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  1. Ferroptosis is a novel form of iron-dependent cell death and participates in the malignant progression of glioblastoma (GBM). Although circular RNAs (circRNAs) are found to play key roles in ferroptosis via se...

    Authors: Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao and Daming Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:307

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:320

  2. Authors: Chongyang Li, Chaowei Deng, Guangzhao Pan, Xue Wang, Kui Zhang, Zhen Dong, Gaichao Zhao, Mengqin Tan, Xiaosong Hu, Shaomin Shi, Juan Du, Haoyan Ji, Xiaowen Wang, Liqun Yang and Hongjuan Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:306

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:230

  3. Molecular tumor boards (MTBs) match molecular alterations with targeted anticancer drugs upon failure of the available therapeutic options. Special and local needs are most likely to emerge through the compara...

    Authors: Gennaro Ciliberto, Marco Canfora, Irene Terrenato, Chiara Agnoletto, Francesco Agustoni, Loredana Amoroso, Gustavo Baldassarre, Giuseppe Curigliano, Angelo Delmonte, Antonella De Luca, Michelangelo Fiorentino, Vanesa Gregorc, Toni Ibrahim, Chiara Lazzari, Angela Mastronuzzi, Paolo Pronzato…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:305
  4. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with ...

    Authors: Lu Wang, Shuangshuang Li, Huanhua Luo, Qi Lu and Shuwen Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:303
  5. Adenosine is a potent immunosuppressant whose levels in the tumor microenvironment (TME) are often much higher than those in normal tissues. Binding of adenosine to its receptor A2aR activates a cascade of gen...

    Authors: Yu Bai, Xin Zhang, Jie Zheng, Ziyi Liu, Zhenfan Yang and Xiaolin Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:302
  6. Early metastasis is a key factor contributing to poor breast cancer (BC) prognosis. Circulating tumor cells (CTCs) are regarded as the precursor cells of metastasis, which are ultimately responsible for the ma...

    Authors: Yufei Long, Tuotuo Chong, Xiaoming Lyu, Lujia Chen, Xiaomin Luo, Oluwasijibomi Damola Faleti, Simin Deng, Fei Wang, Mingliang He, Zhipeng Qian, Hongli Zhao, Wenyan Zhou, Xia Guo, Ceshi Chen and Xin Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:301
  7. Neoadjuvant programmed death receptor-1 (PD-1) inhibitors have drawn increasing attention in locally advanced head and neck squamous cell carcinoma (HNSCC). In this study, we investigated the safety and effica...

    Authors: Xiaotao Huang, Qiaodan Liu, Guihua Zhong, Yingpeng Peng, Ye Liu, Lizhong Liang, Haiyu Hong, Weineng Feng, Shuang Yang, Yaqin Zhang, Shiping Xian, Zhanyu Li, Yuling Zhou, Zhaoyuan Zhang, Wen Jiang, Jun Liang…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:300
  8. Therapeutic strategies engaging the immune system against malignant cells have revolutionized the field of oncology. Proficiency of dendritic cells (DCs) for antigen presentation and immune response has spurre...

    Authors: Natacha Jugniot, Jeremy J. Dahl and Ramasamy Paulmurugan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:299

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:357

  9. The introduction of functional in-silico models, in addition to in-vivo tumor models, opens up new and unlimited possibilities in cancer research and drug development. The world's first digital twin of the A54...

    Authors: Christian Baumgartner
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:298
  10. Aberrantly activated mammalian target of rapamycin complex 1 (mTORC1) plays a vital role in tumor angiogenesis, but its precise mechanisms are still unclear.

    Authors: Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu and Xiaojun Zha
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:297
  11. Liver metastasis (LM) is a major obstacle to the prognosis of gastric cancer (GC) patients, but the molecular mechanism underlying gastric cancer liver metastasis (GC-LM) remains unknown. Exosomes have been id...

    Authors: Shengkui Qiu, Li Xie, Chen Lu, Chao Gu, Yiwen Xia, Jialun Lv, Zhe Xuan, Lang Fang, Jing Yang, Lu Zhang, Zheng Li, Weizhi Wang, Hao Xu, Bowen Li and Zekuan Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:296
  12. Although success was achieved in the therapy for a minority of advanced lung adenocarcinoma (LUAD) patients, anti-programmed death 1 (PD1) resistance was found in most LUAD patients. Here, we aimed to uncover ...

    Authors: Jian Gao, Yong-Qiang Ao, Ling-Xian Zhang, Jie Deng, Shuai Wang, Hai-Kun Wang, Jia-Hao Jiang and Jian-Yong Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:295
  13. The family of ten-eleven translocation dioxygenases (TETs) consists of TET1, TET2, and TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly found to be mutated in age-related clon...

    Authors: Kanak Joshi, Lei Zhang, Peter Breslin S.J., Ameet R. Kini and Jiwang Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:294
  14. Protein arginine methyltransferases (PRMTs) regulate protein biological activity by modulating arginine methylation in cancer and are increasingly recognized as potential drug targets. Inhibitors targeting PRM...

    Authors: Shuangjie Liu, Zhuonan Liu, Chiyuan Piao, Zhe Zhang, Chuize Kong, Lei Yin and Xi Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:293
  15. The management of sub-totally resected sporadic vestibular schwannoma (VS) may include observation, re-resection or irradiation. Identifying the optimal choice can be difficult due to the disease’s variable pr...

    Authors: Moran Amit, Tongxin Xie, Frederico O. Gleber-Netto, Patrick J. Hunt, Gautam U. Mehta, Diana Bell, Deborah A. Silverman, Ismail Yaman, Yi Ye, Jared K. Burks, Gregory N. Fuller, Paul W. Gidley, Marc-Elie Nader, Shaan M. Raza and Franco DeMonte
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:292
  16. Authors: Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou and Dan Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:291

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:21

  17. Authors: Barbara Nuvoli, Raffaela Santoro, Simona Catalani, Serafina Battistelli, Serena Benedetti, Franco Canestrari and Rossella Galati
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:290

    The original article was published in Journal of Experimental & Clinical Cancer Research 2014 33:24

  18. Peptide proteolysis-targeting chimeras (p-PROTACs) with advantages of high specificity and low toxicity have emerged as a powerful technology of targeted protein degradation for biomedical applications. FOXM1,...

    Authors: Kun Wang, Xiaoyong Dai, Albert Yu, Chunyan Feng, Kewei Liu and Laiqiang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:289
  19. Pancreatic ductal adenocarcinoma is prone to metastasis, resulting in short survival and low quality of life. LncRNAs are pivotal orchestrators that participate in various tumor progress. The underlying role a...

    Authors: Min Zhou, Shutao Pan, Tingting Qin, Chunle Zhao, Taoyuan Yin, Yang Gao, Yuhui Liu, Zhenxiong Zhang, Yongkang Shi, Yu Bai, Jun Gong, Xingjun Guo, Min Wang and Renyi Qin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:288
  20. Lymph node metastasis is one of most common determinants of the stage and prognosis of gastric cancer (GC). However, the key molecular events and mechanisms mediating lymph node metastasis remain elusive.

    Authors: Yongxu Jia, Qian Yan, Yinli Zheng, Lei Li, Baifeng Zhang, Zhiwei Chang, Zehua Wang, Hong Tang, Yanru Qin and Xin-Yuan Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:287
  21. Extracellular vesicles (EVs) facilitate the extracellular transfer of proteins, lipids, and nucleic acids and mediate intercellular communication among multiple cells in the tumour environment. Small extracell...

    Authors: Kewen Qian, Wenyan Fu, Tian Li, Jian Zhao, Changhai Lei and Shi Hu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:286
  22. Gasdermin B (GSDMB) over-expression promotes poor prognosis and aggressive behavior in HER2 breast cancer by increasing resistance to therapy. Decoding the molecular mechanism of GSDMB-mediated drug resistance...

    Authors: Manuel Gámez-Chiachio, Ángela Molina-Crespo, Carmen Ramos-Nebot, Jeannette Martinez-Val, Lidia Martinez, Katja Gassner, Francisco J. Llobet, Mario Soriano, Alberto Hernandez, Marco Cordani, Cristina Bernadó-Morales, Eva Diaz, Alejandro Rojo-Sebastian, Juan Carlos Triviño, Laura Sanchez, Ruth Rodríguez-Barrueco…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:285
  23. Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. Here, we aimed to investigate how colorectal cancer (CRC) cel...

    Authors: Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang and Jinhong Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:284

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:313

  24. Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic de...

    Authors: Mehrdad Zarei, Omid Hajihassani, Jonathan J. Hue, Hallie J. Graor, Alexander W. Loftus, Moeez Rathore, Ali Vaziri-Gohar, John M. Asara, Jordan M. Winter and Luke D. Rothermel
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:283
  25. Adrenocortical cancer (ACC) is a rare and aggressive cancer with dismal 5-year survival due to a lack of effective treatments. We aimed to identify a new effective combination of drugs and investigated their s...

    Authors: Dipranjan Laha, Robert R.C. Grant, Prachi Mishra, Myriem Boufraqech, Min Shen, Ya-Qin Zhang, Matthew D. Hall, Martha Quezado, Michelly Sampaio De Melo, Jaydira Del Rivero, Martha Zeiger and Naris Nilubol
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:282
  26. Circular RNA (circRNA), a new class of non-coding RNA, has obvious correlations with the occurrence and development of many diseases, including tumors. This study aimed to investigate the potential roles of ci...

    Authors: Xiaopei Hao, Yao Zhang, Xiaoli Shi, Hanyuan Liu, Zhiying Zheng, Guoyong Han, Dawei Rong, Chuanyong Zhang, Weiwei Tang and Xuehao Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:281
  27. Immune checkpoint inhibitors (ICI) are approved for treatment of recurrent or metastatic oropharyngeal head and neck squamous cell carcinoma in the first- and second-line settings. However, only 15–20% of pati...

    Authors: Anna Tosi, Beatrice Parisatto, Anna Menegaldo, Giacomo Spinato, Maria Guido, Annarosa Del Mistro, Rossana Bussani, Fabrizio Zanconati, Margherita Tofanelli, Giancarlo Tirelli, Paolo Boscolo-Rizzo and Antonio Rosato
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:279
  28. Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic development during which epithelial cells acquire mesenchymal characteristics, and the underlying mechanisms confer malignant feat...

    Authors: Hashem Khanbabaei, Saeedeh Ebrahimi, Juan Luis García-Rodríguez, Zahra Ghasemi, Hossein Pourghadamyari, Milad Mohammadi and Lasse Sommer Kristensen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:278
  29. Ovarian cancer (OC) is a heterogeneous malignancy with various etiology, histopathology, and biological feature. Despite accumulating understanding of OC in the post-genomic era, the preclinical knowledge stil...

    Authors: Tianyu Qin, Junpeng Fan, Funian Lu, Li Zhang, Chen Liu, Qiyue Xiong, Yang Zhao, Gang Chen and Chaoyang Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:277
  30. The extracellular matrix (ECM) is an important component of the tumor microenvironment (TME), having several important roles related to the hallmarks of cancer. In cancer, multiple components of the ECM have b...

    Authors: Ancuta Jurj, Calin Ionescu, Ioana Berindan-Neagoe and Cornelia Braicu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:276
  31. Metastasis is a major determinant of death in patients with hepatocellular carcinoma (HCC). Dissecting key molecular mediators that promote this malignant feature may help yield novel therapeutic insights. Her...

    Authors: Tongyue Zhang, Yijun Wang, Meng Xie, Xiaoyu Ji, Xiangyuan Luo, Xiaoping Chen, Bixiang Zhang, Danfei Liu, Yangyang Feng, Mengyu Sun, Wenjie Huang and Limin Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:275
  32. Severe hypoxia is a prominent character of pancreatic ductal adenocarcinoma (PDAC) microenvironment. In the process of gemcitabine based chemotherapy, PDAC cells are insulted from replication stresses co-induc...

    Authors: Qiu Tu, Xiuyun Liu, Xiaoqing Yao, Ruixue Li, Gaojing Liu, Honglv Jiang, Kaiqin Li, Qiongfang Chen, Xiaoyan Huang, Qing Chang, Guoqiang Xu, Hong Zhu, Peng Shi and Bo Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:274
  33. Lamins, key nuclear lamina components, have been proposed as candidate risk biomarkers in different types of cancer but their accuracy is still debated. AKTIP is a telomeric protein with the property of being ...

    Authors: Mattia La Torre, Chiara Merigliano, Klizia Maccaroni, Alexandre Chojnowski, Wah Ing Goh, Maria Giubettini, Fiammetta Vernì, Cristina Capanni, Daniela Rhodes, Graham Wright, Brian Burke, Silvia Soddu, Romina Burla and Isabella Saggio
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:273
  34. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0717-3

    Authors: Zhikui Liu, Yufeng Wang, Changwei Dou, Liankang Sun, Qing Li, Liang Wang, Qiuran Xu, Wei Yang, Qingguang Liu and Kangsheng Tu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:272
  35. Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past, elesclomol was recognized as an inducer of oxidative stress, but now it has also been found to suppress cancer by inducing c...

    Authors: Peijie Zheng, Chuntao Zhou, Liuyi Lu, Bin Liu and Yuemin Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:271
  36. Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and play fundamental roles in various types of cancer. Current developments in transcriptome analyses unveiled the existence...

    Authors: Jiwei Zhang, Tao Pan, Weiwei Zhou, Ya Zhang, Gang Xu, Qi Xu, Si Li, Yueying Gao, Zhengtao Wang, Juan Xu and Yongsheng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:270
  37. Immunotherapy based on Bi-specific T Cell Engagers (TCE) represents one of the most attractive strategy to treat cancers resistant to conventional therapies. TCE are antibody-like proteins that simultaneously ...

    Authors: Margherita Passariello, Asami Yoshioka, Kota Takahashi, Shu-ichi Hashimoto, Toshikazu Inoue, Koji Nakamura and Claudia De Lorenzo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:269
  38. As our understanding of the mechanisms of cancer treatment has increased, a growing number of studies demonstrate pathways through which DNA damage repair (DDR) affects the immune system. At the same time, the...

    Authors: Congqi Shi, Kaiyu Qin, Anqi Lin, Aimin Jiang, Quan Cheng, Zaoqu Liu, Jian Zhang and Peng Luo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:268
  39. Circular RNA (circRNA) is crucial to the progression of hepatocellular cancer (HCC). In addition, Mitochondrial calcium uniporter regulatory factor 1 (MCUR1) is commonly overexpressed in HCC to increase cellul...

    Authors: Yi Li, Anqi Wu, Lin Chen, Aiting Cai, Yuhao Hu, Zhou Zhou, Qianyi Qi, Yixuan Wu, Donglin Xia, Peixin Dong, Shaoqing Ju and Feng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:267
  40. Colorectal cancer (CRC) remains largely incurable when diagnosed at the metastatic stage. Despite some advances in precision medicine for this disease in recent years, new molecular targets, as well as prognos...

    Authors: Margherita Pergolizzi, Laura Bizzozero, Federica Maione, Elena Maldi, Claudio Isella, Marco Macagno, Elisa Mariella, Alberto Bardelli, Enzo Medico, Caterina Marchiò, Guido Serini, Federica Di Nicolantonio, Federico Bussolino and Marco Arese
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:266
  41. As the field of translational ‘omics has progressed, refined classifiers at both genomic and proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically-applicable way. The int...

    Authors: Karama Asleh, Nazia Riaz and Torsten O. Nielsen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:265
  42. Esophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux disease (GERD) is the main risk factor for the development of Barrett’s esophagus (BE),...

    Authors: Farah Ballout, Heng Lu, Lei Chen, Kannappan Sriramajayam, Jianwen Que, Zhipeng Meng, Timothy C. Wang, Silvia Giordano, Alexander Zaika, Oliver McDonald, Dunfa Peng and Wael El-Rifai
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:264
  43. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1244-6..

    Authors: Xiaocheng Cao, Lihua Liu, Qing Yuan, Xiang Li, Yinghong Cui, Kaiqun Ren, Chang Zou, A. Chen, Chang Xu, Yebei Qiu, Meifang Quan, Jiansong Zhang, Jianguo Cao and Xiangding Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:263
  44. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Wanxu Huang, Hua Li, Qingsong Yu, Wei Xiao and Dan Ohtan Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:262

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:100

  45. Metastasis is the main cause of mortality in cervical cancer (CC). Circular RNAs (circRNAs) have been demonstrated to play a crucial role in carcinoma biology. However, the expression and function of circRNAs ...

    Authors: Leilei Liang, Yunshu Zhu, Jian Li, Jia Zeng and Lingying Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:261
  46. Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-associated mortality. However, molecular mechanisms involved in ccRCC metastasis remain to be fully understood. With the increas...

    Authors: Yanliang Wang, Yu Chen Feng, Yujin Gan, Liu Teng, Li Wang, Ting La, Peilin Wang, Yue Gu, Lei Yan, Na Li, Lina Zhang, Limeng Wang, Rick F. Thorne, Xu Dong Zhang, Huixia Cao and Feng-Min Shao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:260
  47. Radiation-induced bystander effect (RIBE) can promote tumor metastasis contributing to the failure of radiotherapy for esophageal squamous cell carcinoma (ESCC). Aberrant expression of DJ-1 has been identified...

    Authors: Junjie Gu, Yuanyuan Sun, Jiahang Song, Ruiling Zhao, Xiaoke Di, Yumeng Zhang, Xiaolin Ge, Shu Zhang, Yun Gu and Xinchen Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:259
  48. Pancreatic cancer is one of the most difficult cancers to detect early and most patients die from complications arising due to distant organ metastases. The lack of bona fide early biomarkers is one of the pri...

    Authors: Harrys Kishore Charles Jacob, Rossana Signorelli, John Lalith Charles Richard, Tyler Kashuv, Shweta Lavania, Ashley Middleton, Beatriz Aguilar Gomez, Anthony Ferrantella, Haleh Amirian, Junyi Tao, Ayse Burcu Ergonul, Melinda Minucci Boone, Marco Hadisurya, Weiguo Andy Tao, Anton Iliuk, Manoj Kumar Kashyap…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:258

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