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  1. Gliomas represent the most common primary malignant brain tumors, yet little is known about the molecular pathogenesis of these tumors. The highly-regulated Wnt signal transduction pathway is essential for nor...

    Authors: Youxin Zhou, Fang Liu, Qinian Xu and Xiuyun Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:138
  2. Platinum-based chemotherapy has been a standard therapy for advanced non-small cell lung cancer (NSCLC), but it has high toxicity. In China, Shenqi Fuzheng, a newly developed injection concocted from Chinese m...

    Authors: Ju Dong, Shi-Yue Su, Min-Yan Wang and Zhen Zhan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:137
  3. The CIP2A protein is a recently characterized oncoprotein which inhibits protein phosphatase 2A activity. Expression of CIP2A has been detected in several carcinomas, but its expression and significance in pro...

    Authors: Markku H Vaarala, Marja-Riitta Väisänen and Ari Ristimäki
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:136
  4. Malignant tumor cells often express embryonic antigens which share the expression with embryonic stem (ES) cells. The embryonic antigens are usually encoded by ES cell-specific genes, a number of which are ass...

    Authors: Nobuyuki Ehira, Hiroyuki Oshiumi, Misako Matsumoto, Takeshi Kondo, Masahiro Asaka and Tsukasa Seya
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:135

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2014 33:22

  5. The possibility that autologous NK cells could serve as an effective treatment modality for solid tumors has long been considered. However, implementation is hampered by (i) the small number of NK cells in per...

    Authors: Caroline J Voskens, Ryuko Watanabe, Sandra Rollins, Dario Campana, Kenichiro Hasumi and Dean L Mann
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:134
  6. The esophageal cancer related gene 4 (ECRG4) was initially identified and cloned in our laboratory from human normal esophageal epithelium (GenBank accession no.AF325503). ECRG4 was a new tumor suppressor gene...

    Authors: Linwei Li, Chunpeng Zhang, Xiaoyan Li, ShihHsin Lu and Yun Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:133

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:19

  7. We have compared mutation analysis by DNA sequencing and Amplification Refractory Mutation Systemâ„¢ (ARMSâ„¢) for their ability to detect mutations in clinical biopsy specimens.

    Authors: Gillian Ellison, Emma Donald, Gael McWalter, Lucy Knight, Lynn Fletcher, James Sherwood, Mireille Cantarini, Maria Orr and Georgina Speake
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:132
  8. Studies have shown that Dickkopf-1 (DKK-1) is involved in tumorigenesis. Recently, we found that 9 out of 12 human glioma cell lines had high level of DKK-1 protein while the other 3 had very low or non-detect...

    Authors: Youxin Zhou, Wenshuai Li, Qinian Xu and Yulun Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:131
  9. Hepatocellular carcinoma (HCC) is frequently preceded by hepatitis virus infection or alcohol abuse. Genetic backgrounds may increase susceptibility to HCC from these exposures.

    Authors: Ruixing Zhang, Fengbin Zhang, Cuiju Wang, Shunxiang Wang, Yih-Horng Shiao and Zhanjun Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:130
  10. Human 8-oguanine glycosylase 1(hOGG1), voltage-dependent anion channel 1(VDAC1), hexokinase 2(HK-2), represented the process of oxidative DNA damage, cell apoptosis and glycolysis, respectively. This study aim...

    Authors: Peng Guo-Qing, Yang Yuan, Zhong Cai-Gao, Yin Hongling, Hu Gonghua and Tian Yan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:129

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2011 30:53

  11. Colorectal cancer (CRC) screening is key to CRC prevention and mortality reduction, but patient compliance with CRC screening is low. We previously reported a blood-based test for CRC that utilizes a seven-gen...

    Authors: Kok-Thye Yip, Prashanta K Das, David Suria, Chun-Ren Lim, Guey-Hooi Ng and Choong-Chin Liew
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:128
  12. Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibi...

    Authors: Yasuhiro Kidera, Masanobu Tsubaki, Yuzuru Yamazoe, Kaori Shoji, Haruyuki Nakamura, Mitsuhiko Ogaki, Takao Satou, Tatsuki Itoh, Misako Isozaki, Junichi Kaneko, Yoshihiro Tanimori, Masashi Yanae and Shozo Nishida
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:127
  13. Lung cancer is a malignant carcinoma which has the highest morbidity and mortality in Chinese population. Gefitinib, a tyrosine kinase (TK) inhibitor of epidermal growth factor receptor (EGFR), displays anti-t...

    Authors: Yong-Mei Yin, Yi-Ting Geng, Yong-Feng Shao, Xiao-Li Hu, Wei Li, Yong-Qian Shu and Zhao-Xia Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:126
  14. Several studies demonstrated that epidermal growth factor receptor (EGFR) gene copy number (GCN) correlates to the response to tyrosine kinase inhibitors in non small cell lung cancer (NSCLC) and to anti-EGFR ...

    Authors: Giovanni Simone, Anita Mangia, Andrea Malfettone, Vincenza Rubini, Michele Siciliano, Anna Di Benedetto, Irene Terrenato, Flavia Novelli and Marcella Mottolese
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:125
  15. Epithelial ovarian cancer is one of the most malignant cancers in women because metastasis occurs in the most of patients by the time of diagnosis. Cancer cells have strong capacity to form angiogenesis or vas...

    Authors: Pengfei Zhu, Yanxia Ning, Liangqing Yao, Mo Chen and Congjian Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:124
  16. RhoA and RhoC have been proved to be over-expressed in many solid cancers, including colorectal cancer. The reduction of RhoA and RhoC expression by RNA interference (RNAi) resulted growth inhibition of cancer ce...

    Authors: Haibo Wang, Gang Zhao, Xiangping Liu, Aihua Sui, Kun Yang, Ruyong Yao, Zongbao Wang and Qiang Shi
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:123
  17. To investigate the mechanisms of multidrug resistance of brain tumors, to identify the site of cellular expression of P-gp in human brains in situ and to morphologically determine whether an association may ex...

    Authors: Zhenhua Guo, Jin Zhu, Lihua Zhao, Qing Luo and Xianqing Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:122
  18. Anti-CD20 monoclonal antibody treatment has not only increased survival and cure rates in many non-Hodgkin lymphomas, but also has prompted an explosion in the development of novel antibodies and biologically ...

    Authors: Yihu Zheng, Kang Yu, Jimei Du, Lei Jiang, Shenghui Zhang, Yixiang Han, Panpan Yu and Yingxia Tan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:121
  19. The advent of global gene expression profiling has generated unprecedented insight into our molecular understanding of cancer, including breast cancer. For example, human breast cancer patients display signifi...

    Authors: Robin M Hallett, Anna Dvorkin, Christine M Gabardo and John A Hassell
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:120
  20. Slug, Snail, and Twist are transcription factors that regulate the expression of tumor suppressors such as E-cadherin. In this study, we aimed to examine the expression of these transcription factors in human ...

    Authors: Qinchao Yu, Kejun Zhang, Xinsheng Wang, Xiangping Liu and Zemi Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:119
  21. Drug resistance remains a great challenge in the treatment of gastric cancer. The goal of this study was to explore the anti-tumor effects and mechanism of cytokine-induced killer (CIK) cell combined with oxal...

    Authors: Qun Zhao, Hui Zhang, Yong Li, Jun Liu, Xiaojie Hu and Liqiao Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:118
  22. Emerging evidence suggests that ataxia telangiectasia-mutated (ATM) is involved in numerous damage repair signaling pathways and cell-cycle checkpoints. Heterozygous carriers of ATM-mutations have an increased ri...

    Authors: Lin-Bo Gao, Xin-Min Pan, Hong Sun, Xia Wang, Li Rao, Li-Juan Li, Wei-Bo Liang, Mei-Li Lv, Wen-Zhong Yang and Lin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:117
  23. Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Among the SFKs, c-Src and c-Yes are particularly over-expressed or hype...

    Authors: Jang Hyun Lee, Jae-Kyung Pyon, Dong Wook Kim, Sang Han Lee, Hae Seon Nam, Chul Han Kim, Sang Gue Kang, Yoon Jin Lee, Mi Youn Park, Dong Jun Jeong and Moon Kyun Cho
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:116
  24. To compare the biological characteristics of three types of human hepatocellular carcinoma multi-drug resistant cell sub-lines Bel-7402/ADM models established by three methods.

    Authors: Xingguo Zhong, Maoming Xiong, Xiangling Meng and Renhua Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:115
  25. Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus. It was found that CBX7 expression was upregul...

    Authors: Xiao-Wei Zhang, Li Zhang, Wei Qin, Xiao-Hong Yao, Lei-Zhen Zheng, Xin Liu, Jin Li and Wei-Jian Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:114
  26. Women with ductal hyperplasia including usual ductal hyperplasia (UDH) and atypical ductal hyperplasia (ADH) have an increased risk of developing invasive ductal carcinoma (IDC) of breast. The importance of se...

    Authors: Xiao-yun Mao, Chui-feng Fan, Hua-chuan Zheng, Jing Wei, Fan Yao and Feng Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:112
  27. GTPase regulator associated with the focal adhesion kinase (GRAF), a putative tumor suppressor gene, is found inactivated in hematopoietic malignancies by either genetic or epigenetic abnormalities. However, the ...

    Authors: Zhen Qian, Jun Qian, Jiang Lin, Dong-ming Yao, Qin Chen, Run-bi Ji, Yun Li, Gao-fei Xiao and Jian-yong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:111
  28. The cellular apoptosis susceptibility (CSE1L/CAS) protein is highly expressed in cancer, and its expression is positively correlated with high cancer stage, high cancer grade, and worse outcomes of patients. C...

    Authors: Cheng-Jeng Tai, Chung-Huei Hsu, Shing-Chuan Shen, Woan-Ruoh Lee and Ming-Chung Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:110
  29. The incidence of malignant melanoma (MM) was occurring at a faster rate than for most neoplasm worldwide, and melanoma metastasis is still the most formidable problem. So it is necessarily to find some biomark...

    Authors: Man Li, Baogang Zhang, Baocun Sun, Xuan Wang, Xinchao Ban, Tao Sun, Zhiyong Liu and Xiulan Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:109
  30. To evaluate the expression of BCL-2 and BAD genes in tissues of breast carcinoma and investigate the relationship between the expression of BCL-2 and BAD in breast cancer cells with chemosensitivity.

    Authors: Bing Yu, Xin Sun, Hong-yan Shen, Feng Gao, Yuan-ming Fan and Zhi-jun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:107
  31. Previous studies have shown that heat shock proteins (HSPs) were upregulated in various types of tumors and were associated with histological grade, recurrence and metastasis of malignant tumors. In this study...

    Authors: Jing Xu, Kangkai Wang, Xin Zhang, Yuanzheng Qiu, Donghai Huang, Wei Li, Xianzhong Xiao and Yongquan Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:106
  32. Authors: Ondrej Slaby, Jana Jancovicova, Radek Lakomy, Marek Svoboda, Alexandr Poprach, Pavel Fabian, Leos Kren, Jaroslav Michalek and Rostislav Vyzula
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:105

    The original article was published in Journal of Experimental & Clinical Cancer Research 2010 29:90

  33. Drug resistance remains a great challenge in the treatment of pancreatic cancer. The goal of this study was to determine whether TGF-β1 is associated with drug resistance in pancreatic cancer.

    Authors: Ying Chen, Guanzhen Yu, Danghui Yu and Minghua Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:104
  34. Recently, the anti-tumor activity of N-myc downstream-regulated gene 2 (NDRG2) was shown decreased expression in clear cell renal cell carcinoma (CCRCC), but the role of the down-expression of NDRG2 has not be...

    Authors: Jian-Jun Ma, Cheng-Gong Liao, Xue Jiang, Hua-Dong Zhao, Li-Bo Yao and Ting-Yi Bao
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:103
  35. Ovarian cancer is the most fatal gynecologic malignancies in the world. Although, platinum based treatments are widely used, the disease becomes treatment refractory within two years, and novel treatment optio...

    Authors: Bulent Karabulut, Burcak Karaca, Umut Varol, Ugur Muslu, Burcu Cakar, Harika Atmaca, Aslı Kısım, Selim Uzunoglu and Ruchan Uslu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:102
  36. Sulfotransferase (SULT) plays an important role in the formation of estrogen which is usually conferred as a risk factor for breast cancer. Polymorphism of the SULT1A1 may be closely associated with breast can...

    Authors: Yiwei Jiang, Liheng Zhou, Tingting Yan, Zhenzhou Shen, Zhimin Shao and Jinsong Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:101
  37. Currently definitive 5-fluorouracil (5-FU)/cisplatin (CDDP) -based chemotherapy is recognized as one of the most promising treatments for esophageal cancer. A series of studies performed found genetic polymorp...

    Authors: Akiko Kuwahara, Motohiro Yamamori, Megumi Fujita, Tatsuya Okuno, Takao Tamura, Kaori Kadoyama, Noboru Okamura, Tsutomu Nakamura and Toshiyuki Sakaeda
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:100
  38. Klotho, as a new anti-aging gene, can shed into circulation and act as a multi-functional humoral factor that influences multiple biological processes. Recently, published studies suggest that klotho can also ...

    Authors: Bo Chen, Xueli Wang, Weihong Zhao and Jianqing Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:99
  39. The novel gene HA117 is a multidrug resistance (MDR) gene expressed by all-trans retinoic acid-resistant HL-60 cells. In the present study, we compared the multidrug resistance of the HA117 with that of the cl...

    Authors: Lihua Zhao, Xianqing Jin, Youhua Xu, Yuxia Guo, Rui Liang, Zhenhua Guo, Tingfu Chen, Yanhui Sun and Xionghui Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:98
  40. Activating mutations in Kit receptor tyrosine kinase or the related platelet-derived growth factor receptor (PDGFR) play an important role in the pathogenesis of gastrointestinal stromal tumors (GIST).

    Authors: Sean Caenepeel, Lisa Renshaw-Gegg, Angelo Baher, Tammy L Bush, Will Baron, Todd Juan, Raffi Manoukian, Andrew S Tasker, Anthony Polverino and Paul E Hughes
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:96
  41. Hypertension (HT) and hand-foot skin reactions (HFSR) may be related to the activity of bevacizumab and sorafenib. We hypothesized that these toxicities would correspond to favorable outcome in these drugs, th...

    Authors: Lokesh Jain, Tristan M Sissung, Romano Danesi, Elise C Kohn, William L Dahut, Shivaani Kummar, David Venzon, David Liewehr, Bevin C English, Caitlin E Baum, Robert Yarchoan, Giuseppe Giaccone, Jürgen Venitz, Douglas K Price and William D Figg
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:95
  42. To explore the therapeutic effects of thymidine kinase (TK) expressed by enhanced vector pGL3-basic- hTERTp-TK-EGFP-CMV driven by human telomerase reverse transcriptase promoter (hTERTp) as well as cytomegalov...

    Authors: Cong-Xiang Shen, Zhong Wen, Yu-Hong Qian, Shao-Feng Mu and Xiao-Fang Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:94
  43. Nm23 gene was isolated as a metastatic suppressor gene. The antimetastatic effect of Nm23 has been an enigma for more than 10 years. Little is known about its molecular mechanisms. In this study we overexpress...

    Authors: Shangyang She, Boying Xu, Min He, Xiuwan Lan and Qiuyan Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:93
  44. Tumor cell expression of Toll-like receptors (TLRs) can promote inflammation and cell survival in the tumor microenvironment. Toll-like receptor 4 (TLR4) signaling in tumor cells can mediate tumor cell immune ...

    Authors: Huan Yang, Huiqin Zhou, Ping Feng, Xiaoni Zhou, Huiyan Wen, Xiaofang Xie, Haiying Shen and Xueming Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:92
  45. Preclinical toxicity of adaphostin has been related to oxidative stress. This study investigated the regulatory mechanism underlying adaphostin induction of heme oxygenase 1 (HMOX1) which plays a significant r...

    Authors: Nicole D Fer, Robert H Shoemaker and Anne Monks
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:91
  46. MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies have shown altered expression levels of several microRNAs in renal cell carcinoma.

    Authors: Ondrej Slaby, Jana Jancovicova, Radek Lakomy, Marek Svoboda, Alexandr Poprach, Pavel Fabian, Leos Kren, Jaroslav Michalek and Rostislav Vyzula
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:90
  47. ECRG4 has been shown to be a candidate tumor suppressor in several tumors, but its role in glioma remains poorly understood. In this study, we examined the mRNA expression of ECRG4 and investigated its biologi...

    Authors: Wei Li, Xinrui Liu, Bo Zhang, Dongxue Qi, Lihong Zhang, Yuhong Jin and Hongfa Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2010 29:89

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