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  1. PET (Positron Emission Tomography) is a nuclear medicine imaging method, frequently used in oncology during the last years. It is a non-invasive technique that provides quantitative in vivo assessment of physi...

    Authors: Evelina Miele, Gian Paolo Spinelli, Federica Tomao, Angelo Zullo, Filippo De Marinis, Giulia Pasciuti, Luigi Rossi, Federica Zoratto and Silverio Tomao
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:52
    Content type: Review Published on:

  2. Clear cell renal cell carcinoma (ccRCC) is the most frequently encountered tumor in the adult kidney. Many factors are known to take part in the development and progression of this tumor. Nuclear factor kappa ...

    Authors: Ibrahim Meteoglu, Ibrahim H Erdogdu, Nezih Meydan, Muhan Erkus and Sabri Barutca
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:53
    Content type: Research Published on:

  3. The activity of dihydropyrimidine dehydrogenase (DPD), the key enzyme of pyrimidine catabolism, is thought to be an important determinant for the occurrence of severe toxic reactions to 5-fluorouracil (5-FU), ...

    Authors: Ursula Amstutz, Simone Farese, Stefan Aebi and Carlo R Largiadèr
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:54
    Content type: Research Published on:

  4. The RON receptor tyrosine kinase regulates epithelial cell homeostasis and tumorigenesis by transducing multiple signals through its functional domains. The present study was to determine the significance of t...

    Authors: Yi Lu, Hang-Ping Yao and Ming-Hai Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:55
    Content type: Research Published on:

  5. Treatment failure after radiotherapy of head and neck squamous cell carcinoma (HNSCC) could be a significant problem. Our objective is to sensitize SCCVII cells to ionizing radiation in vitro and in vivo through ...

    Authors: Jian Zou, Xiaoming Qiao, Huiping Ye, Yuqiong Yang, Xuelian Zheng, Houyu Zhao and Shixi Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:56
    Content type: Research Published on:

  6. We explore the use of a clinical orthovoltage X-ray treatment unit as a small-animal radiation therapy system in a tumoral model of cervical cancer.

    Authors: Luis-Alberto Medina, Blanca-Ivone Herrera-Penilla, Mario-Alberto Castro-Morales, Patricia García-López, Rafael Jurado, Enrique Pérez-Cárdenas, José Chanona-Vilchis and María-Ester Brandan
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:57
    Content type: Research Published on:

  7. Sticker's sarcoma (also known as transmissible venereal tumor) is a horizontally transmitted neoplasm of the dog, that is passed with coitus. It is a locally aggressive tumor with a low tendency to metastatic ...

    Authors: Enrico P Spugnini, Ivan Dotsinsky, Nikolay Mudrov, Gennaro Citro, Alfredo D'Avino and Alfonso Baldi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:58
    Content type: Research Published on:

  10. Endostatin and anastellin, fragments of collagen type XVIII and fibronectin, respectively, belong to a family of endogenous inhibitors of angiogenesis which inhibit tumor growth and metastasis in a number of m...

    Authors: David M Neskey, Anthony Ambesi, Kevin M Pumiglia and Paula J McKeown-Longo
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:61
    Content type: Research Published on:

  12. Interferon-γ-inducible protein 10 (IP-10) is a potent inhibitor of tumor angiogenesis. It has been reported that the antiangiogenic therapy combined with chemotherapy has synergistic effects.

    Authors: Kai Mei, Lian Wang, Ling Tian, Jingrui Yu, Zhixuan Zhang and Yuquan Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:63
    Content type: Research Published on:

  13. Thymidine phosphorylase (TP) is identical with platelet-derived endothelial cell growth factor (PD-ECGF) which promotes angiogenesis. The aim of this study was to evaluate the cytosol activity of TP in tumor s...

    Authors: Elżbieta Miszczak-Zaborska, Robert Kubiak, Andrzej Bieńkiewicz and Jacek Bartkowiak
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:64
    Content type: Research Published on:

  14. Metatypical cell carcinoma can be considered as a new entity of skin cancer, being an intermediate typology between basal cell carcinomas and squamous cell carcinomas. The behaviour of the metatypical cell car...

    Authors: Mauro Tarallo, Emanuele Cigna, Riccardo Frati, Sergio Delfino, Daniele Innocenzi, Umberto Fama, Annamaria Corbianco and Nicolò Scuderi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:65
    Content type: Review Published on:

  15. The goal of this study was to determine the effects of a selective Cyclooxygenase (COX)-2 inhibitor on the inhibition of tumor growth and pulmonary metastasis in a Lewis Lung Carcinoma (LLC) animal model.

    Authors: Won Park, Young Taek Oh, Jae Ho Han and Hongryull Pyo
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:66
    Content type: Research Published on:

  16. The aim of this retrospective study was to assess the results concerning the regional and systemic toxicity and complications in 242 chemo-hyperthermal treatments (HILPs) for lower limb melanoma.

    Authors: Marcello Pace, Riccardo Gattai, Maria Matteini, Erminia Macera Mascitelli and Paolo Bechi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:67
    Content type: Research Published on:

  17. Cisplatin, a platinum based anticancer drug has played a vital role in the treatment of cancers by chemical agents, but in view of the serious toxicity including nephrotoxicity of cisplatin, various other plat...

    Authors: Shipra Pal, Arpita Sengupta Sadhu, Swarup Patra and Kalyan K Mukherjea
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:68
    Content type: Research Published on:

  18. The helix-loop-helix transcription factor Id-1 (an inhibitor of differentiation and DNA binding) plays a role in development and progression of many tumours. Id-1 is known to exert its effects on the epidermal...

    Authors: Ibrahim Meteoglu, Nezih Meydan and Muhan Erkus
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:69
    Content type: Research Published on:

  19. Tumours are classified according to the most differentiated cells with the exception of carcinomas where a few tumour cells show neuroendocrine differentiation. In this case these cells are regarded as rediffe...

    Authors: Helge L Waldum, Arne K Sandvik, Eiliv Brenna, Reidar Fossmark, Gunnar Qvigstad and Jun Soga
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:70
    Content type: Review Published on:

  20. The understanding of cutaneous pigmentation biology is relevant from the biologic and clinical point of view. The binding of α-melanocortin and its specific receptor, on the plasma membrane of melanin synthesi...

    Authors: Stefania Miccadei, Barbara Pascucci, Mauro Picardo, Pier Giorgio Natali and Donato Civitareale
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:71
    Content type: Research Published on:

  21. RNA interference (RNAi) has been successfully applied in suppression of hepatic cancer genes. In hepatocelluar carcinoma cell, one methionine adenosyltransferase (MAT) isozyme, MATII was found to have two cata...

    Authors: Qun Wang, Quan-yan Liu, Zhi-Su Liu, Qun Qian, Quan Sun and Ding-yu Pan
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:72
    Content type: Research Published on:

  22. The function of promyelocytic leukemia (PML) bodies is not well known but plays an important role in controlling cell proliferation, apoptosis and senescence. This study was undertaken to analyze the clinical ...

    Authors: Toshihiro Matsuo, Takashi Sugita, Shoji Shimose, Tadahiko Kubo, Masataka Ishikawa, Yuji Yasunaga and Mitsuo Ochi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:73
    Content type: Research Published on:

  23. The aim of this study is to evaluate the prognostic factors of overall survival (OS) after haematopoietic stem cell transplant (HSCT) in acute lymphoblastic leukaemia (ALL) patients using accelerated failure t...

    Authors: Kourosh Sayehmiri, Mohammad R Eshraghian, Kazem Mohammad, Kamran Alimoghaddam, Abbas Rahimi Foroushani, Hojjat Zeraati, Banafsheh Golestan and Ardeshir Ghavamzadeh
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:74
    Content type: Research Published on:

  24. Oncogenetic counselling is seldom followed through, even when individuals are eligible according to the test criteria. The basic variables which influence the decision to undergo the genetic counselling proces...

    Authors: Anita Caruso, Cristina Vigna, Gabriella Maggi, Fabio Massimo Sega, Francesco Cognetti and Antonella Savarese
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:75
    Content type: Research Published on:

  25. Chemoresistance is a serious problem in pancreatic cancer, but the mechanism of resistance and strategies against the resistance have not been elucidated. We examined the potential of the phosphatidylinositol ...

    Authors: Masao Fujiwara, Kunihiko Izuishi, Takanori Sano, Mohammad Akram Hossain, Shoji Kimura, Tsutomu Masaki and Yasuyuki Suzuki
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:76
    Content type: Research Published on:

  26. IQGAP1 is a scaffolding protein and overexpressed in many human tumors, including ovarian cancer. However, the contribution of IQGAP1 to invasive properties of ovarian cancer cells remains unknown. Here, we in...

    Authors: Pei-Xin Dong, Nan Jia, Zhu-Jie Xu, Ying-Tao Liu, Da-Jin Li and You-Ji Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:77
    Content type: Research Published on:

  27. Since successful treatment of superficial bladder cancer with BCG requires proper induction of Th1 immunity, we have developed a rBCG-S1PT strain that induced a stronger cellular immune response than BCG. This...

    Authors: Daher C Chade, Ricardo C Borra, Ivan P Nascimento, Fabiola E Villanova, Luciana CC Leite, Enrico Andrade, Miguel Srougi, Kátia L Ramos and Priscila M Andrade
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:78
    Content type: Research Published on:

  28. In sentinel node (SN) detection for cases of early gastric cancer, the submucosal dye injection method appears to be more reasonable than the subserosal injection. To compare the two injection methods, we have...

    Authors: Yoshihisa Yaguchi, Takashi Ichikura, Satoshi Ono, Hironori Tsujimoto, Hidekazu Sugasawa, Naoko Sakamoto, Yusuke Matsumoto, Kazumichi Yoshida, Shigeru Kosuda and Kazuo Hase
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:79
    Content type: Research Published on:

  29. Prophylactic cranial irradiation (PCI) has been demonstrated to reduce or delay the incidence of brain metastases (BM) in locally advanced non-small cell lung carcinoma (LA-NSCLC) patients with various prognos...

    Authors: Ali Aydin Yavuz, Erkan Topkan, Cem Onal and Melek Nur Yavuz
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:80
    Content type: Research Published on:

  30. Treatment of cancer patients with anthracycline antibiotic doxorubicin (DOX) may be complicated by development of acute and chronic congestive heart failure (CHF), malignant arrhythmias and death. The aim of t...

    Authors: Elmir Omerovic, Malin Linbom, Truls Råmunddal, Ann Lindgård, Ingrid Undeland, Ann-Sofie Sandberg and Bassam Soussi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:81
    Content type: Research Published on:

  31. Disseminated soft tissue sarcoma still represents a therapeutic dilemma because effective cytostatics are missing. Therefore we tested TRAIL and Tarolidine (TRD), two substances with apoptogenic properties on ...

    Authors: Adrien Daigeler, Christina Brenzel, Daniel Bulut, Anne Geisler, Christoph Hilgert, Marcus Lehnhardt, Hans U Steinau, Annegret Flier, Lars Steinstraesser, Ludger Klein-Hitpass, Ulrich Mittelkötter, Waldemar Uhl and Ansgar M Chromik
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:82
    Content type: Research Published on:

  32. Lipocalin 2, an iron binding protein, is abnormally expressed in some malignant human cancers and may play an important role in tumor metastasis. However, the roles of lipocalin 2 in breast cancer formation an...

    Authors: Han Shi, Yuchao Gu, Jing Yang, Liang Xu, Wenyi Mi and Wengong Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:83
    Content type: Research Published on:

  33. HPV vaccine is an exciting promise of the preventive medicine. Although HPV-immunization programs still reveal a number of unanswered questions, they represent a novel opportunity for primary prevention agains...

    Authors: Luciano Mariani and Sonia Pagliusi
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:84
    Content type: Editorial Published on:

  34. Gliomas represent the most frequent neoplasm of the central nervous system. Unfortunately, surgical cure of it is practically impossible and their clinical course is primarily determined by the biological beha...

    Authors: Mingyu Zhang, Tao Song, Liang Yang, Ruokun Chen, Lei Wu, Zhuanyi Yang and Jiasheng Fang
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:85
    Content type: Research Published on:

  35. The antiangiogenic agent cilengitide disrupts integrin binding to the extracellular matrix leading to apoptosis of activated endothelial cells. Integrins are also widely expressed in malignant glioma and integ...

    Authors: Leticia Oliveira-Ferrer, Jessica Hauschild, Walter Fiedler, Carsten Bokemeyer, Johannes Nippgen, Ilhan Celik and Gunter Schuch
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:86
    Content type: Research Published on:

  36. To investigate, in vitro, the regulatory effects of tumor-suppressing gene PTEN on mTOR (mammalian target of rapamycin) signaling pathway, the effects of transfected PTEN and rapamycin on the growth inhibition, a...

    Authors: Zhi Y Cheng, Xiao L Guo, Xiao Y Yang, Zhi Y Niu, Shi H Li, Su Y Wang, Hao Chen and Ling Pan
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:87
    Content type: Research Published on:

  37. Microsatellite instability (MSI) at tri- or tetranucleotide repeat markers (elevated microsatellite alterations at selected tetranucleotide repeat, EMAST) has been recently described. But, the underlying genet...

    Authors: Yoo Duk Choi, Jin Choi, Jo Heon Kim, Ji Shin Lee, Jae Hyuk Lee, Chan Choi, Ho Sun Choi, Min Cheol Lee, Chang Soo Park, Sang Woo Juhng and Jong Hee Nam
    Citation: Journal of Experimental & Clinical Cancer Research 2008 27:88
    Content type: Research Published on:

  38. To study the efficacy of whole brain radiotherapy (WBRT) with radiosensitizer in comparison with WBRT alone for patients with brain metastases in terms of overall survival, disease progression, response to tre...

    Authors: Gustavo Arruda Viani, Gustavo Borges Manta, Ellen Carrara Fonseca, Ligia Issa De fendi, Sergio Luis Afonso and Eduardo Jose Stefano
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:1
    Content type: Research Published on:

  39. This study aimed to analyze three-dimensional (3D) dosimetric data of conventional two-dimensional (2D) palliative spinal bone irradiation using different reference points and treatment plans with respect to t...

    Authors: Fundagul Andic, Sule Baz Cifci, Yasemin Ors, Umar Niang, Ahmet Dirier and Mustafa Adli
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:2
    Content type: Research Published on:

  40. Sirolimus is recently reported to have antitumour effects on a large variety of cancers. The present study was performed to investigate sirolimus's ability to inhibit growth in T24 bladder cancer cells.

    Authors: Rosario Pinto-Leite, Pedro Botelho, Eufemia Ribeiro, Paula A Oliveira and Lucios Santos
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:3
    Content type: Research Published on:

  41. Melanin synthesis, the elective trait of melanocytes, is regulated by tyrosinase activity. In tyrosinase-positive amelanotic melanomas this rate limiting enzyme is inactive because of acidic endo-melanosomal p...

    Authors: Fabio Di Domenico, Cesira Foppoli, Carla Blarzino, Marzia Perluigi, Francesca Paolini, Salvatrice Morici, Raffaella Coccia, Chiara Cini and Federico De Marco
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:4
    Content type: Research Published on:

  42. Eukaryotic initiation factor 4E (eIF4E) is elevated in many cancers and is a prognostic indicator in breast cancer. Many pro-tumorigenic proteins are selectively translated via eIF4E, including c-Myc, cyclin D...

    Authors: Heather E Kleiner, Prasad Krishnan, Jesse Tubbs, Mark Smith, Carol Meschonat, Runhua Shi, Mary Lowery-Nordberg, Patrick Adegboyega, Marcia Unger, James Cardelli, Quyen Chu, J Michael Mathis, John Clifford, Arrigo De Benedetti and Benjamin DL Li
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:5
    Content type: Research Published on:

  43. A number of studies have previously shown that the over expression of different ribosomal proteins might play an important role in cancer (i.e. S3a, L10, L16). We have previously reported that RPS2, a 33 Kda r...

    Authors: Min Wang, Youji Hu and Mark E Stearns
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:6
    Content type: Research Published on:

  44. Chondrosarcomas and chordomas are usually chemoresistant bone tumors and may have a poor prognosis when advanced. They are usually associated with worsening pain difficult to control.

    Authors: Liliana Montella, Raffaele Addeo, Vincenzo Faiola, Gregorio Cennamo, Rosario Guarrasi, Elena Capasso, Rosanna Mamone, Michele Caraglia and Salvatore Del Prete
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:7
    Content type: Case report Published on:

  45. Lamin A/C is very important in DNA replication, RNA dependent transcription and nuclear stabilization. Reduced or absent lamin A/C expression has been found to be a common feature of a variety of different can...

    Authors: Zhengrong Wu, Lirong Wu, Desheng Weng, Dazhi Xu, Jian Geng and Fei Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:8
    Content type: Research Published on:

  46. KiSS-1 was identified as a metastasis-suppressing gene in melanoma cells. The KiSS-1 gene product (metastin) was isolated from human placenta as the ligand of GPR54, a G-protein-coupled receptor. The role of meta...

    Authors: Kazuyuki Nagai, Ryuichiro Doi, Fumihiko Katagiri, Tatsuo Ito, Atsushi Kida, Masayuki Koizumi, Toshihiko Masui, Yoshiya Kawaguchi, Kenji Tomita, Shinya Oishi, Nobutaka Fujii and Shinji Uemoto
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:9
    Content type: Research Published on:

  47. Genetic polymorphisms of DNA repair enzymes in the base excision repair (BER) pathway, may lead to genetic instability and lung cancer carcinogenesis. We investigated the interactions among the gene polymorphi...

    Authors: Aiko Miyaishi, Kayo Osawa, Yasunori Osawa, Natsuko Inoue, Kana Yoshida, Mayumi Kasahara, Akimitsu Tsutou, Yoshiki Tabuchi, Kazuo Sakamoto, Noriaki Tsubota and Juro Takahashi
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:10
    Content type: Research Published on:

  50. Key role of angiogenesis in tumor growth and metastasis based on accumulating evidence and recent progress of immunotherapy have led us to investigate vaccine therapy targeting tumor angiogenesis.

    Authors: Kenta Yoshiura, Toshihide Nishishita, Takashi Nakaoka, Naohide Yamashita and Naomi Yamashita
    Citation: Journal of Experimental & Clinical Cancer Research 2009 28:13
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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