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  1. Research has indicated that the emergence of Schwann cells around premalignant lesions of colon cancer might be an early indicator promoting the onset of tumorigenesis. The present study explored the communica...

    Authors: Shengbo Han, Decai Wang, Yan Huang, Zhu Zeng, Peng Xu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Yuhang Hu, Fan Wang, Jie Wang, Yong Zhao, Wenfeng Zhuo and Gang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:348
  2. Esophageal squamous cell carcinoma (ESCC) is one of the most common digestive malignancies with relatively high morbidity and mortality. Emerging evidence suggests circular RNAs (circRNAs) play critical roles ...

    Authors: Chang Wang, Mingxia Zhou, Peiyu Zhu, Chenxi Ju, Jinxiu Sheng, Dan Du, Junhu Wan, Huiqing Yin, Yurong Xing, Hongle Li, Jing He and Fucheng He
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:347
  3. C-Jun, a critical component of AP-1, exerts essential functions in various tumors, including melanoma, and is believed to be a druggable target for cancer therapy. Unfortunately, no effective c-Jun inhibitors ...

    Authors: Pian Yu, Hui Wei, Kaixuan Li, Shiguo Zhu, Jie Li, Chao Chen, Detian Zhang, Yayun Li, Lei Zhu, Xiaoqing Yi, Nian Liu, Panpan Liu, Shuang Zhao, Xiang Chen and Cong Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:346
  4. N4-acetylcytidine (ac4C) as a significant RNA modification has been reported to maintain the stability of mRNA and to regulate the translation process. However, the roles of both ac4C and its ‘writer’ protein N-a...

    Authors: Chi Jin, Tuo Wang, Dongsheng Zhang, Peng Yang, Chuan Zhang, Wen Peng, Kangpeng Jin, Lu Wang, Jiahui Zhou, Chaofan Peng, Yuqian Tan, Jiangzhou Ji, Zhihao Chen, Qingyang Sun, Sheng Yang, Junwei Tang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:345
  5. Vaccine immunotherapy may improve survival in Glioblastoma (GBM). A multicenter phase II trial was designed to determine: (1) the success rate of manufacturing the Aivita GBM vaccine (AV-GBM-1), (2) Adverse Ev...

    Authors: Daniela A. Bota, Thomas H. Taylor, David E. Piccioni, Christopher M. Duma, Renato V. LaRocca, Santosh Kesari, Jose A. Carrillo, Mehrdad Abedi, Robert D. Aiken, Frank P. K. Hsu, Xiao-Tang Kong, Candace Hsieh, Peter G. Bota, Gabriel I. Nistor, Hans S. Keirstead and Robert O. Dillman
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:344
  6. Thymic malignancies are a heterogeneous group of rare cancers for which systemic chemotherapy is the standard treatment in the setting of advanced, recurrent or refractory diseases. Both environmental and gene...

    Authors: Paolo Mendogni, Roberta Affatato, Enrico Cabri, Michela Chiappa, Gloriana Ndembe, Davide Tosi, Alessandro Del Gobbo, Maddalena Fratelli, Eleonora Pardini, Iacopo Petrini, Lorenzo Rosso, Massimo Broggini and Mirko Marabese
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:343
  7. Authors: Rou Zhao, Baoyu He, Qingli Bie, Jinghe Cao, Haoran Lu, Zhixin Zhang, Jing Liang, Li Wei, Huabao Xiong and Bin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:342

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:322

  8. Authors: Ting Yang, Wei-Cong Chen, Pei-Cong Shi, Man-Ru Liu, Tao Jiang, Hu Song, Jia-Qi Wang, Rui-Zhi Fan, Dong-Sheng Pei and Jun Song
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:341

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:139

  9. Acute myeloid leukemia (AML) is an aggressive hematological cancer resulting from uncontrolled proliferation of differentiation-blocked myeloid cells. Seventy percent of AML patients are currently not cured wi...

    Authors: Katie Fooks, Gabriela Galicia-Vazquez, Victor Gife, Alejandro Schcolnik-Cabrera, Zaynab Nouhi, William W. L. Poon, Vincent Luo, Ryan N. Rys, Raquel Aloyz, Alexandre Orthwein, Nathalie A. Johnson, Laura Hulea and Francois E. Mercier
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:340
  10. Authors: Dan Jin, Jiwei Guo, Yan Wu, Weiwei Chen, Jing Du, Lijuan Yang, Xiaohong Wang, Kaikai Gong, Juanjuan Dai, Shuang Miao, Xuelin Li and Guoming Su
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:339

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:6

  11. Aberrant RNA editing of adenosine-to-inosine (A-to-I) has been linked to multiple human cancers, but its role in intrahepatic cholangiocarcinoma (iCCA) remains unknown. We conducted an exome-wide investigation...

    Authors: Chengming Gao, Guangming Zhou, Jie Shi, Peipei Shi, Liang Jin, Yuanfeng Li, Xiaowen Wang, Song Liao, Han Yan, Junjie Wu, Yiming Lu, Yun Zhai, Jinxu Zhang, Haitao Zhang, Hongxing Zhang, Chenning Yang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:338
  12. Altered glycolysis is the most fundamental metabolic change associated with the Warburg effect. Some glycolytic enzymes such as PKM2, the dominant pyruvate kinase in cancer cells, have been shown to engage in ...

    Authors: Yang Wu, Yichun Wang, Hanhui Yao, Heng Li, Fanzheng Meng, Qidong Li, Xiansheng Lin and Lianxin Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:337
  13. The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM protei...

    Authors: Xu Yang, Yan Zhang, Zhiwei Xue, Yaotian Hu, Wenjing Zhou, Zhiyi Xue, Xuemeng Liu, Guowei Liu, Wenjie Li, Xiaofei Liu, Xingang Li, Mingzhi Han and Jian Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:336
  14. Hepatocellular carcinoma (HCC) is the world’s third leading cause of cancer-related death; due to the fast growth and high prevalence of tumor recurrence, the prognosis of HCC patients remains dismal. Long non...

    Authors: Yunshi Cai, Tao Lyu, Hui Li, Chang Liu, Kunlin Xie, Lin Xu, Wei Li, Hu Liu, Jiang Zhu, Yinghao Lyu, Xuping Feng, Tian Lan, Jiayin Yang and Hong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:335
  15. N6-methyladenosine (m6A) modification plays a critical role in progression of hepatocellular carcinoma (HCC), and aerobic glycolysis is a hallmark of cancer including HCC. However, the role of YTHDF3, one member ...

    Authors: Rong Zhou, Wen Ni, Chao Qin, Yunxia Zhou, Yuqing Li, Jianping Huo, Lijuan Bian, Aijun Zhou and Jianming Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:334
  16. Mesothelioma is an aggressive disease with limited therapeutic options. The growth factor progranulin plays a critical role in several cancer models, where it regulates tumor initiation and progression. Recent...

    Authors: Elisa Ventura, Christopher Xie, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Antonio Giordano and Andrea Morrione
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:333
  17. The biological function of lncRNA ELF3-AS1 remains largely unknown in cancers. The cause of SNAI2 overexpression in tumor metastasis remains largely unclear. The molecular mechanisms underlying the high co-exp...

    Authors: Dandan Li, Li Shen, Xudong Zhang, Zhen Chen, Pan Huang, Congcong Huang and Shanshan Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:332
  18. Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant tumor characterized by an intensive desmoplastic reaction due to the exaggerated presence of the extracellular (ECM) matrix components. Liver fibrob...

    Authors: Serena Mancarella, Isabella Gigante, Grazia Serino, Elena Pizzuto, Francesco Dituri, Maria F. Valentini, Jingxiao Wang, Xin Chen, Raffaele Armentano, Diego F. Calvisi and Gianluigi Giannelli
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:331
  19. Glycolysis metabolism is an attractive target for cancer therapy. Reprogramming metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with limited treatment options. The ubiq...

    Authors: Liang Zhao, Min Kang, Xiaomeng Liu, Zhenran Wang, Yan Wang, Haiqiang Chen, Wenhui Liu, Shiqian Liu, Baibei Li, Chong Li, Antao Chang and Bo Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:330
  20. Aerobic glycolysis has been recognized as one of the growth-promoting metabolic alterations of cancer cells. Emerging evidence indicates that nuclear factor κB (NF-κB) plays significant roles in metabolic adap...

    Authors: Lingjun Chen, Xianyi Lin, Yiming Lei, Xuan Xu, Qi Zhou, Yan Chen, Huiling Liu, Jie Jiang, Yidong Yang, Fengping Zheng and Bin Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:329
  21. Radioresistance is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure. Previous studies have focused on the deficits in cellular apoptosis as a mechanism for radioresistance; however, additi...

    Authors: Muping Di, Jingjing Miao, Qiuzhong Pan, Zonglong Wu, Boyu Chen, Muru Wang, Jingjing Zhao, Huageng Huang, Jiewen Bai, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Desheng Weng, Lin Wang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:328
  22. Central nervous system (CNS) metastases are a major cause of death in patients with cancer. Tumor cells must survive during their migration and dissemination in various sites and niches. The brain is considere...

    Authors: Maria M. Caffarel and Mounia S. Braza
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:327
  23. Poor infiltration of functioning T cells renders tumors unresponsive to checkpoint-blocking immunotherapies. Here, we identified a combinatorial in situ immunomodulation strategy based on the administration of...

    Authors: Valeria Lucarini, Ombretta Melaiu, Silvia D’Amico, Fabio Pastorino, Patrizia Tempora, Marco Scarsella, Marco Pezzullo, Adele De Ninno, Valentina D’Oria, Michele Cilli, Laura Emionite, Paola Infante, Lucia Di Marcotullio, Maria Antonietta De Ioris, Giovanni Barillari, Rita Alaggio…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:326
  24. Improvement of efficacy of immune checkpoint blockade (ICB) remains a major clinical goal. Association of ICB with immunomodulatory epigenetic drugs is an option. However, epigenetic inhibitors show a heteroge...

    Authors: Andrea Anichini, Alessandra Molla, Gabriella Nicolini, Valentina Eleonora Perotti, Francesco Sgambelluri, Alessia Covre, Carolina Fazio, Maria Fortunata Lofiego, Anna Maria Di Giacomo, Sandra Coral, Antonella Manca, Maria Cristina Sini, Marina Pisano, Teresa Noviello, Francesca Caruso, Silvia Brich…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:325
  25. Aerotaxis, the chemotactism to oxygen, is well documented in prokaryotes. We previously reported for the first time that non-tumorigenic breast epithelial cells also display unequivocal directional migration t...

    Authors: Ivan Mikaelian, Rudy Gadet, Mathieu Deygas, Philippe Bertolino, Anca Hennino, Germain Gillet, Ruth Rimokh, Sid-Ali Berremila, Michel Péoc’h and Philippe Gonzalo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:324
  26. Intratumoral heterogeneity is the primary challenge in the treatment of glioblastoma (GBM). The presence of glioma stem cells (GSCs) and their conversion between different molecular phenotypes contribute to th...

    Authors: Zijie Gao, Jianye Xu, Yang Fan, Zongpu Zhang, Huizhi Wang, Mingyu Qian, Ping Zhang, Lin Deng, Jie Shen, Hao Xue, Rongrong Zhao, Teng Zhou, Xing Guo and Gang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:323
  27. Cancer stem cells (CSCs) are regarded as the "seed cells" for tumorigenesis, metastasis, recurrence and drug resistance. However, specific surface markers of CSCs of different origins have not been documented.

    Authors: Rou Zhao, Baoyu He, Qingli Bie, Jinghe Cao, Haoran Lu, Zhixin Zhang, Jing Liang, Li Wei, Huabao Xiong and Bin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:322

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:342

  28. Medulloblastoma (MB) patients with MYC oncogene amplification or overexpression exhibit extremely poor clinical outcomes and respond poorly to current therapies. Epigenetic deregulation is very common in MYC-d...

    Authors: Matthew J. Kling, Varun Kesherwani, Nitish K. Mishra, Gracey Alexander, Erin M. McIntyre, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter and Nagendra K. Chaturvedi
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:321
  29. In the last two decades, clinical oncology has been revolutionized by the advent of targeted drugs. However, the efficacy of these therapies is significantly limited by primary and acquired resistance, that re...

    Authors: Sabrina Rizzolio, Silvia Giordano and Simona Corso
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:319
  30. Tumour hypoxia is a known and extensively researched phenomenon that occurs in both solid and haematological malignancies. As cancer cells proliferate, demand for oxygen can outstrip supply reducing tumour oxy...

    Authors: Bill Harris, Sana Saleem, Natalie Cook and Emma Searle
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:318
  31. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1188-x.

    Authors: Zhikui Liu, Yufeng Wang, Liang Wang, Bowen Yao, Liankang Sun, Runkun Liu, Tianxiang Chen, Yongshen Niu, Kangsheng Tu and Qingguang Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:317
  32. Bone metastasis occurs when tumour cells dissociate from primary tumours, enter the circulation (circulating tumour cells, CTCs), and colonize sites in bone (disseminated tumour cells, DTCs). The bone marrow s...

    Authors: Rongchen Dai, Mengfan Liu, Xincheng Xiang, Zhichao Xi and Hongxi Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:316
  33. Tumor-initiating cells (TIC), also known as cancer stem cells, are considered a specific subpopulation of cells necessary for cancer initiation and metastasis; however, the mechanisms by which they acquire met...

    Authors: Donatella Delle Cave, Silvia Buonaiuto, Bruno Sainz Jr, Marco Fantuz, Maria Mangini, Alessandro Carrer, Annalisa Di Domenico, Tea Teresa Iavazzo, Gennaro Andolfi, Carme Cortina, Marta Sevillano, Christopher Heeschen, Vincenza Colonna, Marco Corona, Antonio Cucciardi, Martina Di Guida…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:315
  34. Beta-1,3-galactosyltransferase-4 (B3GALT4) plays a critical regulatory role in tumor biology. However, the role of B3GALT4 in modulating the tumor microenvironment (TME) of neuroblastoma (NB) remains unknown.

    Authors: Yong-Liang Sha, Yun Liu, Jia-Xing Yang, Yang-Yang Wang, Bao-Cheng Gong, Yan Jin, Tong-Yuan Qu, Fan-Tong Xia, Lei Han and Qiang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:314
  35. Authors: Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang and Jinhong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:313

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:284

  36. Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance. Patient-derived organoids have demonstrated great pote...

    Authors: Sebastian Schuth, Solange Le Blanc, Teresa G. Krieger, Julia Jabs, Miriam Schenk, Nathalia A. Giese, Markus W. Büchler, Roland Eils, Christian Conrad and Oliver Strobel
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:312
  37. Medulloblastoma is the most common malignant pediatric brain tumor and group 3 subtype medulloblastoma (G3-MB) exhibits the worst prognosis. Super enhancers (SEs) are large clusters of enhancers that play impo...

    Authors: Meng Li, Yujie Han, Chaochen Wang, Wenfeng Kang, Wenyan Jiang, Lei Zhang and Yujie Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:311
  38. The HER3 protein, that belongs to the ErbB/HER receptor tyrosine kinase (RTK) family, is expressed in several types of tumors. That fact, together with the role of HER3 in promoting cell proliferation, implica...

    Authors: Lucía Gandullo-Sánchez, Alberto Ocaña and Atanasio Pandiella
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:310
  39. Aberrant activation of the MET receptor in cancer is sustained by genetic alterations or, more frequently, by transcriptional upregulations. A fraction of MET-amplified or mutated tumors are sensible to MET ta...

    Authors: Cristina Chiriaco, Chiara Donini, Marco Cortese, Stefano Ughetto, Chiara Modica, Ilaria Martinelli, Alessia Proment, Letizia Vitali, Lara Fontani, Monica Casucci, Paolo Maria Comoglio, Silvia Giordano, Dario Sangiolo, Valeria Leuci and Elisa Vigna
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:309
  40. Ferroptosis is a novel form of iron-dependent cell death and participates in the malignant progression of glioblastoma (GBM). Although circular RNAs (circRNAs) are found to play key roles in ferroptosis via se...

    Authors: Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao and Daming Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:307

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:320

  41. Authors: Chongyang Li, Chaowei Deng, Guangzhao Pan, Xue Wang, Kui Zhang, Zhen Dong, Gaichao Zhao, Mengqin Tan, Xiaosong Hu, Shaomin Shi, Juan Du, Haoyan Ji, Xiaowen Wang, Liqun Yang and Hongjuan Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:306

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:230

  42. Molecular tumor boards (MTBs) match molecular alterations with targeted anticancer drugs upon failure of the available therapeutic options. Special and local needs are most likely to emerge through the compara...

    Authors: Gennaro Ciliberto, Marco Canfora, Irene Terrenato, Chiara Agnoletto, Francesco Agustoni, Loredana Amoroso, Gustavo Baldassarre, Giuseppe Curigliano, Angelo Delmonte, Antonella De Luca, Michelangelo Fiorentino, Vanesa Gregorc, Toni Ibrahim, Chiara Lazzari, Angela Mastronuzzi, Paolo Pronzato…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:305
  43. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with ...

    Authors: Lu Wang, Shuangshuang Li, Huanhua Luo, Qi Lu and Shuwen Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:303
  44. Adenosine is a potent immunosuppressant whose levels in the tumor microenvironment (TME) are often much higher than those in normal tissues. Binding of adenosine to its receptor A2aR activates a cascade of gen...

    Authors: Yu Bai, Xin Zhang, Jie Zheng, Ziyi Liu, Zhenfan Yang and Xiaolin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:302
  45. Early metastasis is a key factor contributing to poor breast cancer (BC) prognosis. Circulating tumor cells (CTCs) are regarded as the precursor cells of metastasis, which are ultimately responsible for the ma...

    Authors: Yufei Long, Tuotuo Chong, Xiaoming Lyu, Lujia Chen, Xiaomin Luo, Oluwasijibomi Damola Faleti, Simin Deng, Fei Wang, Mingliang He, Zhipeng Qian, Hongli Zhao, Wenyan Zhou, Xia Guo, Ceshi Chen and Xin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:301
  46. Neoadjuvant programmed death receptor-1 (PD-1) inhibitors have drawn increasing attention in locally advanced head and neck squamous cell carcinoma (HNSCC). In this study, we investigated the safety and effica...

    Authors: Xiaotao Huang, Qiaodan Liu, Guihua Zhong, Yingpeng Peng, Ye Liu, Lizhong Liang, Haiyu Hong, Weineng Feng, Shuang Yang, Yaqin Zhang, Shiping Xian, Zhanyu Li, Yuling Zhou, Zhaoyuan Zhang, Wen Jiang, Jun Liang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:300
  47. Therapeutic strategies engaging the immune system against malignant cells have revolutionized the field of oncology. Proficiency of dendritic cells (DCs) for antigen presentation and immune response has spurre...

    Authors: Natacha Jugniot, Jeremy J. Dahl and Ramasamy Paulmurugan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:299

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:357

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