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  1. Content type: Research

    mTOR signaling pathway and its downstream serine/threonine kinase p70S6k were frequently activated in human cancers. The dysregulation of the mTOR pathway has been found to be a contributing factor of a variet...

    Authors: Li Xiao, Yi C Wang, Wu S Li and Yan Du

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:152

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  2. Content type: Research

    Many experimental data evidence that over-expression of various growth factors cause disorders in cell proliferation. The role of the Fibroblast Growth Factors (FGF) in growth control is indisputable: in parti...

    Authors: Gianfranco Risuleo, Marina Ciacciarelli, Mauro Castelli and Gaspare Galati

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:151

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  3. Content type: Research

    Gene targeted therapy refers to any therapy focused on one of the many biological features of the tumor. Such features are mediated by specific genes that are involved in tumor metastasis, recurrence, poor res...

    Authors: Jun Wan, Jinben Ma, Ju Mei and Genfa Shan

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:150

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  4. Content type: Research

    More studies based on gene expression data have been reported in great detail, however, one major challenge for the methodologists is the choice of classification methods. The main purpose of this research was...

    Authors: Desheng Huang, Yu Quan, Miao He and Baosen Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:149

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  5. Content type: Research

    Carotid body tumours (CBTs) are very rare lesions which should be treated as soon as possible even when benign since small tumour size permits easier removal and lower incidence of perioperative complications ...

    Authors: Ombretta Martinelli, Luigi Irace, Rita Massa, Sara Savelli, Fabrizia Giannoni, Roberto Gattuso, Bruno Gossetti, Fabrizio Benedetti-Valentini and Luciano Izzo

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:148

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  6. Content type: Research

    Antibody Directed Enzyme Prodrug Therapy (ADEPT) can be used to generate cytotoxic agents at the tumor site. To date non-human enzymes have mainly been utilized in ADEPT. However, these non-human enzymes are i...

    Authors: Sepideh Afshar, Tove Olafsen, Anna M Wu and Sherie L Morrison

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:147

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  7. Content type: Research

    Carbohydrates embedded in the plasma membrane are one of the main actors involved in the communication of cells with the microenvironment. Neuraminic sialic acids are glycocalyx sugars that play important role...

    Authors: Mariano R Gabri, Laura L Otero, Daniel E Gomez and Daniel F Alonso

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:146

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  8. Content type: Review

    To establish a relationship between esophageal squamous cell diseases and the expression of human telomerase reverse transcriptase (hTERT) and Eyes absent 4 (EYA4) mRNA in peripheral blood mononuclear cells.

    Authors: Hao Li, Tao Yu Diao, Zhi Ying Zhou, Fang Yan Yang, Qing Ma and Qing Hui Li

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:145

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  9. Content type: Research

    To detect the expression of multidrug resistance molecules P-glycoprotein (P-gp), Lung resistnce protein (LRP) and Multidrug resistance-associated protein (MRP) and analyze the relationship between them and th...

    Authors: Wen-Qing Hu, Chun-Wei Peng and Yan Li

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:144

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  10. Content type: Research

    Despite aggressive therapy, advanced stage neuroblastoma patients have poor survival rates. Although angiogenesis correlates with advanced tumour stage and plays an important role in determining the tumour res...

    Authors: Gordana Jakovljević, Srđana Čulić, Jasminka Stepan, Aleksandra Bonevski and Sven Seiwerth

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:143

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  11. Content type: Research

    Studies of treatment with octreotide of patients with hepatocellular carcinoma (HCC) gave conflicting results. We analyzed retrospectively the survival of our patients treated with octreotide monotherapy and c...

    Authors: Maximilian Schöniger-Hekele, Joachim Kettenbach, Markus Peck-Radosavljevic and Christian Müller

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:142

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  12. Content type: Research

    The regulation of growth and apoptosis in K562 cells by human bone marrow mesenchymal stem cells (MSCs) from leukemia patients was investigated.

    Authors: Zhaohui Wei, Naiyao Chen, Hongxing Guo, Xueming Wang, Fangyun Xu, Qian Ren, ShiHong Lu, Bin Liu, Lei Zhang and Hui Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:141

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  13. Content type: Research

    Genetic factors are thought to play a role in development for colorectal carcinogenesis. ICAM-1 is a polymorphic gene, thus, the present study investigated the relationship between the polymorphisms of ICAM-1 and...

    Authors: Qing-lei Wang, Bing-hui Li, Bin Liu, Ya-bin Liu, Yue-Ping Liu, Sui-Bing Miao, Yi Han, Jin-Kun Wen and Mei Han

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:139

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  14. Content type: Research

    No single and thoroughly validated imaging method in monitoring of cryoablated renal cell carcinoma (RCC) is available. The purpose of our study was to determine the feasibility of dynamic contrast-enhanced pe...

    Authors: Ettore Squillaci, Guglielmo Manenti, Carmelo Cicciò, Francesca Nucera, Pierluigi Bove, Giuseppe Vespasiani, Laura Russolillo and Giovanni Simonetti

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:138

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  15. Content type: Retraction Note

    Authors: Hyo-Jeong Lee, Jae-Ho Lee, Eun-Ok Lee, Hyo-Jung Lee, Kwan-Hyun Kim, Sun-Hyung Kim, Keun-Sung Lee, Hee-Jae Jung and Sung-Hoon Kim

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:137

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2009 28:102

  16. Content type: Research

    Apoptosis is a major mode of hematological tumor death after radiation. Early detection of apoptosis may be beneficial for cancer adaptive treatment. 99mTc-HYNIC-annexinV has been reported as a promising agent fo...

    Authors: Ming-fang Guo, Yaqing Zhao, Rong Tian, Lin Li, Leiming Guo, Feng Xu, Yong-mei Liu, Yong-bo He, Sen Bai and Jin Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:136

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  17. Content type: Review

    To investigate prostate cancer (Pca) risk in relation to estrogen metabolism, expressed as urinary 2-hydroxyestrone (2-OHE1), 16α-hydroxyestrone (16α-OHE1) and 2-OHE1 to 16α-OHE1 ratio.

    Authors: Maddalena Barba, Li Yang, Holger J Schünemann, Francesca Sperati, Sara Grioni, Saverio Stranges, Kim C Westerlind, Giovanni Blandino, Michele Gallucci, Rossella Lauria, Luca Malorni and Paola Muti

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:135

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  18. Content type: Review

    Chromophobe renal cell carcinoma (ChRCC) is a subtype of renal cell carcinoma (RCC). ChRCC is diagnosed mainly in 6th decade of life. An incidence of ChRCC is similar in both men and woman. Eighty six percent ...

    Authors: Rafał Stec, Bartłomiej Grala, Michał Mączewski, Lubomir Bodnar and Cezary Szczylik

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:134

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  19. Content type: Research

    The epidermal growth factor receptor variant III (EGFRvIII) is the most common variation of EGFR. Because it shows a high frequency in several different types of tumor and has not been detected in normal tissu...

    Authors: Xiao-yi Duan, Dong-gang Han, Ming-xin Zhang and Jian-sheng Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:133

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  20. Content type: Research

    Many studies have shown that colon cancer is an estrogen-dependent carcinoma. This study explored the efficacy of endocrine therapy in colon cancer cells with high metastatic potential (HT29). We investigated ...

    Authors: Yu-Jing Fang, Zhi-Zhong Pan, Li-Ren Li, Zhen-Hai Lu, Li-Yi Zhang and De-Sen Wan

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:132

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  21. Content type: Research

    This study was designed to mainly evaluate the activity and safety of olanzapine compared with 5-hydroxytryptamine3(5-HT3) receptor antagonists for prevention of chemotherapy-induced nausea and vomiting(CINV) in ...

    Authors: Lijun Tan, Jiangtao Liu, Xiuli Liu, Jie Chen, Zhijun Yan, Huifen Yang and Daxin Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:131

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  22. Content type: Research

    Polo-like kinase-1 (PLK-1) is reported to be upregulated in a variety of human tumors and is implicated in cell proliferation and survival. However, its importance in cervical carcinoma has not yet been fully ...

    Authors: Yuan Zhang, Yu Liu, Yuan-Xian Yang, Jia-Hong Xia, Hong-Xiu Zhang, Hua-Bin Li and Chun-Zhao Yu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:130

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  23. Content type: Research

    Expression of the Sp1 transcription factor is induced by hypoxia, and the ADAM17 promoter contains predicted Sp1 binding sites. ADAM17 contributes to hypoxic-induce invasiveness of glioma. In this study, we in...

    Authors: Alexandra Szalad, Mark Katakowski, Xuguang Zheng, Feng Jiang and Michael Chopp

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:129

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  24. Content type: Case study

    Sexual dysfunction following surgery for rectal cancer may be frequent and often severe. The aim of the present study is to evaluate the occurrence of this complication from both a clinical point of view and b...

    Authors: Alberto Pietrangeli, Patrizia Pugliese, Maria Perrone, Isabella Sperduti, Maurizio Cosimelli and Bruno Jandolo

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:128

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  25. Content type: Research

    Although gastric caner (GC) remains the second cause of cancer-related death, useful biomarkers for prognosis are still unavailable. We present here the attempt of mining novel biomarkers for GC prognosis by u...

    Authors: Fu-Ming Qiu, Jie-Kai Yu, Yi-Ding Chen, Qi-Feng Jin, Mei-Hua Sui and Jian Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:126

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  26. Content type: Research

    The aim of this study was to determine the clinicopathological features of gastric cancers with loss of imprinting (LOI) of LIT1. Insulin-like growth factor 2 (IGF2) and H19 in Chinese patients.

    Authors: Yang Lu, Ping Lu, Zhi Zhu, Huimian Xu and Xike Zhu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:125

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  27. Content type: Research

    Vasculogenic mimicry (VM) was increasingly recognized as a form of aggressive melanoma acquiring blood supply. Genistein had attracted much attention as a potential anticancer agent. Therefore, we examined the...

    Authors: Rihong Cong, Qingmin Sun, Li Yang, Haijuan Gu, Ying Zeng and Bin Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:124

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  28. Content type: Research

    Despite of the recent success of EGFR inhibitory agents, the primary drug-resistant becomes a major challenge for EGFR inhibitor therapies. PTEN gene is an important positive regulatory factor for response to ...

    Authors: Hong-Qing Zhuang, Jun Wang, Zhi-Yong Yuan, Lu-Jun Zhao, Ping Wang and Chang-Li Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:123

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  29. Content type: Research

    Hepatocellular carcinoma (HCC), a major cause of cancer death in China, is preceded by chronic hepatitis and liver cirrhosis (LC). Although hepatitis B virus (HBV) has been regarded as a clear etiology of huma...

    Authors: Ning Li, Yunzhu Long, Xuegong Fan, Hongbo Liu, Cui Li, Lizhang Chen and Zhiming Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:122

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  30. Content type: Research

    In cancer patients, MUC1 glycoprotein may carry Lewis y which could be involved in immune response. Purposes: 1- to evaluate the presence of Lewis y and MUC1 in circulating immune complexes (Lewis y/CIC and MU...

    Authors: Marina Isla Larrain, Sandra Demichelis, Marina Crespo, Ezequiel Lacunza, Alberto Barbera, Aldo Cretón, Francisco Terrier, Amada Segal-Eiras and María Virginia Croce

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:121

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  31. Content type: Research

    Germ cell testicular tumors have survival rate that diminishes with high tumor marker levels, such as human chorionic gonadotropin (hCG). hCG may regulate vascular neoformation through vascular endothelial gro...

    Authors: Oscar Arrieta, Rosa Mayela Michel Ortega, Julián Ángeles-Sánchez, Cynthia Villarreal-Garza, Alejandro Avilés-Salas, José G Chanona-Vilchis, Elena Aréchaga-Ocampo, Arturo Luévano-González, Miguel Ángel Jiménez and José Luis Aguilar

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:120

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  32. Content type: Research

    This study was designed to explore the feasibility, safety, and outcomes of pre-operative oxaliplatin-dacarbazine combination therapy for the treatment of advanced soft tissue sarcoma (STS) of the limb.

    Authors: Xiang-Yun Zong, Yang Yu and Hong-Jian Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:119

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  33. Content type: Research

    Vimentin is one of the cytoplasmic intermediate filament proteins which are the major component of the cytoskeleton. In our study we checked the usefulness of vimentin expression in identifying cases of breast...

    Authors: Renata U Kusinska, Radzislaw Kordek, Elzbieta Pluciennik, Andrzej K Bednarek, Janusz H Piekarski and Piotr Potemski

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:118

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  34. Content type: Research

    Recently, the use of hypo-fractionated treatment schemes for the prostate cancer has been encouraged due to the fact that α/β ratio for prostate cancer should be low. However a major concern on the use of hypo...

    Authors: Simona Marzi, Biancamaria Saracino, Maria G Petrongari, Stefano Arcangeli, Sara Gomellini, Giorgio Arcangeli, Marcello Benassi and Valeria Landoni

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:117

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  35. Content type: Research

    Recently, maintaining higher relative dose intensity (RDI) of chemotherapeutic drugs has become a widespread practice in an attempt to achieve better outcomes in the treatment of aggressive lymphoma. The addit...

    Authors: Yoshiki Terada, Hirohisa Nakamae, Ran Aimoto, Hiroshi Kanashima, Erina Sakamoto, Mizuki Aimoto, Eri Inoue, Hideo Koh, Takahiko Nakane, Yasunobu Takeoka, Masahiko Ohsawa, Ki-Ryang Koh, Takahisa Yamane, Yoshitaka Nakao, Kensuke Ohta, Atsuko Mugitani…

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:116

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  36. Content type: Research

    Previously, TP53 codon 72 polymorphisms have been implicated as risk factors for various cancers. A number of studies have conducted on the association of TP53 codon 72 polymorphisms with susceptibility to bre...

    Authors: Wenlei Zhuo, Yunsong Zhang, Zhaolan Xiang, Lei Cai and Zhengtang Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:115

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  37. Content type: Review

    The treatment of soft tissue tumors needs the coordinated adoption of surgery with radiation therapy and eventually, chemotherapy. The radiation therapy (delivered with a linear accelerator) can be preoperativ...

    Authors: Enrico P Spugnini, Gennaro Citro and Alfonso Baldi

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:114

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  38. Content type: Research

    Compounds derived from biologic sources, or biologicals, are increasingly utilized as therapeutic agents in malignancy. Development of anti-cancer targeted therapies from biologics is increasingly being utiliz...

    Authors: Jeffrey B Hoag, Aimel Azizi, Timothy J Doherty, Jason Lu, Rudolph E Willis and Mark E Lund

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:113

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  39. Content type: Research

    Liver cancer is a common malignancy with a high mortality rate. Given the poor prognosis associated with this cancer, many patients seek additional therapies that may improve quality of life or survival. Sever...

    Authors: Ping Wu, Jean Jacques Dugoua, Oghenowede Eyawo and Edward J Mills

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:112

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  40. Content type: Research

    APMCF1 is a novel human gene first cloned from apoptotic MCF-7 cells. Our previous study found ectogenic APMCF1 could induce G1 arrest in hepatocarcinoma cell line HHCC. In order to search its broad expression...

    Authors: Yaqing Zhang, Qinlong Li, Feng Zhu, Jihong Cui, Kainan Li, Qing Li, Ruian Wang, Wenyong Wang, Weihua Wang and Wei Yan

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:111

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  41. Content type: Research

    Despite multidisciplinary treatment, lung cancer remains a highly lethal disease due to poor response to chemotherapy. The identification of therapeutic agents with synergistic effects with traditional drugs i...

    Authors: Hecheng Li, XiaoLi Zhu, Yawei Zhang, Jiaqing Xiang and Haiquan Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:110

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  42. Content type: Research

    Combination chemotherapy with oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) has become a standard regimen for colorectal cancer. An increase of adverse events with combination chemotherapy is predicted i...

    Authors: Shinichi Sugimoto, Kuniyuki Katano, Akiyoshi Kanazawa, Hiroshi Yoshimura, Akihiko Kidani, Hiroshi Takeda, Masato Makino, Nobuhiro Ozaki, Tsuneo Tanaka and Masahide Ikeguchi

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:109

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  43. Content type: Research

    Barrett's mucosa is the precursor of esophageal adenocarcinoma. The molecular mechanisms behind Barrett's carcinogenesis are largely unknown. Experimental models of longstanding esophageal reflux of duodenal-g...

    Authors: Giuseppe Ingravallo, Luigi Dall'Olmo, Daniela Segat, Matteo Fassan, Claudia Mescoli, Emanuela Dazzo, Carlo Castoro, Lorenzo Polimeno, Christian Rizzetto, Maurizio David Baroni, Giovanni Zaninotto, Ermanno Ancona and Massimo Rugge

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:108

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  44. Content type: Research

    Liver cancr is a heterogeneous disease in terms of etiology, biologic and clinical behavior. Very little is known about how many genes concur at the molecular level of tumor development, progression and aggres...

    Authors: Yue-Fang Liu, Bin-Shan Zha, Hui-Lin Zhang, Xiao-Jing Zhu, Yu-Hua Li, Jin Zhu, Xiao-Hong Guan, Zhen-Qing Feng and Jian-Ping Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:107

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  45. Content type: Review

    Genetic instability is known as a cause of oncogenesis. Though Rad18 is reported to function in a post replication mismatch repair system, the relation between the status of Rad18 and human tumorigenesis has n...

    Authors: Tadahiko Nakamura, Shinji Ishikawa, Yoshikatsu Koga, Youhei Nagai, Yu Imamura, Kouei Ikeda, Takeshi Mori, Hiroaki Nomori and Hideo Baba

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:106

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  46. Content type: Research

    Osteosarcoma is a highly malignant bone tumor and is the most commonly encountered malignant bone tumor in children and adolescents. Furthermore, significant numbers of patients eventually develop pulmonary me...

    Authors: Zeng Feng Xin, Yang Kyung Kim and Sung Taek Jung

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:105

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  47. Content type: Research

    Non-synonymous single nucleotide polymorphisms (SNPs) within vital DNA repair genes may cause reduction of activity leaving the genome unrepaired resulting in genomic instability and cancer.

    Authors: Amit Kumar Mitra, Neetu Singh, Vivek Kumar Garg, Rashmi Chaturvedi, Mandira Sharma and Srikanta Kumar Rath

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:104

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  48. Content type: Research

    A reliable and precise classification is essential for successful diagnosis and treatment of cancer. Gene expression microarrays have provided the high-throughput platform to discover genomic biomarkers for ca...

    Authors: Peng Guan, Desheng Huang, Miao He and Baosen Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:103

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