and non-small cell lung cancer (NSCLC) has therapeutic implication. Here we evaluated the ef...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:70 -
MicroRNA-138 functions as a tumor suppressor in osteosarcoma by targeting differentiated embryonic chondrocyte gene 2
MicroRNA-138 (miR-138) has been proven to be a tumor suppressor gene in various types of tumors. However, the expression and the role of miR-138 in human osteosarcoma are still poorly understood. We investigat...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:69 -
Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer
Prohibitin (PHB), a pleiotropic protein overexpressed in several tumor types, has been implicated in the regulation of cell proliferation, invasive migration and survival. However, PHB expression and its biolo...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:68 -
Protein phosphatase 2A-B55δ enhances chemotherapy sensitivity of human hepatocellular carcinoma under the regulation of microRNA-133b
Hepatocellular carcinoma (HCC) remains a major public health problem worldwide. The identification of effective chemotherapeutic targets for advanced HCC patients is urgently required. In this study, we invest...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:67 -
Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization
Circulating tumor cells (CTCs) hold great potential in both clinical application and basic research for the managements of cancer. However, it remains to be an enormous challenge to obtain efficient detection ...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:66 -
EphA1 activation promotes the homing of endothelial progenitor cells to hepatocellular carcinoma for tumor neovascularization through the SDF-1/CXCR4 signaling pathway
Endothelial progenitor cells (EPCs) can migrate to the tumor tissue and enhance the angiogenesis of hepatocellular carcinoma (HCC); thus, they are associated with a poor prognosis. However, the specific molecu...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:65 -
High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia
B-Acute lymphoblastic leukemia (B-ALL) represents a hematologic malignancy with poor clinical outcome and low survival rates in adult patients. Remission rates in Hispanic population are almost 30 % lower and ...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:64 -
Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cγ1 and the ERK1/2 pathway
Sonic hedgehog (SHH) plays critical roles in cell growth and development. Tumor cells express SHH, which can promote cell proliferation and epithelial-to-mesenchymal transition. However, the autocrine SHH path...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:63 -
Topographic expression of the Hippo transducers TAZ and YAP in triple-negative breast cancer treated with neoadjuvant chemotherapy
The Hippo signaling acts as a tumor-suppressor pathway that negatively regulates TAZ and YAP. Increasing evidence supports the activation of TAZ and YAP in breast cancer. Moreover, the Hippo pathway is involve...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:62 -
Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo
Evidences indicate that inflammatory process plays pivotal role in tumor disease. Soluble epoxide hydrolase inhibitors (sEHIs) have been shown to participate in anti-inflammation and tumorigenesis by protectin...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:61 -
miR-539 inhibits prostate cancer progression by directly targeting SPAG5
We conducted multiple microarray datasets analyses from clinical and xenograft tumor tissues to search for disease progression-driving oncogenes in prostate cancer (PCa). Sperm-associated antigen 5 (SPAG5) att...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:60 -
Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells
Ursolic acid (UA), a natural pentacyclic triterpenoid, exerts anti-tumor effects in various cancer types including hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying this remain large...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:59 -
Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell
Microtubule Targeting Agents (MTAs) including paclitaxel, colchicine and vinca alkaloids are widely used in the treatment of various cancers. As with most chemotherapeutic agents, adverse effects and drug resi...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:58 -
Sustained delivery of siRNA/PEI complex from in situ forming hydrogels potently inhibits the proliferation of gastric cancer
Gastric cancer remains a major cause of mortality and morbidity worldwide. In recent years, gene-based therapeutic strategies were confirmed promising in cancer inhibition and attracted great attention. RNA in...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:57 -
Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations
DNA topoisomerase I (Top1) is a DNA unwinding protein and the specific target of the camptothecin class of chemotherapeutic drugs. One of these, irinotecan, acting through its active metabolite SN-38, is used ...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:56 -
Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model
The CXCL12/CXCR4 pathway regulates tumor cell proliferation, metastasis, angiogenesis and the tumor-microenvironment cross-talk in several solid tumors, including glioblastoma (GBM), the most common and fatal ...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:55 -
Phosphatidylserine exposing-platelets and microparticles promote procoagulant activity in colon cancer patients
Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear. We explored t...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:54 -
Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis
Previous study showed that dsP53-285 has the capacity to induce tumor suppressor gene p53 expression by targeting promoter in non-human primates’ cells. And it is well known that TP53 gene is frequently mutant...
Citation: Journal of Experimental & Clinical Cancer Research 2016 35:53
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Official journal of the Regina Elena National Cancer Institute, Scientific Director Gennaro Ciliberto, Rome, Italy
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Citation Impact 2023
Journal Impact Factor: 11.4
5-year Journal Impact Factor: 11.4
Source Normalized Impact per Paper (SNIP): 1.770
SCImago Journal Rank (SJR): 2.806Speed 2023
Submission to first editorial decision (median days): 5
Submission to acceptance (median days): 100Usage 2023
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