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  1. Research

    Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells

    Multiple studies concluded that oncometabolites (e.g. D-2-hydroxyglutarate (2-HG) related to mutant isocitrate dehydrogenase 1/2 (IDH1/2) and lactate) have tumour promoting potential. Regulatory mechanisms implic...

    Zoltán Hujber, Gábor Petővári, Norbert Szoboszlai, Titanilla Dankó, Noémi Nagy, Csilla Kriston, Ildikó Krencz, Sándor Paku, Olivér Ozohanics, László Drahos, András Jeney and Anna Sebestyén

    Journal of Experimental & Clinical Cancer Research 2017 36:74

    Published on: 2 June 2017

  2. Research

    Intake of Boron, Cadmium, and Molybdenum enhances rat thyroid cell transformation

    Epidemiologic data in volcanic areas suggest that environmental factors might be involved in the increase of thyroid cancer (TC) incidence. Recent reports indicate that several heavy metals and metalloids are ...

    Emilia Luca, Laura Fici, Anna Ronchi, Ferdinando Marandino, Esther Diana Rossi, Maria Emiliana Caristo, Pasqualino Malandrino, Marco Russo, Alfredo Pontecorvi, Riccardo Vigneri and Fabiola Moretti

    Journal of Experimental & Clinical Cancer Research 2017 36:73

    Published on: 2 June 2017

  3. Research

    FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells

    Autophagy is a conserved catabolic process to degrade cellular organelles. The role of autophagy in cancer development is complex. Amplification of fibroblast growth factor receptor 1 (FGFR1) is one of the mos...

    Hong Yuan, Zi-Ming Li, Jiaxiang Shao, Wen-Xiang Ji, Weiliang Xia and Shun Lu

    Journal of Experimental & Clinical Cancer Research 2017 36:72

    Published on: 30 May 2017

  4. Review

    hrHPV E5 oncoprotein: immune evasion and related immunotherapies

    The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene i...

    Antonio Carlos de Freitas, Talita Helena Araújo de Oliveira, Marconi Rego Barros Jr. and Aldo Venuti

    Journal of Experimental & Clinical Cancer Research 2017 36:71

    Published on: 25 May 2017

  5. Research

    CIP2A mediates fibronectin-induced bladder cancer cell proliferation by stabilizing β-catenin

    Fibronectin (FN) is associated with tumorigenesis and progression in bladder cancer, however, the underlying mechanisms causing this remain largely unknown. Furthermore, cancerous inhibitor of protein phosphat...

    Fengbin Gao, Tianyuan Xu, Xianjin Wang, Shan Zhong, Shanwen Chen, Minguang Zhang, Xiaohua Zhang, Yifan Shen, Xiaojing Wang, Chen Xu and Zhoujun Shen

    Journal of Experimental & Clinical Cancer Research 2017 36:70

    Published on: 18 May 2017

  6. Erratum

    Erratum to: Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node, intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase

    Franco Di Filippo, Simona Di Filippo, Anna Maria Ferrari, Raffaele Antonetti, Alessandro Battaglia, Francesca Becherini, Laia Bernet, Renzo Boldorini, Catherine Bouteille, Simonetta Buglioni, Paolo Burelli, Rafael Cano, Vincenzo Canzonieri, Pierluigi Chiodera, Alfredo Cirilli, Luigi Coppola…

    Journal of Experimental & Clinical Cancer Research 2017 36:69

    Published on: 16 May 2017

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:193

  7. Research

    Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer

    Patients with metastatic or relapsed gallbladder cancer generally have a poor prognosis. Therefore, targeting metastasis is one arm of therapeutic strategies to treat gallbladder cancer.

    Fei Zhang, Qiang Ma, Zihang Xu, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Yijian Zhang, Lin Jiang, Yunping Hu, Zheng Wang, Xuefeng Wang, Yong Zhang, Wei Gong and Yingbin Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:68

    Published on: 15 May 2017

  8. Research

    Novel glycolipid agents for killing cisplatin-resistant human epithelial ovarian cancer cells

    Chemotherapy resistance is one of the major factors contributing to mortality from human epithelial ovarian cancer (EOC). Identifying drugs that can effectively kill chemotherapy-resistant EOC cells would be a...

    Amani I. Moraya, Jennifer L. Ali, Pranati Samadder, Lisa Liang, Ludivine Coudière Morrison, Tamra E. Werbowetski-Ogilvie, Makanjuola Ogunsina, Frank Schweizer, Gilbert Arthur and Mark W. Nachtigal

    Journal of Experimental & Clinical Cancer Research 2017 36:67

    Published on: 12 May 2017

  9. Research

    AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer

    AHNAK, also known as desmoyokin, is a giant protein with the molecular size of approximately 700 kDa and exerts diverse functions in different types of cancer.

    Bo Chen, Jin Wang, Danian Dai, Qingyu Zhou, Xiaofang Guo, Zhi Tian, Xiaojia Huang, Lu Yang, Hailin Tang and Xiaoming Xie

    Journal of Experimental & Clinical Cancer Research 2017 36:65

    Published on: 12 May 2017

  10. Research

    Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma

    The involvement of lipid metabolism in tumourigenesis and the progression of clear cell renal cell carcinoma (ccRCC) have been reported. However, the role of phospholipid profile alterations in ccRCC has not y...

    Yiqing Du, Qiang Wang, Xingzhong Zhang, Xiaofeng Wang, Caipeng Qin, Zhengzuo Sheng, Huaqi Yin, Changtao Jiang, Jing Li and Tao Xu

    Journal of Experimental & Clinical Cancer Research 2017 36:66

    Published on: 12 May 2017

  11. Research

    Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis

    As a relatively conservative transcriptional regulator in biological evolution, heat shock factor 1 (HSF1) is activated by, and regulates the expression of heat shock proteins (HSPs) in response to a variety o...

    Wenjin Liang, Yong Liao, Jing Zhang, Qi Huang, Wei Luo, Jidong Yu, Jianhua Gong, Yi Zhou, Xuan Li, Bo Tang, Songqing He and Jinghong Yang

    Journal of Experimental & Clinical Cancer Research 2017 36:64

    Published on: 8 May 2017

  12. Research

    FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients

    Epithelial ovarian cancer (EOC) is a spectrum of different diseases, which makes their treatment a challenge. Forkhead box M1 (FOXM1) is an oncogene aberrantly expressed in many solid cancers including serous ...

    Renata A. Tassi, Paola Todeschini, Eric R. Siegel, Stefano Calza, Paolo Cappella, Laura Ardighieri, Moris Cadei, Mattia Bugatti, Chiara Romani, Elisabetta Bandiera, Laura Zanotti, Laura Tassone, Donatella Guarino, Concetta Santonocito, Ettore D. Capoluongo, Luca Beltrame…

    Journal of Experimental & Clinical Cancer Research 2017 36:63

    Published on: 8 May 2017

  15. Research

    HIF-1α promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment

    The incidence and mortality rates of hepatocellular carcinoma (HCC) have steadily increased in recent years. A hypoxic microenvironment is one of the most important characteristics of solid tumors which has be...

    Meili Wang, Xiulan Zhao, Dongwang Zhu, Tieju Liu, Xiaohui Liang, Fang Liu, Yanhui Zhang, Xueyi Dong and Baocun Sun

    Journal of Experimental & Clinical Cancer Research 2017 36:60

    Published on: 27 April 2017

  16. Research

    Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer

    MicroRNAs are endogenously expressed, small non-coding RNAs that modulate gene expression by targeting specific mRNAs, resulting in translational repression or mRNA degradation. Although miR-584-5p has been re...

    Qing Li, Zheng Li, Song Wei, Weizhi Wang, Zheng Chen, Lei Zhang, Liang Chen, Bowen Li, Guangli Sun, Jianghao Xu, Qiang Li, Lu Wang, Zhipeng Xu, Yiwen Xia, Diancai Zhang, Hao Xu…

    Journal of Experimental & Clinical Cancer Research 2017 36:59

    Published on: 21 April 2017

  17. Research

    Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

    Hexokinase (HK) is the rate-limiting enzyme in the first reaction of glycolysis. And Hexokinase 2 (HK2) is most closely related to malignant tumor which expresses at higher level compared with normal cells. HK...

    Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min, Weiguang Sun, Lixia Chen, Guangya Xiang and Hua Li

    Journal of Experimental & Clinical Cancer Research 2017 36:58

    Published on: 20 April 2017

  18. Research

    Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis

    BRCA1 mutated breast cancers are commonly diagnosed as negative for classical hormone receptors i.e. estrogen receptor, progesterone receptor and/or Her2. Due to these common targets b...

    Sabine Heublein, Doris Mayr, Alfons Meindl, Alexandra Kircher, Udo Jeschke and Nina Ditsch

    Journal of Experimental & Clinical Cancer Research 2017 36:57

    Published on: 20 April 2017

  19. Research

    Genotypes of SLC22A4 and SLC22A5 regulatory loci are predictive of the response of chronic myeloid leukemia patients to imatinib treatment

    Through high-throughput next-generation sequencing of promoters of solute carrier and ATP-binding cassette genes, which encode drug transporters, we aimed to identify SNPs associated with the response to imati...

    Monika Jaruskova, Nikola Curik, Rajna Hercog, Vaclava Polivkova, Eliska Motlova, Vladimir Benes, Hana Klamova, Pavla Pecherkova, Petra Belohlavkova, Filip Vrbacky and Katerina Machova Polakova

    Journal of Experimental & Clinical Cancer Research 2017 36:55

    Published on: 18 April 2017

  20. Research

    Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels

    Grb2-associated binder 2 (Gab2) is a scaffolding protein that serves as a critical signaling amplifier downstream of tyrosine kinase receptors. Our previous study has shown that Gab2 induces epithelial-to-mese...

    Chenbo Ding, Junmin Luo, Xiaobo Fan, Longmei Li, Shanshan Li, Kunming Wen, Jihong Feng and Guoqiu Wu

    Journal of Experimental & Clinical Cancer Research 2017 36:56

    Published on: 18 April 2017

  21. Research

    Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-κB/Snail pathway

    Numerous studies have shown that long non-coding RNAs (lncRNAs) play key roles during multiple cancer processes, such as cell proliferation, apoptosis, migration and invasion. The previous studies found that N...

    Zhiliang Lu, Yuan Li, Jingnan Wang, Yun Che, Shouguo Sun, Jianbing Huang, Zhaoli Chen and Jie He

    Journal of Experimental & Clinical Cancer Research 2017 36:54

    Published on: 17 April 2017

  22. Research

    Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

    Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the mechanisms being not well understood. Recently, emerging evidence indicates ...

    Peiming Zheng, Lei Chen, Xiangliang Yuan, Qin Luo, Yi Liu, Guohua Xie, Yanhui Ma and Lisong Shen

    Journal of Experimental & Clinical Cancer Research 2017 36:53

    Published on: 13 April 2017

  23. Research

    The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation

    P73 antisense RNA 1 T (non-protein coding), also known as TP73-AS1, is a long non-coding RNA (lncRNA) which is involved in cell proliferation and the development of tumors. However, the exact effects and molec...

    Shaling Li, Yan Huang, Yun Huang, Yongming Fu, Daolin Tang, Rui Kang, Rongrong Zhou and Xue-gong Fan

    Journal of Experimental & Clinical Cancer Research 2017 36:51

    Published on: 12 April 2017

  24. Research

    Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition

    Osteosarcoma is the most frequent primary malignant bone tumor. Although survival has distinctly increased due to neoadjuvant chemotherapy in the past, patients with metastatic disease and poor response to che...

    Bernd Kubista, Thomas Schoefl, Lisa Mayr, Sushilla van Schoonhoven, Petra Heffeter, Reinhard Windhager, Bernhard K. Keppler and Walter Berger

    Journal of Experimental & Clinical Cancer Research 2017 36:52

    Published on: 12 April 2017

  25. Research

    iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling

    Epithelial–mesenchymal transition (EMT) and dysregulated microRNAs (miRNAs) have important roles in driving chemoresistance. We previously reported that iASPP is a key EMT inducer and could increase cisplatin ...

    Ying Xiong, Fei Sun, Peixin Dong, Hidemichi Watari, Junming Yue, Min-fei Yu, Chun-yan Lan, Yin Wang and Ze-biao Ma

    Journal of Experimental & Clinical Cancer Research 2017 36:48

    Published on: 11 April 2017

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