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  1. Research

    Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer

    Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of t...

    Bernhard Englinger, Sebastian Kallus, Julia Senkiv, Daniela Heilos, Lisa Gabler, Sushilla van Schoonhoven, Alessio Terenzi, Patrick Moser, Christine Pirker, Gerald Timelthaler, Walter Jäger, Christian R. Kowol, Petra Heffeter, Michael Grusch and Walter Berger

    Journal of Experimental & Clinical Cancer Research 2017 36:122

    Published on: 7 September 2017

  2. Research

    Ternary cocktail nanoparticles for sequential chemo-photodynamic therapy

    Previous clinical trials have already demonstrated that combinations of two or more drugs were more effective in the cancer treatment, especially sequential photodynamic design combing with sequential chemothe...

    Li Fan, Saisai Zhao, Qian Yang, Jiali Tan, Chaojun Song and Hong Wu

    Journal of Experimental & Clinical Cancer Research 2017 36:119

    Published on: 6 September 2017

  3. Research

    Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination

    Resistance to adjuvant radiotherapy is a major cause of treatment failure in patients with glioblastoma (GBM). Autophagy inhibitors have been shown to enhance the efficacy of radiotherapy for certain solid tum...

    Xin Zhang, Ran Xu, Chao Zhang, Yangyang Xu, Mingzhi Han, Bin Huang, Anjing Chen, Chen Qiu, Frits Thorsen, Lars Prestegarden, Rolf Bjerkvig, Jian Wang and Xingang Li

    Journal of Experimental & Clinical Cancer Research 2017 36:118

    Published on: 5 September 2017

  4. Research

    Maintenance of stemness is associated with the interation of LRP6 and heparin-binding protein CCN2 autocrined by hepatocellular carcinoma

    The overall response rate of hepatocellular carcinoma (HCC) to chemotherapy is poor. In our previous study, oxaliplatin-resistant HCC is found to exhibit an enhanced stemness, and increased levels of CCN2 and ...

    Qingan Jia, Yang Bu, Zhiming Wang, Bendong Chen, Qiangbo Zhang, Songning Yu and Qingguang Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:117

    Published on: 4 September 2017

  5. Research

    Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis

    Metastatic malignant melanoma is one of the most aggressive malignancies and its treatment remains challenging. Recent studies demonstrate that the melanoma metastasis has correlations with the heightened acti...

    Ping Zhou, Jiaqi Qin, Yuan Li, Guoxia Li, Yinsong Wang, Ning Zhang, Peng Chen and Chunyu Li

    Journal of Experimental & Clinical Cancer Research 2017 36:115

    Published on: 2 September 2017

  6. Research

    NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma

    NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response. However, the roles of NLRP3 inflammasome in the tumorigenesis and development of cancer stem cells (CS...

    Cong-Fa Huang, Lei Chen, Yi-Cun Li, Lei Wu, Guang-Tao Yu, Wen-Feng Zhang and Zhi-Jun Sun

    Journal of Experimental & Clinical Cancer Research 2017 36:116

    Published on: 2 September 2017

  7. Research

    Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1)

    The potential mechanisms regarding how methylation of microRNA(miRNA) CpG Island could regulate cancer cell chemo-resistance remains unclear. This study aims to explore the epigenetic dysregulation mechanism o...

    Yixue Gu, Zhijie Zhang, Jiang Yin, Jiahui Ye, Yin Song, Hao Liu, Yan Xiong, Minying Lu, Guopei Zheng and Zhimin He

    Journal of Experimental & Clinical Cancer Research 2017 36:114

    Published on: 31 August 2017

  8. Research

    Exosomes isolated from cancer patients’ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells

    Horizontal transfer of malignant traits from the primary tumor to distant organs, through blood circulating factors, has recently become a thoroughly studied metastatic pathway to explain cancer dissemination....

    Mohamed Abdouh, Dana Hamam, Zu-Hua Gao, Vincenzo Arena, Manuel Arena and Goffredo Orazio Arena

    Journal of Experimental & Clinical Cancer Research 2017 36:113

    Published on: 30 August 2017

  9. Research

    Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma

    Chemotherapy is one of major therapeutic regimens for neuroblastoma (NB) in children. However, recurrence and metastasis associated with poor prognosis caused by acquired multidrug resistance remains a challen...

    Yi Wang, Kai Chen, Yihong Cai, Yuanxia Cai, Xiaojun Yuan, Lifeng Wang, Zhixiang Wu and Yeming Wu

    Journal of Experimental & Clinical Cancer Research 2017 36:111

    Published on: 16 August 2017

  10. Research

    Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism

    Radiotherapy has been used increasingly to treat primary hepatocellular carcinoma. Clinically, the main cause of radiotherapy failure is cellular radioresistance, conferred via glycolytic metabolism. Our previ...

    Li Yu, Yifan Sun, Jingjing Li, Yan Wang, Yuxing Zhu, Yong Shi, Xiaojun Fan, Jianda Zhou, Ying Bao, Jie Xiao, Ke Cao and Peiguo Cao

    Journal of Experimental & Clinical Cancer Research 2017 36:110

    Published on: 15 August 2017

  11. Research

    The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells

    Glioblastoma (GBM) is a highly migratory, invasive, and angiogenic brain tumor. Like vascular endothelial growth factor-A (VEGF-A), placental growth factor (PlGF) promotes GBM angiogenesis. VEGF-A is a ligand ...

    Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Lucia Lisi, Elena Bonanno, Manuel Scimeca, Eskil Eskilsson, Thomas Daubon, Hrvoje Miletic, Lucia Ricci Vitiani, Roberto Pallini, Pierluigi Navarra, Rolf Bjerkvig, Stefania D’Atri, Pedro Miguel Lacal…

    Journal of Experimental & Clinical Cancer Research 2017 36:106

    Published on: 10 August 2017

  12. Research

    Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)

    Pancreatic cancer is susceptible to gemcitabine resistance, and patients receive less benefit from gemcitabine chemotherapy. Previous studies report that gambogic acid possesses antineoplastic properties; howe...

    Guanggai Xia, Hongcheng Wang, Ziliang Song, Qingcai Meng, Xiuyan Huang and Xinyu Huang

    Journal of Experimental & Clinical Cancer Research 2017 36:107

    Published on: 10 August 2017

  13. Review

    Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids

    Under hypoxic conditions, tumor cells undergo a series of adaptations that promote evolution of a more aggressive tumor phenotype including the activation of DNA damage repair proteins, altered metabolism, and...

    Stephen Riffle and Rashmi S. Hegde

    Journal of Experimental & Clinical Cancer Research 2017 36:102

    Published on: 3 August 2017

  14. Research

    Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer

    Twist1 is involved in tumor initiation and progression, which especially contributes to tumor invasion and metastasis. Wogonoside is the main in-vivo metabolite of wogonin, and it is also a natural product wit...

    Yuyuan Yao, Kai Zhao, Zhou Yu, Haochuan Ren, Li Zhao, Zhiyu Li, Qinglong Guo and Na Lu

    Journal of Experimental & Clinical Cancer Research 2017 36:103

    Published on: 3 August 2017

  15. Research

    Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis

    Ferritin plays a central role in the intracellular iron metabolism; the molecule is a nanocage of 24 subunits of the heavy and light types. The heavy subunit (FHC) is provided of a ferroxidase activity and thu...

    I. Aversa, F. Zolea, C. Ieranò, S. Bulotta, A. M. Trotta, M. C. Faniello, C. De Marco, D. Malanga, F. Biamonte, G. Viglietto, G. Cuda, S. Scala and F. Costanzo

    Journal of Experimental & Clinical Cancer Research 2017 36:104

    Published on: 3 August 2017

  16. Research

    Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells

    Epidermal growth factor receptor (EGFR) plays a pivotal role in the pathophysiology of esophageal squamous cell carcinoma (ESCC). However, the clinical effects of EGFR inhibitors on ESCC are controversial. Thi...

    Masahiro Yoshioka, Shinya Ohashi, Tomomi Ida, Yukie Nakai, Osamu Kikuchi, Yusuke Amanuma, Junichi Matsubara, Atsushi Yamada, Shin’ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa, Tsutomu Chiba, Hiroshi Seno and Manabu Muto

    Journal of Experimental & Clinical Cancer Research 2017 36:101

    Published on: 1 August 2017

  17. Research

    Regulation of human glioma cell apoptosis and invasion by miR-152-3p through targeting DNMT1 and regulating NF2

    MiRNAs are involved in aberrant DNA methylation through regulation of DNA methyltransferases (DNMTs) in the pathogenesis and progression of glioblastomas (GBM). MiR-152-3p was down-expressed in human malignanc...

    Jin Sun, Xinhua Tian, Junqing Zhang, Yanlin Huang, Xiaoning Lin, Luyue Chen and Shizhong Zhang

    Journal of Experimental & Clinical Cancer Research 2017 36:100

    Published on: 1 August 2017

  18. Research

    miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma

    miR-500a-3p has been demonstrated to be involved in the development, progression and metastasis in several human cancers. Constitutive activation of JAK/STAT3 signaling pathway has been reported to play an imp...

    Chunlin Jiang, Jianting Long, Baoxian Liu, Ming Xu, Wei Wang, Xiaoyan Xie, Xiaolin Wang and Ming Kuang

    Journal of Experimental & Clinical Cancer Research 2017 36:99

    Published on: 27 July 2017

  19. Review

    Curcumin: the spicy modulator of breast carcinogenesis

    Worldwide breast cancer is the most common cancer in women. For many years clinicians and the researchers are examining and exploring various therapeutic modalities for breast cancer. Yet the disease has remai...

    Urmila Banik, Subramani Parasuraman, Arun Kumar Adhikary and Nor Hayati Othman

    Journal of Experimental & Clinical Cancer Research 2017 36:98

    Published on: 19 July 2017

  20. Research

    Ibrutinib, a Bruton’s tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma

    Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor, is a novel anticancer drug used for treating several types of cancers....

    Jin Wang, Xiaoyang Liu, Yongzhi Hong, Songtao Wang, Pin Chen, Aihua Gu, Xiaoyuan Guo and Peng Zhao

    Journal of Experimental & Clinical Cancer Research 2017 36:96

    Published on: 17 July 2017

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