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  1. Oncogenic roles of epidermal growth factor receptor pathway substrate no.8 (EPS8) have been widely reported in various tumors, making targeting of EPS8 an appealing prospect. Here, we describe the role of EPS8...

    Authors: Yiran Chen, Xiaoling Xie, Anqin Wu, Lei Wang, Yuxing Hu, Honghao Zhang and Yuhua Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:12

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:233

  2. Autophagy is a dynamic physiological process that can generate energy and nutrients for cell survival during stress. Autophagy can regulate the migration and invasive ability in cancer cells. However, the conn...

    Authors: Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Yan Li, Lei Dong, Zhihong Zong, Xiangdong Hua, Dongming Su, Hangyu Li and Jingang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:9
  3. Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been recognized as a distinct leukemia entity in the 2016 World Health Organization (WHO) classification. The genetic events underlying oncoge...

    Authors: Hongjun Jin, Liyuan Yang, Lu Wang, Zailin Yang, Qian Zhan, Yao Tao, Qin Zou, Yuting Tang, Jingrong Xian, Shuaishuai Zhang, Yipei Jing and Ling Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:8
  4. Tetrandrine is a bisbenzylisoquinoline alkaloid isolated from the Chinese medicinal herb Stephania tetrandra S. Moore. We previously demonstrated that tetrandrine exhibits potent antitumor effects in many types o...

    Authors: Zhenxing Zhang, Ting Liu, Man Yu, Kangdi Li and Wenhua Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:7
  5. Stress-Inducible Protein-1 (STIP1) is a co-chaperone that associates directly with heat shock proteins, and regulates motility of various types of cancer. In the present study, we investigated the role of STIP...

    Authors: Linlin Huang, Ertao Zhai, Shirong Cai, Yi Lin, Junbin Liao, Huilin Jin, Sui Peng, Lixia Xu, Minhu Chen and Zhirong Zeng
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:6
  6. Cancer remains as one of the leading cause of death worldwide. The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Although most studies have ...

    Authors: Nyanbol Kuol, Lily Stojanovska, Vasso Apostolopoulos and Kulmira Nurgali
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:5
  7. Pancreatic stellate cells (PSCs), a major component of the tumor microenvironment in pancreatic cancer, play roles in cancer progression as well as drug resistance. Culturing various cells in microfluidic (mic...

    Authors: Ji-Hyun Lee, Seul-Ki Kim, Iftikhar Ali Khawar, Su-Yeong Jeong, Seok Chung and Hyo-Jeong Kuh
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:4
  8. Recent studies have shown that interferon-γ (IFN-γ)-induced galectin-9 expression in Kupffer cells plays an essential role in modulatingthe microenvironment of hepatitis-associated hepatocellular carcinoma (HC...

    Authors: Shaofei Chen, Jiarui Pu, Jie Bai, Yuping Yin, Ke Wu, Jiliang Wang, Xiaoming Shuai, Jinbo Gao, Kaixiong Tao, Guobin Wang and Hang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:3
  9. Osteosarcoma (OS) is the most common primary malignant tumor of bone, which preferentially develops lung metastasis. Although standard chemotherapy has significantly improved long-term survival over the past f...

    Authors: Angela De Luca, Lavinia Raimondi, Francesca Salamanna, Valeria Carina, Viviana Costa, Daniele Bellavia, Riccardo Alessandro, Milena Fini and Gianluca Giavaresi
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:2
  10. The receptors of Notch family play an important role in controlling the development, differentiation, and function of multiple cell types. The aim of this study is to investigate the role of Notch1 signaling u...

    Authors: Zike Yang, Yanxia Qi, Nan Lai, Jiahe Zhang, Zehong Chen, Mingyu Liu, Wan Zhang, Rongcheng Luo and Shijun Kang
    Citation: Journal of Experimental & Clinical Cancer Research 2018 37:1
  11. Patients with gastric cancer commonly have a poor prognosis, owing to its invasiveness and distant metastasis. Recent studies have confirmed the pivotal role of long non-coding RNAs (lncRNAs) in tumorigenesis ...

    Authors: Yanxia Huang, Jing Zhang, Lidan Hou, Ge Wang, Hui Liu, Rui Zhang, Xiaoyu Chen and Jinshui Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:194

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:155

  12. Golgi Membrane Protein 1 (GOLM1), a protein involved in the trafficking of proteins through the Golgi apparatus, has been shown to be oncogenic in a variety of human cancers. Here, we examined the role of GOLM...

    Authors: Ran Xu, Jianxiong Ji, Xin Zhang, Mingzhi Han, Chao Zhang, Yangyang Xu, Yuzhen Wei, Shuai Wang, Bin Huang, Anjing Chen, Di Zhang, Qing Zhang, Wenjie Li, Zheng Jiang, Jian Wang and Xingang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:193
  13. In the past decade, the oncology community has witnessed major advances in the understanding of cancer biology and major breakthroughs in several different therapeutic areas, from solid tumors to hematological...

    Authors: Talia Golan, Michele Milella, Aliza Ackerstein and Ranaan Berger
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:192
  14. To assess the oncologic outcomes of hypofractionated whole breast irradiation (Hypo-WBI).

    Authors: Paola Pinnarò, Carolina Giordano, Alessia Farneti, Adriana Faiella, Giuseppe Iaccarino, Valeria Landoni, Diana Giannarelli, Patrizia Vici, Lidia Strigari and Giuseppe Sanguineti
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:191
  15. Chemoresistance is a major obstacle that limits the benefits of 5-Fluorouracil (5-Fu)-based chemotherapy for colon cancer patients. Autophagy is an important cellular mechanism underlying chemoresistance. Rece...

    Authors: Pan Zhang, Ze-Lin Lai, Hui-Fen Chen, Min Zhang, An Wang, Tao Jia, Wen-Qin Sun, Xi-Min Zhu, Xiao-Feng Chen, Zheng Zhao and Jun Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:190
  16. Telomeres are specialized nucleoprotein structures responsible for protecting chromosome ends in order to prevent the loss of genomic information. Telomere maintenance is required for achieving immortality by ...

    Authors: Luca Pompili, Carlo Leonetti, Annamaria Biroccio and Erica Salvati
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:189
  17. The nuclear epigenetic integrator UHRF1 is known to play a key role with DNMT1 in maintaining the DNA methylation patterns during cell division. Among UHRF1 partners, TIP60 takes part in epigenetic regulations...

    Authors: Waseem Ashraf, Christian Bronner, Liliyana Zaayter, Tanveer Ahmad, Ludovic Richert, Mahmoud Alhosin, Abdulkhaleg Ibrahim, Ali Hamiche, Yves Mely and Marc Mousli
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:188
  18. Development of resistance to 5-fluorouracil (5-FU) is a major problem in treatment of various cancers including pancreatic cancer. In this study, we reveal important resistance mechanisms and photochemical str...

    Authors: Kaja Lund, Cathrine Elisabeth Olsen, Judith Jing Wen Wong, Petter Angell Olsen, Nina Therese Solberg, Anders Høgset, Stefan Krauss and Pål Kristian Selbo
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:187
  19. Gliomas are the most common primary tumors in central nervous system. The prognosis of the patients with glioma is poor regardless of the development of therapeutic strategies. Its aggressive behavior mainly d...

    Authors: Dian-gang Chen, Bo Zhu, Sheng-qing Lv, Hongfan Zhu, Jinliang Tang, Changlin Huang, Qingrui Li, Pu Zhou, Dong-lin Wang and Guang-hui Li
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:186
  20. Mantle cell lymphoma (MCL) is an aggressive disease, with poor prognosis and a limited survival. However, some patients with indolent MCL can survive beyond 7~10 years. These patients remain largely asymptomat...

    Authors: Haige Ye, Aakash Desai, Dongfeng Zeng, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed and Michael L. Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:185
  21. In the publication of this article [1], the molecule weight of GPR30 in figures was incorrectly, this should have been 55 kDa, and not 38 kDa.

    Authors: Jing Tian, Yong Wang, Xing Zhang, Qianyao Ren, Rong Li, Yue Huang, Huiling Lu and Jian Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:184

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:153

  22. The early occurrence regional nodal and distant metastases cholangiocarcinoma (CCA) is one of the major reasons for its poor prognosis. However, the related mechanisms are largely elusive. Recently, increasing...

    Authors: Jihua Nie, Jingying Zhang, Lili Wang, Lunjie Lu, Qian Yuan, Fangmei An, Shuyu Zhang and Yang Jiao
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:183
  23. Novel therapies tailored to the molecular composition of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. We investigated the regulatory network of long intergenic non-protein ...

    Authors: Lianghai Wang, Xiaodan Yu, Zhiyu Zhang, Lijuan Pang, Jiang Xu, Jinfang Jiang, Weihua Liang, Yuhang Chai, Jun Hou and Feng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:182
  24. Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is cata...

    Authors: Liang Zong, Ke Chen, Zhengdong Jiang, Xin Chen, Liankang Sun, Jiguang Ma, Cancan Zhou, Qinhong Xu, Wanxing Duan, Liang Han, Jianjun Lei, Xuqi Li, Qingyong Ma and Zheng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:181
  25. Accumulating evidence demonstrates that the Urokinase Receptor (uPAR) regulates tumor cell migration through its assembly in composite regulatory units with transmembrane receptors, and uPAR88–92 is the minimal s...

    Authors: Concetta Ragone, Michele Minopoli, Vincenzo Ingangi, Giovanni Botti, Federica Fratangelo, Antonello Pessi, Maria Patrizia Stoppelli, Paolo Antonio Ascierto, Gennaro Ciliberto, Maria Letizia Motti and Maria Vincenza Carriero
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:180
  26. A growing amount of evidence has indicated that PSAT1 is an oncogene that plays an important role in cancer progression and metastasis. In this study, we explored the expression and function of PSAT1 in estrog...

    Authors: Song Gao, Anqi Ge, Shouping Xu, Zilong You, Shipeng Ning, Yashuang Zhao and Da Pang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:179
  27. Docetaxel-based chemotherapy failure in advanced prostate carcinoma has partly been attributed to the resistance of prostate cancer (PC) cells to docetaxel-induced apoptosis. Hence, there is an urgent need to ...

    Authors: Zhan Yang, Jin-Suo Chen, Jin-Kun Wen, Hai-Tao Gao, Bin Zheng, Chang-Bao Qu, Kai-Long Liu, Man-Li Zhang, Jun-Fei Gu, Jing-Dong Li, Yan-Ping Zhang, Wei Li, Xiao-Lu Wang and Yong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:178
  28. Recurrence with distant metastases has become the predominant pattern of failure in locally advanced rectal cancer (LARC), thus the integration of new antineoplastic agents into preoperative fluoropyrimidine-b...

    Authors: Manuela Terranova-Barberio, Biagio Pecori, Maria Serena Roca, Serena Imbimbo, Francesca Bruzzese, Alessandra Leone, Paolo Muto, Paolo Delrio, Antonio Avallone, Alfredo Budillon and Elena Di Gennaro
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:177
  29. Renal cancers account for more than 3% of all adult malignancies and cause more than 23,400 deaths per year in China alone. The four most common types of kidney tumours include clear cell, papillary, chromopho...

    Authors: Qifeng Wang, Hualei Gan, Chengshu Chen, Yifeng Sun, Jinying Chen, Midie Xu, Weiwei Weng, Liyu Cao, Qinghua Xu and Jian Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:176
  30. Forkhead box A1 (FOXA1) expression is associated with various types of tumors; however, the function and underlying mechanism of FOXA1 in the development of hepatocellular carcinoma (HCC) remains obscure.

    Authors: Shujiao He, Junyi Zhang, Wan Zhang, Fengsheng Chen and Rongcheng Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:175
  31. Osimertinib is a third-generation EGFR-TKI with a high selective potency against T790M-mutant NSCLC patients. Considering that osimertinib can lead to enhanced HER-2 expression on cell surface and HER-2 overex...

    Authors: Silvia La Monica, Daniele Cretella, Mara Bonelli, Claudia Fumarola, Andrea Cavazzoni, Graziana Digiacomo, Lisa Flammini, Elisabetta Barocelli, Roberta Minari, Nadia Naldi, Pier Giorgio Petronini, Marcello Tiseo and Roberta Alfieri
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:174
  32. Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. miR-141-3p is an extensively studied miRNA in cancers and downregulation of miR-141-3p has been widely reported to be involved ...

    Authors: Shuai Huang, Qingde Wa, Jincheng Pan, Xinsheng Peng, Dong Ren, Yan Huang, Xiao Chen and Yubo Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:173
  33. Pharmacology-based target identification has become a novel strategy leading to the discovery of novel pathological biomarkers. Ellagic acid (EA), a dietary polyphenol compound, exhibits potent anticancer acti...

    Authors: Neng Wang, Qi Wang, Hailin Tang, Fengxue Zhang, Yifeng Zheng, Shengqi Wang, Jin Zhang, Zhiyu Wang and Xiaoming Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:172

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:118

  34. Cancer stem cells (CSCs) are regarded as the main cell type responsible for the initiation, metastasis, drug resistance, and recurrence of cancer. But the mechanism by which cancer stem cells maintain their st...

    Authors: Qiaohua Peng, Jiale Qin, Yanan Zhang, Xiaodong Cheng, Xinyu Wang, Weiguo Lu, Xing Xie and Songfa Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:171
  35. ALX4 is a paired-like homedomain transcription factor mainly expressed in the mesenchymal compartment of variety of developing tissues, but its functions, regulation mechanisms and clinical values in breast ca...

    Authors: Juntang Yang, Fei Han, Wenbin Liu, Hongqiang Chen, Xianglin Hao, Xiao Jiang, Li Yin, Yongsheng Huang, Jia Cao, Huidong Zhang and Jinyi Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:170
  36. Glioblastoma Multiforme is the deadliest type of brain tumor and is characterized by very poor prognosis with a limited overall survival. Current optimal therapeutic approach has essentially remained unchanged...

    Authors: Claudia Abbruzzese, Silvia Matteoni, Michele Signore, Luca Cardone, Kavindra Nath, Jerry D. Glickson and Marco G. Paggi
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:169
  37. Previous studies have indicated that tumor mitochondrial DNA (mtDNA) mutations are primarily shaped by relaxed negative selection, which is contradictory to the critical roles of mtDNA mutations in tumorigenes...

    Authors: Deyang Li, Xiaohong Du, Xu Guo, Lei Zhan, Xin Li, Chun Yin, Cheng Chen, Mingkun Li, Bingshan Li, Hushan Yang and Jinliang Xing
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:168
  38. Apigenin is a flavonoid widely distributed in plant kingdom that exerts cytotoxic effects against a variety of solid and haematological cancers. In this study, we investigated the effect of apigenin against pr...

    Authors: Marisa Granato, Maria Saveria Gilardini Montani, Roberta Santarelli, Gabriella D’Orazi, Alberto Faggioni and Mara Cirone
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:167
  39. Drug resistance is one of the major concerns in the treatment of hepatocellular carcinoma (HCC). The aim of the present study was to determine whether aberrant high expression of the inhibitor of differentiati...

    Authors: Xin Yin, Bei Tang, Jing-Huan Li, Yan Wang, Lan Zhang, Xiao-Ying Xie, Bo-Heng Zhang, Shuang-Jian Qiu, Wei-Zhong Wu and Zheng-Gang Ren
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:166
  40. Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in trophoblasts. Disturbance of this spatial and...

    Authors: H. Huebner, R. Strick, D. L. Wachter, S. Kehl, P. L. Strissel, R. Schneider-Stock, A. Hartner, W. Rascher, L. C. Horn, M. W. Beckmann, M. Ruebner and F. B. Fahlbusch
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:165
  41. Parallel to complex alteration in molecular and cellular events, enrichment of cancer stem cells (CSC) contributes significantly in deliberation and maintenance of cisplatin resistance. Cisplatin mediated CSC ...

    Authors: Bhushan Thakur and Pritha Ray
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:164
  42. Oral squamous cell carcinoma (OSCC) invades surrounding tissues by upregulating matrix metalloproteinases (MMPs) -2 and −9, which causes over-expression of the Hedgehog signaling proteins Shh and Gli-1 and deg...

    Authors: Haixia Fan, Haixia Li, Guanyao Liu, Wei Cong, Hong Zhao, Wenwu Cao and Jinhua Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:163
  43. Glioblastoma multiforme (GBM) is characterized by lethal aggressiveness and patients with GBM are in urgent need for new therapeutic avenues to improve quality of life. Current studies on tumor invasion focuse...

    Authors: Chao Zhang, Xin Zhang, Ran Xu, Bin Huang, An-Jing Chen, Chao Li, Jian Wang and Xin-Gang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:162
  44. Dysregulation of miRNAs is associated with cancer development by coordinately suppressing abundant target genes. Emerging evidence indicates that miR-31 plays a dual role in tumorigenicity. However, whether mi...

    Authors: Yanping Gao, Jun Yi, Kai Zhang, Fan Bai, Bing Feng, Rui Wang, Xiaoyuan Chu, Longbang Chen and Haizhu Song
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:161
  45. Gastric cancer (GC) is among the most commonly cancer occurred in Asian, especially in China. With its high heterogeneity and few of validated drug targets, GC remains to be one of the most under explored area...

    Authors: Jia-Qi Wu, Jing Zhai, Chong-Yong Li, Ai-Min Tan, Ping Wei, Li-Zong Shen and Ming-Fang He
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:160
  46. Though androgen deprivation therapy is the standard treatment for prostate cancer (PCa), most patients would inevitably progress to castration-resistant prostate cancer (CRPC) which is the main cause of PCa de...

    Authors: Zhixin Ling, Xiaoyan Wang, Tao Tao, Lei Zhang, Han Guan, Zonghao You, Kai Lu, Guangyuan Zhang, Shuqiu Chen, Jianping Wu, Jinke Qian, Hui Liu, Bin Xu and Ming Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:159
  47. MicroRNAs function as key regulators in various human cancers, including breast cancer (BC). MiR-361-5p has been proved to be a tumor suppressor in colorectal cancer and gastric cancer in our previous study. I...

    Authors: Fei Ma, Lei Zhang, Li Ma, Yiyun Zhang, Jianguo Zhang and Baoliang Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:158
  48. Claudin-6 (CLDN6), a member of CLDN family and a key component of tight junction, has been reported to function as a tumor suppressor in breast cancer. However, whether CLDN6 plays any role in breast cancer ch...

    Authors: Minlan Yang, Yanru Li, Xiangfeng Shen, Yang Ruan, Yan Lu, Xiangshu Jin, Peiye Song, Yantong Guo, Xiaoli Zhang, Huinan Qu, Yijia Shao and Chengshi Quan
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:157
  49. Transgelin-2 (TAGLN2) is a member of the calponin family of actin-bundling proteins that is involved in the regulation of cell morphology, motility, and cell transformation. Here, the clinical significance and...

    Authors: Ming-Zhi Han, Ran Xu, Yang-Yang Xu, Xin Zhang, Shi-Lei Ni, Bin Huang, An-Jing Chen, Yu-Zhen Wei, Shuai Wang, Wen-Jie Li, Qing Zhang, Gang Li, Xin-Gang Li and Jian Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:155

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