Articles

Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation

Improvement of radiotherapy efficacy requires better insight in the dynamic responses that occur during irradiation. Here, we aimed to identify the molecular responses that are triggered during clinically appl...

Authors: Ruben S. A. Goedegebuure, Esther A. Kleibeuker, Francesca M. Buffa, Kitty C. M. Castricum, Syed Haider, Iris A. Schulkens, Luuk ten Kroode, Jaap van den Berg, Maarten A. J. M. Jacobs, Anne-Marie van Berkel, Nicole C. T. van Grieken, Sarah Derks, Ben J. Slotman, Henk M. W. Verheul, Adrian L. Harris and Victor L. Thijssen

Hypoxia-dependent drivers of melanoma progression

Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment and promotes cancer progression and resistance to therapy. Many studies reported the essential role of hypoxia in regul...

Authors: Simona D’Aguanno, Fabiana Mallone, Marco Marenco, Donatella Del Bufalo and Antonietta Moramarco

ROC1 promotes the malignant progression of bladder cancer by regulating p-IκBα/NF-κB signaling

Regulator of cullins 1 (ROC1) is an important catalytic subunit of cullin–RING E3 ligase. Nuclear factor-kappa B (NF-κB) signaling is closely related to tumor invasion and metastasis. Earlier, we reported that...

Authors: Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang and Jianxin Qiu

circPVT1 regulates medullary thyroid cancer growth and metastasis by targeting miR-455-5p to activate CXCL12/CXCR4 signaling

Medullary thyroid cancer (MTC) represents 13.4 % of all thyroid cancers-related deaths. The treatments for MTC are very limited especially for patients with distal metastasis. Therefore, it is critical to unde...

Authors: Xun Zheng, Shu Rui, Xiao-Fei Wang, Xiu-He Zou, Yan-Ping Gong and Zhi-Hui Li

José Baselga M.D., Ph.D. (1959–2021) leading cancer researcher and oncologist

Authors: Moshe Elkabets and Giovanni Blandino

Correction to: Genistein inhibits stemness of SKOV3 cells induced by macrophages co-cultured with ovarian cancer stem-like cells through IL-8/STAT3 axis

Authors: Yingxia Ning, Weifeng Feng, Xiaocheng Cao, Kaiqun Ren, Meifang Quan, A. Chen, Chang Xu, Yebei Qiu, Jianguo Cao, Xiang Li and Xin Luo

The immune cell landscape of metastatic uveal melanoma correlates with overall survival

Uveal melanoma (UM) represents the most common primary intra-ocular malignancy in adults. Up to 50% of the patients develop distant metastases within 10 years from diagnosis, with the liver as the most common ...

Authors: Anna Tosi, Rocco Cappellesso, Angelo Paolo Dei Tos, Valentina Rossi, Camillo Aliberti, Jacopo Pigozzo, Alessio Fabozzi, Marta Sbaraglia, Stella Blandamura, Paola Del Bianco, Vanna Chiarion-Sileni and Antonio Rosato

Pyroptosis: a new paradigm of cell death for fighting against cancer

Unraveling the mystery of cell death is one of the most fundamental progresses of life sciences during the past decades. Regulated cell death (RCD) or programmed cell death (PCD) is not only essential in embry...

Authors: Yixin Tan, Quanzhu Chen, Xiaoling Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Xiayu Li, Jianbo Yang, Bo Xiang and Mei Yi

ROS and TGFβ: from pancreatic tumour growth to metastasis

Transforming growth factor β (TGFβ) signalling pathway switches between anti-tumorigenic function at early stages of cancer formation and pro-tumorigenic effects at later stages promoting cancer metastasis. A ...

Authors: Chao-Hui Chang and Siim Pauklin

The lnc-CTSLP8 upregulates CTSL1 as a competitive endogenous RNA and promotes ovarian cancer metastasis

Ovarian cancer is highly lethal and has a poor prognosis due to metastasis. Long non-coding RNAs (lncRNAs) are key regulators of tumor development, but their role in ovarian cancer metastasis remains unclear.

Authors: Xinjing Wang, Xiaoduan Li, Feikai Lin, Huizhen Sun, Yingying Lin, Ziliang Wang and Xipeng Wang

ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis

Among the common preventable cancers of women, cervical cancer has the highest morbidity. It is curable if detected at an early stage. However, reliable diagnostic and prognostic markers, which relate to physi...

Authors: Li Li, Yijia Gong, Ke Xu, Weihong Chen, Jiuyi Xia, Zhaobo Cheng, Lili Li, Renjie Yu, Junhao Mu, Xin Le, Qin Xiang, Weiyan Peng, Junying Tang and Tingxiu Xiang

ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-β receptor II in breast cancer

Radiotherapy is a conventional and effective local treatment for breast cancer. However, residual or recurrent tumors appears frequently because of radioresistance. Novel predictive marker and the potential th...

Authors: Xiaoqing Sun, Zhenyu He, Ling Guo, Caiqin Wang, Chuyong Lin, Liping Ye, Xiaoqing Wang, Yue Li, Meisongzhu Yang, Sailan Liu, Xin Hua, Wen Wen, Chao Lin, Zhiqing Long, Wenwen Zhang, Han Li…

KLF5-induced BBOX1-AS1 contributes to cell malignant phenotypes in non-small cell lung cancer via sponging miR-27a-5p to up-regulate MELK and activate FAK signaling pathway

Non-small cell lung cancer (NSCLC) is a major histological subtype of lung cancer with high mortality and morbidity. A substantial amount of evidence demonstrates long non-coding RNAs (lncRNA) as critical regu...

Authors: Jiang Shi, Chao Yang, Jinlu An, Dexun Hao, Cong Liu, Jumin Liu, Jing Sun and Junguang Jiang

The emerging role of β-secretases in cancer

BACE1 and BACE2 belong to a class of proteases called β-secretases involved in ectodomain shedding of different transmembrane substrates. These enzymes have been extensively studied in Alzheimer's disease as t...

Authors: Francesco Farris, Vittoria Matafora and Angela Bachi

N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies

The N6-methyladenosine (m6A) modification is a dynamic and reversible epigenetic modification, which is co-transcriptionally deposited by a methyltransferase complex, removed by a demethylase, and recognized b...

Authors: Fenghua Tan, Mengyao Zhao, Fang Xiong, Yumin Wang, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Yi He, Lei Shi, Fuyan Wang, Bo Xiang, Ming Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng…

Correction to: TRIM29 facilitates the epithelial-tomesenchymal transition and the progression of colorectal cancer via the activation of the Wnt/β-catenin signaling pathway

An amendment to this paper has been published and can be accessed via the original article.

Authors: Juntao Sun, Tianyu Zhang, Mengmeng Cheng, Liwen Hong, Chen Zhang, Mengfan Xie, Peijun Sun, Rong Fan, Zhengting Wang, Lei Wang and Jie Zhong

Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities

Tankyrase 1 (TNKS1) and tankyrase 2 (TNKS2) are two homologous proteins that are gaining increasing importance due to their implication in multiple pathways and diseases such as cancer. TNKS1/2 interact with a...

Authors: Esteban Zamudio-Martinez, Ana Belén Herrera-Campos, Alberto Muñoz, José Manuel Rodríguez-Vargas and F. Javier Oliver

Correction to: MicroRNA-224 sustains Wnt/β-catenin signaling and promotes aggressive phenotype of colorectal cancer

Authors: Tingting Li, Qiuhua Lai, Shuyang Wang, Juanjuan Cai, Zhiyuan Xiao, Danling Deng, Liuqing He, Hongli Jiao, Yaping Ye, Li Liang, Yanqing Ding and Wenting Liao

Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis

Breast cancer is a heterogeneous disease with a complex microenvironment consisting of tumor cells, immune cells, fibroblasts and vascular cells. These cancer-associated cells shape the tumor microenvironment ...

Authors: Xueqi Yan, Yinghong Xie, Fan Yang, Yijia Hua, Tianyu Zeng, Chunxiao Sun, Mengzhu Yang, Xiang Huang, Hao Wu, Ziyi Fu, Wei Li, Shiping Jiao and Yongmei Yin

Inhibition of retinoic acid receptor α phosphorylation represses the progression of triple-negative breast cancer via transactivating miR-3074-5p to target DHRS3

Retinoids are promising agents in the treatment of different types of neoplasia including estrogen receptor-positive breast cancers, whereas refractoriness/low sensitivity is observed in triple-negative breast...

Authors: Siyue Lou, Hang Gao, Huanwu Hong, Zhihui Zhu and Huajun Zhao

Current status of ctDNA in precision oncology for hepatocellular carcinoma

The conventional method used to obtain a tumor biopsy for hepatocellular carcinoma (HCC) is invasive and does not evaluate dynamic cancer progression or assess tumor heterogeneity. It is thus imperative to cre...

Authors: Yan Li, Yuanyuan Zheng, Liwei Wu, Jingjing Li, Jie Ji, Qiang Yu, Weiqi Dai, Jiao Feng, Jianye Wu and Chuanyong Guo

Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing

Glioblastomas stem-like cells (GSCs) by invading the brain parenchyma, remains after resection and radiotherapy and the tumoral microenvironment become stiffer. GSC invasion is reported as stiffness sensitive ...

Authors: Emilie Marhuenda, Christine Fabre, Cunjie Zhang, Martà Martin-Fernandez, Thomas Iskratsch, Ali Saleh, Luc Bauchet, Julien Cambedouzou, Jean-Philippe Hugnot, Hugues Duffau, James W. Dennis, David Cornu and Norbert Bakalara

Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5′-deoxy-5-fluorocytidine (5′-DFCR)

Pemetrexed (MTA) plus cisplatin combination therapy is considered the standard of care for patients with advanced non-small-cell lung cancer (NSCLC). However, in advanced NSCLC, the 5-year survival rate is bel...

Authors: Yanyun Gao, Philipp Zens, Min Su, Camila Anna Gemperli, Haitang Yang, Haibin Deng, Zhang Yang, Duo Xu, Sean R. R. Hall, Sabina Berezowska, Patrick Dorn, Ren-Wang Peng, Ralph Alexander Schmid, Wenxiang Wang and Thomas Michael Marti

Correction to: Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yan Chen, Zhonghu Li, Mengyun Zhang, Bo Wang, Jiaxin Ye, Yang Zhang, Di Tang, Dandan Ma, Weidong Jin, Xiaowu Li and Shuguang Wang

IκBα targeting promotes oxidative stress-dependent cell death

Oxidative stress is a hallmark of many cancers. The increment in reactive oxygen species (ROS), resulting from an increased mitochondrial respiration, is the major cause of oxidative stress. Cell fate is known...

Authors: Giovanna Carrà, Giuseppe Ermondi, Chiara Riganti, Luisella Righi, Giulia Caron, Alessio Menga, Enrica Capelletto, Beatrice Maffeo, Marcello Francesco Lingua, Federica Fusella, Marco Volante, Riccardo Taulli, Angelo Guerrasio, Silvia Novello, Mara Brancaccio, Rocco Piazza…

Correction to: KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity

An amendment to this paper has been published and can be accessed via the original article.

Authors: Kai Teng, Shi Wei, Chi Zhang, Jiewei Chen, Jinbin Chen, Kanghua Xiao, Jun Liu, Miaomiao Dai, Xinyuan Guan, Jingping Yun and Dan Xie

The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway

Glioma is the most common and malignant tumor of central nervous system. The tumor initiation, self-renewal, and multi-lineage differentiation abilities of glioma stem cells (GSCs) are responsible for glioma p...

Authors: Junshuang Zhao, Yang Jiang, Haiying Zhang, Jinpeng Zhou, Lian Chen, Hao Li, Jinkun Xu, Guoqing Zhang and Zhitao Jing

N-acetyl cysteine induces quiescent-like pancreatic stellate cells from an active state and attenuates cancer-stroma interactions

Pancreatic stellate cells (PSCs) occupy the majority of the pancreatic cancer microenvironment, contributing to aggressive behavior of pancreatic cancer cells (PCCs). Recently, anti-fibrotic agents have proven...

Authors: Haimin Feng, Taiki Moriyama, Kenoki Ohuchida, Nan Sheng, Chika Iwamoto, Koji Shindo, Kengo Shirahane, Naoki Ikenaga, Shuntaro Nagai, Kohei Nakata, Kazuhiro Mizumoto and Masafumi Nakamura

Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway

Cancer stem cell (CSC)-related chemoresistance leads to poor outcome of the patients with colorectal cancer (CRC). In this study, we identified the chemoresistance-relevant molecules and decipher the involved ...

Authors: Xiaofeng Liu, Kunqi Su, Xiaoyan Sun, Yang Jiang, Lijun Wang, Chenyu Hu, Chunfeng Zhang, Min Lu, Xiaojuan Du and Baocai Xing

SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia

Hypoxia, a condition of oxygen deprivation, is considered a hallmark of tumor microenvironment regulating several pathways and promoting cancer progression and resistance to therapy. Semaphorins, a family of a...

Authors: Elisabetta Valentini, Marta Di Martile, Donatella Del Bufalo and Simona D’Aguanno

Correction to: Short hairpin RNA- mediated gene knockdown of FOXM1 inhibits the proliferation and metastasis of human colon cancer cells through reversal of epithelial-to-mesenchymal transformation

An amendment to this paper has been published and can be accessed via the original article.

Authors: KanKan Yang, LinHua Jiang, You Hu, Jing Yu, HenFeng Chen, YiZhou Yao and XinGuo Zhu

Resolvin D1 reduces cancer growth stimulating a protective neutrophil-dependent recruitment of anti-tumor monocytes

Innovative therapies to target tumor-associated neutrophils (PMN) are of clinical interest, since these cells are centrally involved in cancer inflammation and tumor progression. Resolvin D1 (RvD1) is a lipid ...

Authors: Domenico Mattoscio, Elisa Isopi, Alessia Lamolinara, Sara Patruno, Alessandro Medda, Federica De Cecco, Susanna Chiocca, Manuela Iezzi, Mario Romano and Antonio Recchiuti

Correction to: ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma

An amendment to this paper has been published and can be accessed via the original article.

Authors: Qian Chen, Xiao-Wei Zhou, Ai-Jun Zhang and Kang He

Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignant cancers worldwide, and liver cancer has increased in mortality due to liver cancer because it was detected at an advanced stages in patients w...

Authors: Sanghwa Kim, Minji Lee, Yeonhwa Song, Su-Yeon Lee, Inhee Choi, I-Seul Park, Jiho Kim, Jin-sun Kim, Kang mo Kim and Haeng Ran Seo

NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer

NOD-like receptors affect multiple stages of cancer progression in many malignancies. NACHT, LRR, and PYD domain-containing protein 7 (NLRP7) is a member of the NOD-like receptor family, although its role in t...

Authors: Bing Li, Zhi-Peng Qi, Dong-Li He, Zhang-Han Chen, Jing-Yi Liu, Meng-Wai Wong, Jia-Wei Zhang, En-Pan Xu, Qiang Shi, Shi-Lun Cai, Di Sun, Li-Qing Yao, Ping-Hong Zhou and Yun-Shi Zhong

Dehydrodiisoeugenol inhibits colorectal cancer growth by endoplasmic reticulum stress-induced autophagic pathways

Dehydrodiisoeugenol (DEH), a novel lignan component extracted from nutmeg, which is the seed of Myristica fragrans Houtt, displays noticeable anti-inflammatory and anti-allergic effects in digestive system diseas...

Authors: Changhong Li, Kui Zhang, Guangzhao Pan, Haoyan Ji, Chongyang Li, Xiaowen Wang, Xin Hu, Ruochen Liu, Longfei Deng, Yi Wang, Liqun Yang and Hongjuan Cui

Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer

Pancreatic cancer is a malignant tumor and ranks the sixth in incidence among cancers. Circular RNA (circRNA) has been reported to regulate the progression of pancreatic cancer. However, the effects of circ-me...

Authors: Xiaoxiao Zhou, Kun Liu, Jing Cui, Jiongxin Xiong, Heshui Wu, Tao Peng and Yao Guo

Novel LncRNA OXCT1-AS1 indicates poor prognosis and contributes to tumorigenesis by regulating miR-195/CDC25A axis in glioblastoma

Long noncoding RNAs (lncRNAs) contribute to multiple biological processes in human glioblastoma (GBM). However, identifying a specific lncRNA target remains a challenge. In this study, bioinformatics methods a...

Authors: Chen Zhong, Qian Yu, Yucong Peng, Shengjun Zhou, Zhendong Liu, Yong Deng, Leiguang Guo, Shiguang Zhao and Gao Chen

Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancer

PARP inhibitors (PARPi) benefit only a fraction of breast cancer patients with BRCA mutations, and their efficacy is even more limited in triple-negative breast cancer (TNBC) due to clinical primary and acquir...

Authors: Xiuzhi Zhu, Li Chen, Binhao Huang, Xiaoguang Li, Liu Yang, Xin Hu, Yizhou Jiang, Zhimin Shao and Zhonghua Wang

Hypoxia-dependent expression of MAP17 coordinates the Warburg effect to tumor growth in hepatocellular carcinoma

Reprogrammed glucose metabolism, also known as the Warburg effect, which is essential for tumor progression, is regarded as a hallmark of cancer. MAP17, a small 17-kDa non-glycosylated membrane protein, is fre...

Authors: Fangyuan Dong, Rongkun Li, Jiaofeng Wang, Yan Zhang, Jianfeng Yao, Shu-Heng Jiang, Xiaona Hu, Mingxuan Feng and Zhijun Bao

Chemotherapy-elicited exosomal miR-378a-3p and miR-378d promote breast cancer stemness and chemoresistance via the activation of EZH2/STAT3 signaling

Not all breast cancer (BC) patients who receive neoadjuvant chemotherapy achieve a pathologic complete response (pCR), but the reasons for this are unknown. Previous studies have shown that exosomes produced i...

Authors: Qianxi Yang, Shaorong Zhao, Zhendong Shi, Lixia Cao, Jingjing Liu, Teng Pan, Dongdong Zhou and Jin Zhang

The role of the circadian clock in cancer hallmark acquisition and immune-based cancer therapeutics

The circadian system temporally regulates physiology to maintain homeostasis. Co-opting and disrupting circadian signals appear to be distinct attributes that are functionally important for the development of ...

Authors: Elizabeth Cash, Sandra Sephton, Cassandra Woolley, Attia M. Elbehi, Anu R. I., Bene Ekine-Afolabi and Victor C. Kok

HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression

Hepatoma is a common malignancy of the liver. The abnormal high expression of alpha-fetoprotein (AFP) is intimately associated with hepatoma progress, but the mechanism of transcriptional regulation and singul...

Authors: Zhengyi Cao, Yuning Cheng, Jiyin Wang, Yujuan Liu, Ruixiang Yang, Wei Jiang, Hui Li and Xiaowei Zhang

MITF induces escape from innate immunity in melanoma

The application of immune-based therapies has revolutionized cancer treatment. Yet how the immune system responds to phenotypically heterogeneous populations within tumors is poorly understood. In melanoma, on...

Authors: Luis Sánchez-del-Campo, Román Martí-Díaz, María F. Montenegro, Rebeca González-Guerrero, Trinidad Hernández-Caselles, Enrique Martínez-Barba, Antonio Piñero-Madrona, Juan Cabezas-Herrera, Colin R. Goding and José Neptuno Rodríguez-López

Patient-derived organoids and high grade serous ovarian cancer: from disease modeling to personalized medicine

High grade serous ovarian cancer (HGSOC) is among the deadliest human cancers and its prognosis remains extremely poor. Tumor heterogeneity and rapid acquisition of resistance to conventional chemotherapeutic ...

Authors: Camilla Nero, Giuseppe Vizzielli, Domenica Lorusso, Eleonora Cesari, Gennaro Daniele, Matteo Loverro, Giovanni Scambia and Claudio Sette

Correction to: Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway

An amendment to this paper has been published and can be accessed via the original article.

Authors: Gangjun Yuan, Xin Chen, Zhuowei Liu, Wensu Wei, Qinghai Shu, Hussein Abou-Hamdan, Lijuan Jiang, Xiangdong Li, Rixin Chen, Laurent Désaubry, Fangjian Zhou and Dan Xie

Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo

Colorectal cancer (CRC) is a clinically challenging malignant tumor worldwide. As a natural product and sesquiterpene lactone, Costunolide (CTD) has been reported to possess anticancer activities. However, the...

Authors: Hai Huang, Song Park, Haibo Zhang, Sijun Park, Wookbong Kwon, Enugyung Kim, Xiujuan Zhang, Soyoung Jang, Duhak Yoon, Seong-Kyoon Choi, Jun-koo Yi, Sung-hyun Kim, Zigang Dong, Mee-hyun Lee, Zaeyoung Ryoo and Myoung Ok Kim

Elafin promotes tumour metastasis and attenuates the anti-metastatic effects of erlotinib via binding to EGFR in hepatocellular carcinoma

Elafin is a serine protease inhibitor critical for host defence. We previously reported that Elafin was associated with the recurrence of early-stage hepatocellular carcinoma (HCC) after surgery. However, the ...

Authors: Chenwei Wang, Yadi Liao, Wei He, Hong Zhang, Dinglan Zuo, Wenwu Liu, Zhiwen Yang, Jiliang Qiu, Yichuan Yuan, Kai Li, Yuanping Zhang, Yongjin Wang, Yunxing Shi, Yuxiong Qiu, Song Gao, Yunfei Yuan…

ChrXq27.3 miRNA cluster functions in cancer development

MicroRNAs (miRNAs) regulate the expression of their target genes post-transcriptionally; thus, they are deeply involved in fundamental biological processes. miRNA clusters contain two or more miRNA-encoding ge...

Authors: Kosuke Yoshida, Akira Yokoi, Yusuke Yamamoto and Hiroaki Kajiyama

Correction to: Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yuhui Zhang, Weibin Huang, Yujie Yuan, Jin Li, Jing Wu, Jie Yu, Yulong He, Zhewei Wei and Changhua Zhang