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  1. Molecular oxygen (O2) is a universal electron acceptor that is eventually synthesized into ATP in the mitochondrial respiratory chain of all metazoans. Therefore, hypoxia biology has become an organizational prin...

    Authors: Mingyao Huang, Liang Yang, Xueqiang Peng, Shibo Wei, Qing Fan, Shuo Yang, Xinyu Li, Bowen Li, Hongyuan Jin, Bo Wu, Jingang Liu and Hangyu Li
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:185
    Content type: Review Published on:

  2. The activator protein-1 (AP-1) family of transcription factors modulate a diverse range of cellular signalling pathways into outputs which can be oncogenic or anti-oncogenic. The transcription of relevant gene...

    Authors: Andrew Brennan, James T. Leech, Neil M. Kad and Jody M. Mason
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:184
    Content type: Review Published on:

  3. NEK2, a serine/threonine kinase involved in mitosis, has been found to function in chromosome instability, tumor progression and metastasis, but its role in cervical cancer radioresistance remains unknown.

    Authors: Tie Xu, Yulan Zeng, Linli Shi, Qin Yang, Yeshan Chen, Gang Wu, Guiling Li and Shuangbing Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:183
    Content type: Research Published on:

  4. Glioma is the most common and lethal primary brain tumor in adults, and angiogenesis is one of the key factors contributing to its proliferation, aggressiveness, and malignant transformation. However, the disc...

    Authors: Yang Jiang, Jinpeng Zhou, Junshuang Zhao, Haiying Zhang, Long Li, Hao Li, Lian Chen, Jiangfeng Hu, Wei Zheng and Zhitao Jing
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:182
    Content type: Research Published on:

  5. Nicotine, an active ingredient in tobacco, can promote epithelial-to-mesenchymal transition (EMT) processes that enhance the aggressiveness of a number of human cancers. In the present study, we investigated w...

    Authors: Qiwen Ben, Wei An, Yunwei Sun, Aihua Qian, Jun Liu, Duowu Zou and Yaozong Yuan
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:181
    Content type: Research Published on:

  6. Triple-negative breast cancer (TNBC) is a uniquely aggressive cancer with high rates of relapse due to resistance to chemotherapy. TNBC expresses higher levels of programmed cell death-ligand 1 (PD-L1) compare...

    Authors: Simona Camorani, Margherita Passariello, Lisa Agnello, Silvia Esposito, Francesca Collina, Monica Cantile, Maurizio Di Bonito, Ilya V. Ulasov, Monica Fedele, Antonella Zannetti, Claudia De Lorenzo and Laura Cerchia
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:180
    Content type: Research Published on:

  7. Accumulating evidence demonstrates the essential role of long non-coding RNA (lncRNA) in various types of cancers, including pancreatic cancer. However, the functions and regulation mechanism of lncRNA PMSB8-A...

    Authors: Hao Zhang, Changhao Zhu, Zhiwei He, Shiyu Chen, Lin Li and Chengyi Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:179
    Content type: Research Published on:

  8. Osteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improv...

    Authors: Juncheng Cui, Dylan Dean, Francis J. Hornicek, Zhiwei Chen and Zhenfeng Duan
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:178
    Content type: Review Published on:

  9. A pronounced polarization of healthcare resources and workforce towards the prevention of the rapid spread of SARS-CoV-2 occurred at the expenses of the majority of chronic diseases and cancer, thus jeopardizi...

    Authors: Assunta De Luca, Francesco Ripa di Meana, Branka Vujovic, Aldo Morrone, Chiara Degirolamo, Gennaro Ciliberto and Tiziana Lavalle
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:177
    Content type: Commentary Published on:

  10. Exosomes are emerging as important mediators of the cross-talk between tumor cells and the microenvironment. The communication between tumor-derived exosomes and macrophages has a critical role in facilitating...

    Authors: Manman Liang, Xingwu Chen, Lijing Wang, Lilong Qin, Hanli Wang, Zhengui Sun, Wenying Zhao and Biao Geng
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:176
    Content type: Research Published on:

  11. Overexpression of eukaryotic translation initiation factor 3H (EIF3H) predicts cancer progression and poor prognosis, but the mechanism underlying EIF3H as an oncogene remains unclear in esophageal squamous ce...

    Authors: Xiaobin Guo, Rui Zhu, Aiping Luo, Honghong Zhou, Fang Ding, Hongxin Yang and Zhihua Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:175
    Content type: Research Published on:

  12. Inhibition of p38 MAPK signalling leads to glioblastoma multiform (GBM) tumourigenesis. Nevertheless, the molecular mechanism that induces p38 MAPK signalling pathway silencing during GBM genesis has yet to be...

    Authors: Yang Xu, Qian Sun, Fan’en Yuan, Huimin Dong, Huikai Zhang, Rongxin Geng, Yangzhi Qi, Xiaoxing Xiong, Qianxue Chen and Baohui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:174
    Content type: Research Published on:

  13. A number of novel anticancer drugs have been developed in recent years. However, the mortality of cancer patients remains high because of the emergence of drug resistance. It was reported that drug resistance ...

    Authors: Cheng Yang, Jiayu Zhang, Yukui Ma, Chunfu Wu, Wei Cui and Lihui Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:173
    Content type: Review Published on:

  14. Lysine succinylation is an emerging posttranslational modification that has garnered increased attention recently, but its role in gastric cancer (GC) remains underexplored.

    Authors: Xiang Li, Chen Zhang, Ting Zhao, Zhongping Su, Mengjing Li, Jiancheng Hu, Jianfei Wen, Jiajia Shen, Chao Wang, Jinshun Pan, Xianmin Mu, Tao Ling, Yingchang Li, Hao Wen, Xiaoren Zhang and Qiang You
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:172
    Content type: Research Published on:

  15. The Covid-19 pandemic has challenged hard the national health systems worldwide. According to the national policy issued in March 2020 in response to the evolving Covid-19 pandemic, several hospitals were re-c...

    Authors: Fabio Pelle, Sonia Cappelli, Franco Graziano, Loredana Piarulli, Flavia Cavicchi, Domenico Magagnano, Assunta De Luca, Roy De Vita, Marcello Pozzi, Maurizio Costantini, Antonio Varanese, Massimo Panimolle, Pietro Paolo Gullo, Maddalena Barba, Patrizia Vici, Enrico Vizza…
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:171
    Content type: Commentary Published on:

  16. The platinum-based chemotherapy is the first-line regimen for the treatment of Non-small cell lung cancer (NSCLC). However, the therapeutic efficiency is largely limited by tenacious chemo-insensitivity that r...

    Authors: Boshi Wang, Tiantian Jing, Weilin Jin, Jinnan Chen, Chengsi Wu, Mingrong Wang and Yizhen Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:170
    Content type: Research Published on:

  18. cAMP responsive element binding protein 5 (CREB5) is a transcriptional activator in eukaryotic cells that can regulate gene expression. Previously, we found that CREB5 was involved in the occurrence and develo...

    Authors: Shuyang Wang, Junfeng Qiu, Lei Liu, Cailin Su, Lu Qi, Chengmei Huang, Xiaoning Chen, Yaxin Zhang, Yaping Ye, Yanqing Ding, Li Liang and Wenting Liao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:168
    Content type: Research Published on:

  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Weiwei Sheng, Xiaoyang Shi, Yiheng Lin, Jingtong Tang, Chao Jia, Rongxian Cao, Jian Sun, Guosen Wang, Lei Zhou and Ming Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:167
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:16

  20. Nasopharyngeal carcinoma (NPC) is an epithelial cancer emerging from the lining of nasopharyngeal mucosa, with extremely frequent occurrence in east and southeast Asia. For the purpose of exploring roles of th...

    Authors: Xiang Qing, Guo-lin Tan, Huo-wang Liu, Wei Li, Jin-gang Ai, Shan-shan Xiong, Meng-qing Yang and Tian-sheng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:166
    Content type: Research Published on:

  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qiaoge Zhang, Ge Song, Lili Yao, Yankun Liu, Min Liu, Shengping Li and Hua Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:165
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:14

  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zichao Li, Luying Zhang, Mingquan Gao, Mei Han, Kaili Liu, Zhuang Zhang, Zhi Gong, Lifei Xing, Xianzhou Shi, Kui Lu and Hui Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:164
    Content type: Retraction Note Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:8

  23. As metastasis is a major cause of death in cancer patients, new anti-metastatic strategies are needed to improve cancer therapy outcomes. Numerous pathways have been shown to contribute to migration and invasi...

    Authors: Madiha Kanwal, Michal Smahel, Mark Olsen, Jana Smahelova and Ruth Tachezy
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:163
    Content type: Review Published on:

  24. Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metas...

    Authors: Yue Ning, Hongmei Zheng, Yuting Zhan, Sile Liu, Yang yang, Hongjing Zang, Jiadi Luo, Qiuyuan Wen and Songqing Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:162
    Content type: Review Published on:

  25. Estrogen receptor α (ERα) signaling is a defining and driving event in most breast cancers; ERα is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) ...

    Authors: Ana Luísa Cartaxo, Marta F. Estrada, Giacomo Domenici, Ruben Roque, Fernanda Silva, Emilio J. Gualda, Pablo Loza-Alvarez, George Sflomos, Cathrin Brisken, Paula M. Alves, Saudade André and Catarina Brito
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:161
    Content type: Research Published on:

  26. Colorectal cancer (CRC) is one of the causes of cancer-related death worldwide. The aim of our study was to disclose the expression pattern and underlying molecular mechanism of circular RNA TADA2A (circTADA2A...

    Authors: Zhen Li, Hongyu Yao, Shihao Wang, Guobin Li and Xiaoming Gu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:160
    Content type: Research Published on:

  27. Emerging evidence has shown that dysregulated expression of long noncoding RNAs (lncRNAs) is implicated in liver hepatocellular carcinoma (HCC). However, the role and molecular mechanism of differentially expr...

    Authors: Hui He, Yawei Wang, Peng Ye, Dehui Yi, Ying Cheng, Haibo Tang, Zhi Zhu, Xun Wang and Shi Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:159
    Content type: Research Published on:

  28. Chemoresistance is emerging as a major barrier to successful treatment in acute myeloid leukemia (AML), and evasion of apoptosis is among the fundamental underlying mechanisms. Therefore, unraveling molecular ...

    Authors: Yihua Pang, Yanan Zhao, Yan Wang, Xinlu Wang, Ruiqing Wang, Na Liu, Peng Li, Min Ji, Jingjing Ye, Tao Sun, Jingxin Li, Daoxin Ma, Fei Lu and Chunyan Ji
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:158
    Content type: Research Published on:

  29. Many cancer-associated single nucleotide polymorphisms (SNPs) are located in the genomic regions of long non-coding RNAs (lncRNAs). Mechanisms of these SNPs in connection to cancer risk are not fully understood.

    Authors: Tienan Feng, Nannan Feng, Tengteng Zhu, Qiang Li, Qi Zhang, Yu Wang, Ming Gao, Baosen Zhou, Herbert Yu, Min Zheng and Biyun Qian
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:157
    Content type: Research Published on:

  30. Breast cancer (BC) is a malignant breast tumor confronted with high invasion, metastasis and recurrence rate, and adipocytes are the largest components in breast tissue. The aberrant adipocytes, especially the...

    Authors: Chongru Zhao, Min Wu, Ning Zeng, Mingchen Xiong, Weijie Hu, Wenchang Lv, Yi Yi, Qi Zhang and Yiping Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:156
    Content type: Review Published on:

  31. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yanxia Huang, Jing Zhang, Lidan Hou, Ge Wang, Hui Liu, Rui Zhang, Xiaoyu Chen and Jinshui Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:155
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:194

  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Kun Qiao, Shipeng Ning, Lin Wan, Hao Wu, Qin Wang, Xingda Zhang, Shouping Xu and Da Pang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:154
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:418

  33. Hypoxia plays a relevant role in tumor-related inflammation toward the metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β (IL-β) and its cognate receptor IL1R1 contribute...

    Authors: Rosamaria Lappano, Marianna Talia, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Domenica Scordamaglia, Rita Guzzi, Anna Maria Miglietta, Ernestina Marianna De Francesco, Antonino Belfiore, Andrew H. Sims and Marcello Maggiolini
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:153
    Content type: Research Published on:

  34. Type 1 and 2 diabetes confer an increased risk of pancreatic cancer (PaC) of similar magnitude, suggesting a common mechanism. The recent finding that PaC incidence increases linearly with increasing fasting g...

    Authors: Stefano Menini, Carla Iacobini, Luisa de Latouliere, Isabella Manni, Martina Vitale, Emanuela Pilozzi, Carlo Pesce, Paola Cappello, Francesco Novelli, Giulia Piaggio and Giuseppe Pugliese
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:152
    Content type: Research Published on:

  35. Pancreatic cancer (PC) is one of the most aggressive cancers and has an extremely poor prognosis worldwide. Long noncoding RNA (lncRNA) has been reported to be a potential prognostic biomarker in the initiatio...

    Authors: Qing Han, Junhe Li, Jianping Xiong and Zhiwang Song
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:151
    Content type: Research Published on:

  36. Hepatocellular carcinoma (HCC) is one of the most prevalent common cancer worldwide with high mortality. Transforming growth factor-β (TGF-β) signaling pathway was reported dysregulated during liver cancer for...

    Authors: Zhao Huang, Jingyuan Wen, Jingjing Yu, Jingyu Liao, Sha Liu, Ning Cai, Huifang Liang, Xiaoping Chen, Zeyang Ding and Bixiang Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:150
    Content type: Research Published on:

  37. Non-small cell lung cancer (NSCLC) cells derived intracellular and extracellular programmed cell death ligand 1 (PD-L1) promoted cancer progression and drug resistance, and facilitated tumor immune evasion. Ho...

    Authors: Weijun Hong, Min Xue, Jun Jiang, Yajuan Zhang and Xiwen Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:149
    Content type: Research Published on:

  38. Collagens are the most abundant proteins in extra cellular matrix and important components of tumor microenvironment. Recent studies have showed that aberrant expression of collagens can influence tumor cell b...

    Authors: Ting Wang, Haojie Jin, Jingying Hu, Xi Li, Haoyu Ruan, Huili Xu, Lin Wei, Weihua Dong, Fei Teng, Jianren Gu, Wenxin Qin, Xiaoying Luo and Yujun Hao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:148
    Content type: Research Published on:

  39. Colorectal cancer (CRC) is one of the most common malignancies, and it’s expected that the CRC burden will substantially increase in the next two decades. New biomarkers for targeted treatment and associated m...

    Authors: Xiaojuan Wang, Fan Wu, Han Wang, Xiaoyuan Duan, Rong Huang, Amannisa Tuersuntuoheti, Luying Su, Shida Yan, Yuechao Zhao, Yan Lu, Kai Li, Jinjie Yao, Zhiwen Luo, Lei Guo, Jianmei Liu, Xiao Chen…
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:147
    Content type: Research Published on:

  40. The signal transducer and activator of transcription-3 (STAT-3) can facilitate cancer progression and metastasis by being constitutively active via various signaling. Abundant evidence has indicated that STAT-...

    Authors: Ming Hong, Selena Lee, Jacob Clayton, Wildman Yake and Jinke Li
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:146
    Content type: Research Published on:

  41. Mounting evidence suggests that solid tumors display the features of collective invasion, however, the molecular mechanisms are far from clear. This study aims to verify the role and the underlying mechanisms ...

    Authors: Shi-Jie Wang, Dong Chao, Wei Wei, Gang Nan, Jia-Yue Li, Fen-Ling Liu, Ling Li, Jian-Li Jiang, Hong-Yong Cui and Zhi-Nan Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:145
    Content type: Research Published on:

  42. Esophageal squamous cell carcinoma (ESCC) is one of the most lethal forms of adult cancer with poor prognosis. Substantial evidence indicates that reactive oxygen species (ROS) are important modulators of aggr...

    Authors: Zhenchuan Liu, Shaorui Gu, Tiancheng Lu, Kaiqing Wu, Lei Li, Chenglai Dong and Yongxin Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:144
    Content type: Research Published on:

  43. Cervical cancer is one of the most common cancers among females worldwide and advanced patients have extremely poor prognosis. However, adverse reactions and accumulating resistance to radiation therapy requir...

    Authors: Shuzhen Tian, Lili Lou, Mengyuan Tian, Guangping Lu, Jianghua Tian and Xi Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:143
    Content type: Research Published on:

  44. Sirtuin 6 (Sirt6) is a highly conserved ADP-ribosylase and NAD+ dependent deacylase, involved in broad cellular processes. This molecule possesses contradictory roles in carcinogenesis, as it has been document...

    Authors: Juan Yang, Ying Li, Ya Zhang, Xiaosheng Fang, Na Chen, Xiangxiang Zhou and Xin Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:142
    Content type: Research Published on:

  45. Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of H19 in colorectal cancer (CRC) metastasis and the underlying mechanism are stil...

    Authors: Yuhui Zhang, Weibin Huang, Yujie Yuan, Jin Li, Jing Wu, Jie Yu, Yulong He, Zhewei Wei and Changhua Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:141
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2021 40:111

  46. Exosomal microRNAs (miRNAs or miRs) from bone marrow-derived mesenchymal stem cells (UCMSCs) have emerged as promising therapeutic strategies for cancer treatment. The current study aimed to elucidate the unde...

    Authors: Zhanfeng He, Weihao Li, Tianliang Zheng, Donglei Liu and Song Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:140
    Content type: Research Published on:

  47. Long noncoding RNAs (lncRNAs) are considered critical regulators in cancers; however, the clinical significance and mechanisms of MAPKAPK5-AS1 (hereinafter referred to as MK5-AS1) in colorectal cancer (CRC) re...

    Authors: Ting Yang, Wei-Cong Chen, Pei-Cong Shi, Man-Ru Liu, Tao Jiang, Hu Song, Jia-Qi Wang, Rui-Zhi Fan, Dong-Sheng Pei and Jun Song
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:139
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:341

  48. The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics that ensure the somatic inheritance of differentiated state is defined as a crucial factor influencing malignant ph...

    Authors: Rui Chen, Mengxian Zhang, Yangmei Zhou, Wenjing Guo, Ming Yi, Ziyan Zhang, Yanpeng Ding and Yali Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:138
    Content type: Review Published on:

  49. Hypoxia, a fundamental characteristic of glioma, is considered to promote tumor malignancy by inducing process of epithelial mesenchymal transition (EMT). Ferritin Light Chain (FTL) is one of the iron metaboli...

    Authors: Junhui Liu, Lun Gao, Na Zhan, Pengfei Xu, Ji’an Yang, Fan’en Yuan, Yang Xu, Qiang Cai, Rongxin Geng and Qianxue Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:137
    Content type: Research Published on:

  50. Accumulating evidence have highlighted the importance of long noncoding RNAs (lncRNAs) in multiple cancers development and progression. Cancer susceptibility candidate 9 (CASC9) is a novel long non-coding RNA ...

    Authors: Yonghao Zhan, Lianghao Zhang, Shuanbao Yu, Jianguo Wen, Yuchen Liu and Xuepei Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:136
    Content type: Research Published on:

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  • Citation Impact 2023
    Journal Impact Factor: 11.4
    5-year Journal Impact Factor: 11.4
    Source Normalized Impact per Paper (SNIP): 1.770
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    Submission to first editorial decision (median days): 5
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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