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  1. Integrin-linked kinase (ILK) is a multifunctional adaptor protein which is involved with protein signalling within cells to modulate malignant (cancer) cell movement, cell cycle, metastasis and epithelial–mese...

    Authors: Xiang Zhuang, Mengxin Lv, Zhenyu Zhong, Luyu Zhang, Rong Jiang and Junxia Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:130
  2. Hepatocellular carcinoma (HCC) is associated with inflammation, and roughly 30 % of the global population shows serological evidence of current or past infection with hepatitis B or hepatitis C virus. Resident...

    Authors: Lingxiang Kong, Yongjie Zhou, Hong Bu, Tao Lv, Yujun Shi and Jiayin Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:131
  3. In ovarian cancer (OC) cells, Snail was reported to induce the epithelial-to-mesenchymal transition (EMT), which is a critical step in OC metastasis. At present little is known about controlling Snail expressi...

    Authors: Peixin Dong, Ying Xiong, Hidemichi Watari, Sharon J. B. Hanley, Yosuke Konno, Kei Ihira, Takahiro Yamada, Masataka Kudo, Junming Yue and Noriaki Sakuragi
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:132
  4. The effects of PIM-1 on the progression of pancreatic cancer remain unclear, and the prognostic value of PIM-1 levels in tissues is controversial. Additionally, the expression levels and clinical value of PIM-...

    Authors: Jianwei Xu, Guangbing Xiong, Zhe Cao, Hua Huang, Tianxiao Wang, Lei You, Li Zhou, Lianfang Zheng, Ya Hu, Taiping Zhang and Yupei Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:133
  5. Yes-associated protein (YAP), an essential component of Hippo pathway, was identified as an oncoprotein which participated in the progression of various malignancies. However, its role in chronic myeloid leuke...

    Authors: Hui Li, Zhenglan Huang, Miao Gao, Ningshu Huang, Zhenhong Luo, Huawei Shen, Xin Wang, Teng Wang, Jing Hu and Wenli Feng
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:134
  6. Variant ATM heterozygotes have an increased risk of developing cancer, cardiovascular diseases, and diabetes. Costs and time of sequencing and ATM variant complexity make large-scale, general population screening...

    Authors: Andrea Prodosmo, Amelia Buffone, Manlio Mattioni, Agnese Barnabei, Agnese Persichetti, Aurora De Leo, Marialuisa Appetecchia, Arianna Nicolussi, Anna Coppa, Salvatore Sciacchitano, Carolina Giordano, Paola Pinnarò, Giuseppe Sanguineti, Lidia Strigari, Gabriele Alessandrini, Francesco Facciolo…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:135

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2016 35:185

  7. Mutations in the p53 oncosuppressor gene are highly frequent in human cancers. These alterations are mainly point mutations in the DNA binding domain of p53 and disable p53 from transactivating target genes de...

    Authors: Alessia Garufi, Giuseppa Pistritto, Mara Cirone and Gabriella D’Orazi
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:136
  8. The antimalarial drug Pyrimethamine has been suggested to exert an antitumor activity by inducing apoptotic cell death in cancer cells, including metastatic melanoma cells. However, the dose of Pyrimethamine t...

    Authors: Chiara Tommasino, Lucrezia Gambardella, Maria Buoncervello, Roger J. Griffin, Bernard T. Golding, Manuela Alberton, Daniele Macchia, Massimo Spada, Bruna Cerbelli, Giulia d’Amati, Walter Malorni, Lucia Gabriele and Anna Maria Giammarioli
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:137
  9. Increased exposure to multitargeted kinase inhibitor sunitinib is associated with improved outcome, emphasizing the importance of maintaining adequate dosing and drug levels. The currently approved schedule (5...

    Authors: Maria Rovithi, Richard R. de Haas, Richard J. Honeywell, Dennis Poel, Godefridus J. Peters, Arjan W. Griffioen and Henk M. W. Verheul
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:138
  10. Prostatic hyperplasia (PH) is a common urologic disease that affects mostly elderly men. PH can be classified as benign prostatic hyperplasia (BPH), or prostate cancer (PCa) based on its severity. Oxidative st...

    Authors: Udensi K. Udensi and Paul B. Tchounwou
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:139
  11. Interleukin-1 receptor associated kinase 1 (IRAK1), as a down-stream of toll-like receptor (TLR) signaling, plays important roles in series of malignancies. However, the role of IRAK1 in hepatocellular carcino...

    Authors: Ning Li, Jinhua Jiang, Jing Fu, Ting Yu, Bibo Wang, Wenhao Qin, An Xu, Mengchao Wu, Yao Chen and Hongyang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:140
  12. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of tumor progression. However, the role and molecular mechanism of lncRNA XIST in gastric cancer is still unknown.

    Authors: Dong-liang Chen, Huai-qiang Ju, Yun-xin Lu, Le-zong Chen, Zhao-lei Zeng, Dong-sheng Zhang, Hui-yan Luo, Feng Wang, Miao-zhen Qiu, De-shen Wang, Da-zhi Xu, Zhi-wei Zhou, Helene Pelicano, Peng Huang, Dan Xie, Feng-hua Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:142

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:208

  13. Dendritic cells (DCs) mount tumor-associated antigens (TAAs), and the double-stranded RNA adjuvant Poly(I:C) stimulates Toll-like receptor 3 (TLR3) signal in DC, which in turn induces type I interferon (IFN) a...

    Authors: Yohei Takeda, Masahiro Azuma, Misako Matsumoto and Tsukasa Seya
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:143
  14. WNT5A (-/-) mammary tissue has been shown to exhibit increased ductal elongation, suggesting elevated mammary cell migration. Increased epithelial cell migration/invasion has often but not always been linked t...

    Authors: Chandra Prakash Prasad, Shivendra Kumar Chaurasiya, William Guilmain and Tommy Andersson
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:144
  15. The recently identified phenomenon of double-stranded RNA (dsRNA)-mediated gene activation (RNAa) has been studied extensively, as it is present in humans, mice, and Caenorhabditis elegans, suggesting that dsRNA-...

    Authors: Huan-Lei Wu, Sen-Mao Li, Jia Hu, Xiao Yu, Hua Xu, Zhong Chen and Zhang-Qun Ye
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:145
  16. We have previously shown that the eukaryotic elongation factor subunit 1B gamma (eEF1Bγ) interacts with the RNA polymerase II (pol II) alpha-like subunit “C” (POLR2C), alone or complexed, in the pol II enzyme....

    Authors: Cinzia Pisani, Annalisa Onori, Francesca Gabanella, Francesca Delle Monache, Antonella Borreca, Martine Ammassari-Teule, Maurizio Fanciulli, Maria Grazia Di Certo, Claudio Passananti and Nicoletta Corbi
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:146
  17. Chemo-resistance is still a major obstacle in efforts to overcome acute myeloid leukemia (AML). An emerging concept has proposed that interactions between the bone marrow (BM) microenvironment and leukemia cel...

    Authors: Yuanmei Zhai, Jing Zhang, Hui Wang, Wei Lu, Sihong Liu, Yehua Yu, Wei Weng, Zhiyong Ding, Qi Zhu and Jun Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:147
  18. Tissue inhibitor matrix metalloproteinase 1 (TIMP1) plays a vital role in carcinogenesis, yet its precise functional roles and regulation remain unclear. In this study, we aim to investigate its biological fun...

    Authors: Guohe Song, Shifeng Xu, Hong Zhang, Yupeng Wang, Chao Xiao, Tao Jiang, Leilei Wu, Tao Zhang, Xing Sun, Lin Zhong, Chongzhi Zhou, Zhaowen Wang, Zhihai Peng, Jian Chen and Xiaoliang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:148
  19. Hsp90 proteins are important therapeutic targets for many anti-cancer drugs in clinical trials. Geldanamycin (GA) was identified as the first natural inhibitor of Hsp90, increasing evidence suggests that GA wa...

    Authors: Zhirui Zhang, Hong-Mei Li, Can Zhou, Qixiang Li, Linyan Ma, Zixuan Zhang, Yiming Sun, Lirong Wang, Xudong Zhang, Bing Zhu, Young-Soo Hong, Cheng-Zhu Wu and Hao Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:149
  20. Breast cancer is one of the leading cause of cancer-related deaths in women worldwide and increasing rapidly in developing countries. In the present study, we investigated the potential role and association of...

    Authors: Nirmala Jagadish, Sumit Agarwal, Namita Gupta, Rukhsar Fatima, Sonika Devi, Vikash Kumar, Vaishali Suri, Rajive Kumar, Vitusha Suri, Trilok Chand Sadasukhi, Anju Gupta, Abdul S. Ansari, Nirmal Kumar Lohiya and Anil Suri
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:150
  21. Increased expression of epidermal growth factor receptor (EGFR) and its ligands is associated with poor prognosis and chemoresistance in many carcinoma types, but its role in head and neck squamous cell carcin...

    Authors: Jian Gao, Camilla H. Ulekleiv and Trond S. Halstensen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:151
  22. Transducin-like enhancer of Split3 (TLE3) serves as a transcriptional corepressor during cell differentiation and shows multiple roles in different kinds of cancers. Recently, TLE3 together with many other gen...

    Authors: Run-Wei Yang, Ying-Yue Zeng, Wen-Ting Wei, Yan-Mei Cui, Hui-Ying Sun, Yue-Long Cai, Xin-Xin Nian, Yun-Teng Hu, Yu-Ping Quan, Sheng-Lu Jiang, Meng Wang, Ya-Li Zhao, Jun-Feng Qiu, Ming-Xuan Li, Jia-Huan Zhang, Mei-Rong He…
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:152

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:277

  23. Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation. These insults elicit activation of ce...

    Authors: Roberta Visconti, Rosa Della Monica and Domenico Grieco
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:153
  24. Authors: Corina Buta, Eva Benabou, Marie Lequoy, Hélène Régnault, Dominique Wendum, Fatiha Merabtene, Hamza Chettouh, Lynda Aoudjehane, Filomena Conti, Yves Chrétien, Olivier Scatton, Olivier Rosmorduc, Françoise Praz, Laetitia Fartoux and Christèle Desbois-Mouthon
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:154

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:126

  25. Genetically induced hepatocellular carcinoma (HCC) models are generally used to investigate carcinogenesis pathways, but very few attempts were made to valorize them for pharmacological testing. This study des...

    Authors: Mihaela Ignat, Cherif Youssef Akladios, Véronique Lindner, Konstantin Khetchoumian, Marius Teletin, Didier Muttter, Pierre Marc Aprahamian and Jacques Marescaux
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:155
  26. Exosomes are nanoscale extracellular membrane vesicles that are created by the fusion of an intracellular multivesicular body with the cell membrane. They are widely distributed in serum, urine, saliva and oth...

    Authors: Wenting Xu, Zhen Yang and Nonghua Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:156
  27. Among several types of tumor, lung cancer is considered one of the most fatal and still the main cause of cancer-related deaths. Although chemotherapeutic agents can improve survival and quality of life compar...

    Authors: Mohanad Aldarouish and Cailian Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:157
  28. LCL161, a novel Smac mimetic, is known to have anti-tumor activity and improve chemosensitivity in various cancers. However, the function and mechanisms of the combination of LCL161 and paclitaxel in non-small...

    Authors: Chengcheng Yang, Huangzhen Wang, Boxiang Zhang, Yimeng Chen, Yamin Zhang, Xin Sun, Guodong Xiao, Kejun Nan, Hong Ren and Sida Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:158
  29. Exosomes are carriers of intercellular information and regulate the tumor microenvironment. They play an important role in drug resistance by transporting RNA molecules and proteins. However, their effects on ...

    Authors: Zhen Qu, Junhua Wu, Junyi Wu, Dongjun Luo, Chunping Jiang and Yitao Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:159
  30. Long non-coding RNA (lncRNA) H19 has been reported to involve in many kinds of human cancers and functions as an oncogene. Our previous study found that H19 was over-expressed in gallbladder cancer (GBC) and w...

    Authors: Shou-Hua Wang, Fei Ma, Zhao-hui Tang, Xiao-Cai Wu, Qiang Cai, Ming-Di Zhang, Ming-Zhe Weng, Di Zhou, Jian-Dong Wang and Zhi-Wei Quan
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:160

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:55

  31. Osteosarcoma is the most prevalent primary malignant bone tumor, but treatment is difficult and prognosis remains poor. Recently, large-dose chemotherapy has been shown to improve outcome but this approach can...

    Authors: Baochang Qi, Tiecheng Yu, Chengxue Wang, Tiejun Wang, Jihang Yao, Xiaomeng Zhang, Pengfei Deng, Yongning Xia, Wolfgang G. Junger and Dahui Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:161
  32. Gliomas are the most common type of primary brain tumour in the central nervous system of adults. The long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP) is transcribed from the 5′ tip of t...

    Authors: Li-Min Xu, Lei Chen, Feng Li, Run Zhang, Zong-yang Li, Fan-Fan Chen and Xiao-Dan Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:162
  33. Recently, tumor initiating cells (TICs), which possess self-renewal and other stem cell properties, are regarded as the cause of tumor initiation, recurrence and metastasis. The isolation and identification of...

    Authors: Yanhui Zhang, Baocun Sun, Xiulan Zhao, Huizhi Sun, Wei Cui, Zhiyong Liu, Xin Yao and Xueyi Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:163
  34. Aberrant expression of Retinoic acid receptor γ (RARγ) is implicated in cancer development. Our previous study identified that RARγ functions as a tumor promoter to drive hepatocellular carcinoma (HCC) growth....

    Authors: Wen-Juan Gan, Jing-Ru Wang, Xiao-Li Zhu, Xiao-Shun He, Peng-Da Guo, Shen Zhang, Xiu-Ming Li, Jian-Ming Li and Hua Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:164
  35. Accumulating researches have shown that epithelial-mesenchymal transition (EMT) contributes to tumor metastasis. Leptin, a key adipokine secreted from adipocytes, shapes the tumor microenvironment, potentiates...

    Authors: Lan Wei, Kuangfa Li, Xueli Pang, Bianqin Guo, Min Su, Yunxiu Huang, Nian Wang, Feihu Ji, Changli Zhong, Junhong Yang, Zhiqian Zhang, Yulin Jiang, Yifeng Liu and Tingmei Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:166
  36. Embelin is a potent dual inhibitor of 5-lipoxigenase (5-LOX) and microsomal prostaglandin E2 synthase (mPGES)-1 that suppresses proliferation of human glioma cells and induces apoptosis by inhibiting XIAP and ...

    Authors: S. Zappavigna, M. Scuotto, A. M. Cossu, D. Ingrosso, M. De Rosa, C. Schiraldi, R. Filosa and M. Caraglia
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:167
  37. Developing safe and effective cancer vaccine formulations is a primary focus in the field of cancer immunotherapy. Dendritic cells (DC) are currently employed as cellular vaccine in clinical trials of tumor im...

    Authors: Soodabeh Iranpour, Vahid Nejati, Nowruz Delirezh, Pouria Biparva and Sadegh Shirian
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:168
  38. Clinicians are confronted with an increasing number of patients with thyroid nodules. Reliable preoperative diagnosis of thyroid nodules remains a challenge because of inconclusive cytological examination of f...

    Authors: Qing-Xuan Wang, En-Dong Chen, Ye-Feng Cai, Quan Li, Yi-Xiang Jin, Wen-Xu Jin, Ying-Hao Wang, Zhou-Ci Zheng, Lu Xue, Ou-Chen Wang and Xiao-Hua Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:169

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:18

  39. TRIM62 (tripartite motif containing 62) has been found to act as a tumor suppressor of several cancers. However, its precise biological role and related mechanism remain unknown in cervical cancer (CC).

    Authors: Tian-Yu Liu, Jian Chen, Chun-Liang Shang, Hong-Wei Shen, Jia-Ming Huang, Yan-Chun Liang, Wei Wang, Yun-He Zhao, Duo Liu, Man Shu, Lu-Yan Guo, Zheng Hu and Shu-Zhong Yao
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:170
  40. Interleukin-7 receptor (IL-7R) is involved in the abnormal function of solid tumors, but the role and regulatory mechanisms of IL-7R in HBV-related hepatocellular carcinoma (HCC) are still unclear.

    Authors: Fanyun Kong, Wei Hu, Kai Zhou, Xiao Wei, Yanbo Kou, Hongjuan You, Kuiyang Zheng and Renxian Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:172
  41. The metastatic cascade is a complex and multistep process with many potential barriers. Recently, miR-193a has been reported to be a suppressive miRNA in multiple types of cancers, but its underlying anti-onco...

    Authors: Junjie Chen, Shenmeng Gao, Chunjing Wang, Zhonggai Wang, Huxiang Zhang, Kate Huang, Bin Zhou, Haiying Li, Zhijie Yu, Jianbo Wu and Chengshui Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:173

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:31

  42. Gastric cancer (GC) is characterized by the excessive deposition of extracellular matrix, which is thought to contribute to this tumor’s malignant behavior. Epithelial-mesenchymal transition (EMT) is regarded ...

    Authors: Yang Chong, Dong Tang, Qingquan Xiong, Xuetong Jiang, Chuanqi Xu, Yuqin Huang, Jie Wang, Huaicheng Zhou, Youquan Shi, Xiaoqing Wu and Daorong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:175
  43. Cancer stem cells (CSCs) are important in the tumorigenesis and progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) play crucial roles regulating CD133+ and EpCAM+ CSCs in HCC, although it is unclea...

    Authors: Xi Zhang, Peng Jiang, Ling Shuai, Kai Chen, Zhonghu Li, Yujun Zhang, Yan Jiang and Xiaowu Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:176
  44. Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and histone changes is a main hallmark of cancer. Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1) is a potent oncogene overe...

    Authors: Mahmoud Alhosin, Ziad Omran, Mazin A. Zamzami, Abdulrahman L. Al-Malki, Hani Choudhry, Marc Mousli and Christian Bronner
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:174
  45. miRNAs are critical post-transcriptional regulators of gene expression and key mediators of tumourigenesis. miR-501-5p is newly identified to be involved in the tumor progression, but its biological role and m...

    Authors: Dongmei Fan, Baoqi Ren, Xiaojun Yang, Jia Liu and Zhengzheng Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:177
  46. Lapachol is a natural naphthoquinone compound that possesses extensive biological activities. The aim of this study is to investigate the inhibitory effects of lapachol on rat C6 glioma both in vitro and in vi...

    Authors: Huanli Xu, Qunying Chen, Hong Wang, Pingxiang Xu, Ru Yuan, Xiaorong Li, Lu Bai and Ming Xue
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:178
  47. DNA damage response (DDR) defects imply genomic instability and favor tumor progression but make the cells vulnerable to the pharmacological inhibition of the DNA repairing enzymes. Targeting cellular proteins...

    Authors: Aniello Cerrato, Francesco Morra and Angela Celetti
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:179
  48. The integration of human papilloma virus (HPV) into host genome is one of the critical steps that lead to the progression of precancerous lesion into cancer. However, the mechanisms and consequences of such in...

    Authors: Jun-Wei Zhao, Fang Fang, Yi Guo, Tai-Lin Zhu, Yun-Yun Yu, Fan-Fei Kong, Ling-Fei Han, Dong-Sheng Chen and Fang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2016 35:180

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