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  1. Immune checkpoint inhibitors (ICIs) have made a breakthrough in the treatment of different types of tumors, leading to improvement in survival, even in patients with advanced cancers. Despite the good clinical...

    Authors: Simone Camelliti, Valentino Le Noci, Francesca Bianchi, Claudia Moscheni, Francesca Arnaboldi, Nicoletta Gagliano, Andrea Balsari, Marina Chiara Garassino, Elda Tagliabue, Lucia Sfondrini and Michele Sommariva
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:236
  2. Cancer-associated fibroblasts (CAFs) and vasculogenic mimicry (VM) play important roles in the occurrence and development of tumors. However, the relationship between CAFs and VM formation, especially in gallb...

    Authors: Mu-Su Pan, Hui Wang, Kamar Hasan Ansari, Xin-Ping Li, Wei Sun and Yue-Zu Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:234

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:236

  3. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s13046-020-01746-0.

    Authors: Huan Yan, Hong Li, Pengyun Li, Xia Li, Jianjian Lin, Linlin Zhu, Maria A. Silva, Xiaofang Wang, Ping Wang and Zhan Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:233

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:237

  4. Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several epithelial cancers and is closely associated with poor prognosis. However, the role of TM4SF1 and its potential mechanism in colorectal ...

    Authors: Qiang Tang, Jinhuang Chen, Ziyang Di, Wenzheng Yuan, Zili Zhou, Zhengyi Liu, Shengbo Han, Yanwei Liu, Guoguang Ying, Xiaogang Shu and Maojun Di
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:232
  5. Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs particip...

    Authors: Yalu Zhang, Qiaofei Liu and Quan Liao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:231
  6. Lycorine hydrochloride (LH), an alkaloid extracted from the bulb of the Lycoris radiata, is considered to have anti-viral, anti-malarial, and anti-tumorous effects. At present, the underlying mechanisms of LH in ...

    Authors: Chongyang Li, Chaowei Deng, Guangzhao Pan, Xue Wang, Kui Zhang, Zhen Dong, Gaichao Zhao, Mengqin Tan, Xiaosong Hu, Shaomin Shi, Juan Du, Haoyan Ji, Xiaowen Wang, Liqun Yang and Hongjuan Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:230

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:306

  7. Dysregulation of long non-coding RNAs (lncRNAs) is responsible for cancer initiation and development, positioning lncRNAs as not only biomarkers but also promising therapeutic targets for cancer treatment. A g...

    Authors: Dong-Yan Zhang, Qing-Can Sun, Xue-Jing Zou, Yang Song, Wen-Wen Li, Ze-Qin Guo, Shan-Shan Liu, Li Liu and De-Hua Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:229
  8. Novel, less toxic, cost-effective and safe therapeutic strategies are needed to improve treatment of chronic lymphocytic leukemia (CLL). Ascorbic acid (AA, vitamin C) has shown a potential anti-cancer therapeu...

    Authors: Walaa Darwiche, Cathy Gomila, Hakim Ouled-Haddou, Marie Naudot, Cécile Doualle, Pierre Morel, Florence Nguyen-Khac, Loïc Garçon, Jean-Pierre Marolleau and Hussein Ghamlouch
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:228
  9. Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, whose main molecular trait is the MAPK pathway activation due to KRAS mutation, which is present in 90% of cases.

    Authors: Claudio Luchini, Gaetano Paolino, Paola Mattiolo, Maria L. Piredda, Alessandro Cavaliere, Marina Gaule, Davide Melisi, Roberto Salvia, Giuseppe Malleo, Jae Il Shin, Sarah Cargnin, Salvatore Terrazzino, Rita T. Lawlor, Michele Milella and Aldo Scarpa
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:227
  10. Increased tissue stiffness is a common feature of malignant solid tumors, often associated with metastasis and poor patient outcomes. Vitronectin, as an extracellular matrix anchorage glycoprotein related to a...

    Authors: Amparo López-Carrasco, Susana Martín-Vañó, Rebeca Burgos-Panadero, Ezequiel Monferrer, Ana P. Berbegall, Beatriz Fernández-Blanco, Samuel Navarro and Rosa Noguera
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:226
  11. Colon cancer represents one of the leading causes of gastrointestinal tumors in industrialized countries, and its incidence appears to be increasing at an alarming rate. Accumulating evidence has unveiled the ...

    Authors: Longgang Wang, Jinxiang Guo, Jin Zhou, Dongyang Wang, Xiuwen Kang and Lei Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:225
  12. Hypoxia is the major influence factor in physiological and pathological courses which are mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions within solid tumors. Under normo...

    Authors: Tiansheng Li, Chao Mao, Xiang Wang, Ying Shi and Yongguang Tao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:224
  13. Accumulating evidence supports that lysine-specific demethylase 5 (KDM5) family members act as oncogenic drivers. This study was performed to elucidate the potential effects of KDM5A on prostate cancer (PCa) p...

    Authors: Chen Du, Caihong Lv, Yue Feng and Siwen Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:223
  14. Radioresistance is the major obstacle in radiation therapy (RT) for hepatocellular carcinoma (HCC). Dysregulation of DNA damage response (DDR), which includes DNA repair and cell cycle checkpoints activation, ...

    Authors: Jingyuan Sun, Zhenru Zhu, Wenwen Li, Mengying Shen, Chuanhui Cao, Qingcan Sun, Zeqin Guo, Li Liu and Dehua Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:222
  15. Peritoneal metastasis (PM) is an important pathological process in the progression of gastric cancer (GC). The metastatic potential of tumor and stromal cells is governed by hypoxia, which is a key molecular f...

    Authors: Xiaoxun Wang, Xiaofang Che, Yang Yu, Yu Cheng, Ming Bai, Zichang Yang, Qiqiang Guo, Xiaochen Xie, Danni Li, Min Guo, Kezuo Hou, Wendong Guo, Xiujuan Qu and Liu Cao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:221
  16. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Lihua Guo, Hua Bai, Dongling Zou, Tao Hong, Jie Liu, Jiaqiang Huang, Pengfei He, Qi Zhou and Jinsheng He
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:220

    The original article was published in Journal of Experimental & Clinical Cancer Research 2014 33:99

  17. Small cell lung cancer (SCLC) is a deadly neuroendocrine tumor with limited therapeutic options. Recent data suggest that histone deacetylases (HDACs) and the phosphatidylinositol 3-kinase (PI3K) pathway play ...

    Authors: Liying Ma, Xing Bian and Wenchu Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:219

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:7

  18. Glioblastoma is a common disease of the central nervous system (CNS), with high morbidity and mortality. In the infiltrate in the tumor microenvironment, tumor-associated macrophages (TAMs) are abundant, which...

    Authors: Shuai Han, Wei Zhen, Tongqi Guo, Jianjun Zou and Fuyong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:218
  19. Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outco...

    Authors: Kara M. Ruicci, Jalna Meens, Paul Plantinga, William Stecho, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil, Joe S. Mymryk, John W. Barrett, Christopher J. Howlett, Paul C. Boutros, Laurie Ailles and Anthony C. Nichols
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:217
  20. Long noncoding RNA (lncRNA) Linc00337 has been implicated in lung, gastric, colorectal and esophageal squamous cell carcinoma progression via various mechanisms; however, its clinicopathological significance a...

    Authors: Huakai Wang, Shiyong Yu, Huan Peng, Yijun Shu, Wenjie Zhang, Qi Zhu, Yingxia Wu, Yijun Xu, Jiqi Yan and Honggang Xiang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:216
  21. Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of DNA, is often present in tumor cells. Recent studies have revealed that oncogene amplification via ecDNA is widespread across a diverse...

    Authors: Xiang Gu, Jie Yu, Peiwei Chai, Shengfang Ge and Xianqun Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:215
  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jian Zhang, Xin Wen, Xian-Yue Ren, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Ying Sun, Na Liu and Jun Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:214

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:109

  23. Despite the introduction of several novel therapeutic approaches that improved survival, metastatic castration-resistant prostate cancer (mCRPC) remains an incurable disease. Herein we report the synergistic a...

    Authors: Federica Iannelli, Maria Serena Roca, Rita Lombardi, Chiara Ciardiello, Laura Grumetti, Simona De Rienzo, Tania Moccia, Carlo Vitagliano, Angela Sorice, Susan Costantini, Maria Rita Milone, Biagio Pucci, Alessandra Leone, Elena Di Gennaro, Rita Mancini, Gennaro Ciliberto…
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:213
  24. The X-linked gene WTX (also called AMER1) has been reported to function as a tumour suppressor gene in Wilms’ tumour. In our previous study, WTX expression was shown to be significantly reduced in gastric canc...

    Authors: Jian Li, Danli Ye, Peng Shen, Xiaorong Liu, Peirong Zhou, Guifang Zhu, Yangwei Xu, Yun Fu, Xuanqi Li, Jingbo Sun, Jia Xu and Qingling Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:212

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:46

  25. Even though new therapies are available against melanoma, novel approaches are needed to overcome resistance and high-toxicity issues. In the present study the anti-melanoma activity of Nicotinamide (NAM), the...

    Authors: Francesca Scatozza, Federica Moschella, Daniela D’Arcangelo, Stefania Rossi, Claudio Tabolacci, Claudia Giampietri, Enrico Proietti, Francesco Facchiano and Antonio Facchiano
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:211
  26. Inflammation response of epithelial mucosa to chemo- radiotherapy cytotoxic effects leads to mucositis, a painful side effect of antineoplastic treatments. About 40% of the patients treated with chemotherapy d...

    Authors: Claudio Pulito, Antonio Cristaudo, Caterina La Porta, Stefano Zapperi, Giovanni Blandino, Aldo Morrone and Sabrina Strano
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:210
  27. Our previous study showed that calreticulin (CRT) promoted EGF-induced epithelial-mesenchymal transition (EMT) in pancreatic cancer (PC) via Integrin/EGFR-ERK/MAPK signaling. We next investigated the novel sig...

    Authors: Weiwei Sheng, Guosen Wang, Jingtong Tang, Xiaoyang Shi, Rongxian Cao, Jian Sun, Yi Heng Lin, Chao Jia, Chuanping Chen, Jianping Zhou and Ming Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:209
  28. High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal prognosis with a median survival of le...

    Authors: Faiqa Mudassar, Han Shen, Geraldine O’Neill and Eric Hau
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:208

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:375

  29. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) acting as crucial regulators in tumorigenesis. However, its biological functions of lncRNAs in colorectal cancer (CRC) have not been systemat...

    Authors: Xiaojian Zhu, Fanqin Bu, Ting Tan, Qilin Luo, Jinfeng Zhu, Kang Lin, Jun Huang, Chen Luo and Zhengming Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:207
  30. Although the aberrant expression and function of most Ca2+-permeable channels are known to promote gastrointestinal tumors, the association between transient receptor potential vanilloid receptor 1 (TRPV1) channe...

    Authors: Nannan Gao, Feng Yang, Siyuan Chen, Hanxing Wan, Xiaoyan Zhao and Hui Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:206
  31. The survival rate is poor in breast cancer patients with brain metastases. Thus, new concepts for therapeutic approaches are required. During metastasis, the cytoskeleton of cancer cells is highly dynamic and ...

    Authors: Julia Arnold, Juliana Schattschneider, Christine Blechner, Christoph Krisp, Hartmut Schlüter, Michaela Schweizer, Marcus Nalaskowski, Leticia Oliveira-Ferrer and Sabine Windhorst
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:205
  32. Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment—composed of tumor ce...

    Authors: Xianjie Jiang, Jie Wang, Xiangying Deng, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Ke Cao, Hao Deng, Yi He, Qianjin Liao, Bo Xiang, Ming Zhou, Can Guo, Zhaoyang Zeng, Guiyuan Li…
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:204
  33. N6-Methyladenosine (m6A) modification has been implicated in multiple processes for colon cancer development. IGF2BP3 was a newly reported m6A reader, whereas its role in colon cancer remains unclear.

    Authors: Zhou Yang, Tingfeng Wang, Dejun Wu, Zhijun Min, Jingyun Tan and Bo Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:203
  34. Globally, colorectal cancer (CRC) affects more than 1 million people each year. In addition to non-modifiable and other environmental risk factors, Fusobacterium nucleatum infection has been linked to CRC recentl...

    Authors: Pin Guo, Zibin Tian, Xinjuan Kong, Lin Yang, Xinzhi Shan, Bingzi Dong, Xueli Ding, Xue Jing, Chen Jiang, Na Jiang and Yanan Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:202
  35. Although cisplatin-based chemotherapy represents the standard regimen for osteosarcoma (OS), OS patients often exhibit treatment failure and poor prognosis due to chemoresistance to cisplatin. Emerging researc...

    Authors: Dong Yang, Tianyang Xu, Lin Fan, Kaiyuan Liu and Guodong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:201

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:17

  36. SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in ...

    Authors: Andrea Sacconi, Sara Donzelli, Claudio Pulito, Stefano Ferrero, Francesca Spinella, Aldo Morrone, Marta Rigoni, Fulvia Pimpinelli, Fabrizio Ensoli, Giuseppe Sanguineti, Raul Pellini, Nishant Agrawal, Evgeny Izumchenko, Gennaro Ciliberto, Aldo Giannì, Paola Muti…
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:200
  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xun Wang, Zhenlong Yu, Chao Wang, Wei Cheng, Xiangge Tian, Xiaokui Huo, Yan Wang, Chengpeng Sun, Lei Feng, Jinshan Xing, Yulong Lan, Dongdong Sun, Qingjuan Hou, Baojing Zhang, Xiaochi Ma and Bo Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:199

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:93

  38. Advanced colorectal adenocarcinoma (CRAC), featured by distinctive histopathological appearance, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a group of heterogeneous cancers...

    Authors: Hang-Ping Yao, Xiang-Min Tong, Rachel Hudson and Ming-Hai Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:198
  39. Autophagy is an intracellular process through which intracellular components are recycled in response to nutrient or growth factor deficiency to maintain homeostasis. We identified the peptide autophagy-relate...

    Authors: Yang Yang, Qi Wang, Dongjian Song, Ruirui Zen, Lei Zhang, Yingjun Wang, Heying Yang, Da Zhang, Jia Jia, Jiao Zhang and Jiaxiang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:197
  40. Glioblastoma is the most common primary malignant intracranial tumor with poor clinical prognosis in adults. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) function as important regulators...

    Authors: Xiaoming Zhang, Wanxiang Niu, Maolin Mu, Shanshan Hu and Chaoshi Niu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:196
  41. Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment. Among this class of drugs, ponatinib (PON) has been shown to have...

    Authors: Diana Corallo, Fabio Pastorino, Marcella Pantile, Elena Mariotto, Federico Caicci, Giampietro Viola, Mirco Ponzoni, Gian Paolo Tonini and Sanja Aveic
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:195
  42. Nuclear casein kinase and cyclin-dependent kinase substrate (NUCKS), a novel gene first reported in 2001, is a member of the high mobility group (HMG) family. Although very little is known regarding the biolog...

    Authors: Erhu Zhao, Liying Feng, Longchang Bai and Hongjuan Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:194
  43. Angiogenesis, a basic requirement for tumor cell survival, is considered to be a malignant characteristic of small cell lung cancer (SCLC) and is closely related to the poor outcomes of SCLC patients. miR-141 ...

    Authors: Shuangshuang Mao, Zhiliang Lu, Sufei Zheng, Hao Zhang, Guochao Zhang, Feng Wang, Jianbing Huang, Yuanyuan Lei, Xinfeng Wang, Chengming Liu, Nan Sun and Jie He
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:193
  44. The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the mo...

    Authors: Yuhao Zhang, Xiuchao Geng, Qiang Li, Jianglong Xu, Yanli Tan, Menglin Xiao, Jia Song, Fulin Liu, Chuan Fang and Hong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:192
  45. Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be in...

    Authors: Sifeng Tao, Qiang Chen, Chen Lin and Haiying Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:191
  46. Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been testified to be overexpressed in prostate cancer and strongly related to patients’ poor prognosis. However, the functions of ...

    Authors: Xiang Zhang, Dawei Wang, Boke Liu, Xingwei Jin, Xianjin Wang, Junwei Pan, Weichao Tu and Yuan Shao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:190
  47. Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs)...

    Authors: Alberto Ocaña and Atanasio Pandiella
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:189
  48. Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle t...

    Authors: Yilan Yang, Jurui Luo, Xingxing Chen, Zhaozhi Yang, Xin Mei, Jinli Ma, Zhen Zhang, Xiaomao Guo and Xiaoli Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:188
  49. Natural antisense transcripts (NATs), which are transcribed from opposite strands of DNA with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to post-translational modif...

    Authors: Shanshan Zhao, Xue Zhang, Shuo Chen and Song Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:187
  50. Bladder cancer (BC) is a common genitourinary malignancy worldwide. Circular RNAs (circRNAs) participate in cancer development, including BC; thus, the roles of circRNAs in this process have attracted signific...

    Authors: Mingming Jin, Shengjie Lu, Yue Wu, Chen Yang, Chunzi Shi, Yanqiu Wang and Gang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:186

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 11.4
    5-year Journal Impact Factor: 11.4
    Source Normalized Impact per Paper (SNIP): 1.770
    SCImago Journal Rank (SJR): 2.806

    Speed 2023
    Submission to first editorial decision (median days): 5
    Submission to acceptance (median days): 100

    Usage 2023
    Downloads: 3,003,080
    Altmetric mentions: 3,022