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  1. Bcl-x pre-mRNA splicing serves as a typical example to study the impact of alternative splicing in the modulation of cell death. Dysregulation of Bcl-x apoptotic isoforms caused by precarious equilibrium splic...

    Authors: Zhihui Dou, Dapeng Zhao, Xiaohua Chen, Caipeng Xu, Xiaodong Jin, Xuetian Zhang, Yupei Wang, Xiaodong Xie, Qiang Li, Cuixia Di and Hong Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:194

    Content type: Review

    Published on:

  2. Circular RNAs (circRNAs) are a new type of extensive non-coding RNAs that regulate the activation and progression of different human diseases, including cancer. However, information on the underlying mechanism...

    Authors: Jie Shi, Xin Lv, Lizhong Zeng, Wei Li, Yujie Zhong, Jingyan Yuan, Shanshan Deng, Boxuan Liu, Bo Yuan, Yang Chen, Zongjuan Ming, Xia Yang, Ping Fang, Shuanying Yang and Guoan Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:193

    Content type: Research

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  3. Tetraspanins CD151, a transmembrane 4 superfamily protein, has been identified participating in the initiation of a variety of cancers. However, the precise function of CD151 in non-small cell lung cancer (NSC...

    Authors: Jianjie Zhu, Tingting Cai, Jieqi Zhou, Wenwen Du, Yuanyuan Zeng, Ting Liu, Yulong Fu, Yue Li, Qian Qian, Xiuwei H. Yang, Qinglin Li, Jian-an Huang and Zeyi Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:192

    Content type: Research

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  4. Muscle invasive bladder cancer (MIBC) remains amongst the deadliest genitourinary malignancies due to treatment failure and extensive molecular heterogeneity, delaying effective targeted therapeutics. Hypoxia ...

    Authors: Andreia Peixoto, Dylan Ferreira, Rita Azevedo, Rui Freitas, Elisabete Fernandes, Marta Relvas-Santos, Cristiana Gaiteiro, Janine Soares, Sofia Cotton, Beatriz Teixeira, Paula Paulo, Luís Lima, Carlos Palmeira, Gabriela Martins, Maria José Oliveira, André M. N. Silva…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:191

    Content type: Research

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  5. Pyroptosis is a lytic cell death form executed by gasdermins family proteins. Induction of tumor pyroptosis promotes anti-tumor immunity and is a potential cancer treatment strategy. Triptolide (TPL) is a natu...

    Authors: Jing Cai, Mei Yi, Yixin Tan, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong and Bo Xiang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:190

    Content type: Research

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  6. Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcr...

    Authors: Vid Mlakar, Edouard Morel, Simona Jurkovic Mlakar, Marc Ansari and Fabienne Gumy-Pause

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:189

    Content type: Review

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  7. Hypoxia signaling, especially the hypoxia inducible factor (HIF) pathway, is a major player in clear cell renal cell carcinoma (ccRCC), which is characterized by disorders in lipid and glycogen metabolism. How...

    Authors: Ren Liu, Yuanfa Feng, Yulin Deng, Zhihao Zou, Jianheng Ye, Zhiduan Cai, Xuejin Zhu, Yingke Liang, Jianming Lu, Hui Zhang, Yong Luo, Zhaodong Han, Yangjia Zhuo, Qingling Xie, Chi Tin Hon, Yuxiang Liang…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:188

    Content type: Research

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  8. Glioma is one of the most aggressive malignant brain tumors that is characterized with inevitably infiltrative growth and poor prognosis. ARST is a novel lncRNA whose expression level is significantly decrease...

    Authors: Jun Sun, Dong He, Yibing Fu, Rui Zhang, Hua Guo, Zhaojuan Wang, Yanan Wang, Taihong Gao, Yanbang Wei, Yuji Guo, Qi Pang and Qian Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:187

    Content type: Research

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  9. Vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have been the mainstay of treatment for patients with advanced renal cell carcinoma (RCC). Despite its early promising results in decre...

    Authors: Revati Sharma, Elif Kadife, Mark Myers, George Kannourakis, Prashanth Prithviraj and Nuzhat Ahmed

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:186

    Content type: Review

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  10. Colorectal cancer (CRC) is a complex and heterogeneous disease, characterized by dismal prognosis and low survival rate in the advanced (metastatic) stage. During the last decade, the establishment of novel pr...

    Authors: Erika Durinikova, Kristi Buzo and Sabrina Arena

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:185

    Content type: Review

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  11. The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) are two most representative immune checkpoint pathways, which negatively regula...

    Authors: Hao Zhang, Ziyu Dai, Wantao Wu, Zeyu Wang, Nan Zhang, Liyang Zhang, Wen-Jing Zeng, Zhixiong Liu and Quan Cheng

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:184

    Content type: Review

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  12. Tumor cells are known to release large numbers of exosomes containing active substances that participate in cancer progression. Abnormally expressed long noncoding RNAs (lncRNAs) have been confirmed to regulat...

    Authors: Xueqiang Peng, Xinyu Li, Shuo Yang, Mingyao Huang, Shibo Wei, Yingbo Ma, Yan Li, Bo Wu, Hongyuan Jin, Bowen Li, Shilei Tang, Qing Fan, Jingang Liu, Liang Yang and Hangyu Li

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:183

    Content type: Research

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  13. Aberrant lipogenicity and deregulated autophagy are common in most advanced human cancer and therapeutic strategies to exploit these pathways are currently under consideration. Group III Phospholipase A2 (sPLA...

    Authors: Upasana Ray, Debarshi Roy, Ling Jin, Prabhu Thirusangu, Julie Staub, Yinan Xiao, Eleftheria Kalogera, Andrea E. Wahner Hendrickson, Grace D. Cullen, Krista Goergen, Ann L. Oberg and Viji Shridhar

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:182

    Content type: Research

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  14. Neuroblastoma (NB) represents the most frequent and aggressive form of extracranial solid tumor of infants. Nucleolin (NCL) is a protein overexpressed and partially localized on the cell surface of tumor cells...

    Authors: Chiara Brignole, Veronica Bensa, Nuno A. Fonseca, Genny Del Zotto, Silvia Bruno, Ana F. Cruz, Fabiana Malaguti, Barbara Carlini, Fabio Morandi, Enzo Calarco, Patrizia Perri, Vera Moura, Laura Emionite, Michele Cilli, Francesco De Leonardis, Annalisa Tondo…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:180

    Content type: Research

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  15. Exosomes have emerged as critical mediators of intercellular communication. Hypoxia is widely recognized as a key regulator of tumor aggressiveness, and significantly affects exosome release by tumor cells. Ho...

    Authors: Fengqiang Yu, Mingqiang Liang, Yu Huang, Weidong Wu, Bin Zheng and Chun Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:179

    Content type: Research

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  16. Colorectal cancer (CRC), despite the advances in screening and surveillance, remains the second most common cause of cancer death worldwide. The biological inadequacy of pre-clinical models to fully recapitula...

    Authors: Giulia Rizzo, Andrea Bertotti, Simonetta Maria Leto and Stefania Vetrano

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:178

    Content type: Review

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  17. Hepatocellular carcinoma (HCC) cells-secreted exosomes (exo) could stimulate M2 macrophage polarization and promote HCC progression, but the related mechanism of long non-coding RNA distal-less homeobox 6 anti...

    Authors: Lin-pei Wang, Jing Lin, Xiao-qiu Ma, Dong-yao Xu, Chun-feng Shi, Wei Wang and Xiao-jie Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:177

    Content type: Research

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  18. Cancer-associated fibroblasts (CAFs) comprise a heterogeneous population of stromal cells within the tumour microenvironment. CAFs exhibit both tumour-promoting and tumour-suppressing functions, making them ex...

    Authors: Freja Albjerg Venning, Kamilla Westarp Zornhagen, Lena Wullkopf, Jonas Sjölund, Carmen Rodriguez-Cupello, Pontus Kjellman, Mikkel Morsing, Morteza Chalabi Hajkarim, Kyoung Jae Won, Janine Terra Erler and Chris Denis Madsen

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:175

    Content type: Research

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  19. Although new developments of surgery, chemotherapy, radiotherapy, and immunotherapy treatments for cancer have improved patient survival, the emergence of chemoresistance in cancer has significant impacts on t...

    Authors: Guo-Hua Li, Qiang Qu, Ting-Ting Qi, Xin-Qi Teng, Hai-Hong Zhu, Jiao-Jiao Wang, Qiong Lu and Jian Qu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:174

    Content type: Review

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  20. Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, includ...

    Authors: Di Ye, Huanji Xu, Hongwei Xia, Chenliang Zhang, Qiulin Tang and Feng Bi

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:173

    Content type: Research

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  21. Although hepatocellular carcinoma (HCC) is one of the deadliest health burdens worldwide, few drugs are available for its clinical treatment. However, in recent years, major breakthroughs have been made in the...

    Authors: Xiang-Yuan Luo, Kong-Ming Wu and Xing-Xing He

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:172

    Content type: Review

    Published on:

  22. Intensive evidence has highlighted the effect of aberrant alternative splicing (AS) events on cancer progression when triggered by dysregulation of the SR protein family. Nonetheless, the underlying mechanism ...

    Authors: Jun-Xian Du, Yi-Hong Luo, Si-Jia Zhang, Biao Wang, Cong Chen, Gui-Qi Zhu, Ping Zhu, Cheng-Zhe Cai, Jing-Lei Wan, Jia-Liang Cai, Shi-Ping Chen, Zhi Dai and Wei Zhu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:171

    Content type: Research

    Published on:

  23. Pseudouridine synthase (PUS) 7 is a member of the PUS family that catalyses pseudouridine formation. It has been shown to be involved in intellectual development and haematological malignancies. Nevertheless, ...

    Authors: Dan Song, Ming Guo, Shuai Xu, Xiaotian Song, Bin Bai, Zhengyan Li, Jie Chen, Yanxin An, Yongzhan Nie, Kaichun Wu, Shiqi Wang and Qingchuan Zhao

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:170

    Content type: Research

    Published on:

  24. Patients were prone to have poor prognosis once dormant tumor cells being reactivated. However, the molecular mechanism of tumor cell dormancy remains poorly understood. This study aimed to investigate the fun...

    Authors: Xiao Yang, Jia-shun Wu, Mao Li, Wei-long Zhang, Xiao-lei Gao, Hao-fan Wang, Xiang-hua Yu, Xin Pang, Mei Zhang, Xin-hua Liang and Ya-ling Tang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:169

    Content type: Research

    Published on:

  25. Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with poor prognosis and limited treatment options. Hypoxia is a key hallmark of TNBC. Metabolic adaptation promotes progres...

    Authors: Qiao Li, Manran Liu, Yan Sun, Ting Jin, Pengpeng Zhu, Xueying Wan, Yixuan Hou and Gang Tu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:168

    Content type: Research

    Published on:

  26. Citation: Journal of Experimental & Clinical Cancer Research 2021 40:167

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:92

  27. Osteosarcoma (OS) is the most common primary bone cancer in adolescents and lung metastasis is the leading cause of death in patients with OS. However, the molecular mechanisms that promote OS growth and metas...

    Authors: Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai and Wei Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:166

    Content type: Research

    Published on:

  28. Soft tissue sarcomas (STS) are a rare group of solid neoplasm including among others liposarcoma, leiomyosarcoma (L-sarcoma) and undifferentiated pleomorphic sarcoma (UPS) entities. The current first-line trea...

    Authors: Alessandro De Vita, Federica Recine, Giacomo Miserocchi, Federica Pieri, Chiara Spadazzi, Claudia Cocchi, Silvia Vanni, Chiara Liverani, Anna Farnedi, Francesco Fabbri, Valentina Fausti, Roberto Casadei, Francesca Brandolini, Giorgio Ercolani, Davide Cavaliere, Alberto Bongiovanni…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:165

    Content type: Research

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  29. Temozolomide (TMZ) resistance limits its application in glioma. Exosome can carry circular RNAs (circRNAs) to regulate drug resistance via sponging microRNAs (miRNAs). miRNAs can control mRNA expression by reg...

    Authors: Chenyu Ding, Xuehan Yi, Xiangrong Chen, Zanyi Wu, Honghai You, Xiaoyong Chen, Gaoqi Zhang, Yong Sun, Xingyao Bu, Xiyue Wu, Zhangya Lin, Jianjun Gu, Yuanxiang Lin and Dezhi Kang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:164

    Content type: Research

    Published on:

  30. Single-cell RNA sequencing (scRNA-seq) is a tool for studying gene expression at the single-cell level that has been widely used due to its unprecedented high resolution. In the present review, we outline the ...

    Authors: Lvyuan Li, Fang Xiong, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Yi He, Lei Shi, Fuyan Wang, Qianjin Liao, Bo Xiang, Ming Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:163

    Content type: Review

    Published on:

  31. Colorectal cancer (CRC) is a common tumor characterized by its high mortality. However, the underlying molecular mechanisms that drive CRC tumorigenesis are unclear. Clock genes have important roles in tumor d...

    Authors: Meng Cao, Yi Wang, Yijing Xiao, Dandan Zheng, Chunchun Zhi, Xin Xia and Xiaoqin Yuan

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:162

    Content type: Research

    Published on:

  32. Improvement of radiotherapy efficacy requires better insight in the dynamic responses that occur during irradiation. Here, we aimed to identify the molecular responses that are triggered during clinically appl...

    Authors: Ruben S. A. Goedegebuure, Esther A. Kleibeuker, Francesca M. Buffa, Kitty C. M. Castricum, Syed Haider, Iris A. Schulkens, Luuk ten Kroode, Jaap van den Berg, Maarten A. J. M. Jacobs, Anne-Marie van Berkel, Nicole C. T. van Grieken, Sarah Derks, Ben J. Slotman, Henk M. W. Verheul, Adrian L. Harris and Victor L. Thijssen

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:161

    Content type: Research

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  33. The immunosuppressive tumour microenvironment is a critical factor in the initiation and progression of glioblastoma (GBM), which is characterized by an abundance of tumour-associated macrophages (TAMs) but a ...

    Authors: Qun Chen, Jing Jin, Xin Huang, Fan Wu, Hongguang Huang and Renya Zhan

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:160

    Content type: Research

    Published on:

  34. Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment and promotes cancer progression and resistance to therapy. Many studies reported the essential role of hypoxia in regul...

    Authors: Simona D’Aguanno, Fabiana Mallone, Marco Marenco, Donatella Del Bufalo and Antonietta Moramarco

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:159

    Content type: Review

    Published on:

  35. Regulator of cullins 1 (ROC1) is an important catalytic subunit of cullin–RING E3 ligase. Nuclear factor-kappa B (NF-κB) signaling is closely related to tumor invasion and metastasis. Earlier, we reported that...

    Authors: Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang and Jianxin Qiu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:158

    Content type: Research

    Published on:

  36. Medullary thyroid cancer (MTC) represents 13.4 % of all thyroid cancers-related deaths. The treatments for MTC are very limited especially for patients with distal metastasis. Therefore, it is critical to unde...

    Authors: Xun Zheng, Shu Rui, Xiao-Fei Wang, Xiu-He Zou, Yan-Ping Gong and Zhi-Hui Li

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:157

    Content type: Research

    Published on:

  37. Authors: Yingxia Ning, Weifeng Feng, Xiaocheng Cao, Kaiqun Ren, Meifang Quan, A. Chen, Chang Xu, Yebei Qiu, Jianguo Cao, Xiang Li and Xin Luo

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:155

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:19

  38. Uveal melanoma (UM) represents the most common primary intra-ocular malignancy in adults. Up to 50% of the patients develop distant metastases within 10 years from diagnosis, with the liver as the most common ...

    Authors: Anna Tosi, Rocco Cappellesso, Angelo Paolo Dei Tos, Valentina Rossi, Camillo Aliberti, Jacopo Pigozzo, Alessio Fabozzi, Marta Sbaraglia, Stella Blandamura, Paola Del Bianco, Vanna Chiarion-Sileni and Antonio Rosato

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:154

    Content type: Research

    Published on:

  39. Unraveling the mystery of cell death is one of the most fundamental progresses of life sciences during the past decades. Regulated cell death (RCD) or programmed cell death (PCD) is not only essential in embry...

    Authors: Yixin Tan, Quanzhu Chen, Xiaoling Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Xiayu Li, Jianbo Yang, Bo Xiang and Mei Yi

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:153

    Content type: Review

    Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:219

  40. Transforming growth factor β (TGFβ) signalling pathway switches between anti-tumorigenic function at early stages of cancer formation and pro-tumorigenic effects at later stages promoting cancer metastasis. A ...

    Authors: Chao-Hui Chang and Siim Pauklin

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:152

    Content type: Review

    Published on:

  41. Ovarian cancer is highly lethal and has a poor prognosis due to metastasis. Long non-coding RNAs (lncRNAs) are key regulators of tumor development, but their role in ovarian cancer metastasis remains unclear.

    Authors: Xinjing Wang, Xiaoduan Li, Feikai Lin, Huizhen Sun, Yingying Lin, Ziliang Wang and Xipeng Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:151

    Content type: Research

    Published on:

  42. Among the common preventable cancers of women, cervical cancer has the highest morbidity. It is curable if detected at an early stage. However, reliable diagnostic and prognostic markers, which relate to physi...

    Authors: Li Li, Yijia Gong, Ke Xu, Weihong Chen, Jiuyi Xia, Zhaobo Cheng, Lili Li, Renjie Yu, Junhao Mu, Xin Le, Qin Xiang, Weiyan Peng, Junying Tang and Tingxiu Xiang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:150

    Content type: Research

    Published on:

  43. Radiotherapy is a conventional and effective local treatment for breast cancer. However, residual or recurrent tumors appears frequently because of radioresistance. Novel predictive marker and the potential th...

    Authors: Xiaoqing Sun, Zhenyu He, Ling Guo, Caiqin Wang, Chuyong Lin, Liping Ye, Xiaoqing Wang, Yue Li, Meisongzhu Yang, Sailan Liu, Xin Hua, Wen Wen, Chao Lin, Zhiqing Long, Wenwen Zhang, Han Li…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:149

    Content type: Research

    Published on:

  44. Non-small cell lung cancer (NSCLC) is a major histological subtype of lung cancer with high mortality and morbidity. A substantial amount of evidence demonstrates long non-coding RNAs (lncRNA) as critical regu...

    Authors: Jiang Shi, Chao Yang, Jinlu An, Dexun Hao, Cong Liu, Jumin Liu, Jing Sun and Junguang Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:148

    Content type: Research

    Published on:

  45. BACE1 and BACE2 belong to a class of proteases called β-secretases involved in ectodomain shedding of different transmembrane substrates. These enzymes have been extensively studied in Alzheimer's disease as t...

    Authors: Francesco Farris, Vittoria Matafora and Angela Bachi

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:147

    Content type: Review

    Published on:

  46. The N6-methyladenosine (m6A) modification is a dynamic and reversible epigenetic modification, which is co-transcriptionally deposited by a methyltransferase complex, removed by a demethylase, and recognized b...

    Authors: Fenghua Tan, Mengyao Zhao, Fang Xiong, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Yi He, Lei Shi, Fuyan Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:146

    Content type: Review

    Published on:

  47. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Juntao Sun, Tianyu Zhang, Mengmeng Cheng, Liwen Hong, Chen Zhang, Mengfan Xie, Peijun Sun, Rong Fan, Zhengting Wang, Lei Wang and Jie Zhong

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:145

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:104

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