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  1. Prospective, randomized, pilot clinical study was conducted to evaluate the beneficial effects of inositol hexaphosphate (IP6) + Inositol in breast cancer patients treated with adjuvant therapy.

    Authors: Ivan Bačić, Nikica Družijanić, Robert Karlo, Ivan Škifić and Stjepan Jagić

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:12

    Content type: Research

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  2. The Sézary syndrome is an aggressive leukemic form of cutaneous T cell lymphoma and there is no cure of this disease. Until now there is no true animal model for Sézary syndrome, by which new drugs against the...

    Authors: Udo Doebbeling

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:11

    Content type: Research

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  3. SIAH proteins are the human members of an highly conserved family of E3 ubiquitin ligases. Several data suggest that SIAH proteins may have a role in tumor suppression and apoptosis. Previously, we reported th...

    Authors: Heriberto Bruzzoni-Giovanelli, Plinio Fernandez, Lucía Veiga, Marie-Pierre Podgorniak, Darren J Powell, Marco M Candeias, Samia Mourah, Fabien Calvo and Mónica Marín

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:10

    Content type: Research

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  4. Accelerated hypofractionation is an attractive approach for adjuvant whole breast radiotherapy. In this study we evaluated the adverse effects at least 3 years post an accelerated hypofractionated whole breast...

    Authors: Paola Pinnarò, Antonella Soriani, Valeria Landoni, Carolina Giordano, Maria Papale, Annelisa Marsella, Laura Marucci, Giorgio Arcangeli and Lidia Strigari

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:9

    Content type: Research

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  5. Survivin is known playing a role in drug resistance. However, its role in bortezomib-mediated inhibition of growth and induction of apoptosis is unclear. There are conflicting reports for the effect of bortezo...

    Authors: Xiang Ling, Diane Calinski, Asher A Chanan-Khan, Muxiang Zhou and Fengzhi Li

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:8

    Content type: Research

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  6. The knowledge of Epidermal growth factor receptor (EGFR) expression in metastases of NSCLC was limited. In receptor-mediated targeted nuclide radiotherapy, tumor cells are killed with delivered radiation and t...

    Authors: Chuangzhou Rao, Qiongge Hu, Jianhua Ma, Jian Li, Chen Zhang, Li Shen and Qichun Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:7

    Content type: Research

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  7. The Tientsin Albino 2 (TA2) mouse is an inbred strain originating from the Kunming strain. It has a high incidence of spontaneous breast cancer without the need for external inducers or carcinogens. Until now,...

    Authors: Yanjun Gu, Shiwu Zhang, Qiang Wu, Shaoyan Xu, Yanfen Cui, Zhengduo Yang, Xiulan Zhao and Baocun Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:6

    Content type: Research

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  8. Lymph node status is an important prognostic factor and a criterion for adjuvant therapy in uterine cancers. While detection of micrometastases by ultrastaging techniques is correlated to prognosis in several ...

    Authors: Corinne Bézu, Charles Coutant, Marcos Ballester, Jean-Guillaume Feron, Roman Rouzier, Serge Uzan and Emile Daraï

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:5

    Content type: Review

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  9. Endometriosis is a common disease characterized by the presence of a functional endometrium outside the uterine cavity, causing pelvic pain, dysmenorrheal, and infertility. This disease has been associated to ...

    Authors: Daniel E Machado, Plínio T Berardo, Celia Y Palmero and Luiz E Nasciutti

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:4

    Content type: Research

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  10. bFGF is an important growth factor for glioma cell proliferation and invasion, while connexin 43 is implicated in the suppression of glioma growth. Correspondingly, gliomas have been shown to have reduced, or ...

    Authors: Biao Zhang, Xuequan Feng, Jinhuan Wang, Xinnu Xu, Hongsheng Liu and Na Lin

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:3

    Content type: Research

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  11. Renal cell carcinoma (RCC) is a cancer of increasing incidence and mortality. Currently, there are no immunohistochemical prognostic markers for RCCs in routine use. The aim of this study was to examine for th...

    Authors: Hanna Ronkainen, Saila Kauppila, Pasi Hirvikoski and Markku H Vaarala

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:2

    Content type: Research

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  12. The aim of this study is to examine the safety and distribution of Ad-EGFP-MDR1, an adenovirus encoding human multidurg resistance gene (human MDR1), in the mice colon carcinoma model.

    Authors: ZhenZhen Zhao, Wei Liu, YuXi Su, Jin Zhu, GaiHuan Zheng, Qing Luo and XianQing Jin

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:1

    Content type: Research

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  13. Epigenetic silencing of tumor suppressor genes associated with promoter methylation is considered to be a hallmark of oncogenesis. RASSF1A is a candidate tumor suppressor gene which was found to be inactivated...

    Authors: Tao Wang, Hongli Liu, Yeshan Chen, Wei Liu, Jing Yu and Gang Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:160

    Content type: Research

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  14. The results from the published studies on the association between hypoxia-inducible factor -1α (HIF-1α) polymorphisms and cancer risk are conflicting. In this meta-analysis, we aimed to investigate the associatio...

    Authors: Tongfeng Zhao, Jing Lv, Jiangpei Zhao and Marius Nzekebaloudou

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:159

    Content type: Research

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  15. Twist is a basic helix-loop-helix (bHLH) transcriptional factor that has been identified to play an important role in epithelial-mesenchymal transition (EMT)-mediated metastasis through the regulation of E-cad...

    Authors: Ken Sasaki, Shoji Natsugoe, Sumiya Ishigami, Masataka Matsumoto, Hiroshi Okumura, Tetsuro Setoyama, Yasuto Uchikado, Yoshiaki Kita, Kiyokazu Tamotsu, Akihiko Sakamoto, Tetsuhiro Owaki and Takashi Aikou

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:158

    Content type: Research

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  16. Despite the fact that genetic counseling in oncology provides information regarding objective risks, it can be found a contrast between the subjective and objective risk.

    Authors: Anita Caruso, Cristina Vigna, Bruna Marozzo, Fabio M Sega, Isabella Sperduti, Francesco Cognetti and Antonella Savarese

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:157

    Content type: Research

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  17. CENP-E, one of spindle checkpoint proteins, plays a crucial role in the function of spindle checkpoint. Once CENP-E expression was interrupted, the chromosomes can not separate procedurally, and may result in ...

    Authors: Zijie Liu, Kang Ling, Xia Wu, Ju Cao, Bin Liu, Suyan Li, Qiong Si, Yan Cai, Chen Yan, Yan Zhang and Yaguang Weng

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:156

    Content type: Research

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  18. Bladder cancer is the ninth most common malignancy in the world. Successful clinical management remains a challenge. In order To search for novel targeted and efficacious treatment, we sought to investigate an...

    Authors: Wei Tang, Yunfeng He, Shengcai Zhou, Yongping Ma and Geli Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:155

    Content type: Research

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  19. Lewis y antigen is difucosylated oligosaccharide and is carried by glycoconjugates at cell surface. Elevated expression of Lewis y has been found in 75% of ovarian tumor, and the high expression level is corre...

    Authors: Juanjuan Liu, Bei Lin, Yingying Hao, Yue Qi, Liancheng Zhu, Feifei Li, Dawo Liu, Jianping Cong, Shulan Zhang and Masao Iwamori

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:154

    Content type: Research

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  20. Excision repair cross-complementing group 1 (ERCC1) and group 2 (ERCC2) proteins play important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of DNA repair genes are sus...

    Authors: Zhihua Yin, Meng Su, Xuelian Li, Mingchuan Li, Rui Ma, Qincheng He and Baosen Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:153

    Content type: Research

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  21. mTOR signaling pathway and its downstream serine/threonine kinase p70S6k were frequently activated in human cancers. The dysregulation of the mTOR pathway has been found to be a contributing factor of a variet...

    Authors: Li Xiao, Yi C Wang, Wu S Li and Yan Du

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:152

    Content type: Research

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  22. Many experimental data evidence that over-expression of various growth factors cause disorders in cell proliferation. The role of the Fibroblast Growth Factors (FGF) in growth control is indisputable: in parti...

    Authors: Gianfranco Risuleo, Marina Ciacciarelli, Mauro Castelli and Gaspare Galati

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:151

    Content type: Research

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  23. Gene targeted therapy refers to any therapy focused on one of the many biological features of the tumor. Such features are mediated by specific genes that are involved in tumor metastasis, recurrence, poor res...

    Authors: Jun Wan, Jinben Ma, Ju Mei and Genfa Shan

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:150

    Content type: Research

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  24. More studies based on gene expression data have been reported in great detail, however, one major challenge for the methodologists is the choice of classification methods. The main purpose of this research was...

    Authors: Desheng Huang, Yu Quan, Miao He and Baosen Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:149

    Content type: Research

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  25. Carotid body tumours (CBTs) are very rare lesions which should be treated as soon as possible even when benign since small tumour size permits easier removal and lower incidence of perioperative complications ...

    Authors: Ombretta Martinelli, Luigi Irace, Rita Massa, Sara Savelli, Fabrizia Giannoni, Roberto Gattuso, Bruno Gossetti, Fabrizio Benedetti-Valentini and Luciano Izzo

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:148

    Content type: Research

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  26. Antibody Directed Enzyme Prodrug Therapy (ADEPT) can be used to generate cytotoxic agents at the tumor site. To date non-human enzymes have mainly been utilized in ADEPT. However, these non-human enzymes are i...

    Authors: Sepideh Afshar, Tove Olafsen, Anna M Wu and Sherie L Morrison

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:147

    Content type: Research

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  27. Carbohydrates embedded in the plasma membrane are one of the main actors involved in the communication of cells with the microenvironment. Neuraminic sialic acids are glycocalyx sugars that play important role...

    Authors: Mariano R Gabri, Laura L Otero, Daniel E Gomez and Daniel F Alonso

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:146

    Content type: Research

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  28. To establish a relationship between esophageal squamous cell diseases and the expression of human telomerase reverse transcriptase (hTERT) and Eyes absent 4 (EYA4) mRNA in peripheral blood mononuclear cells.

    Authors: Hao Li, Tao Yu Diao, Zhi Ying Zhou, Fang Yan Yang, Qing Ma and Qing Hui Li

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:145

    Content type: Review

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  29. To detect the expression of multidrug resistance molecules P-glycoprotein (P-gp), Lung resistnce protein (LRP) and Multidrug resistance-associated protein (MRP) and analyze the relationship between them and th...

    Authors: Wen-Qing Hu, Chun-Wei Peng and Yan Li

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:144

    Content type: Research

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  30. Despite aggressive therapy, advanced stage neuroblastoma patients have poor survival rates. Although angiogenesis correlates with advanced tumour stage and plays an important role in determining the tumour res...

    Authors: Gordana Jakovljević, Srđana Čulić, Jasminka Stepan, Aleksandra Bonevski and Sven Seiwerth

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:143

    Content type: Research

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  31. Studies of treatment with octreotide of patients with hepatocellular carcinoma (HCC) gave conflicting results. We analyzed retrospectively the survival of our patients treated with octreotide monotherapy and c...

    Authors: Maximilian Schöniger-Hekele, Joachim Kettenbach, Markus Peck-Radosavljevic and Christian Müller

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:142

    Content type: Research

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  32. The regulation of growth and apoptosis in K562 cells by human bone marrow mesenchymal stem cells (MSCs) from leukemia patients was investigated.

    Authors: Zhaohui Wei, Naiyao Chen, Hongxing Guo, Xueming Wang, Fangyun Xu, Qian Ren, ShiHong Lu, Bin Liu, Lei Zhang and Hui Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:141

    Content type: Research

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  33. Genetic factors are thought to play a role in development for colorectal carcinogenesis. ICAM-1 is a polymorphic gene, thus, the present study investigated the relationship between the polymorphisms of ICAM-1 and...

    Authors: Qing-lei Wang, Bing-hui Li, Bin Liu, Ya-bin Liu, Yue-Ping Liu, Sui-Bing Miao, Yi Han, Jin-Kun Wen and Mei Han

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:139

    Content type: Research

    Published on:

  34. No single and thoroughly validated imaging method in monitoring of cryoablated renal cell carcinoma (RCC) is available. The purpose of our study was to determine the feasibility of dynamic contrast-enhanced pe...

    Authors: Ettore Squillaci, Guglielmo Manenti, Carmelo Cicciò, Francesca Nucera, Pierluigi Bove, Giuseppe Vespasiani, Laura Russolillo and Giovanni Simonetti

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:138

    Content type: Research

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  35. Authors: Hyo-Jeong Lee, Jae-Ho Lee, Eun-Ok Lee, Hyo-Jung Lee, Kwan-Hyun Kim, Sun-Hyung Kim, Keun-Sung Lee, Hee-Jae Jung and Sung-Hoon Kim

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:137

    Content type: Retraction Note

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2009 28:102

  36. Apoptosis is a major mode of hematological tumor death after radiation. Early detection of apoptosis may be beneficial for cancer adaptive treatment. 99mTc-HYNIC-annexinV has been reported as a promising agent fo...

    Authors: Ming-fang Guo, Yaqing Zhao, Rong Tian, Lin Li, Leiming Guo, Feng Xu, Yong-mei Liu, Yong-bo He, Sen Bai and Jin Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:136

    Content type: Research

    Published on:

  37. To investigate prostate cancer (Pca) risk in relation to estrogen metabolism, expressed as urinary 2-hydroxyestrone (2-OHE1), 16α-hydroxyestrone (16α-OHE1) and 2-OHE1 to 16α-OHE1 ratio.

    Authors: Maddalena Barba, Li Yang, Holger J Schünemann, Francesca Sperati, Sara Grioni, Saverio Stranges, Kim C Westerlind, Giovanni Blandino, Michele Gallucci, Rossella Lauria, Luca Malorni and Paola Muti

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:135

    Content type: Review

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  38. Chromophobe renal cell carcinoma (ChRCC) is a subtype of renal cell carcinoma (RCC). ChRCC is diagnosed mainly in 6th decade of life. An incidence of ChRCC is similar in both men and woman. Eighty six percent ...

    Authors: Rafał Stec, Bartłomiej Grala, Michał Mączewski, Lubomir Bodnar and Cezary Szczylik

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:134

    Content type: Review

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  39. The epidermal growth factor receptor variant III (EGFRvIII) is the most common variation of EGFR. Because it shows a high frequency in several different types of tumor and has not been detected in normal tissu...

    Authors: Xiao-yi Duan, Dong-gang Han, Ming-xin Zhang and Jian-sheng Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:133

    Content type: Research

    Published on:

  40. Many studies have shown that colon cancer is an estrogen-dependent carcinoma. This study explored the efficacy of endocrine therapy in colon cancer cells with high metastatic potential (HT29). We investigated ...

    Authors: Yu-Jing Fang, Zhi-Zhong Pan, Li-Ren Li, Zhen-Hai Lu, Li-Yi Zhang and De-Sen Wan

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:132

    Content type: Research

    Published on:

  41. This study was designed to mainly evaluate the activity and safety of olanzapine compared with 5-hydroxytryptamine3(5-HT3) receptor antagonists for prevention of chemotherapy-induced nausea and vomiting(CINV) in ...

    Authors: Lijun Tan, Jiangtao Liu, Xiuli Liu, Jie Chen, Zhijun Yan, Huifen Yang and Daxin Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:131

    Content type: Research

    Published on:

  42. Polo-like kinase-1 (PLK-1) is reported to be upregulated in a variety of human tumors and is implicated in cell proliferation and survival. However, its importance in cervical carcinoma has not yet been fully ...

    Authors: Yuan Zhang, Yu Liu, Yuan-Xian Yang, Jia-Hong Xia, Hong-Xiu Zhang, Hua-Bin Li and Chun-Zhao Yu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:130

    Content type: Research

    Published on:

  43. Expression of the Sp1 transcription factor is induced by hypoxia, and the ADAM17 promoter contains predicted Sp1 binding sites. ADAM17 contributes to hypoxic-induce invasiveness of glioma. In this study, we in...

    Authors: Alexandra Szalad, Mark Katakowski, Xuguang Zheng, Feng Jiang and Michael Chopp

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:129

    Content type: Research

    Published on:

  44. Sexual dysfunction following surgery for rectal cancer may be frequent and often severe. The aim of the present study is to evaluate the occurrence of this complication from both a clinical point of view and b...

    Authors: Alberto Pietrangeli, Patrizia Pugliese, Maria Perrone, Isabella Sperduti, Maurizio Cosimelli and Bruno Jandolo

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:128

    Content type: Case study

    Published on:

  45. Although gastric caner (GC) remains the second cause of cancer-related death, useful biomarkers for prognosis are still unavailable. We present here the attempt of mining novel biomarkers for GC prognosis by u...

    Authors: Fu-Ming Qiu, Jie-Kai Yu, Yi-Ding Chen, Qi-Feng Jin, Mei-Hua Sui and Jian Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:126

    Content type: Research

    Published on:

  46. The aim of this study was to determine the clinicopathological features of gastric cancers with loss of imprinting (LOI) of LIT1. Insulin-like growth factor 2 (IGF2) and H19 in Chinese patients.

    Authors: Yang Lu, Ping Lu, Zhi Zhu, Huimian Xu and Xike Zhu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:125

    Content type: Research

    Published on:

  47. Vasculogenic mimicry (VM) was increasingly recognized as a form of aggressive melanoma acquiring blood supply. Genistein had attracted much attention as a potential anticancer agent. Therefore, we examined the...

    Authors: Rihong Cong, Qingmin Sun, Li Yang, Haijuan Gu, Ying Zeng and Bin Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:124

    Content type: Research

    Published on:

  48. Despite of the recent success of EGFR inhibitory agents, the primary drug-resistant becomes a major challenge for EGFR inhibitor therapies. PTEN gene is an important positive regulatory factor for response to ...

    Authors: Hong-Qing Zhuang, Jun Wang, Zhi-Yong Yuan, Lu-Jun Zhao, Ping Wang and Chang-Li Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:123

    Content type: Research

    Published on:

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