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  1. Mounting evidence has suggested the essential role of long non-coding RNAs (lncRNAs) in a plethora of malignant tumors, including hepatocellular carcinoma. However, the underlyling mechanisms of lncRNAs remain...

    Authors: Guizhi Jia, Yan Wang, Chengjie Lin, Shihui Lai, Hongliang Dai, Zhiqian Wang, Luo Dai, Huizhao Su, Yanjie Song, Naiwen Zhang, Yukuan Feng and Bo Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:299
  2. Authors: Jing Cai, Mei Yi, Yixin Tan, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong and Bo Xiang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:298

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:190

  3. Chemoresistance is the major cause of chemotherapy failure in patients with colorectal cancer (CRC). Protein tyrosine kinase 6 (PTK6) is aberrantly overexpressed in clinical CRC tissues undergoing chemotherapy...

    Authors: Chaoqun Liu, Zhihua Pan, Qian Chen, Zetao Chen, Weiwei Liu, Ling Wu, Muhong Jiang, Wandie Lin, Yujie Zhang, Weihao Lin, Rui Zhou and Liang Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:297
  4. Although tumor-infiltrating T cells represent a favorable prognostic marker for cancer patients, the majority of these cells are rendered with an exhausted phenotype. Hence, there is an unmet need to identify ...

    Authors: Ioannis Morianos, Aikaterini Tsitsopoulou, Konstantinos Potaris, Dimitrios Valakos, Ourania Fari, Giannis Vatsellas, Clementine Bostantzoglou, Andreas Photiades, Mina Gaga, Georgina Xanthou and Maria Semitekolou
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:295
  5. Long non-coding RNA (LncRNA) controls cell proliferation and plays a significant role in the initiation and progression of esophageal squamous cell carcinoma (ESCC). N6-methyladenosine (m6A) modification now i...

    Authors: Yuanbo Cui, Chunyan Zhang, Shanshan Ma, Zhe Li, Wenjie Wang, Ya Li, Yingchao Ma, Jiarui Fang, Yaping Wang, Wei Cao and Fangxia Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:294
  6. Polysialic acid (polySia) modifies six cell surface proteins in humans mainly during fetal development and some blood cells in adults. Two genes in humans, ST8SIA2 and ST8SIA4, code for polysialyltransferases tha...

    Authors: Gregory R. Moe, Lindsay M. Steirer, Joshua A. Lee, Adarsha Shivakumar and Alejandro D. Bolanos
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:293
  7. Ovarian cancer (OC) progression is an unmet medical challenge. Since omental metastases were palpated harder than their primary counterparts during cytoreductive surgery of patients with epithelial ovarian can...

    Authors: Xiao Wei, Hua Lou, Dongchen Zhou, Yijuan Jia, Huayi Li, Quanfu Huang, Jingjing Ma, Zongyuan Yang, Chaoyang Sun, Yunchong Meng, Sen Xu, Xin Yang, Xiaoting Li, Teng Ji, Zhongzhen Guo and Qinglei Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:292
  8. The progression of prostate cancer (PC) to the highly aggressive metastatic castration-resistant prostate cancer (mCRPC) or neuroendocrine prostate cancer (NEPC) is a fatal condition and the underlying molecul...

    Authors: Wookbong Kwon, Seong-Kyoon Choi, Daehwan Kim, Hyeon-Gyeom Kim, Jin-Kyu Park, Jee Eun Han, Gil-Jae Cho, Sungho Yun, Wookyung Yu, Se-Hyeon Han, Yun-Sok Ha, Jun Nyung Lee, Tae Gyun Kwon, Dong-Hyung Cho, Jun-Koo Yi, Myoung Ok Kim…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:291
  9. Accumulating evidence indicates that circRNAs may serve as essential regulators in the progression of several human cancers, but the function and mechanism of circRNAs in intrahepatic cholangiocarcinoma (ICC) ...

    Authors: Ya-Ping Xu, Ze-Ning Dong, Si-Wei Wang, Yi-Min Zheng, Chi Zhang, Ying-Qun Zhou, Yu-Jie Zhao, Yan Zhao, Feng Wang, Rui Peng, Mao-Chun Tang, Dou-sheng Bai, Xiao-Yong Huang and Chuan-Yong Guo
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:290
  10. The development of persistent endoplasmic reticulum (ER) stress is one of the cornerstones of prostate carcinogenesis; however, the mechanism is missing. Also, alcohol is a physiological ER stress inducer, and...

    Authors: Artem N. Pachikov, Ryan R. Gough, Caroline E. Christy, Mary E. Morris, Carol A. Casey, Chad A. LaGrange, Ganapati Bhat, Anatoly V. Kubyshkin, Iryna I. Fomochkina, Evgeniya Y. Zyablitskaya, Tatiana P. Makalish, Elena P. Golubinskaya, Kateryna A. Davydenko, Sergey N. Eremenko, Jean-Jack M. Riethoven, Amith S. Maroli…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:289
  11. Patients with advanced colorectal cancer (CRC) have a poor prognosis. Combinations of immunotherapies and anti-angiogenic agents are currently being evaluated in clinical trials. In this study, the multikinase...

    Authors: Dennis Doleschel, Sabine Hoff, Susanne Koletnik, Anne Rix, Dieter Zopf, Fabian Kiessling and Wiltrud Lederle
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:288
  12. Emerging evidence demonstrates that lncRNAs play pivotal roles in tumor energy metabolism; however, the detailed mechanisms of lncRNAs in the regulation of tumor glycolysis remain largely unknown.

    Authors: Hongtao Liu, Qing Zhang, Yinsen Song, Yibin Hao, Yunxia Cui, Xin Zhang, Xueying Zhang, Yue Qin, Guangzhao Zhu, Feng Wang, Jinghan Dang, Shanshan Ma, Yanting Zhang, Wenna Guo, Shenglei Li, Fangxia Guan…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:287

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:329

  13. Scarce drug penetration in solid tumours is one of the possible causes of the limited efficacy of chemotherapy and is related to the altered tumour microenvironment. The abnormal tumour extracellular matrix (E...

    Authors: Lavinia Morosi, Marina Meroni, Paolo Ubezio, Ilaria Fuso Nerini, Lucia Minoli, Luca Porcu, Nicolò Panini, Marika Colombo, Barbara Blouw, David W. Kang, Enrico Davoli, Massimo Zucchetti, Maurizio D’Incalci and Roberta Frapolli
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:286
  14. The recent discovery of immune checkpoint inhibitors is a significant milestone in cancer immunotherapy research. However, some patients with primary or adaptive drug resistance might not benefit from the over...

    Authors: Taofei Zeng, Yuqing Cao, Tianqiang Jin, Yu Tian, Chaoliu Dai and Feng Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:285
  15. Chemotherapy resistance remains a barrier to improving the prognosis of epithelial ovarian cancer (EOC). ALKBH5 has recently been shown to be one of the RNA N6-methyladenosine (m6A) demethyltransferases associ...

    Authors: Sipei Nie, Lin Zhang, Jinhui Liu, Yicong Wan, Yi Jiang, Jing Yang, Rui Sun, Xiaolling Ma, Guodong Sun, Huangyang Meng, Mengting Xu and Wenjun Cheng
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:284
  16. Successful colorectal cancer (CRC) therapy often depends on the accurate identification of primary tumours with invasive potential. There is still a lack of identified pathological factors associated with dise...

    Authors: Patrycja Przygodzka, Ewelina Sochacka, Kamila Soboska, Marcin Pacholczyk, Izabela Papiewska-Pająk, Tomasz Przygodzki, Przemysław Płociński, Steven Ballet, An De Prins and Joanna Boncela
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:283
  17. Glioblastoma Multiforme (GBM) is a malignant primary brain tumor in which the standard treatment, ionizing radiation (IR), achieves a median survival of about 15 months. GBM harbors glioblastoma stem-like cell...

    Authors: Hyunkoo Kang, Sungmin Lee, Kyeongmin Kim, Jaewan Jeon, Seok-Gu Kang, HyeSook Youn, Hae Yu Kim and BuHyun Youn
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:282
  18. 223Ra is currently used for treatment of metastatic castration resistant prostate cancer patients (mCRPC) bone metastases with fixed standard activity. Individualized treatments, based on adsorbed dose (AD) in ta...

    Authors: Rosa Sciuto, Sandra Rea, Sara Ungania, Antonella Testa, Valentina Dini, Maria Antonella Tabocchini, Clarice Patrono, Antonella Soriani, Valentina Palma, Raffaella Marconi and Lidia Strigari
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:281
  19. Recurrent hepatocellular carcinoma (HCC) shows strong resistance to sorafenib, and the tumor-repopulating cells (TRCs) with cancer stem cell-like properties are considered a driver for its high recurrent rate ...

    Authors: Feng Qi, Wenxing Qin, Yao Zhang, Yongde Luo, Bing Niu, Quanlin An, Biwei Yang, Keqing Shi, Zhijie Yu, Junwei Chen, Xin Cao and Jinglin Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:280
  20. Dysregulated expression and activation of receptor tyrosine kinases (RTKs) are associated with a range of human cancers. However, current RTK-targeting strategies exert little effect on pancreatic cancer, a hi...

    Authors: Enliang Li, Xing Huang, Gang Zhang and Tingbo Liang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:279
  21. Glioblastoma multiforme (GBM), a lethal brain tumor, remains the most daunting challenge in cancer therapy. Overexpression and constitutive activation of PDGFs and PDGFRα are observed in most GBM; however, ava...

    Authors: Gong Peng, Yin Wang, Pengfei Ge, Christopher Bailey, Peng Zhang, Di Zhang, Zhaoli Meng, Chong Qi, Qian Chen, Jingtao Chen, Junqi Niu, Pan Zheng, Yang Liu and Yan Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:278
  22. Authors: Run-Wei Yang, Ying-Yue Zeng, Wen-Ting Wei, Yan-Mei Cui, Hui-Ying Sun, Yue-Long Cai, Xin-Xin Nian, Yun-Teng Hu, Yu-Ping Quan, Sheng-Lu Jiang, Meng Wang, Ya-Li Zhao, Jun-Feng Qiu, Ming-Xuan Li, Jia-Huan Zhang, Mei-Rong He…
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:277

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:152

  23. Leader cells are a subset of cancer cells that coordinate the complex cell-cell and cell-matrix interactions required for ovarian cancer migration, invasion, tumour deposition and are negatively associated wit...

    Authors: Nazanin Karimnia, Amy L. Wilson, Emma Green, Amelia Matthews, Thomas W. Jobling, Magdalena Plebanski, Maree Bilandzic and Andrew N. Stephens
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:276
  24. Cold-inducible RNA binding protein (CIRP) is a newly discovered proto-oncogene. In this study, we investigated the role of CIRP in the progression of non-small cell lung cancer (NSCLC) using patient tissue sam...

    Authors: Yi Liao, Jianguo Feng, Weichao Sun, Chao Wu, Jingyao Li, Tao Jing, Yuteng Liang, Yonghui Qian, Wenlan Liu and Haidong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:275
  25. Metastasis is most often the root cause of cancer-related death. Human short stature homeobox 2 (SHOX2), a homeodomain transcription factor, is a novel inducer of epithelial-to-mesenchymal transition in breast...

    Authors: Yong Teng, Reid Loveless, Elayne M Benson, Li Sun, Austin Y Shull and Chloe Shay
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:274
  26. Expression of aberrant cyclin G2 is a key factor contributing to cancer biological processes, including glioma. However, the potential underlying mechanisms of cyclin G2 in the glioma tumor immune microenviron...

    Authors: Sen Li, Chenyang Zhao, Jinlan Gao, Xinbin Zhuang, Shuang Liu, Xuesha Xing, Qi Liu, Chen Chen, Shusen Wang and Yang Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:273
  27. Recent studies have investigated the role of circular RNAs (circRNAs) as significant regulatory factors in multiple cancer progression. Nevertheless, the biological functions of circRNAs and the underlying mec...

    Authors: Chaofan Peng, Yuqian Tan, Peng Yang, Kangpeng Jin, Chuan Zhang, Wen Peng, Lu Wang, Jiahui Zhou, Ranran Chen, Tuo Wang, Chi Jin, Jiangzhou Ji, Yifei Feng, Junwei Tang and Yueming Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:272
  28. Epithelial ovarian cancer (EOC) is the most common gynecologic disorder. Even with the recent progresses made towards the use of new therapeutics, it still represents the most lethal gynecologic malignancy in ...

    Authors: Delphine Fessart, Jacques Robert, Cecile Hartog, Eric Chevet, Frederic Delom and Guillaume Babin
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:271
  29. Recent studies highlighted the increased frequency of AR-low or -negative prostate cancers (PCas) and the importance of AR-independent mechanisms in driving metastatic castration-resistant PCa (mCRPC) developm...

    Authors: Yakun Luo, Virginie Vlaeminck-Guillem, Silvère Baron, Sarah Dallel, Chang Xian Zhang and Muriel Le Romancer
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:270
  30. Cancer immunotherapy has gained attention as the supreme therapeutic modality for the treatment of various malignancies. Adoptive T-cell therapy (ACT) is one of the most distinctive modalities of this therapeu...

    Authors: Sasan Ghaffari, Nastaran Khalili and Nima Rezaei
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:269
  31. Germ cell tumors (GCTs) are developmental cancers, tightly linked to embryogenesis and germ cell development. The recent and expanding field of RNA modifications is being increasingly implicated in such molecu...

    Authors: Vera Miranda-Gonçalves, João Lobo, Catarina Guimarães-Teixeira, Daniela Barros-Silva, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert H. J. Looijenga, Rui Henrique and Carmen Jerónimo
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:268
  32. Immune checkpoint molecules, also known as cosignaling molecules, are pivotal cell-surface molecules that control immune cell responses by either promoting (costimulatory molecules) or inhibiting (coinhibitory...

    Authors: Baokang Wu, Chongli Zhong, Qi Lang, Zhiyun Liang, Yizhou Zhang, Xin Zhao, Yang Yu, Heming Zhang, Feng Xu and Yu Tian
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:267
  33. Recently, a variety of clinical trials have shown that apatinib, a small-molecule anti-angiogenic drug, exerts promising inhibitory effects on multiple solid tumors, including non-small cell lung cancer (NSCLC...

    Authors: Chunfeng Xie, Xu Zhou, Chunhua Liang, Xiaoting Li, Miaomiao Ge, Yue Chen, Juan Yin, Jianyun Zhu and Caiyun Zhong
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:266

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:349

  34. Autophagy is an intracellular degradation system that removes unnecessary or dysfunctional components and recycles them for other cellular functions. Over the years, a mutual regulation between lipid metabolis...

    Authors: Francesca Ascenzi, Claudia De Vitis, Marcello Maugeri-Saccà, Christian Napoli, Gennaro Ciliberto and Rita Mancini
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:265
  35. Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two major contributors to poor therapeutic responses during cancer intervention. Pyroptosis, a lytic and inflammatory programm...

    Authors: Reid Loveless, Ryan Bloomquist and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:264
  36. Mutant isocitrate dehydrogenase 1/2 (mIDH1/2) gain a novel function for the conversion of α-ketoglutarate (α-KG) to oncometabolite R-2-hydroxyglutarate (R-2-HG). Two molecular entities namely enasidenib (AG-221) ...

    Authors: Kun Yao, Hua Liu, Jiajun Yin, Jianmin Yuan and Hong Tao
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:263
  37. Liver cancer, mainly hepatocellular carcinoma, is one of the deadliest cancers worldwide and has a poor prognosis due to insufficient understanding of hepatocarcinogenesis. Previous studies have revealed that ...

    Authors: Juanjuan Luo, Chunjiao Lu, Meilan Feng, Lu Dai, Maya Wang, Yang Qiu, Huilu Zheng, Yao Liu, Li Li, Bo Tang, Chuan Xu, Yajun Wang and Xiaojun Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:262
  38. Circular RNAs (circRNAs) are becoming a unique member of non-coding RNAs (ncRNAs) with emerging evidence of their regulatory roles in various cancers. However, with regards to pancreatic ductal adenocarcinoma ...

    Authors: Taoyue Yang, Peng Shen, Qun Chen, Pengfei Wu, Hao Yuan, Wanli Ge, Lingdong Meng, Xumin Huang, Yuzhe Fu, Yihan Zhang, Weikang Hu, Yi Miao, Zipeng Lu and Kuirong Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:261
  39. Despite marked advances in the clinical therapies, clinical outcome of most T-cell acute lymphoblastic leukemia (T-ALL) patients remains poor, due to the high risk of relapse, even after complete remission. Pr...

    Authors: Fangce Wang, Zheng Li, Jie Zhou, Guangming Wang, Wenjun Zhang, Jun Xu and Aibin Liang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:259
  40. Human CUB and Sushi multiple domains 1 (CSMD1) is a large membrane-bound tumor suppressor in breast cancer. The current study aimed to elucidate the molecular mechanism underlying the effect of CSMD1 in highl...

    Authors: Chrysostomi Gialeli, Emre Can Tuysuz, Johan Staaf, Safia Guleed, Veronika Paciorek, Matthias Mörgelin, Konstantinos S. Papadakos and Anna M. Blom
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:258

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:135

  41. Based on previous studies highlighting that the induction of cyclooxygenase-2 (COX-2) and high prostaglandin E2 (PGE2) levels contribute to the pathogenesis of malignant pleural mesothelioma (MPM), and that ar...

    Authors: Barbara Nuvoli, Barbara Antoniani, Roberta Libener, Antonio Maconi, Andrea Sacconi, Mariantonia Carosi and Rossella Galati
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:257

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:15

  42. Treatment of renal cancer has significantly improved with the arrival to the clinic of kinase inhibitors and immunotherapies. However, the disease is still incurable in advanced stages. The fact that several a...

    Authors: Sara García-Alonso, Inés Romero-Pérez, Lucía Gandullo-Sánchez, Luis Chinchilla, Alberto Ocaña, Juan Carlos Montero and Atanasio Pandiella
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:256
  43. High-risk neuroblastoma patients have a 5-year survival rate of less than 50%. It’s an urgent need to identify new therapeutic targets and the appropriate drugs. Exportin-1 (XPO1), also known as chromosomal re...

    Authors: Lijia Pan, Cheng Cheng, Peiwen Duan, Kai Chen, Yeming Wu and Zhixiang Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:255
  44. The incidence of renal cell carcinoma (RCC) is increasing worldwide with an approximate 20% mortality rate. The challenge in RCC is the therapy-resistance. Cancer resistance to treatment employs multiple mecha...

    Authors: Fengzhi Li, Ieman A. M. Aljahdali, Renyuan Zhang, Kent L. Nastiuk, John J. Krolewski and Xiang Ling
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:254
  45. Nuclear factor­κB (NF-κB) plays a vital role in hepatocellular carcinoma (HCC). β-arrestin1 (ARRB1) has been proved to enhance the activity of NF-κBp65, and our previous study indicated that ARRB1 promotes hep...

    Authors: Xuan Xu, Yiming Lei, Lingjun Chen, Haoxiong Zhou, Huiling Liu, Jie Jiang, Yidong Yang and Bin Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:253
  46. Authors: Li Fan, Qian Yang, Jiali Tan, Youbei Qiao, Qiaofeng Wang, Jingya He, Hong Wu and Yongsheng Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:252

    The original article was published in Journal of Experimental & Clinical Cancer Research 2015 34:106

  47. Pancreatic cancer is a complex disease with a desmoplastic stroma, extreme hypoxia, and inherent resistance to therapy. Understanding the signaling and adaptive response of such an aggressive cancer is key to ...

    Authors: Silpa Gampala, Fenil Shah, Xiaoyu Lu, Hye-ran Moon, Olivia Babb, Nikkitha Umesh Ganesh, George Sandusky, Emily Hulsey, Lee Armstrong, Amber L. Mosely, Bumsoo Han, Mircea Ivan, Jing-Ruey Joanna Yeh, Mark R. Kelley, Chi Zhang and Melissa L. Fishel
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:251
  48. Authors: Jun Li, Rumeng Yang, Yuting Dong, Manyao Chen, Yu Wang and Guoping Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:249

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:38

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    Journal Impact Factor: 11.4
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    Source Normalized Impact per Paper (SNIP): 1.770
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