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  1. In our previous study, it was well defined that IGFBP7 was an important tumor suppressor gene in colorectal cancer (CRC). We aimed to uncover the downstream molecules responsible for IGFBP7's behaviour in this st...

    Authors: Wenjing Ruan, Yinghong Wang, Yu Ma, Xiaoming Xing, Jie Lin, Jing Cui and Maode Lai

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:41

    Content type: Research

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  2. The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC). Although EGFR and Her-2 are frequently overexpressed in OSCC, few studies evaluated...

    Authors: Vanessa F Bernardes, Frederico O Gleber-Netto, Sílvia F Sousa, Tarcília A Silva and Maria Cássia F Aguiar

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:40

    Content type: Research

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  3. Definitions of basal-like breast cancer phenotype vary, and microarray-based expression profiling analysis remains the gold standard for the identification of these tumors. Immunohistochemical identification o...

    Authors: Radzislaw Kordek, Piotr Potemski, Renata Kusinska, Elzbieta Pluciennik and Andrzej Bednarek

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:39

    Content type: Research

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  4. The objective of this study was to evaluate the efficacy and safety of pemetrexed plus cisplatin/carboplatin in locally advanced or metastatic non-small cell lung cancer (NSCLC) patients previously treated wit...

    Authors: Guan-Zhong Zhang, Shun-Chang Jiao and Zhao-Ting Meng

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:38

    Content type: Research

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  5. To investigate whether dendritic cell (DC) precursors, recruited by injection of chemokine ligand 3 (CCL3) and CCL20, induce anti-tumor immunity against gastric cancer induced by a DC vaccine expressing melanoma ...

    Authors: Songbing He, Liang Wang, Yugang Wu, Dechun Li and Yanyun Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:37

    Content type: Research

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  6. Analysis of gene expression and gene mutation may add information to be different from ordinary pathological tissue diagnosis. Since samples obtained endoscopically are very small, it is desired that more sens...

    Authors: Koji Nonogaki, Akihiro Itoh, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Hiroshi Matsubara, Yuya Itoh, Yosuke Nakamura, Masanao Nakamura, Ryoji Miyahara, Naoki Ohmiya, Masatoshi Ishigami, Yoshiaki Katano, Hidemi Goto and Yoshiki Hirooka

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:36

    Content type: Research

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  7. This study explored the response of nasopharyngeal carcinoma cells to TGF-β1-induced growth suppression and investigated the roles of the TGF-β/Smad signaling pathway in nasopharyngeal carcinoma cells.

    Authors: Jian Xiao, Qi Xiang, Ye-Chen Xiao, Zhi-Jian Su, Zhi-Feng Huang, Qi-Hao Zhang, Yi Tan, Xiao-Kun Li and Ya-Dong Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:35

    Content type: Research

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  8. PIK3CA is one of the genes most frequently mutated in human cancers and it is a potential target for personalized therapy. The aim of this study was to assess the frequency and type of PIK3CA mutations in gastric...

    Authors: Stefano Barbi, Ivana Cataldo, Giovanni De Manzoni, Samantha Bersani, Simona Lamba, Silvia Mattuzzi, Alberto Bardelli and Aldo Scarpa

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:32

    Content type: Research

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  9. In spite of recent advances in diagnostic and therapeutic measures, the prognosis of hepatocellular carcinoma (HCC) patients remains poor. Therefore, it is crucial to understand what factors are involved in pr...

    Authors: Ke Zheng, Hong-Yuan Li, Xin-Liang Su, Xiao-Yi Wang, Tian Tian, Fan Li and Guo-Sheng Ren

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:31

    Content type: Research

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  10. The past two decades have witnessed an increasing appreciation of the role of the tumor microenvironment, of genetic and epigenetic alterations in normal cells adjacent to tumors and of the migration of normal...

    Authors: Razvan T Radulescu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:30

    Content type: Review

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  11. MicroRNAs are non-coding RNA molecules that posttranscriptionally regulate expression of target genes and have been implicated in the progress of cancer proliferation, differentiation and apoptosis. The aim of...

    Authors: Bao Song, Chuanxi Wang, Jie Liu, Xingwu Wang, Liyan Lv, Ling Wei, Li Xie, Yan Zheng and Xianrang Song

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:29

    Content type: Research

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  12. The secreted protein acidic and rich in cysteine (SPARC) plays a pivotal role in regulating cell-matrix interactions and tumor angiogenesis, proliferation, and migration. Detection of SPARC gene methylation may b...

    Authors: Jun Gao, Jian Song, Haojie Huang, Zhaoshen Li, Yiqi Du, Jia Cao, Minghui Li, Shunli Lv, Han Lin and Yanfang Gong

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:28

    Content type: Research

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  13. Circulating bone marrow-derived endothelial progenitor cells (EPCs) have been reported to participate in tumor angiogenesis and growth; however, the role of circulating EPCs in tumor progression is controversi...

    Authors: Yajuan Su, Lei Zheng, Qian Wang, Weiqi Li, Zhen Cai, Shilong Xiong and Jie Bao

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:27

    Content type: Research

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  14. Wnt inhibitory factor-1(WIF-1) acts as a Wnt-antagonists and tumor suppressor, but hypermethylation of WIF-1 gene promoter and low expression activate Wnt signaling aberrantly and induce the development of var...

    Authors: Zhuanyi Yang, Ying Wang, Jiasheng Fang, Fenghua Chen, Jinfang Liu, Jun Wu and Yanjin Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:26

    Content type: Research

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  15. Giant cell tumor is an infrequent and unpredictable bony lesion. Although numerous attempts have been made to predict the behaviour of GCT, there are no definite biological or histological parameters to determ...

    Authors: Faisham W Ismail, Aminudin M Shamsudin, Zulmi Wan, Salzihan M Daud and Mutum S Samarendra

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:25

    Content type: Research

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  16. Perineural invasion is a common path for cholangiocarcinoma (CCA) metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It is often an early event in a disease that is commo...

    Authors: Fang-Zhen Shen, Bing-Yuan Zhang, Yu-Jie Feng, Zhuo-Xia Jia, Bing An, Chang-Chang Liu, Xi-Yun Deng, Anil D Kulkarni and Yun Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:24

    Content type: Review

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  17. Anti-HER-2 antibodies targeting distinct epitopes have different biological functions on cancer cells. In a previous study, we demonstrated that anti-HER-2 engineering antibody ChA21 was able to bind to subdom...

    Authors: AnLi Zhang, Hua Xue, XiaoGuang Ling, Yi Gao, Feng Yang, LianSheng Cheng, Jing Liu and Qiang Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:23

    Content type: Research

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  18. It is known that thiazolidinediones are involved in regulating the expression of various genes, including the vascular endothelial growth factor (VEGF) gene via peroxisome proliferator-activated receptor γ (PP...

    Authors: Takayuki Yoshizaki, Wataru Motomura, Sachie Tanno, Shima Kumei, Yumiko Yoshizaki, Satoshi Tanno and Toshikatsu Okumura

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:22

    Content type: Research

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  19. Taurolidine (TRD) represents an anti-infective substance with anti-neoplastic activity in many malignant cell lines. So far, the knowledge about the cell death inducing mechanisms and pathways activated by TRD...

    Authors: Ansgar M Chromik, Adrien Daigeler, Daniel Bulut, Annegret Flier, Christina May, Kamran Harati, Jan Roschinsky, Dominique Sülberg, Peter R Ritter, Ulrich Mittelkötter, Stephan A Hahn and Waldemar Uhl

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:21

    Content type: Research

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  20. To retrospectively review the incidence, treatment efficacy, we followed up newly diagnosed chronic myelogenous leukemia (CML) patients residing in Shanghai during 2001-2006.

    Authors: Ai-Hua Wang, Yan-Yan Wang, Yu Yao, Zi-Zhen Xu, Li Zhou, Li Wang, Li Zhang, Yu Chen, Zhi-Xiang Shen, Jiong Hu and Jun-Min Li

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:20

    Content type: Research

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  21. Hereditary hemochromatosis (HH) is an autosomal recessive disorder mainly associated with homozygosity for the C282Y and H63D mutations in the hemochromatosis (HFE) gene. The reports about the C282Y and H63D m...

    Authors: Fei Jin, Li-Shuai Qu and Xi-Zhong Shen

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:18

    Content type: Research

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  22. To better search for potential markers for hepatocellular carcinoma (HCC) invasion and metastasis, proteomic approach was applied to identify potential metastasis biomarkers associated with HCC.

    Authors: Long Wu, Chun-Wei Peng, Jin-Xuan Hou, Yan-Hua Zhang, Chuang Chen, Liang-Dong Chen and Yan Li

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:17

    Content type: Research

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  23. The chemokine receptors CXCR4 and CCR7 play an important role in cancer invasion and metastasis. This study investigated the expression of CXCR4, CCR7, CXCL12, CCL21, and EGFR to illustrate the role of these b...

    Authors: Yixin Liu, Ru Ji, Jingyong Li, Qiang Gu, Xiulan Zhao, Tao Sun, Jinjing Wang, Jiangbo Li, Qiuyue Du and Baocun Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:16

    Content type: Research

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  24. The combination of gemcitabine (GEM) and S-1, an oral 5-fluorouracil (5-FU) derivative, has been shown to be a promising regimen for patients with unresectable pancreatic cancer.

    Authors: Bunzo Nakata, Ryosuke Amano, Shigetomi Nakao, Tatsuro Tamura, Osamu Shinto, Toshiki Hirakawa, Yoshihiro Okita, Nobuya Yamada and Kosei Hirakawa

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:15

    Content type: Research

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  25. Genome-wide RNA interference screening study revealed that loss of expression of insulin-like growth factor binding protein 7 (IGFBP7) is a critical step in development of a malignant melanoma (MM), and this s...

    Authors: Rong-Yi Chen, Hong-Xiang Chen, Jia-Xi Lin, Wei-Bing She, Ping Jiang, Li Xu and Ya-Ting Tu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:13

    Content type: Research

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  26. Prospective, randomized, pilot clinical study was conducted to evaluate the beneficial effects of inositol hexaphosphate (IP6) + Inositol in breast cancer patients treated with adjuvant therapy.

    Authors: Ivan Bačić, Nikica Družijanić, Robert Karlo, Ivan Škifić and Stjepan Jagić

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:12

    Content type: Research

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  27. The Sézary syndrome is an aggressive leukemic form of cutaneous T cell lymphoma and there is no cure of this disease. Until now there is no true animal model for Sézary syndrome, by which new drugs against the...

    Authors: Udo Doebbeling

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:11

    Content type: Research

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  28. SIAH proteins are the human members of an highly conserved family of E3 ubiquitin ligases. Several data suggest that SIAH proteins may have a role in tumor suppression and apoptosis. Previously, we reported th...

    Authors: Heriberto Bruzzoni-Giovanelli, Plinio Fernandez, Lucía Veiga, Marie-Pierre Podgorniak, Darren J Powell, Marco M Candeias, Samia Mourah, Fabien Calvo and Mónica Marín

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:10

    Content type: Research

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  29. Accelerated hypofractionation is an attractive approach for adjuvant whole breast radiotherapy. In this study we evaluated the adverse effects at least 3 years post an accelerated hypofractionated whole breast...

    Authors: Paola Pinnarò, Antonella Soriani, Valeria Landoni, Carolina Giordano, Maria Papale, Annelisa Marsella, Laura Marucci, Giorgio Arcangeli and Lidia Strigari

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:9

    Content type: Research

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  30. Survivin is known playing a role in drug resistance. However, its role in bortezomib-mediated inhibition of growth and induction of apoptosis is unclear. There are conflicting reports for the effect of bortezo...

    Authors: Xiang Ling, Diane Calinski, Asher A Chanan-Khan, Muxiang Zhou and Fengzhi Li

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:8

    Content type: Research

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  31. The knowledge of Epidermal growth factor receptor (EGFR) expression in metastases of NSCLC was limited. In receptor-mediated targeted nuclide radiotherapy, tumor cells are killed with delivered radiation and t...

    Authors: Chuangzhou Rao, Qiongge Hu, Jianhua Ma, Jian Li, Chen Zhang, Li Shen and Qichun Wei

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:7

    Content type: Research

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  32. The Tientsin Albino 2 (TA2) mouse is an inbred strain originating from the Kunming strain. It has a high incidence of spontaneous breast cancer without the need for external inducers or carcinogens. Until now,...

    Authors: Yanjun Gu, Shiwu Zhang, Qiang Wu, Shaoyan Xu, Yanfen Cui, Zhengduo Yang, Xiulan Zhao and Baocun Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:6

    Content type: Research

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  33. Lymph node status is an important prognostic factor and a criterion for adjuvant therapy in uterine cancers. While detection of micrometastases by ultrastaging techniques is correlated to prognosis in several ...

    Authors: Corinne Bézu, Charles Coutant, Marcos Ballester, Jean-Guillaume Feron, Roman Rouzier, Serge Uzan and Emile Daraï

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:5

    Content type: Review

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  34. Endometriosis is a common disease characterized by the presence of a functional endometrium outside the uterine cavity, causing pelvic pain, dysmenorrheal, and infertility. This disease has been associated to ...

    Authors: Daniel E Machado, Plínio T Berardo, Celia Y Palmero and Luiz E Nasciutti

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:4

    Content type: Research

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  35. bFGF is an important growth factor for glioma cell proliferation and invasion, while connexin 43 is implicated in the suppression of glioma growth. Correspondingly, gliomas have been shown to have reduced, or ...

    Authors: Biao Zhang, Xuequan Feng, Jinhuan Wang, Xinnu Xu, Hongsheng Liu and Na Lin

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:3

    Content type: Research

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  36. Renal cell carcinoma (RCC) is a cancer of increasing incidence and mortality. Currently, there are no immunohistochemical prognostic markers for RCCs in routine use. The aim of this study was to examine for th...

    Authors: Hanna Ronkainen, Saila Kauppila, Pasi Hirvikoski and Markku H Vaarala

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:2

    Content type: Research

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  37. The aim of this study is to examine the safety and distribution of Ad-EGFP-MDR1, an adenovirus encoding human multidurg resistance gene (human MDR1), in the mice colon carcinoma model.

    Authors: ZhenZhen Zhao, Wei Liu, YuXi Su, Jin Zhu, GaiHuan Zheng, Qing Luo and XianQing Jin

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:1

    Content type: Research

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  38. Epigenetic silencing of tumor suppressor genes associated with promoter methylation is considered to be a hallmark of oncogenesis. RASSF1A is a candidate tumor suppressor gene which was found to be inactivated...

    Authors: Tao Wang, Hongli Liu, Yeshan Chen, Wei Liu, Jing Yu and Gang Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:160

    Content type: Research

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  39. The results from the published studies on the association between hypoxia-inducible factor -1α (HIF-1α) polymorphisms and cancer risk are conflicting. In this meta-analysis, we aimed to investigate the associatio...

    Authors: Tongfeng Zhao, Jing Lv, Jiangpei Zhao and Marius Nzekebaloudou

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:159

    Content type: Research

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  40. Twist is a basic helix-loop-helix (bHLH) transcriptional factor that has been identified to play an important role in epithelial-mesenchymal transition (EMT)-mediated metastasis through the regulation of E-cad...

    Authors: Ken Sasaki, Shoji Natsugoe, Sumiya Ishigami, Masataka Matsumoto, Hiroshi Okumura, Tetsuro Setoyama, Yasuto Uchikado, Yoshiaki Kita, Kiyokazu Tamotsu, Akihiko Sakamoto, Tetsuhiro Owaki and Takashi Aikou

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:158

    Content type: Research

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  41. Despite the fact that genetic counseling in oncology provides information regarding objective risks, it can be found a contrast between the subjective and objective risk.

    Authors: Anita Caruso, Cristina Vigna, Bruna Marozzo, Fabio M Sega, Isabella Sperduti, Francesco Cognetti and Antonella Savarese

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:157

    Content type: Research

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  42. CENP-E, one of spindle checkpoint proteins, plays a crucial role in the function of spindle checkpoint. Once CENP-E expression was interrupted, the chromosomes can not separate procedurally, and may result in ...

    Authors: Zijie Liu, Kang Ling, Xia Wu, Ju Cao, Bin Liu, Suyan Li, Qiong Si, Yan Cai, Chen Yan, Yan Zhang and Yaguang Weng

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:156

    Content type: Research

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  43. Bladder cancer is the ninth most common malignancy in the world. Successful clinical management remains a challenge. In order To search for novel targeted and efficacious treatment, we sought to investigate an...

    Authors: Wei Tang, Yunfeng He, Shengcai Zhou, Yongping Ma and Geli Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:155

    Content type: Research

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  44. Lewis y antigen is difucosylated oligosaccharide and is carried by glycoconjugates at cell surface. Elevated expression of Lewis y has been found in 75% of ovarian tumor, and the high expression level is corre...

    Authors: Juanjuan Liu, Bei Lin, Yingying Hao, Yue Qi, Liancheng Zhu, Feifei Li, Dawo Liu, Jianping Cong, Shulan Zhang and Masao Iwamori

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:154

    Content type: Research

    Published on:

  45. Excision repair cross-complementing group 1 (ERCC1) and group 2 (ERCC2) proteins play important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of DNA repair genes are sus...

    Authors: Zhihua Yin, Meng Su, Xuelian Li, Mingchuan Li, Rui Ma, Qincheng He and Baosen Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:153

    Content type: Research

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  46. mTOR signaling pathway and its downstream serine/threonine kinase p70S6k were frequently activated in human cancers. The dysregulation of the mTOR pathway has been found to be a contributing factor of a variet...

    Authors: Li Xiao, Yi C Wang, Wu S Li and Yan Du

    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:152

    Content type: Research

    Published on:

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