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  1. Mesothelin, a secreted protein, is overexpressed in some cancers, including pancreatic cancer. Rescent studies have shown that overexpression of mesothelin significantly increased tumor cell proliferation, and...

    Authors: Chunning Zheng, Wei Jia, Yong Tang, HuiLiang Zhao, Yingsheng Jiang and Shaochuan Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:84
    Content type: Research Published on:

  2. Metastasis via the lymphatic system is promoted by lymphangiogenesis. Alterations of the lymphatic channels during the progression of metastasis to regional lymph nodes (LNs) remain unexplored. To examine whet...

    Authors: Ryuki Ozasa, Jun Ohno, Teruaki Iwahashi and Kunihisa Taniguchi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:83
    Content type: Research Published on:

  3. Neuro-oncological population well expresses the complexity of neurological disability due to the multiple neurological deficits that affect these patients. Moreover, due to the therapeutical opportunities surv...

    Authors: Michelangelo Bartolo, Chiara Zucchella, Andrea Pace, Alessandro Marco De Nunzio, Mariano Serrao, Giorgio Sandrini and Francesco Pierelli
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:82
    Content type: Research Published on:

  5. It is well known that genetic alternation of epidermal growth factor receptor (EGFR) plays critical roles in tumorgenesis of lung cancer and can predict outcome of non-small-cell lung cancer treatment, especially...

    Authors: Jian Zhu, Yuyan Wang, Jianchun Duan, Hua Bai, Zhijie Wang, Lai Wei, Jun Zhao, Minglei Zhuo, Shuhang Wang, Lu Yang, Tongtong An, Meina Wu and Jie Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:80
    Content type: Research Published on:

  6. It is mandatory to confirm the absence of mutations in the KRAS gene before treating metastatic colorectal cancers with epidermal growth factor receptor inhibitors, and similar regulations are being considered fo...

    Authors: Sylwia Jancik, Jiri Drabek, Jitka Berkovcova, Yong Zhong Xu, Marcela Stankova, Jiri Klein, Vitezslav Kolek, Josef Skarda, Tomas Tichy, Ivona Grygarkova, Danuta Radzioch and Marian Hajduch
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:79
    Content type: Research Published on:

  7. The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above t...

    Authors: Laure Bobyk, Magali Edouard, Pierre Deman, Julia Rousseau, Jean-François Adam, Jean-Luc Ravanat, François Estève, Jacques Balosso, Rolf F Barth and Hélène Elleaume
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:78
    Content type: Research Published on:

  8. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have become a treatment option in non-small-cell lung cancer (NSCLC) patients. However, despite their use in this disease, a significan...

    Authors: Samuel Murray, Vasilios Karavasilis, Mattheos Bobos, Evangelia Razis, Savvas Papadopoulos, Christos Christodoulou, Paris Kosmidis and George Fountzilas
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:77
    Content type: Research Published on:

  9. Treatment protocols for nasopharyngeal carcinoma (NPC) developed in the past decade have significantly improved patient survival. In most NPC patients, however, the disease is diagnosed at late stages, and for...

    Authors: Adel M Zaatar, Chun Ren Lim, Chin Wei Bong, Michelle Mei Lin Lee, Jian Jiek Ooi, David Suria, Rakesh Raman, Samuel Chao, Hengxuan Yang, Soon Bin Neoh and Choong-Chin Liew
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:76
    Content type: Research Published on:

  10. Although hypoxia is known to promote hepatoma cell invasion and migration, little is known regarding the molecular mechanisms of this process. Our previous research showed that loss of Tg737 is associated with...

    Authors: Nan You, Weihui Liu, Lijun Tang, Xiao Zhong, Ru Ji, Ning Zhang, Desheng Wang, Yong He, Kefeng Dou and Kaishan Tao
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:75
    Content type: Research Published on:

  11. The efficiency of HSV-tk/GCV system is not high because of insufficient gene transfer and incompletely initiative of host antineoplastic potency. The present study was designed to assess the antitumor efficacy...

    Authors: Shuhui Hong, Ping Zhang, Hui Zhang, Lin Jia, Xun Qu, Qifeng Yang, Fengnian Rong and Beihua Kong
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:74
    Content type: Research Published on:

  12. To study the hypothesis that gemcitabine treatment augments the chemoresistance to gemcitabine by clusterin (sCLU) upregulation. Clusterin inhibition could augment the chemosensitivity of human pancreatic canc...

    Authors: Yong Tang, Fenghua Liu, Chunning Zheng, Shaochuan Sun and Yingsheng Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:73
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2013 32:42

  13. It is important to understand the mechanisms by which the cells integrate signals from different receptors. Several lines of evidence implicate epidermal growth factor (EGF) receptor (EGFR) in the pathophysiol...

    Authors: Ingun Heiene Tveteraas, Kristin Meisdalen Müller, Monica Aasrum, John Ødegård, Olav Dajani, Tormod Guren, Dagny Sandnes and Thoralf Christoffersen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:72
    Content type: Research Published on:

  14. Expression levels of CD133, a cancer stem cell marker, and of the α-subunit of the dystroglycan (α-DG) complex, have been previously reported to be altered in colorectal cancers.

    Authors: Claudio Coco, Gian Franco Zannoni, Emanuele Caredda, Stefano Sioletic, Alma Boninsegna, Mario Migaldi, Gianluca Rizzo, Luca Reggiani Bonetti, Giannicola Genovese, Egidio Stigliano, Achille Cittadini and Alessandro Sgambato
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:71
    Content type: Research Published on:

  15. Hsp90-beta and annexin A1 were investigated as prognostic factors because of their apparent association with tumorigenesis. However, the effect of Hsp90-beta and annexin A1 in lung cancer remains poorly unders...

    Authors: Rong Biaoxue, Jiang Xiling, Yang Shuanying, Zhang Wei, Cai Xiguang, Wang Jinsui and Zhang Min
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:70
    Content type: Research Published on:

  16. Although significant progress has been made in the treatment of lymphomas, many lymphomas exhibit resistance to cell death, suggesting a defective Fas signaling, which remains poorly understood. We previously ...

    Authors: Urszula Daniluk, Celine Kerros, Rong-Hua Tao, Jillian F Wise, Xue Ao, Zuzana Berkova and Felipe Samaniego
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:69
    Content type: Research Published on:

  17. Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins...

    Authors: Anke Van den Broeck, Hugo Vankelecom, Rudy Van Eijsden, Olivier Govaere and Baki Topal
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:68
    Content type: Research Published on:

  19. Propofol is one of the most commonly used intravenous anaesthetic agents during cancer resection surgery, but the effect of propofol on gallbladder cancer is not clear. NF-E2-related factor 2 (Nrf2) is abundan...

    Authors: Lingmin Zhang, Ning Wang, Suna Zhou, Wenguang Ye, Guixia Jing and Mingxin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:66
    Content type: Research Published on:

  20. EGFR mutation is a strong predictive factor of EGFR-TKIs therapy. However, at least 10% of patients with EGFR wild-type are responsive to TKIs, suggesting that other determinants of outcome besides EGFR mutati...

    Authors: Fen Wang, Shuhang Wang, Zhijie Wang, Jianchun Duan, Tongtong An, Jun Zhao, Hua Bai and Jie Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:65
    Content type: Research Published on:

  21. Prolyl hydroxylase domain 3 (PHD3) is a hypoxia inducible factor-α (HIFα) regulator; it degrades HIFα in the presence of oxygen. Recently, there have been an increasing number of studies about the role of PHD3...

    Authors: Qi-Lian Liang, Zhou-Yu Li, Yuan Zhou, Qiu-Long Liu, Wen-Ting Ou and Zhi-Gang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:64
    Content type: Research Published on:

  22. Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented protein that exploits its kinase activity to modulate key molecular pathways in cancer to restrain tumor growth and induce response to therap...

    Authors: Gabriella D’Orazi, Cinzia Rinaldo and Silvia Soddu
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:63
    Content type: Review Published on:

  23. Evidence indicates that CYP1A1 MspI polymorphism might be a possible risk factor for several malignancies. A growing body of literature has been devoted to the association of CYP1A1 MspI polymorphism with acut...

    Authors: Wenlei Zhuo, Liang Zhang, Yan Wang, Bo Zhu and Zhengtang Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:62
    Content type: Research Published on:

  24. Iodine 125 (125I) seed irradiation can be used as an important supplementary treatment for unresectable advanced gastric cancer. Here, we aim to comprehensively elucidate the biological effects induced by 125I...

    Authors: Zhen-Huan Ma, Yong Yang, Lei Zou and Kai-Yuan Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:61
    Content type: Research Published on:

  25. Cardiotoxicity is a major complication of anticancer drugs, including anthracyclines and 5-fluorouracil(5-FU) and it can have detrimental effects both in patients and workers involved in the preparation of che...

    Authors: Monica Lamberti, Stefania Porto, Monica Marra, Silvia Zappavigna, Anna Grimaldi, Daniela Feola, Delia Pesce, Silvio Naviglio, Annamaria Spina, Nicola Sannolo and Michele Caraglia
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:60
    Content type: Research Published on:

  26. Invasive ductal carcinoma is the most common type of breast malignancy, with varying molecular features and resistance to treatment. Although CD44+/CD24- cells are believed to act as breast cancer stem cells a...

    Authors: Yan Lin, Ying Zhong, Heng Guan, Xiaohui Zhang and Qiang Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:59
    Content type: Research Published on:

  28. The purpose of the current study was to determine whether a tropical ginger derived compound 1’-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wi...

    Authors: Vinita Batra, Zanobia Syed, Jennifer N Gill, Malari A Coburn, Patrick Adegboyega, John DiGiovanni, J Michael Mathis, Runhua Shi, John L Clifford and Heather E Kleiner-Hancock
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:57
    Content type: Research Published on:

  29. The progression of many solid tumors is characterized by the release of tumor-associated proteases and the detection of tumor specific proteolytic activity in serum specimens is a promising diagnostic tool in ...

    Authors: Peter Findeisen, Victor Costina, Diego Yepes, Ralf Hofheinz and Michael Neumaier
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:56
    Content type: Research Published on:

  30. It is still technically difficult to collect high purity cancer cells from tumor tissues, which contain noncancerous cells. We hypothesized that xenograft models of NOG mice expressing enhanced green fluoresce...

    Authors: Kentaro Shima, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Takaho Okada, Naoaki Sakata, Noriyuki Omura, Yo Kitamura, Fuyuhiko Motoi, Toshiki Rikiyama, Yu Katayose, Shinichi Egawa, Naoto Ishii, Akira Horii and Michiaki Unno
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:55
    Content type: Research Published on:

  31. Lung cancer is the major cause of cancer death globally, it is often diagnosed at an advanced stage and has one of the lowest survival rates of any type of cancer. The common interest in the field of lung canc...

    Authors: Peng Guan, Zhihua Yin, Xuelian Li, Wei Wu and Baosen Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:54
    Content type: Research Published on:

  33. In our previous study, we detected decreased expression of phospho-Smad1/5/8 and its upstream signaling molecule, bone morphogenetic protein receptor IB subunit (BMPR-IB), in certain glioblastoma tissues, unli...

    Authors: Shuang Liu, Feng Yin, Wenhong Fan, Shuwei Wang, Xin-ru Guo, Jian-ning Zhang, Zeng-min Tian and Ming Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:52
    Content type: Research Published on:

  35. New chemotherapic agents and new protocols in oncology have led to an increasing survival rate in patients affected by tumors. However, this increased use has been accompanied by a growth in the incidence of c...

    Authors: Gabriella Fabbrocini, Norma Cameli, Maria Concetta Romano, Maria Mariano, Luigia Panariello, Dario Bianca and Giuseppe Monfrecola
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:50
    Content type: Research Published on:

  36. Gastrokine-1 (GKN1), a secreted protein, is specifically expressed in gastric mucosa to protect and maintain the integrity of gastric epithelium. The present study investigated differential expression of GKN1 ...

    Authors: Wei Mao, Jie Chen, Tie-Li Peng, Xiao-Fei Yin, Lian-Zhou Chen and Min-Hu Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:49
    Content type: Research Published on:

  37. Baicalin, a flavone present in Scutellaria baicalensis Georgi, inhibits the growth of human leukemia and myeloma cells through induction of apoptosis.

    Authors: Yi Huang, Jianda Hu, Jing Zheng, Jing Li, Tiannan Wei, Zhihong Zheng and Yingyu Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:48
    Content type: Research Published on:

  38. Progress in recent years strengthened the concept of cellular tumor vaccinations. However, a crucial barrier to successful cancer immunotherapy is tumor-mediated immunosuppression. Tumor-derived soluble factor...

    Authors: Alexander Shimabukuro-Vornhagen, Andreas Draube, Tanja M Liebig, Achim Rothe, Matthias Kochanek and Michael S von Bergwelt-Baildon
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:47
    Content type: Research Published on:

  39. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor associated with gastric carcinogenesis. 3,3'-Diindolylmethane (DIM) is a relatively non-toxic selective AhR modulator. This study was ...

    Authors: Xiao-Fei Yin, Jie Chen, Wei Mao, Yu-Hong Wang and Min-Hu Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:46
    Content type: Research Published on:

  40. To understand the role of proteases involved in human thyroid cancer progression and tissue invasion, thyrocytes from other species could potentially be used provided their characteristics are similar. It is n...

    Authors: Eleonore Fröhlich, Elke Maier and Richard Wahl
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:45
    Content type: Research Published on:

  41. Chloride intracellular channel 1 (CLIC1) is expressed ubiquitously in human tissues and is involved in the regulation of cell cycle, cell proliferation and differentiation. Recent studies have shown that CLIC1...

    Authors: Liang Wang, Shiming He, Yanyang TU, Peigang Ji, Jianhai Zong, Jingyu Zhang, Fuqiang Feng, Jipei Zhao, Yongsheng Zhang and Guodong Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:44
    Content type: Research Published on:

  42. Recent studies have shown dysregulation in TJ structure of several cancers including breast. Claudin-5 is a protein member of the TJ structure expressed in both endothelial and epithelial cells. This study exa...

    Authors: Astrid Escudero-Esparza, Wen G Jiang and Tracey A Martin
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:43
    Content type: Research Published on:

  43. Previous studies suggested that estrogen receptor alpha (ERα) plays an important role in the chemoresistance of breast cancers. However, large random trials failed to demonstrate any benefit of the concurrent ...

    Authors: Zhinong Jiang, Junlan Guo, Jianguo Shen, Mei Jin, Shuduo Xie and Linbo Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:42
    Content type: Research Published on:

  44. Sigma-2 receptor ligands have been studied for treatment of pancreatic cancer because they are preferentially internalized by proliferating cells and induce apoptosis. This mechanism of apoptosis is poorly und...

    Authors: John R Hornick, Suwanna Vangveravong, Dirk Spitzer, Carmen Abate, Francesco Berardi, Peter Goedegebuure, Robert H Mach and William G Hawkins
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:41
    Content type: Research Published on:

  45. Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. VEGF is believed to implicate poor prognosis in various cancers. The overexpress...

    Authors: Lei Yang, Shuo You, Vikas Kumar, Chaoyue Zhang and Ya Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:40
    Content type: Research Published on:

  46. We have reported previously that overexpression of glucose-regulated protein 78 (GRP78) promotes the invasion of hepatocellular carcinoma. However, whether GRP78 knockdown affects the extracellular matrix degr...

    Authors: Hongdan Li, Huijuan Song, Junsheng Luo, Jia Liang, Song Zhao and Rongjian Su
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:39
    Content type: Research Published on:

  47. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level. The dysregulation of miRNAs has been linked to a series of diseases, including various ty...

    Authors: Ruimin Ma, Tao Jiang and Xixiong Kang
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:38
    Content type: Review Published on:

  48. Vascular endothelial growth factor (VEGF) plays a critical role in tumor angiogenesis. Bevacizumab is a humanized monoclonal antibody that neutralizes VEGF. We examined the impact on radiation response by bloc...

    Authors: Tien Hoang, Shyhmin Huang, Eric Armstrong, Jens C Eickhoff and Paul M Harari
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:37
    Content type: Research Published on:

  49. Stanniocalcin-1 (STC-1) is a potential marker of disseminated tumor cells (DTCs). The aim of this study was to examine STC-1 expression in peripheral blood (PB) and bone marrow (BM) of esophageal squamous cell...

    Authors: Haizhu Song, Biao Xu and Jun Yi
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:35
    Content type: Research Published on:

  50. This study was designed to establish a biomarker risk model for predicting bone metastasis in stage III non-small cell lung cancer (NSCLC).

    Authors: Zhen Zhou, Zhi-Wei Chen, Xiao-Hua Yang, Lan Shen, Xing-Hao Ai, Shun Lu and Qing-Quan Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:34
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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