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  1. The existence of cancer stem cells in hepatocellular carcinoma (HCC) has been verified by characterizing side population (SP) cells based on efflux of Hoechst 33342 dye from stem cells. Recent advances in micr...

    Authors: Ren Li, Niansong Qian, Kaishan Tao, Nan You, Xinchuan Wang and Kefeng Dou

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:169

    Content type: Research

    Published on:

  2. The Open Archive Initiative (OAI) refers to a movement started around the '90s to guarantee free access to scientific information by removing the barriers to research results, especially those related to the e...

    Authors: Elisabetta Poltronieri, Ivana Truccolo, Corrado Di Benedetto, Mauro Castelli, Mauro Mazzocut and Gaetana Cognetti

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:168

    Content type: Research

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  3. ChromograninA in prostate carcinoma (PC) indicate NE differentiation. This tumour is more aggressive and resistant to hormone therapy.

    Authors: Marialuisa Appetecchia, Aurela Meçule, Giuseppe Pasimeni, Concetta V Iannucci, Piero De Carli, Roberto Baldelli, Agnese Barnabei, Giovanni Cigliana, Isabella Sperduti and Michele Gallucci

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:166

    Content type: Research

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  4. Imatinib, a selective tyrosine kinase inhibitor, has been used as a standard first-line therapy for irresectable and metastasized gastrointestinal stromal tumor (GIST) patients. Unfortunately, most patients re...

    Authors: Hoang Thanh Chi, Bui Thi Kim Ly, Takahiro Taguchi, Toshiki Watanabe and Yuko Sato

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:165

    Content type: Research

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  5. More data about TACE and pTACE seem necessary to better define the global treatment strategy for HCC. Aim of our analysis was to evaluate the role of TACE, either with lipiodol (traditional) or drug-eluting mi...

    Authors: Mario Scartozzi, Gianluca Svegliati Baroni, Luca Faloppi, Marzia Di Pietro Paolo, Chiara Pierantoni, Roberto Candelari, Rossana Berardi, Stefania Antognoli, Cinzia Mincarelli, Andrea Risaliti, Cristina Marmorale, Ettore Antico, Antonio Benedetti and Stefano Cascinu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:164

    Content type: Research

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  6. In spite of its establishment from the peripheral blood of a case with acute myeloid leukemia (AML)-M1, HPB-AML-I shows plastic adherence with spindle-like morphology. In addition, lipid droplets can be induce...

    Authors: Bambang Ardianto, Takeshi Sugimoto, Seiji Kawano, Shimpei Kasagi, Siti NA Jauharoh, Chiyo Kurimoto, Eiji Tatsumi, Keiko Morikawa, Shunichi Kumagai and Yoshitake Hayashi

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:163

    Content type: Research

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  7. Somatostatin prevents cell proliferation by inducing apoptosis. Downregulation of the XAF1 transcript may occur during the development of prostate cancer. It is interesting to evaluate the potential regulatory ef...

    Authors: Zhaoquan Xing, Zunlin Zhou, Rong Yu, Shuling Li, Chunde Li, Sten Nilsson and Zhaoxu Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:162

    Content type: Research

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  8. Pim-1 is a serine-threonine kinase which promotes early transformation, cell proliferation and cell survival during tumorigenesis. Several studies have demonstrated that Pim-1 kinase play a role in different c...

    Authors: Shengjie Guo, Xiaopeng Mao, Junxing Chen, Bin Huang, Chu Jin, Zhenbo Xu and Shaopeng Qiu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:161

    Content type: Research

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  9. Urinary bladder cancer is a common malignancy worldwide, and outcomes for patients with advanced bladder cancer remain poor. Antiproliferative factor (APF) is a potent glycopeptide inhibitor of epithelial cell...

    Authors: Hanief M Shahjee, Kristopher R Koch, Li Guo, Chen-Ou Zhang and Susan K Keay

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:160

    Content type: Research

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  10. Saikosaponin-a and -d, two naturally occurring compounds derived from Bupleurum radix, have been shown to exert anti-cancer activity in several cancer cell lines. However, the effect of combination of saikosap...

    Authors: Qiong Wang, Xue-lian Zheng, Lan Yang, Fang Shi, Lin-bo Gao, Ying-jia Zhong, Hong Sun, Fan He, Yong Lin and Xia Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:159

    Content type: Research

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  11. Chordoma was a typically slow-growing tumor. The therapeutic approach to chordoma had traditionally relied mainly on surgical therapy. And the main reason for therapeutic failure was resistance to chemotherapy...

    Authors: Zhengang Ji, Hua Long, Yunsheng Hu, Xiuchun Qiu, Xiang Chen, Zhao Li, Degang Fan, Baoan Ma and Qingyu Fan

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:158

    Content type: Research

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  12. The present report was designed to investigate the origins of elevated oxidative stress measured in cancer patients in our previous work related to a case-control study (17 cases, 43 controls) on oesophageal c...

    Authors: Stéphanie Lagadu, Mathilde Lechevrel, François Sichel, Jean Breton, Didier Pottier, Rémy Couderc, Fathi Moussa and Virginie Prevost

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:157

    Content type: Research

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  13. This study was conducted to investigate the expression of CXCR4 in portal vein tumor thrombus (PVTT) tissue and its possible role in the invasiveness of tumor thrombus cells.

    Authors: Nan Li, Weixing Guo, Jie Shi, Jie Xue, Huasheng Hu, Dong Xie, Mengchao Wu and Shuqun Cheng

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:156

    Content type: Research

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  14. Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described for different types of cancers and might be associated with cancer risk ...

    Authors: Ruixing Zhang, Rui Wang, Fengbin Zhang, Chensi Wu, Haiyan Fan, Yan Li, Cuiju Wang and Zhanjun Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:155

    Content type: Research

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  15. Molecular therapies that target genetic abnormalities in leukemic cells and their affected signaling pathways have been emerging in pediatric acute lymphoblastic leukemia (ALL). Glycogen synthase kinase-3β (GS...

    Authors: Yanni Hu, Xiaoyan Gu, Ruiyan Li, Qing Luo and Youhua Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:154

    Content type: Research

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  16. Pleomorphic malignant fibrous histiocytoma (MFH) is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a m...

    Authors: Jun Nishio, Hiroshi Iwasaki, Kazuki Nabeshima, Masako Ishiguro, Teruto Isayama and Masatoshi Naito

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:153

    Content type: Research

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  17. Noninvasive and tissue-specific technologies of gene transfection would be valuable in clinical gene therapy. This present study was designed to determine whether it could enhance gene transfection in vivo by the...

    Authors: Zhi-Yi Chen, Kun Liang and Ri-Xiang Qiu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:152

    Content type: Research

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  18. MicroRNAs are important gene regulators that potentially play a profound role in tumorigenesis. Increasing evidence indicates that miR-145 is a tumor suppressor capable of inhibiting breast and colon cancer ce...

    Authors: Zhe Chen, Huazong Zeng, Yong Guo, Pei Liu, Hui Pan, Anmei Deng and Jian Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:151

    Content type: Research

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  19. Glucocorticoid (GC) resistance is frequently seen in acute lymphoblastic leukemia of T-cell lineage (T-ALL). In this study we investigate the potential and mechanism of using rapamycin to restore the sensitivi...

    Authors: Ling Gu, Chenyan Zhou, Huajun Liu, Ju Gao, Qiang Li, Dezhi Mu and Zhigui Ma

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:150

    Content type: Research

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  20. Management of peritoneal dissemination is the most critical problem in gastric cancer. This study was performed to investigate the inhibitory effects of valproic acid (VPA) on a highly peritoneal-seeding cell ...

    Authors: Yasumichi Yagi, Sachio Fushida, Shinichi Harada, Jun Kinoshita, Isamu Makino, Katsunobu Oyama, Hidehiro Tajima, Hideto Fujita, Hiroyuki Takamura, Itasu Ninomiya, Takashi Fujimura, Tetsuo Ohta, Masakazu Yashiro and Kosei Hirakawa

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:149

    Content type: Research

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  21. Colloidal silver has been used as an antimicrobial and disinfectant agent. However, there is scarce information on its antitumor potential. The aim of this study was to determine if colloidal silver had cytoto...

    Authors: Moisés A Franco-Molina, Edgar Mendoza-Gamboa, Crystel A Sierra-Rivera, Ricardo A Gómez-Flores, Pablo Zapata-Benavides, Paloma Castillo-Tello, Juan Manuel Alcocer-González, Diana F Miranda-Hernández, Reyes S Tamez-Guerra and Cristina Rodríguez-Padilla

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:148

    Content type: Research

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  22. Deletions within the short arm of chromosome 7 are observed in approximately 25% of adult and 10% of Wilms pediatric renal tumors. Within Wilms tumors, the region of interest has been delineated to a 2-Mb mini...

    Authors: Kimberly R Blish, Kathryn A Clausen, Gregory A Hawkins, A Julian Garvin, Mark C Willingham, Julie C Turner, Frank M Torti and Suzy V Torti

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:147

    Content type: Research

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  23. Epidemiological studies have clearly validated the association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Patients with chronic HBV infection are at increased risk of HCC, in...

    Authors: Zhong-Jun Wu, Yu Zhu, De-Rong Huang and Zhi-Qiang Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:146

    Content type: Research

    Published on:

  24. Norcantharidin, the demethylated analog of cantharidin derived from a traditional Chinese medicine, Mylabris, has been used in the treatment of anti-cancer effects. However, the detailed mechanisms underlying ...

    Authors: Cheng Chang, You-Qing Zhu, Juan-juan Mei, Shi-quan Liu and Jun Luo

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:145

    Content type: Research

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  25. Real-time reverse transcription PCR (qRT-PCR) is frequently used for gene expression quantification due to its methodological reproducibility and sensitivity. The gene expression is quantified by normalization...

    Authors: Lise Aa Sørby, Solveig N Andersen, Ida RK Bukholm and Morten B Jacobsen

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:144

    Content type: Research

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  26. The Polycomb group (PcG) genes are a class of regulators responsible for maintaining homeotic gene expression throughout cell division. PcG expression is deregulated in some types of human cancer. Both Bmi-1 and ...

    Authors: You-Wei Lu, Jin Li and Wei-Jian Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:143

    Content type: Research

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  27. Radiotherapy has been shown to be an effective for the treatment human glioma and consists of 30 fractions of 2 Gy each for 6-7 weeks in the tumor volume with margins. However. in preclinical studies, many dif...

    Authors: Sandrine Vinchon-Petit, Delphine Jarnet, Eric Jadaud, Loïc Feuvret, Emmanuel Garcion and Philippe Menei

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:142

    Content type: Research

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  28. To study on expressions and clinical significances of CD133 protein and CD133 mRNA in primary lesion of gastric adenocarcinoma (GC).

    Authors: Ji-wei Yu, Peng Zhang, Ju-gang Wu, Sheng-hua Wu, Xiao-qiang Li, Shi-ting Wang, Rui-qi Lu, Xiao-chun Ni and Bo-jian Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:141

    Content type: Research

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  29. HBO1 (histone acetyltransferase binding to ORC1) is a histone acetyltransferase (HAT) which could exert oncogenic function in breast cancer. However, the biological role and underlying mechanism of HBO1 in bre...

    Authors: Wen-zhong Wang, Hai-ou Liu, Yi-hong Wu, Yi Hong, Jun-wu Yang, Ye-heng Liu, Wei-bin Wu, Lei Zhou, Lin-lin Sun, Jie-jie Xu, Xiao-jing Yun and Jian-xin Gu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:140

    Content type: Research

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  30. Peritoneal dissemination is one of the main causes of death in gastric cancer patients. Transforming growth factor-beta1 (TGF-β1), one of the most potent fibrotic stimuli for mesothelial cells, may play a key ...

    Authors: Zhi-Dong Lv, Di Na, Fu-Nan Liu, Zong-Min Du, Zhe Sun, Zhen Li, Xiao-Yang Ma, Zhen-Ning Wang and Hui-Mian Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:139

    Content type: Research

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  31. Gliomas represent the most common primary malignant brain tumors, yet little is known about the molecular pathogenesis of these tumors. The highly-regulated Wnt signal transduction pathway is essential for nor...

    Authors: Youxin Zhou, Fang Liu, Qinian Xu and Xiuyun Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:138

    Content type: Research

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  32. Platinum-based chemotherapy has been a standard therapy for advanced non-small cell lung cancer (NSCLC), but it has high toxicity. In China, Shenqi Fuzheng, a newly developed injection concocted from Chinese m...

    Authors: Ju Dong, Shi-Yue Su, Min-Yan Wang and Zhen Zhan

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:137

    Content type: Research

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  33. The CIP2A protein is a recently characterized oncoprotein which inhibits protein phosphatase 2A activity. Expression of CIP2A has been detected in several carcinomas, but its expression and significance in pro...

    Authors: Markku H Vaarala, Marja-Riitta Väisänen and Ari Ristimäki

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:136

    Content type: Research

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  34. Malignant tumor cells often express embryonic antigens which share the expression with embryonic stem (ES) cells. The embryonic antigens are usually encoded by ES cell-specific genes, a number of which are ass...

    Authors: Nobuyuki Ehira, Hiroyuki Oshiumi, Misako Matsumoto, Takeshi Kondo, Masahiro Asaka and Tsukasa Seya

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:135

    Content type: Research

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    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2014 33:22

  35. The possibility that autologous NK cells could serve as an effective treatment modality for solid tumors has long been considered. However, implementation is hampered by (i) the small number of NK cells in per...

    Authors: Caroline J Voskens, Ryuko Watanabe, Sandra Rollins, Dario Campana, Kenichiro Hasumi and Dean L Mann

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:134

    Content type: Research

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  36. The esophageal cancer related gene 4 (ECRG4) was initially identified and cloned in our laboratory from human normal esophageal epithelium (GenBank accession no.AF325503). ECRG4 was a new tumor suppressor gene...

    Authors: Linwei Li, Chunpeng Zhang, Xiaoyan Li, ShihHsin Lu and Yun Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:133

    Content type: Research

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    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:19

  37. We have compared mutation analysis by DNA sequencing and Amplification Refractory Mutation System™ (ARMS™) for their ability to detect mutations in clinical biopsy specimens.

    Authors: Gillian Ellison, Emma Donald, Gael McWalter, Lucy Knight, Lynn Fletcher, James Sherwood, Mireille Cantarini, Maria Orr and Georgina Speake

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:132

    Content type: Research

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  38. Studies have shown that Dickkopf-1 (DKK-1) is involved in tumorigenesis. Recently, we found that 9 out of 12 human glioma cell lines had high level of DKK-1 protein while the other 3 had very low or non-detect...

    Authors: Youxin Zhou, Wenshuai Li, Qinian Xu and Yulun Huang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:131

    Content type: Research

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  39. Hepatocellular carcinoma (HCC) is frequently preceded by hepatitis virus infection or alcohol abuse. Genetic backgrounds may increase susceptibility to HCC from these exposures.

    Authors: Ruixing Zhang, Fengbin Zhang, Cuiju Wang, Shunxiang Wang, Yih-Horng Shiao and Zhanjun Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:130

    Content type: Research

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  40. Human 8-oguanine glycosylase 1(hOGG1), voltage-dependent anion channel 1(VDAC1), hexokinase 2(HK-2), represented the process of oxidative DNA damage, cell apoptosis and glycolysis, respectively. This study aim...

    Authors: Peng Guo-Qing, Yang Yuan, Zhong Cai-Gao, Yin Hongling, Hu Gonghua and Tian Yan

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:129

    Content type: Research

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    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:53

  41. Colorectal cancer (CRC) screening is key to CRC prevention and mortality reduction, but patient compliance with CRC screening is low. We previously reported a blood-based test for CRC that utilizes a seven-gen...

    Authors: Kok-Thye Yip, Prashanta K Das, David Suria, Chun-Ren Lim, Guey-Hooi Ng and Choong-Chin Liew

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:128

    Content type: Research

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  42. Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibi...

    Authors: Yasuhiro Kidera, Masanobu Tsubaki, Yuzuru Yamazoe, Kaori Shoji, Haruyuki Nakamura, Mitsuhiko Ogaki, Takao Satou, Tatsuki Itoh, Misako Isozaki, Junichi Kaneko, Yoshihiro Tanimori, Masashi Yanae and Shozo Nishida

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:127

    Content type: Research

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  43. Lung cancer is a malignant carcinoma which has the highest morbidity and mortality in Chinese population. Gefitinib, a tyrosine kinase (TK) inhibitor of epidermal growth factor receptor (EGFR), displays anti-t...

    Authors: Yong-Mei Yin, Yi-Ting Geng, Yong-Feng Shao, Xiao-Li Hu, Wei Li, Yong-Qian Shu and Zhao-Xia Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:126

    Content type: Research

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  44. Several studies demonstrated that epidermal growth factor receptor (EGFR) gene copy number (GCN) correlates to the response to tyrosine kinase inhibitors in non small cell lung cancer (NSCLC) and to anti-EGFR ...

    Authors: Giovanni Simone, Anita Mangia, Andrea Malfettone, Vincenza Rubini, Michele Siciliano, Anna Di Benedetto, Irene Terrenato, Flavia Novelli and Marcella Mottolese

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:125

    Content type: Research

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  45. Epithelial ovarian cancer is one of the most malignant cancers in women because metastasis occurs in the most of patients by the time of diagnosis. Cancer cells have strong capacity to form angiogenesis or vas...

    Authors: Pengfei Zhu, Yanxia Ning, Liangqing Yao, Mo Chen and Congjian Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:124

    Content type: Research

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  46. RhoA and RhoC have been proved to be over-expressed in many solid cancers, including colorectal cancer. The reduction of RhoA and RhoC expression by RNA interference (RNAi) resulted growth inhibition of cancer ce...

    Authors: Haibo Wang, Gang Zhao, Xiangping Liu, Aihua Sui, Kun Yang, Ruyong Yao, Zongbao Wang and Qiang Shi

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:123

    Content type: Research

    Published on:

  47. To investigate the mechanisms of multidrug resistance of brain tumors, to identify the site of cellular expression of P-gp in human brains in situ and to morphologically determine whether an association may ex...

    Authors: Zhenhua Guo, Jin Zhu, Lihua Zhao, Qing Luo and Xianqing Jin

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:122

    Content type: Research

    Published on:

  48. Anti-CD20 monoclonal antibody treatment has not only increased survival and cure rates in many non-Hodgkin lymphomas, but also has prompted an explosion in the development of novel antibodies and biologically ...

    Authors: Yihu Zheng, Kang Yu, Jimei Du, Lei Jiang, Shenghui Zhang, Yixiang Han, Panpan Yu and Yingxia Tan

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:121

    Content type: Research

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  49. The advent of global gene expression profiling has generated unprecedented insight into our molecular understanding of cancer, including breast cancer. For example, human breast cancer patients display signifi...

    Authors: Robin M Hallett, Anna Dvorkin, Christine M Gabardo and John A Hassell

    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:120

    Content type: Research

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