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  1. Hypoxia-inducible factor-1 alpha (HIF-1α) maybe an important regulatory factor for angiogenesis of small cell lung cancer (SCLC). Our study aimed to investigate the effect of HIF-1α on angiogenic potential of ...

    Authors: Jun Wan, Huiping Chai, Zaicheng Yu, Wei Ge, Ningning Kang, Wanli Xia and Yun Che
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:77
    Content type: Research Published on:

  2. Malignant gliomas are the most common in central nervous system cancer. Genome-wide association study identifies that CDKN2A was a susceptibility loci for glioma. The CDKN2A/cyclin-dependent kinase 4, 6/Retino...

    Authors: Weidong Liu, Guohua Lv, Yawei Li, Lei li and Bing Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:76
    Content type: Research Published on:

  3. Alcohol consumption is an established risk factor for breast cancer metastasis. Yet, the mechanism by which alcohol promotes breast cancer metastases is unknown. The ability of cancer cells to invade through t...

    Authors: Amy W Wong, Qiwei X Paulson, Jina Hong, Renee E Stubbins, Karen Poh, Emily Schrader and Nomeli P Nunez
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:75
    Content type: Research Published on:

  4. Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme in the mevalonate pathway leads to suppression of...

    Authors: Masashi Yanae, Masanobu Tsubaki, Takao Satou, Tatsuki Itoh, Motohiro Imano, Yuzuru Yamazoe and Shozo Nishida
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:74
    Content type: Research Published on:

  6. Zoledronic acid (ZOL) is widely used for preventing bone loss in early breast cancer patients. However, the adverse effects caused by ZOL itself should not be neglected. Musculoskeletal disorders were common a...

    Authors: Wen-Bin Zhou, Peng-Ling Zhang, Xiao-An Liu, Tao Yang and Wei He
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:72
    Content type: Research Published on:

  7. To investigate the effects of ulinastatin and docetaxel on invasion of breast cancer cells and expression of uPA, uPAR and ERK, breast cancer MDA-MB-231 and MCF-7 cells.

    Authors: Jie Luo, Xin Sun, Feng Gao, Xiaoliang Zhao, Biao Zhong, Hong Wang and Zhijun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:71
    Content type: Research Published on:

  9. MRI plays a key role in the preclinical development of new drugs, diagnostics and their delivery systems. However, very high installation and running costs of existing superconducting MRI machines limit the sp...

    Authors: Henrike Caysa, Hendrik Metz, Karsten Mäder and Thomas Mueller
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:69
    Content type: Research Published on:

  10. The human multi-drug resistance gene (MDR1), which encodes the major trans-membrane transporter P-glycoprotein (P-gp), was found to be associated with susceptibility to cancer and response to chemotherapy. The C3...

    Authors: Nizar M Mhaidat, Osama Y Alshogran, Omar F Khabour, Karem H Alzoubi, Ismail I Matalka, William J Haddadin, Ibraheem O Mahasneh and Ahmad N Aldaher
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:68
    Content type: Research Published on:

  11. Our study aims to evaluate the anti-growth effects of recombinant immunotoxin (IT) anti-c-Met/PE38KDEL on gastric cancer cells, and its mechnisms.

    Authors: Xu Wei, Zhu Xiao Juan, Feng Xiao Min, Cai Nan, Zhang Xiu Hua, Feng Zheng Qing and Liu Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:67
    Content type: Research Published on:

  12. Oxymatrine, an isolated extract from traditional Chinese herb Sophora Flavescens Ait, has been traditionally used for therapy of anti-hepatitis B virus, anti-inflammation and anti-anaphylaxis. The present study w...

    Authors: Qi Ling, Xiao Xu, Xuyong Wei, Weibing Wang, Bin Zhou, Bei Wang and Shusen Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:66
    Content type: Research Published on:

  13. Overall therapeutic outcomes of advanced non-small-cell lung cancer (NSCLC) are poor. The dendritic cell (DC) immunotherapy has been developed as a new strategy for the treatment of lung cancer. The purpose of...

    Authors: Maurício W Perroud Jr, Helen N Honma, Aristóteles S Barbeiro, Simone CO Gilli, Maria T Almeida, José Vassallo, Sara TO Saad and Lair Zambon
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:65
    Content type: Research Published on:

  14. Approximately 20% of children and adolescents in Europe are overweight. Survivors of pediatric acute lymphoblastic leukemia (ALL) are at increased risk of overweight and obesity. The purpose of this study was ...

    Authors: Szymon Skoczen, Przemyslaw J Tomasik, Miroslaw Bik-Multanowski, Marcin Surmiak, Walentyna Balwierz, Jacek J Pietrzyk, Krystyna Sztefko, Jolanta Gozdzik, Danuta Galicka-Latała and Wojciech Strojny
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:64
    Content type: Research Published on:

  15. The human coagulation trigger tissue factor (TF) is overexpressed in several types of cancer and involved in tumor growth, vascularization, and metastasis. To explore the role of TF in biological processes of ...

    Authors: Chengcheng Xu, Qi Gui, Wenshu Chen, Leiming Wu, Wei Sun, Ni Zhang, Qinzi Xu, Jianing Wang and Xiangning Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:63
    Content type: Research Published on:

  16. Monocyte recruited into the tumor and maturation to tumor-associated macrophage (TAM). Interleukin-10(IL-10) is a potent immunosuppressive cytokine, which can be secreted from both primary tumor and stromal cells...

    Authors: Rui Wang, Meng Lu, Haiquan Chen, Sufeng Chen, Xiaoyang Luo, Ying Qin and Jie Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:62
    Content type: Research Published on:

  17. Hypoxia inducible factor-1 (HIF-1) has been considered as a critical transcriptional factor in response to hypoxia. It can increase P-glycoprotein (P-Gp) thus generating the resistant effect to chemotherapy. A...

    Authors: Wen-sen Jin, Zhao-lu Kong, Zhi-fen Shen, Yi-zun Jin, Wu-kui Zhang and Guang-fu Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:61
    Content type: Research Published on:

  18. MTA1(metastasis associated-1) is a tumor metastasis associated candidate gene and overexpression in many human tumors, including breast cancer. In this study, we investigated depressive effect on MTA1 by MTA1-...

    Authors: Qingming Jiang, Hui Zhang and Ping Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:60
    Content type: Research Published on:

  19. Circulating levels of novel long-chain hydroxy fatty acids (called GTAs) were recently discovered in the serum of healthy subjects which were shown to be reduced in subjects with colorectal cancer (CRC), indep...

    Authors: Shawn A Ritchie, Dushmanthi Jayasinghe, Gerald F Davies, Pearson Ahiahonu, Hong Ma and Dayan B Goodenowe
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:59
    Content type: Research Published on:

  21. Epidermal Growth Factor Receptor (EGFR) mutations, especially in-frame deletions in exon 19 (ΔLRE) and a point mutation in exon 21 (L858R) predict gefitinib sensitivity in patients with non-small cell lung can...

    Authors: Sandrine Dufort, Marie-Jeanne Richard, Sylvie Lantuejoul and Florence de Fraipont
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:57
    Content type: Research Published on:

  22. Signal transducer and activator of transcription 3 (STAT3) is a key signaling molecule and a central cytoplasmic transcription factor, implicated in the regulation of growth. Its aberrant activation has been d...

    Authors: Diana David, Lakshmy M Rajappan, Krishna Balachandran, Jissa V Thulaseedharan, Asha S Nair and Radhakrishna M Pillai
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:56
    Content type: Research Published on:

  24. Although the addition of bevacizumab significantly improves the efficacy of chemotherapy for advanced breast cancer, regulatory concerns still exist with regard to the magnitude of the benefits and the overall...

    Authors: Federica Cuppone, Emilio Bria, Vanja Vaccaro, Fabio Puglisi, Alessandra Fabi, Isabella Sperduti, Paolo Carlini, Michele Milella, Cecilia Nisticò, Michelangelo Russillo, Paola Papaldo, Gianluigi Ferretti, Matti Aapro, Diana Giannarelli and Francesco Cognetti
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:54
    Content type: Research Published on:

  26. An advantage of the Intensity Modulated Radiotherapy (IMRT) technique is the feasibility to deliver different therapeutic dose levels to PTVs in a single treatment session using the Simultaneous Integrated Boo...

    Authors: Vicente Bruzzaniti, Armando Abate, Massimo Pedrini, Marcello Benassi and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:52
    Content type: Research Published on:

  27. The expression of chemokine receptors CCR7 has been studied in relation to tumor dissemination and poor prognosis in a limited number of cancers. No such studies have been done on CCR7 expression in non-Hodgki...

    Authors: Jing Yang, Shengyi Wang, Guofan Zhao and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:51
    Content type: Research Published on:

  28. Maintenance therapy is emerging as a treatment strategy in the management of advanced non small cell lung cancer (NSCLC). Initial trials addressing the question of duration of combination chemotherapy failed t...

    Authors: Silvia Novello, Michele Milella, Marcello Tiseo, Giuseppe Banna, Diego Cortinovis, Massimo Di Maio, Marina Garassino, Paolo Maione, Olga Martelli, Tiziana Vavalà and Emilio Bria
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:50
    Content type: Review Published on:

  29. The present study was conducted to evaluate the tumor suppressive effects of bone marrow derived mesenchymal stem cells (MSCs) in an experimental hepatocellular carcinoma (HCC) model in rats and to investigate...

    Authors: Mohamed T Abdel aziz, Mohamed F El Asmar, Hazem M Atta, Soheir Mahfouz, Hanan H Fouad, Nagwa K Roshdy, Laila A Rashed, Dina Sabry, Amira A Hassouna and Fatma M Taha
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:49
    Content type: Research Published on:

  30. To explore the potential role of CpG motif-containing oligonucleotides (CpG-ODN) in modulating the expression of FasL in HepG2 and Fas in Jurkat cells in vitro, and to examine the effect of CpG-ODN treatment on t...

    Authors: Jianfeng Zheng, Rongquan Fu, Jing Li and Xiaozhong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:48
    Content type: Research Published on:

  31. Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells ...

    Authors: Zhu Xishan, An Guangyu, Song Yuguang and Zhang Hongmei
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:47
    Content type: Research Published on:

  32. Vasculogenic mimicry (VM), as a new blood supply for tumor growth and hematogenous metastases, has been recently described in highly aggressive human melanoma cells, etc. We previously reported VM in human gal...

    Authors: Wei Sun, Yue Z Fan, Wen Z Zhang and Chun Y Ge
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:46
    Content type: Research Published on:

  33. Many factors influence breast cancer progression, including the ability of progenitor cells to sustain or increase net tumour cell numbers. Our aim was to define whether alterations in putative progenitor popu...

    Authors: Simona Donatello, Lance Hudson, David C Cottell, Alfonso Blanco, Igor Aurrekoetxea, Martin J Shelly, Peter A Dervan, Malcolm R Kell, Maurice Stokes, Arnold DK Hill and Ann M Hopkins
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:45
    Content type: Research Published on:

  34. Silibinin, a natural polyphenolic flavonoid, has been reported to induce cell death in various cancer cell types. However, the molecular mechanism is not clearly defined. Our previous study showed that silibin...

    Authors: Ji C Jeong, Won Y Shin, Thae H Kim, Chae H Kwon, Jae H Kim, Yong K Kim and Ki H Kim
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:44
    Content type: Research Published on:

  35. To conserve laryngeal function and elevate living quality of laryngeal squamous cell carcinoma (LSCC) patients, we designed antisense oligodeoxynucleotides (AS-ODNs) to reduce expression of ATM and to enhance ...

    Authors: Jun Feng, Jian Zou, Li Li, Yongsheng Zhao and Shixi Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:43
    Content type: Research Published on:

  36. Fermented wheat germ extract (FWGE) is currently used as nutrition supplement for cancer patients. Limited recent data suggest antiproliferative, antimetastatic and immunological effects which were at least in...

    Authors: Thomas Mueller, Karin Jordan and Wieland Voigt
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:42
    Content type: Research Published on:

  37. Over-expressed in numerous cancers, Ubiquitin-like containing PHD Ring Finger 1 (UHRF1, also known as ICBP90 or Np95) is characterized by a SRA domain (Set and Ring Associated) which is found only in the UHRF fam...

    Authors: Mahmoud Alhosin, Tanveer Sharif, Marc Mousli, Nelly Etienne-Selloum, Guy Fuhrmann, Valérie B Schini-Kerth and Christian Bronner
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:41
    Content type: Review Published on:

  38. Kaposi Sarcoma (KS) is a malignancy of endothelial skin cells with multifocal localization on the skin, lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection, spec...

    Authors: Francesco M Solivetti, Fulvia Elia, Alessandra Latini, Carlo Cota, Paola Cordiali-Fei and Aldo Di Carlo
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:40
    Content type: Research Published on:

  39. To evaluate activity and tolerability of two anthracycline-containing regimens as first-line treatment for anthracycline-naïve relapsed breast cancer patients.

    Authors: Patrizia Vici, Giuseppe Colucci, Francesco Giotta, Domenico Sergi, Gianfranco Filippelli, Pasquale Perri, Claudio Botti, Enrico Vizza, Armando Carpino, Laura Pizzuti, Agnese Latorre, Diana Giannarelli, Massimo Lopez and Luigi Di Lauro
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:39
    Content type: Research Published on:

  40. The human epidermal growth factor receptor 2 (HER2) and p53 pathways may be involved in chemotherapy sensitivity and/or resistance. We explore the value of HER2 and p53 status to foretell docetaxel sensitivity...

    Authors: Andrea Camerini, Sara Donati, Paolo Viacava, Olimpia Siclari, Cheti Puccetti, Gianna Tartarelli, Chiara Valsuani, Filomena De Luca, Leonardo Martini, Andrea Cavazzana and Domenico Amoroso
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:38
    Content type: Research Published on:

  41. Cancer cells are known to secrete the stress molecules MICA and MICB that activate cytotoxicity by lymphocytes and NK cells through their NKG2D receptor as a mechanism of immunological defense. This work was u...

    Authors: Benny Weiss-Steider, Isabel Soto-Cruz, Christian A Martinez-Campos and Jorge Flavio Mendoza-Rincon
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:37
    Content type: Research Published on:

  42. There has been insufficient examination of the factors affecting long-term survival of more than 5 years in patients with leukemia that is not in remission at transplantation.

    Authors: Hideo Koh, Hirohisa Nakamae, Kiyoyuki Hagihara, Takahiko Nakane, Masahiro Manabe, Yoshiki Hayashi, Mitsutaka Nishimoto, Yukari Umemoto, Mika Nakamae, Asao Hirose, Eri Inoue, Atsushi Inoue, Masahiro Yoshida, Masato Bingo, Hiroshi Okamura, Ran Aimoto…
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:36
    Content type: Research Published on:

  43. Iodine 125 (125I) seed irradiation is an effective treatment for unresectable pancreatic cancers. However, the radiobiological mechanisms underlying brachytherapy remain unclear. Therefore, we investigated the in...

    Authors: Jian-xia Ma, Zhen-dong Jin, Pei-ren Si, Yan Liu, Zheng Lu, Hong-yu Wu, Xue Pan, Luo-wei Wang, Yan-fang Gong, Jun Gao and Li Zhao-shen
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:35
    Content type: Research Published on:

  44. Cancer cells have increased levels of transferrin receptor and lower levels of ferritin, an iron deficient phenotype that has led to the use of iron chelators to further deplete cells of iron and limit cancer ...

    Authors: Zhen Li, Hiroki Tanaka, Floyd Galiano and Jonathan Glass
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:34
    Content type: Research Published on:

  47. Various angiogenic regulators are involved in angiogenesis cascade. Transcription factor Ets-1 plays important role in angiogenesis, remodeling of extracellular matrix, and tumor metastasis. Ets-1 target genes...

    Authors: Zijing Lin, Yu Liu, Yuhui Sun and Xiuping He
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:31
    Content type: Research Published on:

  48. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have been widely used for the treatment of non-small cell lung cancer (NSCLC). KRAS and EGFR somatic mutations in NSCLC may predict resistanc...

    Authors: Leina Sun, Qiang Zhang, Huanling Luan, Zhongli Zhan, Changli Wang and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:30
    Content type: Research Published on:

  49. Ovarian cancer remains the leading cause of death from gynaecological malignancy. More than 60% of the patients are presenting the disease in stage III or IV. In spite of combination of chemotherapy and surger...

    Authors: Caroline van Haaften, Colin C Duke, Arij M Weerheim, Nico PM Smit, Paul MM van Haard, Firouz Darroudi and Baptist JMZ Trimbos
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:29
    Content type: Research Published on:

  50. To elucidate whether rapamycin, the inhibitor of mTOR (mammalian target of rapamycin), can potentiate the cytotoxic effect of docetaxel in lung cancer cells and to probe the mechanism underlying such enhancement.

    Authors: Huiyan Niu, Jiahe Wang, Hui Li and Ping He
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:28
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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