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  1. Primary liver cancer (PLC) is a common malignancy with high morbidity and mortality. Poor prognosis and easy recurrence on PLC patients calls for optimizations of the current conventional treatments and the ex...

    Authors: Yuanyuan Zheng, Yan Li, Jiao Feng, Jingjing Li, Jie Ji, Liwei Wu, Qiang Yu, Weiqi Dai, Jianye Wu, Yingqun Zhou and Chuanyong Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:250

    Content type: Review

    Published on:

  2. Citation: Journal of Experimental & Clinical Cancer Research 2021 40:249

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:38

  3. The identification of novel targets is of paramount importance to develop more effective drugs and improve the treatment of non-small cell lung cancer (NSCLC), the leading cause of cancer-related deaths worldw...

    Authors: Beatrice Parma, Vignesh Ramesh, Paradesi Naidu Gollavilli, Aarif Siddiqui, Luisa Pinna, Annemarie Schwab, Sabine Marschall, Shuman Zhang, Christian Pilarsky, Francesca Napoli, Marco Volante, Sophia Urbanczyk, Dirk Mielenz, Henrik Daa Schrøder, Marc Stemmler, Heiko Wurdak…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:248

    Content type: Research

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  4. Sarcomas are a very heterogeneous group of tumors with intrinsic developmental programs derived from the cell of origin. This implies a functional hierarchy inside tumors governed by sarcoma stem cells. Theref...

    Authors: Manuel Pedro Jimenez-García, Antonio Lucena-Cacace, Daniel Otero-Albiol and Amancio Carnero

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:247

    Content type: Research

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  5. Head and neck squamous cell carcinoma (HNSCC) is heterogeneous in etiology, phenotype and biology. Patient-derived xenografts (PDX) maintain morphology and molecular profiling of the original tumors and have b...

    Authors: Daniel Strüder, Theresa Momper, Nina Irmscher, Mareike Krause, Jan Liese, Sebastian Schraven, Annette Zimpfer, Sarah Zonnur, Ann-Sophie Burmeister, Björn Schneider, Bernhard Frerich, Robert Mlynski, Christina Große-Thie, Christian Junghanss and Claudia Maletzki

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:246

    Content type: Research

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  6. Ribosomal L1 domain-containing protein 1 (RSL1D1) is a nucleolar protein that is essential in cell proliferation. In the current opinion, RSL1D1 translocates to the nucleoplasm under nucleolar stress and inhib...

    Authors: Li Ding, Zhiping Zhang, Chenhong Zhao, Lei Chen, Zhiqiang Chen, Jie Zhang, Yaxian Liu, Yesen Nie, Yanzhi He, Kai Liao and Xinyue Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:245

    Content type: Research

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  7. Tumor recurrence is one of the major challenges in clinical management of chordoma. Despite R0-resection, approximately 50% of chordomas recur within ten years after initial surgery. The underlying molecular p...

    Authors: Carolin Seeling, André Lechel, Michael Svinarenko, Peter Möller, Thomas F. E. Barth and Kevin Mellert

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:244

    Content type: Research

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  8. Cellular senescence is a complex physiological state whose main feature is proliferative arrest. Cellular senescence can be considered the reverse of cell immortalization and continuous tumor growth. However, ...

    Authors: Daniel Otero-Albiol and Amancio Carnero

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:243

    Content type: Review

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  9. Immunotherapeutic treatments are gaining attention due to their effective anti-tumor response. Particularly, the revolution of immune checkpoint inhibitors (ICIs) produces promising outcomes for various cancer...

    Authors: Krishnapriya M. Varier, Hemavathi Dhandapani, Wuling Liu, Jialei Song, Chunlin Wang, Anling Hu, Yaacov Ben-David, Xiangchun Shen, Yanmei Li and Babu Gajendran

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:242

    Content type: Review

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  10. As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of their lipid-lowering effec...

    Authors: Wen Jiang, Jin-Wei Hu, Xu-Ran He, Wei-Lin Jin and Xin-Yang He

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:241

    Content type: Review

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  11. The yearly Think Tank Meeting of the Italian Network for Tumor Biotherapy (NIBIT) Foundation, brings together in Siena, Tuscany (Italy), experts in immuno-oncology to review the learnings from current immunoth...

    Authors: Michele Maio, Michael Lahn, Anna Maria Di Giacomo, Alessia Covre, Luana Calabrò, Ramy Ibrahim and Bernard Fox

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:240

    Content type: Meeting Report

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  12. Management of triple-negative breast cancer (TNBC) is still challenging because of its aggressive clinical behavior and limited targeted treatment options. Cisplatin represents a promising chemotherapeutic com...

    Authors: Lisa Agnello, Silvia Tortorella, Annachiara d’Argenio, Clarissa Carbone, Simona Camorani, Erica Locatelli, Luigi Auletta, Domenico Sorrentino, Monica Fedele, Antonella Zannetti, Mauro Comes Franchini and Laura Cerchia

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:239

    Content type: Research

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  13. Extracellular vesicles (EVs) containing specific subsets of functional biomolecules are released by all cell types and analysis of circulating EVs can provide diagnostic and prognostic information. To date, li...

    Authors: Francesca Pontis, Luca Roz, Mavis Mensah, Miriam Segale, Massimo Moro, Giulia Bertolini, Ilaria Petraroia, Giovanni Centonze, Anna Maria Ferretti, Paola Suatoni, Ugo Pastorino, Orazio Fortunato and Gabriella Sozzi

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:237

    Content type: Research

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  14. Citation: Journal of Experimental & Clinical Cancer Research 2021 40:236

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:234

  15. Circular RNAs (circRNAs) are involved in diverse processes that drive cancer development. However, the expression landscape and mechanistic function of circRNAs in osteosarcoma (OS) remain to be studied.

    Authors: Bingsheng Yang, Lutao Li, Ge Tong, Zhirui Zeng, Jianye Tan, Zexin Su, Zhengwei Liu, Jiezhao Lin, Wenwen Gao, Jianping Chen, Sisi Zeng, Guofeng Wu, Lin Li, Shuang Zhu, Qiuzhen Liu and Lijun Lin

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:235

    Content type: Research

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  16. Authors: Yujun Tang, Yishi Lu, Yuan Chen, Lei Luo, Lei Cai, Bangjian Peng, Wenbin Huang, Hangyu Liao, Liang Zhao and Mingxin Pan

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:234

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:473

  17. Che-1/AATF (Che-1) is an RNA polymerase II binding protein involved in several cellular processes, including proliferation, apoptosis and response to stress. We have recently demonstrated that Che-1 is able to...

    Authors: Valeria Catena, Tiziana Bruno, Simona Iezzi, Silvia Matteoni, Annalisa Salis, Cristina Sorino, Gianluca Damonte and Maurizio Fanciulli

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:232

    Content type: Research

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  18. Neutrophils are the most abundant type of white blood cells circulating throughout the bloodstream and are often considered the frontline defenders in innate immunity. However, neutrophils are increasingly bei...

    Authors: Livia Ronchetti, Nouha Setti Boubaker, Maddalena Barba, Patrizia Vici, Aymone Gurtner and Giulia Piaggio

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:231

    Content type: Review

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  19. The intrinsic immuno-ge7nomic characteristics of colorectal cancer cells that affect tumor biology and shape the tumor immune microenvironment (TIM) are unclear.

    Authors: Eun Jeong Cho, Minsuh Kim, Daum Jo, Jihye Kim, Ji-Hye Oh, Hee Chul Chung, Sun-hye Lee, Deokhoon Kim, Sung-Min Chun, Jihun Kim, Hyeonjin Lee, Tae Won Kim, Chang Sik Yu, Chang Ohk Sung and Se Jin Jang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:230

    Content type: Research

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  20. Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, characterized by a poor prognosis mainly due to recurrence and therapeutic resistance. It has been widely demonstra...

    Authors: Mariachiara Buccarelli, Quintino Giorgio D’Alessandris, Paola Matarrese, Cristiana Mollinari, Michele Signore, Andrea Cappannini, Maurizio Martini, Pierluigi D’Aliberti, Gabriele De Luca, Francesca Pedini, Alessandra Boe, Mauro Biffoni, Roberto Pallini and Lucia Ricci-Vitiani

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:228

    Content type: Research

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  21. Colorectal cancer (CRC) is a common malignant tumor. Circular RNAs (circRNAs) have been reported to take part in the progression of CRC. However, the functions of circ_0084615 in CRC development are still unde...

    Authors: Zhipeng Jiang, Qinwen Tai, Xiaojun Xie, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang and Shuang Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:227

    Content type: Research

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  22. Renal cell carcinomas (RCC) are characterized by the deregulation of several hundred hyperosmolality-responsive genes. High expression of a subset of these genes including the Ran binding protein 3 like (RANBP3L)...

    Authors: Dmitry Chernyakov, Alexander Groß, Annika Fischer, Nicola Bornkessel, Christoph Schultheiss, Dennis Gerloff and Bayram Edemir

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:226

    Content type: Research

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  23. Genes in the Ras pathway have somatic mutations in at least 60 % of colorectal cancers. Despite activating the same pathway, the BRAF V600E mutation and the prevalent mutations in codon 12 and 13 of KRAS have all...

    Authors: Snehangshu Kundu, Muhammad Akhtar Ali, Niklas Handin, Louis P. Conway, Veronica Rendo, Per Artursson, Liqun He, Daniel Globisch and Tobias Sjöblom

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:225

    Content type: Research

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  24. To block repairs of DNA damages, especially the DNA double strand break (DSB) repair, can be used to induce cancer cell death. DSB repair depends on a sequential activation of DNA repair factors that may be po...

    Authors: Xiao Lei, Kun Cao, Yuanyuan Chen, Hui Shen, Zhe Liu, Hongran Qin, Jianming Cai, Fu Gao and Yanyong Yang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:224

    Content type: Research

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  25. tRNA-derived small noncoding RNAs (sncRNAs) are mainly categorized into tRNA halves (tiRNAs) and fragments (tRFs). Biological functions of tiRNAs in human solid tumor are attracting more and more attention, bu...

    Authors: Litao Han, Hejing Lai, Yichen Yang, Jiaqian Hu, Zhe Li, Ben Ma, Weibo Xu, Wanlin Liu, Wenjun Wei, Duanshu Li, Yu Wang, Qiwei Zhai, Qinghai Ji and Tian Liao

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:222

    Content type: Research

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  26. Tumor immunity consists of various types of cells, which serve an important role in antitumor therapy. The gastrointestinal tract is colonized by trillions of microorganisms, which form the gut microbiota. In ...

    Authors: Xinyi Liu, Yanjie Chen, Si Zhang and Ling Dong

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:221

    Content type: Review

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  27. Metastasis is a major challenge in cervical cancer treatment. Previous studies have shown that the dual functional protein apurinic/apyrimidinic endonuclease 1 (APE1) promotes tumor metastasis and is overexpre...

    Authors: Qing Li, Zhi-Wei Zhou, Wei Duan, Cheng-Yuan Qian, Shu-Nan Wang, Meng-Sheng Deng, Dan Zi, Jian-Min Wang, Cheng-Yi Mao, Guanbin Song, Dong Wang, Kenneth D. Westover and Cheng-Xiong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:220

    Content type: Research

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  28. Liver cancer stem cells (LCSCs) play key roles in the metastasis, recurrence, and chemotherapeutic resistance of hepatocellular carcinoma (HCC). Our previous research showed that the POSTN gene is closely related...

    Authors: Gang Chen, Yi Wang, Xin Zhao, Xiao-zai Xie, Jun-gang Zhao, Tuo Deng, Zi-yan Chen, Han-bin Chen, Yi-fan Tong, Zhen Yang, Xi-wei Ding, Peng-yi Guo, Hai-tao Yu, Li-jun Wu, Si-na Zhang, Qian-dong Zhu…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:218

    Content type: Research

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  29. It has been well documented that the tumor microenvironment (TME) plays a key role in the promotion of drug resistance, the support of tumor progression, invasiveness, metastasis, and even the maintenance of a...

    Authors: Pablo Hernández-Camarero, Elena López-Ruiz, Juan Antonio Marchal and Macarena Perán

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:217

    Content type: Review

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  30. Epithelial-to-mesenchymal transition (EMT) and aerobic glycolysis are fundamental processes implicated in cancer metastasis. Although increasing evidence demonstrates an association between EMT induction and e...

    Authors: Peixin Dong, Ying Xiong, Yosuke Konno, Kei Ihira, Noriko Kobayashi, Junming Yue and Hidemichi Watari

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:216

    Content type: Research

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  31. There has been a recent surge in interest in predicting biological effects associated with genomic alterations in order to implement personalized cancer treatment strategies. However, no reports have yet evalu...

    Authors: Yasutoshi Fujii, Atsushi Ono, C. Nelson Hayes, Hiroshi Aikata, Masami Yamauchi, Shinsuke Uchikawa, Kenichiro Kodama, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Daiki Miki, Wataru Okamoto, Tomokazu Kawaoka, Masataka Tsuge, Michio Imamura…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:215

    Content type: Research

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  32. Mesothelial E- and P-selectins substantially mediate the intraperitoneal spread of Pancreatic ductal adenocarcinoma (PDA) cells in xenograft models. In the absence of selectins in the host, the integrin subuni...

    Authors: Marius Kemper, Alina Schiecke, Hanna Maar, Sergey Nikulin, Andrey Poloznikov, Vladimir Galatenko, Michael Tachezy, Florian Gebauer, Tobias Lange, Kristoffer Riecken, Alexander Tonevitsky, Achim Aigner, Jakob Izbicki, Udo Schumacher and Daniel Wicklein

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:214

    Content type: Research

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  33. Immunotherapy is currently under intensive investigation as a potential breakthrough treatment option for glioblastoma. Given the anatomical and immunological complexities surrounding glioblastoma, lymphocytes...

    Authors: Jorrit De Waele, Tias Verhezen, Sanne van der Heijden, Zwi N. Berneman, Marc Peeters, Filip Lardon, An Wouters and Evelien L. J. M. Smits

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:213

    Content type: Review

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  34. Recent studies indicate that complement plays pivotal roles in promoting or suppressing cancer progression. We have previously identified C4b-binding protein α-chain (C4BPA) as a serum biomarker for the early ...

    Authors: Kosuke Sasaki, Shigetsugu Takano, Satoshi Tomizawa, Yoji Miyahara, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Mamoru Takada and Masayuki Ohtsuka

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:212

    Content type: Research

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  35. Defects in the DNA damage response (DDR) can lead to genome instability, producing mutations or aberrations that promote the development and progression of cancer. But it also confers such cells vulnerable to ...

    Authors: Yali Wang, Kun Zheng, Yongbiao Huang, Hua Xiong, Jinfang Su, Rui Chen and Yanmei Zou

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:211

    Content type: Review

    Published on:

  36. Leukaemia stem cells (LSCs) are responsible for the initiation, maintenance, and recurrence of acute myeloid leukaemia (AML), an aggressive haematological malignancy associated with drug resistance and relapse...

    Authors: Zheng Li, Fangce Wang, Xiaoxue Tian, Jun Long, Bin Ling, Wenjun Zhang, Jun Xu and Aibin Liang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:210

    Content type: Research

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  37. Tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) was initially considered an immunity guard; however, its function remains controversial. Besides immune cells, lung and colon cancer cells hav...

    Authors: Huanyu Zhang, Guohui Qin, Chaoqi Zhang, Huiyun Yang, Jinyan Liu, Hongwei Hu, Peng Wu, Shasha Liu, Li Yang, Xinfeng Chen, Xueke Zhao, Lidong Wang and Yi Zhang

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:209

    Content type: Research

    Published on:

  38. Authors: Dong-liang Chen, Huai-qiang Ju, Yun-xin Lu, Le-zong Chen, Zhao-lei Zeng, Dong-sheng Zhang, Hui-yan Luo, Feng Wang, Miao-zhen Qiu, De-shen Wang, Da-zhi Xu, Zhi-wei Zhou, Helene Pelicano, Peng Huang, Dan Xie, Feng-hua Wang…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:208

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:142

  39. Gastric adenocarcinoma with peritoneal carcinomatosis (PC) is therapy resistant and leads to poor survival. To study PC in depth, there is an urgent need to develop representative PC-derived cell lines and met...

    Authors: Shumei Song, Yan Xu, Longfei Huo, Shuangtao Zhao, Ruiping Wang, Yuan Li, Ailing W. Scott, Melissa Pool Pizzi, Ying Wang, Yibo Fan, Kazuto Harada, Jiankang Jin, Lang Ma, Xiaodan Yao, Namita D. Shanbhag, Qiong Gan…

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:207

    Content type: Research

    Published on:

  40. Ferroptosis is a newly defined form of regulated cell death characterized by the iron-dependent accumulation of lipid peroxidation and is involved in various pathophysiological conditions, including cancer. Ta...

    Authors: Jingjing Yang, Yulu Zhou, Shuduo Xie, Ji Wang, Zhaoqing Li, Lini Chen, Misha Mao, Cong Chen, Aihua Huang, Yongxia Chen, Xun Zhang, Noor Ul Hassan Khan, Linbo Wang and Jichun Zhou

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:206

    Content type: Research

    Published on:

  41. Triple negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and lack of effective treatment target. Here we screened differentially expressed lncRNAs through bioinformatics analysis ...

    Authors: Xiaonan Sheng, Huijuan Dai, Yueyao Du, Jing Peng, Rui Sha, Fan Yang, Liheng Zhou, Yanping Lin, Shuguang Xu, Yifan Wu, Wenjin Yin and Jinsong Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:205

    Content type: Research

    Published on:

  42. Citation: Journal of Experimental & Clinical Cancer Research 2021 40:204

    Content type: Correction

    Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:94

  43. Chemotherapy and/or immunotherapy are first-line treatments for advanced muscle-invasive bladder cancer (BCa), but the unsatisfactory objective response rate to these treatments yields poor 5-year patient surv...

    Authors: Jingtong Zhang, Qianghua Zhou, Keji Xie, Liang Cheng, Shengmeng Peng, Ruihui Xie, Lixuan Liu, Yangjie Zhang, Wen Dong, Jinli Han, Ming Huang, Yuelong Chen, Tianxin Lin, Jian Huang and Xu Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:203

    Content type: Research

    Published on:

  44. Nasopharyngeal carcinoma (NPC) represents a molecularly paradigmatic tumor given the complex diversity of environmental as well as host dependent factors that are closely implicated in tissue transformation an...

    Authors: Ramon Yarza, Mateo Bover, Maria Teresa Agulló-Ortuño and Lara Carmen Iglesias-Docampo

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:202

    Content type: Review

    Published on:

  45. Zinc transporters have been found to be associated with the pathogenesis of numerous human diseases including cancer. As the most lethal gynecologic malignancy, ovarian cancer is characterized by rapid progres...

    Authors: Xinxin Cheng, Jie Wang, Chunling Liu, Tianduo Jiang, Ningzhi Yang, Dan Liu, Huanhuan Zhao and Zhelong Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2021 40:199

    Content type: Research

    Published on:

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