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  1. SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in ...

    Authors: Andrea Sacconi, Sara Donzelli, Claudio Pulito, Stefano Ferrero, Francesca Spinella, Aldo Morrone, Marta Rigoni, Fulvia Pimpinelli, Fabrizio Ensoli, Giuseppe Sanguineti, Raul Pellini, Nishant Agrawal, Evgeny Izumchenko, Gennaro Ciliberto, Aldo Giannì, Paola Muti…
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:200
    Content type: Research Published on:

  2. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xun Wang, Zhenlong Yu, Chao Wang, Wei Cheng, Xiangge Tian, Xiaokui Huo, Yan Wang, Chengpeng Sun, Lei Feng, Jinshan Xing, Yulong Lan, Dongdong Sun, Qingjuan Hou, Baojing Zhang, Xiaochi Ma and Bo Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:199
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:93

  3. Advanced colorectal adenocarcinoma (CRAC), featured by distinctive histopathological appearance, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a group of heterogeneous cancers...

    Authors: Hang-Ping Yao, Xiang-Min Tong, Rachel Hudson and Ming-Hai Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:198
    Content type: Review Published on:

  4. Autophagy is an intracellular process through which intracellular components are recycled in response to nutrient or growth factor deficiency to maintain homeostasis. We identified the peptide autophagy-relate...

    Authors: Yang Yang, Qi Wang, Dongjian Song, Ruirui Zen, Lei Zhang, Yingjun Wang, Heying Yang, Da Zhang, Jia Jia, Jiao Zhang and Jiaxiang Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:197
    Content type: Research Published on:

  5. Glioblastoma is the most common primary malignant intracranial tumor with poor clinical prognosis in adults. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) function as important regulators...

    Authors: Xiaoming Zhang, Wanxiang Niu, Maolin Mu, Shanshan Hu and Chaoshi Niu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:196
    Content type: Research Published on:

  6. Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment. Among this class of drugs, ponatinib (PON) has been shown to have...

    Authors: Diana Corallo, Fabio Pastorino, Marcella Pantile, Elena Mariotto, Federico Caicci, Giampietro Viola, Mirco Ponzoni, Gian Paolo Tonini and Sanja Aveic
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:195
    Content type: Research Published on:

  7. Nuclear casein kinase and cyclin-dependent kinase substrate (NUCKS), a novel gene first reported in 2001, is a member of the high mobility group (HMG) family. Although very little is known regarding the biolog...

    Authors: Erhu Zhao, Liying Feng, Longchang Bai and Hongjuan Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:194
    Content type: Research Published on:

  8. Angiogenesis, a basic requirement for tumor cell survival, is considered to be a malignant characteristic of small cell lung cancer (SCLC) and is closely related to the poor outcomes of SCLC patients. miR-141 ...

    Authors: Shuangshuang Mao, Zhiliang Lu, Sufei Zheng, Hao Zhang, Guochao Zhang, Feng Wang, Jianbing Huang, Yuanyuan Lei, Xinfeng Wang, Chengming Liu, Nan Sun and Jie He
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:193
    Content type: Research Published on:

  9. The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the mo...

    Authors: Yuhao Zhang, Xiuchao Geng, Qiang Li, Jianglong Xu, Yanli Tan, Menglin Xiao, Jia Song, Fulin Liu, Chuan Fang and Hong Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:192
    Content type: Review Published on:

  10. Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be in...

    Authors: Sifeng Tao, Qiang Chen, Chen Lin and Haiying Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:191
    Content type: Research Published on:

  11. Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been testified to be overexpressed in prostate cancer and strongly related to patients’ poor prognosis. However, the functions of ...

    Authors: Xiang Zhang, Dawei Wang, Boke Liu, Xingwei Jin, Xianjin Wang, Junwei Pan, Weichao Tu and Yuan Shao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:190
    Content type: Research Published on:

  12. Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs)...

    Authors: Alberto Ocaña and Atanasio Pandiella
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:189
    Content type: Review Published on:

  13. Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle t...

    Authors: Yilan Yang, Jurui Luo, Xingxing Chen, Zhaozhi Yang, Xin Mei, Jinli Ma, Zhen Zhang, Xiaomao Guo and Xiaoli Yu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:188
    Content type: Review Published on:

  14. Natural antisense transcripts (NATs), which are transcribed from opposite strands of DNA with partial or complete overlap, affect multiple stages of gene expression, from epigenetic to post-translational modif...

    Authors: Shanshan Zhao, Xue Zhang, Shuo Chen and Song Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:187
    Content type: Review Published on:

  15. Bladder cancer (BC) is a common genitourinary malignancy worldwide. Circular RNAs (circRNAs) participate in cancer development, including BC; thus, the roles of circRNAs in this process have attracted signific...

    Authors: Mingming Jin, Shengjie Lu, Yue Wu, Chen Yang, Chunzi Shi, Yanqiu Wang and Gang Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:186
    Content type: Research Published on:

  16. Molecular oxygen (O2) is a universal electron acceptor that is eventually synthesized into ATP in the mitochondrial respiratory chain of all metazoans. Therefore, hypoxia biology has become an organizational prin...

    Authors: Mingyao Huang, Liang Yang, Xueqiang Peng, Shibo Wei, Qing Fan, Shuo Yang, Xinyu Li, Bowen Li, Hongyuan Jin, Bo Wu, Jingang Liu and Hangyu Li
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:185
    Content type: Review Published on:

  17. The activator protein-1 (AP-1) family of transcription factors modulate a diverse range of cellular signalling pathways into outputs which can be oncogenic or anti-oncogenic. The transcription of relevant gene...

    Authors: Andrew Brennan, James T. Leech, Neil M. Kad and Jody M. Mason
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:184
    Content type: Review Published on:

  18. NEK2, a serine/threonine kinase involved in mitosis, has been found to function in chromosome instability, tumor progression and metastasis, but its role in cervical cancer radioresistance remains unknown.

    Authors: Tie Xu, Yulan Zeng, Linli Shi, Qin Yang, Yeshan Chen, Gang Wu, Guiling Li and Shuangbing Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:183
    Content type: Research Published on:

  19. Glioma is the most common and lethal primary brain tumor in adults, and angiogenesis is one of the key factors contributing to its proliferation, aggressiveness, and malignant transformation. However, the disc...

    Authors: Yang Jiang, Jinpeng Zhou, Junshuang Zhao, Haiying Zhang, Long Li, Hao Li, Lian Chen, Jiangfeng Hu, Wei Zheng and Zhitao Jing
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:182
    Content type: Research Published on:

  20. Nicotine, an active ingredient in tobacco, can promote epithelial-to-mesenchymal transition (EMT) processes that enhance the aggressiveness of a number of human cancers. In the present study, we investigated w...

    Authors: Qiwen Ben, Wei An, Yunwei Sun, Aihua Qian, Jun Liu, Duowu Zou and Yaozong Yuan
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:181
    Content type: Research Published on:

  21. Triple-negative breast cancer (TNBC) is a uniquely aggressive cancer with high rates of relapse due to resistance to chemotherapy. TNBC expresses higher levels of programmed cell death-ligand 1 (PD-L1) compare...

    Authors: Simona Camorani, Margherita Passariello, Lisa Agnello, Silvia Esposito, Francesca Collina, Monica Cantile, Maurizio Di Bonito, Ilya V. Ulasov, Monica Fedele, Antonella Zannetti, Claudia De Lorenzo and Laura Cerchia
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:180
    Content type: Research Published on:

  22. Accumulating evidence demonstrates the essential role of long non-coding RNA (lncRNA) in various types of cancers, including pancreatic cancer. However, the functions and regulation mechanism of lncRNA PMSB8-A...

    Authors: Hao Zhang, Changhao Zhu, Zhiwei He, Shiyu Chen, Lin Li and Chengyi Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:179
    Content type: Research Published on:

  23. Osteosarcoma (OS) is the most common primary bone malignancy and responsible for considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although neoadjuvant chemotherapy has improv...

    Authors: Juncheng Cui, Dylan Dean, Francis J. Hornicek, Zhiwei Chen and Zhenfeng Duan
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:178
    Content type: Review Published on:

  24. A pronounced polarization of healthcare resources and workforce towards the prevention of the rapid spread of SARS-CoV-2 occurred at the expenses of the majority of chronic diseases and cancer, thus jeopardizi...

    Authors: Assunta De Luca, Francesco Ripa di Meana, Branka Vujovic, Aldo Morrone, Chiara Degirolamo, Gennaro Ciliberto and Tiziana Lavalle
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:177
    Content type: Commentary Published on:

  25. Exosomes are emerging as important mediators of the cross-talk between tumor cells and the microenvironment. The communication between tumor-derived exosomes and macrophages has a critical role in facilitating...

    Authors: Manman Liang, Xingwu Chen, Lijing Wang, Lilong Qin, Hanli Wang, Zhengui Sun, Wenying Zhao and Biao Geng
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:176
    Content type: Research Published on:

  26. Overexpression of eukaryotic translation initiation factor 3H (EIF3H) predicts cancer progression and poor prognosis, but the mechanism underlying EIF3H as an oncogene remains unclear in esophageal squamous ce...

    Authors: Xiaobin Guo, Rui Zhu, Aiping Luo, Honghong Zhou, Fang Ding, Hongxin Yang and Zhihua Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:175
    Content type: Research Published on:

  27. Inhibition of p38 MAPK signalling leads to glioblastoma multiform (GBM) tumourigenesis. Nevertheless, the molecular mechanism that induces p38 MAPK signalling pathway silencing during GBM genesis has yet to be...

    Authors: Yang Xu, Qian Sun, Fan’en Yuan, Huimin Dong, Huikai Zhang, Rongxin Geng, Yangzhi Qi, Xiaoxing Xiong, Qianxue Chen and Baohui Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:174
    Content type: Research Published on:

  28. A number of novel anticancer drugs have been developed in recent years. However, the mortality of cancer patients remains high because of the emergence of drug resistance. It was reported that drug resistance ...

    Authors: Cheng Yang, Jiayu Zhang, Yukui Ma, Chunfu Wu, Wei Cui and Lihui Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:173
    Content type: Review Published on:

  29. Lysine succinylation is an emerging posttranslational modification that has garnered increased attention recently, but its role in gastric cancer (GC) remains underexplored.

    Authors: Xiang Li, Chen Zhang, Ting Zhao, Zhongping Su, Mengjing Li, Jiancheng Hu, Jianfei Wen, Jiajia Shen, Chao Wang, Jinshun Pan, Xianmin Mu, Tao Ling, Yingchang Li, Hao Wen, Xiaoren Zhang and Qiang You
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:172
    Content type: Research Published on:

  30. The Covid-19 pandemic has challenged hard the national health systems worldwide. According to the national policy issued in March 2020 in response to the evolving Covid-19 pandemic, several hospitals were re-c...

    Authors: Fabio Pelle, Sonia Cappelli, Franco Graziano, Loredana Piarulli, Flavia Cavicchi, Domenico Magagnano, Assunta De Luca, Roy De Vita, Marcello Pozzi, Maurizio Costantini, Antonio Varanese, Massimo Panimolle, Pietro Paolo Gullo, Maddalena Barba, Patrizia Vici, Enrico Vizza…
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:171
    Content type: Commentary Published on:

  31. The platinum-based chemotherapy is the first-line regimen for the treatment of Non-small cell lung cancer (NSCLC). However, the therapeutic efficiency is largely limited by tenacious chemo-insensitivity that r...

    Authors: Boshi Wang, Tiantian Jing, Weilin Jin, Jinnan Chen, Chengsi Wu, Mingrong Wang and Yizhen Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:170
    Content type: Research Published on:

  33. cAMP responsive element binding protein 5 (CREB5) is a transcriptional activator in eukaryotic cells that can regulate gene expression. Previously, we found that CREB5 was involved in the occurrence and develo...

    Authors: Shuyang Wang, Junfeng Qiu, Lei Liu, Cailin Su, Lu Qi, Chengmei Huang, Xiaoning Chen, Yaxin Zhang, Yaping Ye, Yanqing Ding, Li Liang and Wenting Liao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:168
    Content type: Research Published on:

  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Weiwei Sheng, Xiaoyang Shi, Yiheng Lin, Jingtong Tang, Chao Jia, Rongxian Cao, Jian Sun, Guosen Wang, Lei Zhou and Ming Dong
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:167
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:16

  35. Nasopharyngeal carcinoma (NPC) is an epithelial cancer emerging from the lining of nasopharyngeal mucosa, with extremely frequent occurrence in east and southeast Asia. For the purpose of exploring roles of th...

    Authors: Xiang Qing, Guo-lin Tan, Huo-wang Liu, Wei Li, Jin-gang Ai, Shan-shan Xiong, Meng-qing Yang and Tian-sheng Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:166
    Content type: Research Published on:

  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qiaoge Zhang, Ge Song, Lili Yao, Yankun Liu, Min Liu, Shengping Li and Hua Tang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:165
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:14

  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zichao Li, Luying Zhang, Mingquan Gao, Mei Han, Kaili Liu, Zhuang Zhang, Zhi Gong, Lifei Xing, Xianzhou Shi, Kui Lu and Hui Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:164
    Content type: Retraction Note Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:8

  38. As metastasis is a major cause of death in cancer patients, new anti-metastatic strategies are needed to improve cancer therapy outcomes. Numerous pathways have been shown to contribute to migration and invasi...

    Authors: Madiha Kanwal, Michal Smahel, Mark Olsen, Jana Smahelova and Ruth Tachezy
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:163
    Content type: Review Published on:

  39. Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metas...

    Authors: Yue Ning, Hongmei Zheng, Yuting Zhan, Sile Liu, Yang yang, Hongjing Zang, Jiadi Luo, Qiuyuan Wen and Songqing Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:162
    Content type: Review Published on:

  40. Estrogen receptor α (ERα) signaling is a defining and driving event in most breast cancers; ERα is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) ...

    Authors: Ana Luísa Cartaxo, Marta F. Estrada, Giacomo Domenici, Ruben Roque, Fernanda Silva, Emilio J. Gualda, Pablo Loza-Alvarez, George Sflomos, Cathrin Brisken, Paula M. Alves, Saudade André and Catarina Brito
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:161
    Content type: Research Published on:

  41. Colorectal cancer (CRC) is one of the causes of cancer-related death worldwide. The aim of our study was to disclose the expression pattern and underlying molecular mechanism of circular RNA TADA2A (circTADA2A...

    Authors: Zhen Li, Hongyu Yao, Shihao Wang, Guobin Li and Xiaoming Gu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:160
    Content type: Research Published on:

  42. Emerging evidence has shown that dysregulated expression of long noncoding RNAs (lncRNAs) is implicated in liver hepatocellular carcinoma (HCC). However, the role and molecular mechanism of differentially expr...

    Authors: Hui He, Yawei Wang, Peng Ye, Dehui Yi, Ying Cheng, Haibo Tang, Zhi Zhu, Xun Wang and Shi Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:159
    Content type: Research Published on:

  43. Chemoresistance is emerging as a major barrier to successful treatment in acute myeloid leukemia (AML), and evasion of apoptosis is among the fundamental underlying mechanisms. Therefore, unraveling molecular ...

    Authors: Yihua Pang, Yanan Zhao, Yan Wang, Xinlu Wang, Ruiqing Wang, Na Liu, Peng Li, Min Ji, Jingjing Ye, Tao Sun, Jingxin Li, Daoxin Ma, Fei Lu and Chunyan Ji
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:158
    Content type: Research Published on:

  44. Many cancer-associated single nucleotide polymorphisms (SNPs) are located in the genomic regions of long non-coding RNAs (lncRNAs). Mechanisms of these SNPs in connection to cancer risk are not fully understood.

    Authors: Tienan Feng, Nannan Feng, Tengteng Zhu, Qiang Li, Qi Zhang, Yu Wang, Ming Gao, Baosen Zhou, Herbert Yu, Min Zheng and Biyun Qian
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:157
    Content type: Research Published on:

  45. Breast cancer (BC) is a malignant breast tumor confronted with high invasion, metastasis and recurrence rate, and adipocytes are the largest components in breast tissue. The aberrant adipocytes, especially the...

    Authors: Chongru Zhao, Min Wu, Ning Zeng, Mingchen Xiong, Weijie Hu, Wenchang Lv, Yi Yi, Qi Zhang and Yiping Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:156
    Content type: Review Published on:

  46. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yanxia Huang, Jing Zhang, Lidan Hou, Ge Wang, Hui Liu, Rui Zhang, Xiaoyu Chen and Jinshui Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:155
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:194

  47. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Kun Qiao, Shipeng Ning, Lin Wan, Hao Wu, Qin Wang, Xingda Zhang, Shouping Xu and Da Pang
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:154
    Content type: Correction Published on:

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:418

  48. Hypoxia plays a relevant role in tumor-related inflammation toward the metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β (IL-β) and its cognate receptor IL1R1 contribute...

    Authors: Rosamaria Lappano, Marianna Talia, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Domenica Scordamaglia, Rita Guzzi, Anna Maria Miglietta, Ernestina Marianna De Francesco, Antonino Belfiore, Andrew H. Sims and Marcello Maggiolini
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:153
    Content type: Research Published on:

  49. Type 1 and 2 diabetes confer an increased risk of pancreatic cancer (PaC) of similar magnitude, suggesting a common mechanism. The recent finding that PaC incidence increases linearly with increasing fasting g...

    Authors: Stefano Menini, Carla Iacobini, Luisa de Latouliere, Isabella Manni, Martina Vitale, Emanuela Pilozzi, Carlo Pesce, Paola Cappello, Francesco Novelli, Giulia Piaggio and Giuseppe Pugliese
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:152
    Content type: Research Published on:

  50. Pancreatic cancer (PC) is one of the most aggressive cancers and has an extremely poor prognosis worldwide. Long noncoding RNA (lncRNA) has been reported to be a potential prognostic biomarker in the initiatio...

    Authors: Qing Han, Junhe Li, Jianping Xiong and Zhiwang Song
    Citation: Journal of Experimental & Clinical Cancer Research 2020 39:151
    Content type: Research Published on:

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Journal of Experimental & Clinical Cancer Research

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