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  1. Deletions within the short arm of chromosome 7 are observed in approximately 25% of adult and 10% of Wilms pediatric renal tumors. Within Wilms tumors, the region of interest has been delineated to a 2-Mb mini...

    Authors: Kimberly R Blish, Kathryn A Clausen, Gregory A Hawkins, A Julian Garvin, Mark C Willingham, Julie C Turner, Frank M Torti and Suzy V Torti

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:147

    Content type: Research

    Published on:

  2. Epidemiological studies have clearly validated the association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Patients with chronic HBV infection are at increased risk of HCC, in...

    Authors: Zhong-Jun Wu, Yu Zhu, De-Rong Huang and Zhi-Qiang Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:146

    Content type: Research

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  3. Norcantharidin, the demethylated analog of cantharidin derived from a traditional Chinese medicine, Mylabris, has been used in the treatment of anti-cancer effects. However, the detailed mechanisms underlying ...

    Authors: Cheng Chang, You-Qing Zhu, Juan-juan Mei, Shi-quan Liu and Jun Luo

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:145

    Content type: Research

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  4. Real-time reverse transcription PCR (qRT-PCR) is frequently used for gene expression quantification due to its methodological reproducibility and sensitivity. The gene expression is quantified by normalization...

    Authors: Lise Aa Sørby, Solveig N Andersen, Ida RK Bukholm and Morten B Jacobsen

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:144

    Content type: Research

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  5. The Polycomb group (PcG) genes are a class of regulators responsible for maintaining homeotic gene expression throughout cell division. PcG expression is deregulated in some types of human cancer. Both Bmi-1 and ...

    Authors: You-Wei Lu, Jin Li and Wei-Jian Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:143

    Content type: Research

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  6. Radiotherapy has been shown to be an effective for the treatment human glioma and consists of 30 fractions of 2 Gy each for 6-7 weeks in the tumor volume with margins. However. in preclinical studies, many dif...

    Authors: Sandrine Vinchon-Petit, Delphine Jarnet, Eric Jadaud, Loïc Feuvret, Emmanuel Garcion and Philippe Menei

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:142

    Content type: Research

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  7. To study on expressions and clinical significances of CD133 protein and CD133 mRNA in primary lesion of gastric adenocarcinoma (GC).

    Authors: Ji-wei Yu, Peng Zhang, Ju-gang Wu, Sheng-hua Wu, Xiao-qiang Li, Shi-ting Wang, Rui-qi Lu, Xiao-chun Ni and Bo-jian Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:141

    Content type: Research

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  8. HBO1 (histone acetyltransferase binding to ORC1) is a histone acetyltransferase (HAT) which could exert oncogenic function in breast cancer. However, the biological role and underlying mechanism of HBO1 in bre...

    Authors: Wen-zhong Wang, Hai-ou Liu, Yi-hong Wu, Yi Hong, Jun-wu Yang, Ye-heng Liu, Wei-bin Wu, Lei Zhou, Lin-lin Sun, Jie-jie Xu, Xiao-jing Yun and Jian-xin Gu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:140

    Content type: Research

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  9. Peritoneal dissemination is one of the main causes of death in gastric cancer patients. Transforming growth factor-beta1 (TGF-β1), one of the most potent fibrotic stimuli for mesothelial cells, may play a key ...

    Authors: Zhi-Dong Lv, Di Na, Fu-Nan Liu, Zong-Min Du, Zhe Sun, Zhen Li, Xiao-Yang Ma, Zhen-Ning Wang and Hui-Mian Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:139

    Content type: Research

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  10. Gliomas represent the most common primary malignant brain tumors, yet little is known about the molecular pathogenesis of these tumors. The highly-regulated Wnt signal transduction pathway is essential for nor...

    Authors: Youxin Zhou, Fang Liu, Qinian Xu and Xiuyun Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:138

    Content type: Research

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  11. Platinum-based chemotherapy has been a standard therapy for advanced non-small cell lung cancer (NSCLC), but it has high toxicity. In China, Shenqi Fuzheng, a newly developed injection concocted from Chinese m...

    Authors: Ju Dong, Shi-Yue Su, Min-Yan Wang and Zhen Zhan

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:137

    Content type: Research

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  12. The CIP2A protein is a recently characterized oncoprotein which inhibits protein phosphatase 2A activity. Expression of CIP2A has been detected in several carcinomas, but its expression and significance in pro...

    Authors: Markku H Vaarala, Marja-Riitta Väisänen and Ari Ristimäki

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:136

    Content type: Research

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  13. Malignant tumor cells often express embryonic antigens which share the expression with embryonic stem (ES) cells. The embryonic antigens are usually encoded by ES cell-specific genes, a number of which are ass...

    Authors: Nobuyuki Ehira, Hiroyuki Oshiumi, Misako Matsumoto, Takeshi Kondo, Masahiro Asaka and Tsukasa Seya

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:135

    Content type: Research

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    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2014 33:22

  14. The possibility that autologous NK cells could serve as an effective treatment modality for solid tumors has long been considered. However, implementation is hampered by (i) the small number of NK cells in per...

    Authors: Caroline J Voskens, Ryuko Watanabe, Sandra Rollins, Dario Campana, Kenichiro Hasumi and Dean L Mann

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:134

    Content type: Research

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  15. The esophageal cancer related gene 4 (ECRG4) was initially identified and cloned in our laboratory from human normal esophageal epithelium (GenBank accession no.AF325503). ECRG4 was a new tumor suppressor gene...

    Authors: Linwei Li, Chunpeng Zhang, Xiaoyan Li, ShihHsin Lu and Yun Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:133

    Content type: Research

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    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:19

  16. We have compared mutation analysis by DNA sequencing and Amplification Refractory Mutation System™ (ARMS™) for their ability to detect mutations in clinical biopsy specimens.

    Authors: Gillian Ellison, Emma Donald, Gael McWalter, Lucy Knight, Lynn Fletcher, James Sherwood, Mireille Cantarini, Maria Orr and Georgina Speake

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:132

    Content type: Research

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  17. Studies have shown that Dickkopf-1 (DKK-1) is involved in tumorigenesis. Recently, we found that 9 out of 12 human glioma cell lines had high level of DKK-1 protein while the other 3 had very low or non-detect...

    Authors: Youxin Zhou, Wenshuai Li, Qinian Xu and Yulun Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:131

    Content type: Research

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  18. Hepatocellular carcinoma (HCC) is frequently preceded by hepatitis virus infection or alcohol abuse. Genetic backgrounds may increase susceptibility to HCC from these exposures.

    Authors: Ruixing Zhang, Fengbin Zhang, Cuiju Wang, Shunxiang Wang, Yih-Horng Shiao and Zhanjun Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:130

    Content type: Research

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  19. Human 8-oguanine glycosylase 1(hOGG1), voltage-dependent anion channel 1(VDAC1), hexokinase 2(HK-2), represented the process of oxidative DNA damage, cell apoptosis and glycolysis, respectively. This study aim...

    Authors: Peng Guo-Qing, Yang Yuan, Zhong Cai-Gao, Yin Hongling, Hu Gonghua and Tian Yan

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:129

    Content type: Research

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    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:53

  20. Colorectal cancer (CRC) screening is key to CRC prevention and mortality reduction, but patient compliance with CRC screening is low. We previously reported a blood-based test for CRC that utilizes a seven-gen...

    Authors: Kok-Thye Yip, Prashanta K Das, David Suria, Chun-Ren Lim, Guey-Hooi Ng and Choong-Chin Liew

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:128

    Content type: Research

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  21. Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibi...

    Authors: Yasuhiro Kidera, Masanobu Tsubaki, Yuzuru Yamazoe, Kaori Shoji, Haruyuki Nakamura, Mitsuhiko Ogaki, Takao Satou, Tatsuki Itoh, Misako Isozaki, Junichi Kaneko, Yoshihiro Tanimori, Masashi Yanae and Shozo Nishida

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:127

    Content type: Research

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  22. Lung cancer is a malignant carcinoma which has the highest morbidity and mortality in Chinese population. Gefitinib, a tyrosine kinase (TK) inhibitor of epidermal growth factor receptor (EGFR), displays anti-t...

    Authors: Yong-Mei Yin, Yi-Ting Geng, Yong-Feng Shao, Xiao-Li Hu, Wei Li, Yong-Qian Shu and Zhao-Xia Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:126

    Content type: Research

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  23. Several studies demonstrated that epidermal growth factor receptor (EGFR) gene copy number (GCN) correlates to the response to tyrosine kinase inhibitors in non small cell lung cancer (NSCLC) and to anti-EGFR ...

    Authors: Giovanni Simone, Anita Mangia, Andrea Malfettone, Vincenza Rubini, Michele Siciliano, Anna Di Benedetto, Irene Terrenato, Flavia Novelli and Marcella Mottolese

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:125

    Content type: Research

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  24. Epithelial ovarian cancer is one of the most malignant cancers in women because metastasis occurs in the most of patients by the time of diagnosis. Cancer cells have strong capacity to form angiogenesis or vas...

    Authors: Pengfei Zhu, Yanxia Ning, Liangqing Yao, Mo Chen and Congjian Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:124

    Content type: Research

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  25. RhoA and RhoC have been proved to be over-expressed in many solid cancers, including colorectal cancer. The reduction of RhoA and RhoC expression by RNA interference (RNAi) resulted growth inhibition of cancer ce...

    Authors: Haibo Wang, Gang Zhao, Xiangping Liu, Aihua Sui, Kun Yang, Ruyong Yao, Zongbao Wang and Qiang Shi

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:123

    Content type: Research

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  26. To investigate the mechanisms of multidrug resistance of brain tumors, to identify the site of cellular expression of P-gp in human brains in situ and to morphologically determine whether an association may ex...

    Authors: Zhenhua Guo, Jin Zhu, Lihua Zhao, Qing Luo and Xianqing Jin

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:122

    Content type: Research

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  27. Anti-CD20 monoclonal antibody treatment has not only increased survival and cure rates in many non-Hodgkin lymphomas, but also has prompted an explosion in the development of novel antibodies and biologically ...

    Authors: Yihu Zheng, Kang Yu, Jimei Du, Lei Jiang, Shenghui Zhang, Yixiang Han, Panpan Yu and Yingxia Tan

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:121

    Content type: Research

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  28. The advent of global gene expression profiling has generated unprecedented insight into our molecular understanding of cancer, including breast cancer. For example, human breast cancer patients display signifi...

    Authors: Robin M Hallett, Anna Dvorkin, Christine M Gabardo and John A Hassell

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:120

    Content type: Research

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  29. Slug, Snail, and Twist are transcription factors that regulate the expression of tumor suppressors such as E-cadherin. In this study, we aimed to examine the expression of these transcription factors in human ...

    Authors: Qinchao Yu, Kejun Zhang, Xinsheng Wang, Xiangping Liu and Zemi Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:119

    Content type: Research

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  30. Drug resistance remains a great challenge in the treatment of gastric cancer. The goal of this study was to explore the anti-tumor effects and mechanism of cytokine-induced killer (CIK) cell combined with oxal...

    Authors: Qun Zhao, Hui Zhang, Yong Li, Jun Liu, Xiaojie Hu and Liqiao Fan

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:118

    Content type: Research

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  31. Emerging evidence suggests that ataxia telangiectasia-mutated (ATM) is involved in numerous damage repair signaling pathways and cell-cycle checkpoints. Heterozygous carriers of ATM-mutations have an increased ri...

    Authors: Lin-Bo Gao, Xin-Min Pan, Hong Sun, Xia Wang, Li Rao, Li-Juan Li, Wei-Bo Liang, Mei-Li Lv, Wen-Zhong Yang and Lin Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:117

    Content type: Research

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  32. Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Among the SFKs, c-Src and c-Yes are particularly over-expressed or hype...

    Authors: Jang Hyun Lee, Jae-Kyung Pyon, Dong Wook Kim, Sang Han Lee, Hae Seon Nam, Chul Han Kim, Sang Gue Kang, Yoon Jin Lee, Mi Youn Park, Dong Jun Jeong and Moon Kyun Cho

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:116

    Content type: Research

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  33. To compare the biological characteristics of three types of human hepatocellular carcinoma multi-drug resistant cell sub-lines Bel-7402/ADM models established by three methods.

    Authors: Xingguo Zhong, Maoming Xiong, Xiangling Meng and Renhua Gong

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:115

    Content type: Research

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  34. Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus. It was found that CBX7 expression was upregul...

    Authors: Xiao-Wei Zhang, Li Zhang, Wei Qin, Xiao-Hong Yao, Lei-Zhen Zheng, Xin Liu, Jin Li and Wei-Jian Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:114

    Content type: Research

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  35. Women with ductal hyperplasia including usual ductal hyperplasia (UDH) and atypical ductal hyperplasia (ADH) have an increased risk of developing invasive ductal carcinoma (IDC) of breast. The importance of se...

    Authors: Xiao-yun Mao, Chui-feng Fan, Hua-chuan Zheng, Jing Wei, Fan Yao and Feng Jin

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:112

    Content type: Research

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  36. GTPase regulator associated with the focal adhesion kinase (GRAF), a putative tumor suppressor gene, is found inactivated in hematopoietic malignancies by either genetic or epigenetic abnormalities. However, the ...

    Authors: Zhen Qian, Jun Qian, Jiang Lin, Dong-ming Yao, Qin Chen, Run-bi Ji, Yun Li, Gao-fei Xiao and Jian-yong Li

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:111

    Content type: Research

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  37. The cellular apoptosis susceptibility (CSE1L/CAS) protein is highly expressed in cancer, and its expression is positively correlated with high cancer stage, high cancer grade, and worse outcomes of patients. C...

    Authors: Cheng-Jeng Tai, Chung-Huei Hsu, Shing-Chuan Shen, Woan-Ruoh Lee and Ming-Chung Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:110

    Content type: Review

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  38. The incidence of malignant melanoma (MM) was occurring at a faster rate than for most neoplasm worldwide, and melanoma metastasis is still the most formidable problem. So it is necessarily to find some biomark...

    Authors: Man Li, Baogang Zhang, Baocun Sun, Xuan Wang, Xinchao Ban, Tao Sun, Zhiyong Liu and Xiulan Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:109

    Content type: Research

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  39. To evaluate the expression of BCL-2 and BAD genes in tissues of breast carcinoma and investigate the relationship between the expression of BCL-2 and BAD in breast cancer cells with chemosensitivity.

    Authors: Bing Yu, Xin Sun, Hong-yan Shen, Feng Gao, Yuan-ming Fan and Zhi-jun Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:107

    Content type: Research

    Published on:

  40. Previous studies have shown that heat shock proteins (HSPs) were upregulated in various types of tumors and were associated with histological grade, recurrence and metastasis of malignant tumors. In this study...

    Authors: Jing Xu, Kangkai Wang, Xin Zhang, Yuanzheng Qiu, Donghai Huang, Wei Li, Xianzhong Xiao and Yongquan Tian

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:106

    Content type: Research

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  41. Authors: Ondrej Slaby, Jana Jancovicova, Radek Lakomy, Marek Svoboda, Alexandr Poprach, Pavel Fabian, Leos Kren, Jaroslav Michalek and Rostislav Vyzula

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:105

    Content type: Erratum

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    The original article was published in Journal of Experimental & Clinical Cancer Research 2010 29:90

  42. Drug resistance remains a great challenge in the treatment of pancreatic cancer. The goal of this study was to determine whether TGF-β1 is associated with drug resistance in pancreatic cancer.

    Authors: Ying Chen, Guanzhen Yu, Danghui Yu and Minghua Zhu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:104

    Content type: Research

    Published on:

  43. Recently, the anti-tumor activity of N-myc downstream-regulated gene 2 (NDRG2) was shown decreased expression in clear cell renal cell carcinoma (CCRCC), but the role of the down-expression of NDRG2 has not be...

    Authors: Jian-Jun Ma, Cheng-Gong Liao, Xue Jiang, Hua-Dong Zhao, Li-Bo Yao and Ting-Yi Bao

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:103

    Content type: Research

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  44. Ovarian cancer is the most fatal gynecologic malignancies in the world. Although, platinum based treatments are widely used, the disease becomes treatment refractory within two years, and novel treatment optio...

    Authors: Bulent Karabulut, Burcak Karaca, Umut Varol, Ugur Muslu, Burcu Cakar, Harika Atmaca, Aslı Kısım, Selim Uzunoglu and Ruchan Uslu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:102

    Content type: Research

    Published on:

  45. Sulfotransferase (SULT) plays an important role in the formation of estrogen which is usually conferred as a risk factor for breast cancer. Polymorphism of the SULT1A1 may be closely associated with breast can...

    Authors: Yiwei Jiang, Liheng Zhou, Tingting Yan, Zhenzhou Shen, Zhimin Shao and Jinsong Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:101

    Content type: Research

    Published on:

  46. Currently definitive 5-fluorouracil (5-FU)/cisplatin (CDDP) -based chemotherapy is recognized as one of the most promising treatments for esophageal cancer. A series of studies performed found genetic polymorp...

    Authors: Akiko Kuwahara, Motohiro Yamamori, Megumi Fujita, Tatsuya Okuno, Takao Tamura, Kaori Kadoyama, Noboru Okamura, Tsutomu Nakamura and Toshiyuki Sakaeda

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:100

    Content type: Research

    Published on:

  47. Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also ...

    Authors: Bo Chen, Xueli Wang, Weihong Zhao and Jianqing Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:99

    Content type: Research

    Published on:

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