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  1. Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive ...

    Authors: Filippo Galli, Jesus Vera Aguilera, Belinda Palermo, Svetomir N. Markovic, Paola Nisticò and Alberto Signore
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:89
  2. Overexpression of survivin plays a crucial role in tumorigenesis and correlates with poor prognosis in human malignancies. Thus, survivin has been proposed as an attractive target for new anti-tumor interventi...

    Authors: Ming Li, Feng Gao, Xinfang Yu, Qing Zhao, Li Zhou, Wenbin Liu and Wei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:88
  3. Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown ...

    Authors: Yuexian Zhou, Huifang Zong, Lei Han, Yueqing Xie, Hua Jiang, John Gilly, Baohong Zhang, Huili Lu, Jie Chen, Rui Sun, Zhidi Pan and Jianwei Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:87
  4. The very limited time allowed to face the COVID-19 pandemic poses a pressing challenge to find proper therapeutic approaches. However, synthesis and full investigation from preclinical studies to phase III tri...

    Authors: Gennaro Ciliberto, Rita Mancini and Marco G. Paggi
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:86
  5. In acute myeloid leukemia (AML), internal tandem duplication mutations in the FLT3 tyrosine kinase receptor (FLT3-ITD) are associated with a dismal outcome. Although uncoordinated 51-like kinase 1 (ULK1), whic...

    Authors: Doh Yu Hwang, Ju-In Eom, Ji Eun Jang, Hoi-Kyung Jeung, Haerim Chung, Jin Seok Kim, June-Won Cheong and Yoo Hong Min
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:85
  6. The Ecotropic viral integration site 5 (EVI5), an important protein in regulating cell cycle, cytokinesis and cellular membrane traffic, functions as a stabilizing factor maintaining anaphase-promoting complex...

    Authors: Tingting Cai, Jieqi Zhou, Yuanyuan Zeng, Wenwen Du, Yang Zhang, Ting Liu, Yulong Fu, Jian-an Huang, Qian Qian, Jianjie Zhu, Chunhua Ling and Zeyi Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:84
  7. Our previous studies have confirmed that cobalt chloride (CoCl2) can induce the formation of polyploid giant cancer cells (PGCCs), which is the key to the heterogeneity of solid tumors. PGCC formation is closely ...

    Authors: Kai Liu, Minying Zheng, Qi Zhao, Kexin Zhang, Zugui Li, Fangmei Fu, Hao Zhang, Jiaxing Du, Yuwei Li and Shiwu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:83
  8. Survivin and XIAP are two important members of the inhibitor of apoptosis protein family and have been considered as potential targets for cancer treatment due to their overexpression in large variety of cance...

    Authors: Wanxia Fang, Xiaofang Che, Guohui Li, Anhui Wang, Yizhe Wang, Xiaonan Shi, Kezuo Hou, Xiaojie Zhang, Xiujuan Qu and Yunpeng Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:82

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:384

  9. HER2-positive breast cancer is usually associated to the more aggressive progression and the worse prognosis, but the mechanism underlying the innate resistance to HER2-targeted therapy remains elusive. The sc...

    Authors: Hui Li, Mingming Zhang, Yanli Wei, Farhan Haider, Yitong Lin, Wen Guan, Yanbin Liu, Shaoyang Zhang, Ronghua Yuan, Xia Yang, Shulan Yang and Haihe Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:81
  10. In the original publication of this manuscript [1], there are errors in Fig. 3. The authors declare that the identified errors do not change the results or conclusions of this paper.

    Authors: Jiayan Yan, Yunxi Jia, Han Chen, Wei Chen and Xiaoying Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:80

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:390

  11. The poor prognosis of patients with ovarian cancer is mainly due to cancer progression. γ-Synuclein (SNCG) has reported as a critical player in cancer metastasis. However, its biological roles and mechanism ar...

    Authors: Jing Zhang, Xiao-han Liu, Cong Li, Xiao-xing Wu, Yan-lin Chen, Wen-wen Li, Xian Li, Fan Gong, Qin Tang and Dan Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:79

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:115

  12. The majority of high-risk neuroblastomas can be divided into three distinct molecular subgroups defined by the presence of MYCN amplification, upstream TERT rearrangements or alternative lengthening of telomeres ...

    Authors: S. L. George, V. Parmar, F. Lorenzi, L. V. Marshall, Y. Jamin, E. Poon, P. Angelini and L. Chesler
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:78
  13. Adapter chimeric antigen receptor (CAR) approaches have emerged has promising strategies to increase clinical safety of CAR T-cell therapy. In the UniCAR system, the safety switch is controlled via a target mo...

    Authors: Liliana R. Loureiro, Anja Feldmann, Ralf Bergmann, Stefanie Koristka, Nicole Berndt, Domokos Máthé, Nikolett Hegedüs, Krisztián Szigeti, Paula A. Videira, Michael Bachmann and Claudia Arndt
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:77
  14. GLYR1 has a high mutation frequency in microsatellite instability colorectal cancer (MSI CRC) and is presumed to be a novel tumor suppressor. However, the role of GLYR1 in tumors has never been studied. In par...

    Authors: Zhiyan Hu, Ting Long, Yidan Ma, Jiaxian Zhu, Lingfang Gao, Yan Zhong, Xia Wang, Xiaoyan Wang and Zuguo Li
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:76

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:125

  15. The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which mod...

    Authors: Somshuvra Bhattacharya, Kristin Calar and Pilar de la Puente
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:75
  16. Pancreatic cancer remains one of the most rapidly progressive and deadly malignancies worldwide. Current treatment regimens only result in small improvements in overall survival for patients with this cancer t...

    Authors: Lixia Gao, Zhigang Xu, Zheng Huang, Yan Tang, Donglin Yang, Jiuhong Huang, Leilei He, Manran Liu, Zhongzhu Chen and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:73
  17. In the original publication of this manuscript [1], Fig. 5a needs to be revised, and adjustments have also been made to the captions for Figs. 2, 4, 5 and S1 to improve clarity for the reader.

    Authors: Deyao Shi, Fashuai Wu, Shidai Mu, Binwu Hu, Binlong Zhong, Feng Gao, Xiangcheng Qing, Jianxiang Liu, Zhicai Zhang and Zengwu Shao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:72

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:375

  18. Increasing evidence indicates that epithelial-mesenchymal transition (EMT) can be regulated by microRNAs (miRNAs). miR-615-3p was shown to be involved in tumor development. However, the role of miR-615-3p in t...

    Authors: Bo Lei, Dandan Wang, Ming Zhang, Yuwei Deng, Huijie Jiang and Yiwen Li
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:71
  19. Tumor metastasis is one of the main causes of the high mortality of hepatocellular carcinoma (HCC). E-Twenty Six variant gene 6 (ETV6) is a strong transcriptional repressor, associated with the development and...

    Authors: Chunmei Guo, Chao Gao, Dongting Zhao, Jiahui Li, Jinxia Wang, Xujuan Sun, Qinlong Liu, Lihong Hao, Frederick T. Greenaway, Yuxiang Tian, Shuqing Liu and Ming-Zhong Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:70

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:68

  20. Liquid biopsy (LB) in early-stage, non-metastatic colorectal cancer (CRC) must be sensitive enough to detect extremely low circulating tumor DNA (ctDNA) levels. This challenge has been seldom and non-systemati...

    Authors: Matteo Allegretti, Giuliano Cottone, Fabio Carboni, Ettore Cotroneo, Beatrice Casini, Elena Giordani, Carla Azzurra Amoreo, Simonetta Buglioni, Maria Diodoro, Edoardo Pescarmona, Settimio Zazza, Orietta Federici, Massimo Zeuli, Laura Conti, Giovanni Cigliana, Francesco Fiorentino…
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:69
  21. High grade non-muscle-invasive bladder cancer (HG-NMIBC) is a heterogeneous disease with variable risk of progression. Urinary microRNAs are promising biomarkers for BC detection and surveillance. Let-7c-5p mi...

    Authors: Manuela Spagnuolo, Manuela Costantini, Mariaconsiglia Ferriero, Marco Varmi, Isabella Sperduti, Giulia Regazzo, Lucia Cicchillitti, Ana Belén Díaz Méndez, Giovanni Cigliana, Vincenzo Pompeo, Andrea Russo, Valentina Laquintana, Riccardo Mastroianni, Giulia Piaggio, Umberto Anceschi, Aldo Brassetti…
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:68
  22. Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as e...

    Authors: Shiming Tan, Longzheng Xia, Pin Yi, Yaqian Han, Lu Tang, Qing Pan, Yutong Tian, Shan Rao, Linda Oyang, Jiaxin Liang, Jinguan Lin, Min Su, Yingrui Shi, Deliang Cao, Yujuan Zhou and Qianjin Liao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:67
  23. The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs),...

    Authors: Ji Eun Jang, Ju-In Eom, Hoi-Kyung Jeung, Haerim Chung, Yu Ri Kim, Jin Seok Kim, June-Won Cheong and Yoo Hong Min
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:66
  24. Cancer-associated fibroblasts (CAFs) have been intensively studied in recent studies with aims of finding more concrete evidence on their mechanism of involvement in tumor progression, which is currently unkno...

    Authors: Xijuan Chen, Junqi Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Hong Ge and Yingqiang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:65
  25. Sustained adrenergic signaling secondary to chronic stress promotes cancer progression; however, the underlying mechanisms for this phenomenon remain unclear. Hepatocellular carcinoma (HCC) frequently develops...

    Authors: Xia-Hui Lin, Hua-Hua Liu, Shu-Jung Hsu, Rui Zhang, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren and Rong-Xin Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:64
  26. Glioma is a common brain malignancy with high mortality. The competing endogenous RNA (ceRNA) networks may play key roles in cancer progression. This study was conducted to probe the role of long noncoding RNA...

    Authors: Lifa Huang, Xu Li, Hui Ye, Yajun Liu, Xiaolong Liang, Chao Yang, Lin Hua, Zhaoxian Yan and Xin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:63

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:243

  27. Epidermal growth factor receptor (EGFR) activating mutations play crucial roles in the tumorigenesis of human non-small cell lung cancer (NSCLC). The mechanism regarding how EGFR signaling regulates myeloid ce...

    Authors: Xinyou Yu, Feng Gao, Wei Li, Li Zhou, Wenbin Liu and Ming Li
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:62
  28. Revealing the mechanical role of long non-coding RNAs (lncRNAs) in tumorigenesis can contribute to novel therapeutic target for cancers. The regulatory role of linc01134 in hepatocellular carcinoma (HCC) has n...

    Authors: Zhonghou Rong, Zhiyi Wang, Xinxing Wang, Chengkun Qin and Wenmao Geng
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:61
  29. In the original publication of this manuscript [1], RRS1 stands for ‘Ribosome biogenesis regulatory protein homolog’ instead of ‘resistance to ralstonia solanacearum 1’. This mistake appears 4 times in the man...

    Authors: Wenfei Xia, Yun Liu, Teng Cheng, Tao Xu, Menglu Dong and Xiaopeng Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:60

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:18

  30. Cullin-7 (CUL7) is a member of the DOC domain-containing cullin family and is involved in the regulation of cell transformation. However, the clinical significance, potential mechanism and upstream regulators ...

    Authors: Jianye Xu, Zongpu Zhang, Mingyu Qian, Shaobo Wang, Wei Qiu, Zihang Chen, Zhongzheng Sun, Ye Xiong, Chaochao Wang, Xiaopeng Sun, Rongrong Zhao, Hao Xue and Gang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:59
  31. Human ovarian cancer specific transcript 2 (HOST2) is a long non-coding RNA (lncRNA) reported to be specifically high expressed in human ovarian cancer. However, the mechanism that how HOST2 regulates triple n...

    Authors: Kaiyao Hua, Xiaochong Deng, Jiashu Hu, Changle Ji, Yunhe Yu, Jiayi Li, Xuehui Wang and Lin Fang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:58
  32. Circular RNAs (circRNAs) are a novel class of noncoding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. According to recent studies, circRNAs are involved in the pathoge...

    Authors: Yuzhu Xu, Jun Yu, Zhenli Huang, Bohua Fu, Yu Tao, Xuefei Qi, Yong Mou, Yinan Hu, Yi Wang, Yong Cao, Dingsheng Jiang, Jungang Xie, Yongjian Xu, Jianping Zhao and Weining Xiong
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:57
  33. In the original publication of this manuscript [1], the Fig. 6a invasion si-hsa_circ_0058124_2# group (row 2 right and row 3 right) and Fig. 9c TPC-1 clone formation assay control group (row 1 left) were mispl...

    Authors: Yao Yao, Xinyuan Chen, Hong Yang, Wei Chen, Yichun Qian, Zhongyi Yan, Tian Liao, Weiping Yao, Wenlan Wu, Tonghua Yu, Yun Chen and Yuan Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:56

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:318

  34. Biological role and clinical significance of circular RNAs (circRNAs) remain largely unknown. Herein, we aimed to investigate biological function, molecular mechanism, and clinical significance of a circular R...

    Authors: Chengtao Yu, Zhuoan Cheng, Shaohua Cui, Xiaowei Mao, Botai Li, Yujie Fu, Hui Wang, Haojie Jin, Qing Ye, Xiaojing Zhao, Liyan Jiang and Wenxin Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:55
  35. Exosomes are vesicles of endocytic origin released by various cell types and emerging as important mediators in tumor cells. Human metastases-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-...

    Authors: Jingchao Xu, Yang Xiao, Bing Liu, Shimeng Pan, Qianqian Liu, Yujia Shan, Shuangda Li, Yu Qi, Yiran Huang and Li Jia
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:54
  36. Epithelial ovarian cancer (EOC) is a highly lethal malignancy. Improvement in genetic characterization of EOC patients is required to propose new potential targets, since surgical resection coupled to chemothe...

    Authors: Luyao Guan, Zhang Li, Feifei Xie, Yuzhi Pang, Chenyun Zhang, Haosha Tang, Hao Zhang, Chun Chen, Yaying Zhan, Ting Zhao, Hongyuan Jiang, Xiaona Jia, Yuexiang Wang and Yuan Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:53
  37. Runt-related transcription factor 1 (RUNX1) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters and can accelerate apoptosis in various tumors. However, the r...

    Authors: Mei Hong, Jing He, Duo Li, Yuanyuan Chu, Jiarui Pu, Qiangsong Tong, Harish C. Joshi, Shaotao Tang and Shiwang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:52
  38. In-depth analysis of global RNA sequencing has enabled a comprehensive overview of cellular transcriptomes and revealed the pervasive transcription of divergent RNAs from promoter regions across eukaryotic gen...

    Authors: Lidia Chellini, Valentina Frezza and Maria Paola Paronetto
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:51
  39. Inhibition of ABC transporters is considered the most effective way to circumvent multidrug resistance (MDR). In the present study, we evaluated the MDR modulatory potential of ERK5-IN-1, a potent extracelluar...

    Authors: Fang Wang, Delan Li, ZongHeng Zheng, Kenneth Kin Wah To, Zhen Chen, Mengjun Zhong, Xiaodong Su, Likun Chen and Liwu Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:50
  40. CAR T cell-based therapies have shown promising results in hematological malignancies. Results of CAR T cell projects in solid tumors have been less impressive, and factors including lack of targetable antigen...

    Authors: Elham Masoumi, Leila Jafarzadeh, Hamid Reza Mirzaei, Khadijeh Alishah, Keyvan Fallah-Mehrjardi, Hosein Rostamian, Mohammad Khakpoor-Koosheh, Reza Meshkani, Farshid Noorbakhsh and Jamshid Hadjati
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:49
  41. Molecular profiling of DNA and RNA has provided valuable new insights into the genetic basis of non-malignant and malignant disorders, as well as an increased understanding of basic mechanisms that regulate hu...

    Authors: Maria Teresa Di Martino, Stefania Meschini, Katia Scotlandi, Chiara Riganti, Enrico De Smaele, Francesca Zazzeroni, Massimo Donadelli, Carlo Leonetti and Michele Caraglia
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:48
  42. The promising expectations about personalized medicine have opened the path to routine large-scale sequencing and increased the importance of genetic counseling for hereditary cancers, among which hereditary b...

    Authors: Giulia Federici and Silvia Soddu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:46
  43. In the original publication of this manuscript [1], Fig. 2 contains incorrect labels and feedback loops. The revised version of Fig. 2 is shown below.

    Authors: Xiafeng Peng, Han Gao, Rui Xu, Huiyu Wang, Jie Mei and Chaoying Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:45

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:27

  44. FK506-binding protein 9 (FKBP9) is amplified in high-grade gliomas (HGGs). However, the roles and mechanism(s) of FKBP9 in glioma are unknown.

    Authors: Huizhe Xu, Peng Liu, Yumei Yan, Kun Fang, Dapeng Liang, Xiukun Hou, Xiaohong Zhang, Songyan Wu, Jianmei Ma, Ruoyu Wang, Tao Li, Haozhe Piao and Songshu Meng
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:44
  45. In the original publication of this manuscript [1], Fig. 1 contained a typographical error (‘Metabolic’ incorrectly written as ‘Metabolig’).

    Authors: Maria Carla Bosco, Gabriella D’. Orazi and Donatella Del Bufalo
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:43

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:8

  46. We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly recognized factor that promotes tumor metastasis. In ...

    Authors: Yiyang Jia, Yantong Guo, Qiu Jin, Huinan Qu, Da Qi, Peiye Song, Xiaoli Zhang, Xinqi Wang, Wenhong Xu, Yuan Dong, Yingying Liang and Chengshi Quan
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:42
  47. The oncogene MYCN is critical for tumorigenesis of several types of cancers including neuroblastoma. We previously reported that miR-506-3p repressed MYCN expression in neuroblastoma cells. However, the mechan...

    Authors: Zhenze Zhao, Spencer D. Shelton, Alejandro Oviedo, Amy L. Baker, Collin P. Bryant, Soroush Omidvarnia and Liqin Du
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:41
  48. Osteosarcoma (OS) is an aggressive malignant neoplasm that still suffers from poor prognosis in the case of distal metastases or occurrence of multi-drug resistance. It is therefore crucial to find novel thera...

    Authors: Stefania Lenna, Chiara Bellotti, Serena Duchi, Elisa Martella, Marta Columbaro, Barbara Dozza, Marco Ballestri, Andrea Guerrini, Giovanna Sotgiu, Tommaso Frisoni, Luca Cevolani, Greta Varchi, Mauro Ferrari, Davide Maria Donati and Enrico Lucarelli
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:40
  49. New therapies are urgently needed in melanoma particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors.

    Authors: Wei Liu, Paweł Stachura, Haifeng C. Xu, Nikkitha Umesh Ganesh, Fiona Cox, Ruifeng Wang, Karl S. Lang, Jay Gopalakrishnan, Dieter Häussinger, Bernhard Homey, Philipp A. Lang and Aleksandra A. Pandyra
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:38

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