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  1. Bladder cancer (BC) is a common urothelial malignancy, characterized by a high recurrence rate. The biology of bladder cancer is complex and needs to be deciphered. The latest evidence reveals the critical rol...

    Authors: Cornelia Braicu, Rares Buiga, Roxana Cojocneanu, Mihail Buse, Lajos Raduly, Laura Ancuta Pop, Sergiu Chira, Liviuta Budisan, Ancuta Jurj, Cristina Ciocan, Lorand Magdo, Alexandru Irimie, Florentin Dobrota, Bogdan Petrut and Ioana Berindan-Neagoe
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:433
  2. Inefficient T-cell access to the tumor microenvironment (TME) is among the causes of tumor immune-resistance. Previous evidence demonstrated that targeting CXCR4 improves anti-PD-1/PD-L1 efficacy reshaping TME...

    Authors: Crescenzo D’Alterio, Maria Buoncervello, Caterina Ieranò, Maria Napolitano, Luigi Portella, Giuseppina Rea, Antonio Barbieri, Antonio Luciano, Giosuè Scognamiglio, Fabiana Tatangelo, Anna Maria Anniciello, Mario Monaco, Ernesta Cavalcanti, Piera Maiolino, Giulia Romagnoli, Claudio Arra…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:432
  3. Pancreatic cancer is one of the most lethal malignancies due to frequent late diagnosis, aggressive tumor growth and metastasis formation. Continuously raising incidence rates of pancreatic cancer and a lack o...

    Authors: Claudia M. Kowolik, Min Lin, Jun Xie, Larry E. Overman and David A. Horne
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:431
  4. miR-133a-3p has been recently discovered to be down-regulated in various human malignancies, including breast cancer, and reduced miR-133a-3p levels have been significantly associated with breast cancer cell g...

    Authors: Wanyue Shi, Tingting Tang, Xinping Li, Siwei Deng, Ruiyi Li, Yingshan Wang, Yifei Wang, Tiansong Xia, Yanfeng Zhang, Ke Zen, Liang Jin and Yi Pan
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:429
  5. BMP3 gene is often found hypermethylated and hence inactivated in several types of cancers including colorectal cancer (CRC), indicating that it has a suppressor role in carcinogenesis. Though BMP3 is a reliab...

    Authors: Jialing Wen, Xianglin Liu, Yan Qi, Feng Niu, Zhitong Niu, Wenjing Geng, Zhaowei Zou, Renli Huang, Jianping Wang and Hongzhi Zou
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:428
  6. A promising strategy to overcome the chemoresistance is the tumor blood vessel normalization, which restores the physiological perfusion and oxygenation of tumor vasculature. Thalidomide (Thal) has been shown ...

    Authors: Yanwei Shen, Shuting Li, Xin Wang, Mengying Wang, Qi Tian, Jiao Yang, Jichang Wang, Biyuan Wang, Peijun Liu and Jin Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:427
  7. Polo-like kinase 3 (PLK3) has been documented as a tumor suppressor in several types of malignancies. However, the role of PLK3 in colorectal cancer (CRC) progression and glucose metabolism remains to be known.

    Authors: Baochi Ou, Hongze Sun, Jingkun Zhao, Zhuoqing Xu, Yuan Liu, Hao Feng and Zhihai Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:426
  8. In the original publication of this article, [1] the affiliation for Katia Scotlandi needs to be revised, because the author prefers using its Italian name: Experimental Oncology Lab, Experimental Oncology Lab...

    Authors: Claudia Chiodoni, Maria Teresa Di Martino, Francesca Zazzeroni, Michele Caraglia, Massimo Donadelli, Stefania Meschini, Carlo Leonetti and Katia Scotlandi
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:425

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:128

  9. Merkel cell carcinomas (MCCs) are rare, aggressive, therapeutically-challenging skin tumours that are increasing in incidence and have poor survival rates. The majority are caused by genomic Merkel cell polyom...

    Authors: Lucia Cappabianca, Stefano Guadagni, Rita Maccarone, Michela Sebastiano, Alessandro Chiominto, Antonietta Rosella Farina and Andrew Reay Mackay
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:424
  10. Galectins are beta-galactose specific binding proteins. In human cancers, including hepatocellular carcinoma (HCC), galectin-1 (Gal-1) is often found to be overexpressed. In order to combat the dismal diagnosi...

    Authors: Zoe Leung, Frankie Chi Fat Ko, Sze Keong Tey, Ernest Man Lok Kwong, Xiaowen Mao, Bonnie Hei Man Liu, Angel Po Yee Ma, Yi Man Eva Fung, Chi-Ming Che, Danny Ka Ho Wong, Ching Lung Lai, Irene Oi-Lin Ng and Judy Wai Ping Yam
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:423
  11. Cancer-initiating cell (CIC), a functionally homogeneous stem-like cell population, is resonsible for driving the tumor maintenance and metastasis, and is a source of chemotherapy and radiation-therapy resista...

    Authors: Jinhua Wang, Yajing Xing, Yingying Wang, Yundong He, Liting Wang, Shihong Peng, Lianfang Yang, Jiuqing Xie, Xiaotao Li, Wenwei Qiu, Zhengfang Yi and Mingyao Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:422
  12. The monocyte chemoattractant protein-induced protein (MCPIP) family consists of 4 members (MCPIP1–4) encoded by the ZC3h12A-D genes, which are located at different loci. The common features of MCPIP proteins are ...

    Authors: Katarzyna Miekus, Jerzy Kotlinowski, Agata Lichawska-Cieslar, Janusz Rys and Jolanta Jura
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:421
  13. Glioblastoma is the most common and aggressive brain tumour in adults with a median overall survival of only 14 months after standard therapy with radiation therapy (IR) and temozolomide (TMZ). In a novel mult...

    Authors: Ina Patties, Sonja Kallendrusch, Lisa Böhme, Eva Kendzia, Henry Oppermann, Frank Gaunitz, Rolf-Dieter Kortmann and Annegret Glasow
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:420
  14. Until very few years ago, the oncology community dogmatically excluded any clinical potential for immunotherapy in controlling brain metastases. Therefore, despite the significant therapeutic efficacy of monoc...

    Authors: Anna Maria Di Giacomo, Monica Valente, Alfonso Cerase, Maria Fortunata Lofiego, Francesca Piazzini, Luana Calabrò, Elisabetta Gambale, Alessia Covre and Michele Maio
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:419
  15. An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play essential roles in tumor initiation and progression. LncRNAs act as tumor promoters or suppressors by targeting specific genes...

    Authors: Kun Qiao, Shipeng Ning, Lin Wan, Hao Wu, Qin Wang, Xingda Zhang, Shouping Xu and Da Pang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:418

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:154

  16. MEIS2 has been identified as one of the key transcription factors in the gene regulatory network in the development and pathogenesis of human cancers. Our study aims to identify the regulatory mechanisms of ME...

    Authors: Lei Guan, Ting Li, Nanping Ai, Wei Wang, Bing He, Yanxia Bai, Zhaocai Yu, Mingyue Li, Shanshan Dong, Qingge Zhu, Xiao Xiao Ding, Shiming Zhang, Ming li, Guangbo Tang, Xiaochun Xia, Jing Zhao…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:417
  17. At the beginning of tumorigenesis, newly born cancer cells must successfully avoid attack by the immune system. Although most abnormal cells are efficiently identified and destroyed by the immune system, parti...

    Authors: Kotaro Saga, Jinhee Park, Keisuke Nimura, Norihiko Kawamura, Airi Ishibashi, Norio Nonomura and Yasufumi Kaneda
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:416
  18. In the original publication of this manuscript [1], Fig. 5E lower panel was incorrect due to an error in the preparation of these figures for publication. It was noticed that in the lower panel of Fig. 5E, one...

    Authors: Huiling Lai, Xuejiao Zhao, Yu Qin, Yi Ding, Ruqi Chen, Guannan Li, Marilyne Labrie, Zhiyong Ding, Jianfeng Zhou, Junbo Hu, Ding Ma, Yong Fang and Qinglei Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:415

    The original article was published in Journal of Experimental & Clinical Cancer Research 2018 37:32

  19. Tamoxifen resistance presents a huge clinical challenge for breast cancer patients. An understanding of the mechanisms of tamoxifen resistance can guide development of efficient therapies to prevent drug resis...

    Authors: Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul R. Thompson, Scott A. Coonrod, Xiaoqiu Liu and Xuesen Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:414
  20. CyclinD1 is crucial for cell cycling and can regulate the expression of Dicer, a crucial regulator of microRNA maturation. However, little is known on how CyclinD1 regulates Dicer and miRNA expression, and the...

    Authors: Yongqiang Qi, Da Wang, Wenhua Huang, Bing Wang, Di Huang, Fei Xiong, Xiaoping Chen and Yongjun Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:413
  21. The transcription factor HOXD9 is one of the members of the HOX family, which plays an important role in neoplastic processes. However, the role of HOXD9 in the growth and metastasis of gastric cancer (GC) rem...

    Authors: Huiqiong Zhu, Weiyu Dai, Jiaying Li, Li Xiang, Xiaosheng Wu, Weimei Tang, Yaying Chen, Qiong Yang, Mengwei Liu, Yizhi Xiao, Wenjing Zhang, Jianjiao Lin, Jing Wang, Guangnan Liu, Yong Sun, Ping Jiang…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:412
  22. Long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP), has been demonstrated to be a vital biomarker when evaluating the prognosis of multiple cancers. Nevertheless, the potential function of...

    Authors: Anquan Shang, Weiwei Wang, Chenzheng Gu, Chen Chen, Bingjie Zeng, Yibao Yang, Ping Ji, Junjun Sun, Junlu Wu, Wenying Lu, Zujun Sun and Dong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:411
  23. UFM1 has been found to be involved in the regulation of tumor development. This study aims to clarify the role and potential molecular mechanisms of UFM1 in the invasion and metastasis of gastric cancer.

    Authors: Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Sheng-Liang Qiu, Changhwan Yoon, Ning-Zi Lian, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ying-Hong Yang, Chang-Ming Huang, Chao-Hui Zheng…
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:410

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:307

  24. ATPase associated with a variety of cellular activities (AAA ATPase) family members are closely linked to tumor formation and progression. However, their roles in hepatocellular carcinoma (HCC) largely remain ...

    Authors: Meng-Xuan Zhu, Chuan-Yuan Wei, Peng-Fei Zhang, Dong-Mei Gao, Jie Chen, Yan Zhao, Shuang-Shuang Dong and Bin-Bin Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:409

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:443

  25. Replication-competent oncolytic viruses (OVs) have been proven to be a potent anticancer weapon for clinical therapy. The preexisting neutralizing antibody in patients is a big challenge for oncolytic efficacy...

    Authors: Mao Xia, Dongjun Luo, Jie Dong, Meihong Zheng, Gang Meng, Junhua Wu and Jiwu Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:408
  26. In the publication of this article [1], there are two corrections.

    Authors: Ming Tan, Qian Zhang, Xiaohong Yuan, Yuanzhong Chen and Yong Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:407

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:308

  27. Iron, an indispensable element for life, is involved in all kinds of important physiological activities. Iron promotes cell growth and proliferation, but it also causes oxidative stress damage. The body has a ...

    Authors: Fang Wang, Huanhuan Lv, Bin Zhao, Liangfu Zhou, Shenghang Wang, Jie Luo, Junyu Liu and Peng Shang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:406
  28. Skin cutaneous melanoma (SKCM) is the most lethal form of skin cancer and while incidence rates are declining for most cancers, they have been steadily rising for SKCM. Serine protease inhibitor, kunitz-type, ...

    Authors: Elena Gómez-Abenza, Sofía Ibáñez-Molero, Diana García-Moreno, Inmaculada Fuentes, Leonard I. Zon, Maria C. Mione, María L. Cayuela, Chiara Gabellini and Victoriano Mulero
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:405
  29. Metabolic reprogramming is an important characteristic of tumors. In the progression of pituitary adenomas (PA), abnormal glucose metabolism has been confirmed by us before. However, whether cholesterol metabo...

    Authors: Xiao Ding, Kexia Fan, Jintao Hu, Zhenle Zang, Shunli Zhang, Yin Zhang, Zhichao Lin, Xiangdong Pei, Xin Zheng, Feng Zhu, Hui Yang and Song Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:404
  30. T cells play important roles in anti-tumor immunity. Emerging evidence has revealed that distinct metabolic changes impact the activation and differentiation of T cells. Tailoring immune responses by manipulat...

    Authors: Zhongping Yin, Ling Bai, Wei Li, Tanlun Zeng, Huimin Tian and Jiuwei Cui
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:403
  31. Dihydroartemisinin (DHA) has been shown to exert anticancer activity through iron-dependent reactive oxygen species (ROS) generation, which is similar to ferroptosis, a novel form of cell death. However, wheth...

    Authors: Yibing Chen, Yanjun Mi, Xiaofei Zhang, Qian Ma, Yucen Song, Liwei Zhang, Dandan Wang, Jinliang Xing, Benxin Hou, Haolong Li, Huan Jin, Wei Du and Zhengzhi Zou
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:402
  32. Colon cancer is the second leading cancer worldwide. Recurrent disease and chemotherapeutic drug resistance are very common in the advanced stage of colon cancer. ATP-citrate lyase (ACLY), the first-step rate-...

    Authors: Jun Wen, Xuejie Min, Mengqin Shen, Qian Hua, Yuan Han, Li Zhao, Liu Liu, Gang Huang, Jianjun Liu and Xiaoping Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:401
  33. Neuroblastoma (NB) is one of the deadliest paediatric solid tumours due to its rapid proliferative characteristics. Amplified copies of MYCN are considered the most important marker for the prediction of tumou...

    Authors: Ping Jiang, Mao Huang, Weiwei Qi, Fenghua Wang, Tianyou Yang, Tianxiao Gao, Chuanghua Luo, Jing Deng, Zhonghan Yang, Ti Zhou, Yan Zou, Guoquan Gao and Xia Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:400
  34. Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that is essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell subpopulations displaying intrinsic radioresist...

    Authors: So-Yeon Park, Choong-Jae Lee, Jang-Hyun Choi, Jee-Heun Kim, Ji-Won Kim, Ji-Young Kim and Jeong-Seok Nam
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:399
  35. Growing evidences indicate that circular RNAs (circRNAs) play an important role in the regulation of biological behavior of tumor. We aim to explore the role of circRNA in glioma and elucidate how circRNA acts.

    Authors: Jiansheng Chen, Taoliang Chen, Yubo Zhu, Yan Li, Yuxuan Zhang, Yun Wang, Xiao Li, Xiaomi Xie, Jihui Wang, Min Huang, Xinlin Sun and Yiquan Ke
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:398
  36. Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associa...

    Authors: Alexander Thiem, Sonja Hesbacher, Hermann Kneitz, Teresa di Primio, Markus V. Heppt, Heike M. Hermanns, Matthias Goebeler, Svenja Meierjohann, Roland Houben and David Schrama
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:397
  37. Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in HCC treatment, less than 40% o...

    Authors: Yaojie Fu, Shanshan Liu, Shan Zeng and Hong Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:396
  38. Long non-coding RNA plays a crucial role in the occurrence and progression of glioma. We aimed to explore the function of LINC00174 in cell proliferation, apoptosis, migration, invasion and glycolysis of gliom...

    Authors: Jian Shi, Yang Zhang, Bing Qin, Yongjie Wang and Xiangdong Zhu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:395
  39. FAM92A1–289(abbreviated FAM289) is recognized as one of the newly-discovered putative oncogenes. However, its role and molecular mechanisms in promoting cancer progression has not yet been elucidated. This stu...

    Authors: Xing Rong Guo, Mu Yu Wu, Long Jun Dai, Yu Huang, Meng Ye Shan, Shi Nan Ma, Jue Wang, Hao Peng, Yan Ding, Qiu Fang Zhang, Jun Ming Tang, Xu Zhi Ruan and Dong Sheng Li
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:394
  40. m6A modification has been proved to play an important role in many biological processes. METTL3 as the main methyltransferase for methylation process has been found to be upregulated in many cancers, including...

    Authors: Wen Peng, Jie Li, Ranran Chen, Qiou Gu, Peng Yang, Wenwei Qian, Dongjian Ji, Qingyuan Wang, Zhiyuan Zhang, Junwei Tang and Yueming Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:393
  41. Radioresistance remains a challenge to the successful treatment of various tumors. Intrinsic factors like alterations in signaling pathways regulate response to radiation. RhoC, which has been shown to modulat...

    Authors: Annapurna Pranatharthi, Pavana Thomas, Avinash H. Udayashankar, Chandra Bhavani, Srinag Bangalore Suresh, Sudhir Krishna, Jayashree Thatte, Nirmala Srikantia, Cecil R. Ross and Sweta Srivastava
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:392
  42. Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple c...

    Authors: Qing Yang, Chuandong Lang, Zhengquan Wu, Yuhu Dai, Shaofu He, Wei Guo, Shuai Huang, Hong Du, Dong Ren and Xinsheng Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:391
  43. Dysregulation of microRNAs (miRNAs) play critical roles in cancerous processes. Although miR-3064 was reported to be an important tumor suppressor in ovarian cancer, the cellular impact of miR-3064 on pancreat...

    Authors: Jiayan Yan, Yunxi Jia, Han Chen, Wei Chen and Xiaoying Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:390

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:80

  44. In cancer progression, hypoxia, or low oxygen tension, is a major regulator of tumor aggressiveness and metastasis. However, how cancer cells adapt to the hypoxia and communicate with other mesenchymal cells i...

    Authors: Yu Mao, Yimin Wang, Lixin Dong, Yunjie Zhang, Yanqiu Zhang, Chao Wang, Qiang Zhang, Sen Yang, Liyan Cao, Xinyuan Zhang, Xin Li and Zhanzhao Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:389
  45. Hypoxia is a key feature of breast cancer, which affects cancer development, metastasis and metabolism. Previous studies suggested that circular RNAs (circRNAs) could participate in cancer progression and hypo...

    Authors: Shasha Ren, Jiuzhou Liu, Yun Feng, Zhenyu Li, Liang He, Leilei Li, Xiaozhong Cao, Zhenghua Wang and Yanwu Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:388
  46. In the original publication of this article [1], the Fig. 7 is wrong, but does not affect discussions and conclusions drawn in the article.

    Authors: Qing Yang, Binhui Xie, Hui Tang, Wei Meng, Changchang Jia, Xiaomei Zhang, Yi Zhang, Jianwen Zhang, Heping Li and Binsheng Fu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:387

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:263

  47. Renal cell carcinoma (RCC) is a deadly urological tumor that remains largely incurable. Our limited understanding of key molecular mechanisms underlying RCC invasion and metastasis has hampered efforts to iden...

    Authors: Yong Wang, Jing Su, Yiting Wang, Donghe Fu, Justin E. Ideozu, Hua Geng, Qiqi Cui, Chao Wang, Ruibing Chen, Yixi Yu, Yuanjie Niu and Dan Yue
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:386
  48. In the original publication of this article [1], there are mistakes in Fig. 3A and Fig. 3D.

    Authors: Fei Zhang, Qiang Ma, Zihang Xu, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Yijian Zhang, Lin Jiang, Yunping Hu, Zheng Wang, Xuefeng Wang, Yong Zhang, Wei Gong and Yingbin Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:385

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:68

  49. Aberrant activation of Notch signaling has been causally linked to the metastasis of hepatocellular carcinoma (HCC), however the underlying molecular mechanisms are still poorly understood. RING finger protein...

    Authors: Lei Zhang, Jiewei Chen, Juanjuan Yong, Liang Qiao, Leibo Xu and Chao Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:384

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