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  1. Anti-angiogenic therapies demonstrate anti-tumor effects by decreasing blood supply to tumors and inhibiting tumor growth. However, anti-angiogenic therapy may leads to changes in tumor microenvironment and in...

    Authors: Weilong Zhong, Wendong Yang, Yuan Qin, Wenguang Gu, Yinyin Xue, Yuanhao Tang, Hengwei Xu, Hongzhi Wang, Chao Zhang, Changhua Wang, Bo Sun, Yanrong Liu, Huijuan Liu, Honggang Zhou, Shuang Chen, Tao Sun…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:285

    Content type: Research

    Published on:

  2. Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin-17 (...

    Authors: Bing Yang, Aiwen Wu, Yingqi Hu, Cuijian Tao, Ji Ming Wang, Youyong Lu and Rui Xing

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:283

    Content type: Research

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  3. Lung cancer is the most common cause of cancer-related mortality worldwide despite diagnostic improvements and the development of targeted therapies, notably including epidermal growth factor receptor (EGFR) t...

    Authors: Yi-Ying Wu, Hung-Chang Wu, Jia-En Wu, Kuo-Yen Huang, Shuenn-Chen Yang, Si-Xuan Chen, Chao-Jung Tsao, Keng-Fu Hsu, Yuh-Ling Chen and Tse-Ming Hong

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:282

    Content type: Research

    Published on:

  4. Discoidin domain receptor-1 (DDR1) tyrosine kinase is highly expressed in a variety of human cancers and involved in various steps of tumorigenesis. However, the precise mechanisms underlying the abnormal expr...

    Authors: Sung-Tau Chou, Hsuan-Yu Peng, Kuan-Chi Mo, Yuan-Ming Hsu, Guan-Hsun Wu, Jenn-Ren Hsiao, Su-Fang Lin, Horng-Dar Wang and Shine-Gwo Shiah

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:281

    Content type: Research

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  5. Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology and treatment of cancer, regulation of oncogene by chromatin modifiers at post-transcriptional level i...

    Authors: Rui Yang, Na Liu, Ling Chen, Yiqun Jiang, Ying Shi, Chao Mao, Yating Liu, Min Wang, Weiwei Lai, Haosheng Tang, Menghui Gao, Desheng Xiao, Xiang Wang, Fenglei Yu, Ya Cao, Qin Yan…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:280

    Content type: Research

    Published on:

  6. A better understanding of locally advanced cervical cancer (LACC) is mandatory for further improving the rates of disease control, since a significant proportion of patients still fail to respond or undergo re...

    Authors: Marianna Buttarelli, Gabriele Babini, Giuseppina Raspaglio, Flavia Filippetti, Alessandra Battaglia, Alessandra Ciucci, Gabriella Ferrandina, Marco Petrillo, Carmela Marino, Mariateresa Mancuso, Anna Saran, Maria Elena Villani, Angiola Desiderio, Chiara D’Ambrosio, Andrea Scaloni, Giovanni Scambia…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:279

    Content type: Research

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  7. Partial epithelial mesenchymal transition (p-EMT) was found to play a potential role in the initial stage of metastasis in human head and neck squamous cell carcinoma (HNSCC). Some long noncoding RNAs (lncRNAs...

    Authors: Hong-Gang Xiong, Hao Li, Yao Xiao, Qi-Chao Yang, Lei-Lei Yang, Lei Chen, Lin-Lin Bu, Wen-Feng Zhang, Jia-Li Zhang and Zhi-Jun Sun

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:278

    Content type: Research

    Published on:

  8. The deubiquitinating enzyme ubiquitin-specific protease 3 (USP3) plays a crucial role in numerous biological processes. The aberrant expression of USP3 may have an important role in tumor development. However,...

    Authors: Xiaosheng Wu, Mengwei Liu, Huiqiong Zhu, Jing Wang, Weiyu Dai, Jiaying Li, Danping Zhu, Weimei Tang, Yizhi Xiao, Jianjiao Lin, Wenjing Zhang, Yong Sun, Yi Zhang, Yaying Chen, Guoxin Li, Aimin Li…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:277

    Content type: Research

    Published on:

  9. The E2A gene, which encodes two basic helix–loop–helix transcription factors, E12 and E47, regulates colorectal cancer progression and epithelial-mesenchymal transition. However, whether E2A regulates the tumo...

    Authors: Hongchao Zhao, Chunlin Zhao, Haohao Li, Danhua Zhang and Guanghui Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:276

    Content type: Research

    Published on:

  10. The current chemotherapy regimens may extend survival for patients with metastatic bladder cancer (BCa) for a few months, but eventually most patients succumb to disease because they develop resistance to thei...

    Authors: Chi-Ping Huang, Jinbo Chen, Chi-Cheng Chen, Guodong Liu, Yong Zhang, Edward Messing, Shuyuan Yeh and Chawnshang Chang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:275

    Content type: Research

    Published on:

  11. Local resident normal fibroblasts (NFs) are the major source of cancer-associated fibroblasts (CAFs), which are distinguishable from NFs by their tumor-supportive properties. However, the mechanism and the eff...

    Authors: Yujia Wang, Yue Jing, Liang Ding, Xiaoxin Zhang, Yuxian Song, Sheng Chen, Xingxing Zhao, Xiaofeng Huang, Yumei Pu, Zhiyong Wang, Yanhong Ni and Qingang Hu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:274

    Content type: Research

    Published on:

  12. DEPTOR is an endogenous inhibitor of mTORC1 and mTORC2 that plays a vital role in the progression of human malignances. However, the biological function of DEPTOR in HCC metastasis and the underlying molecular...

    Authors: Jin Chen, Haidan Zhu, Qiumeng Liu, Deng Ning, Zhaoqi Zhang, Long Zhang, Jie Mo, Pengcheng Du, Xu Liu, Shasha Song, Yawei Fan, Huifang Liang, Jikui Liu, Bixiang Zhang and Xiaoping Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:273

    Content type: Research

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  13. Development of resistance to inhibitors of BRAF (BRAFi) and MEK (MEKi) remains a great challenge for targeted therapy in patients with BRAF-mutant melanoma. Here, we explored the role of miRNAs in melanoma acq...

    Authors: Simona Caporali, Adriana Amaro, Lauretta Levati, Ester Alvino, Pedro Miguel Lacal, Simona Mastroeni, Federica Ruffini, Laura Bonmassar, Gian Carlo Antonini Cappellini, Nadia Felli, Alessandra Carè, Ulrich Pfeffer and Stefania D’Atri

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:272

    Content type: Research

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  14. Recently, we have reported the characterization of a novel protein named Coiled-coil Helix Tumor and Metabolism 1 (CHTM1). CHTM1 localizes to both cytosol and mitochondria. Sequence corresponding to CHTM1 is a...

    Authors: Mansi Babbar, Ying Huang, Christopher M. Curtiss and M. Saeed Sheikh

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:271

    Content type: Research

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  15. Gliomas represent the most common type of malignant brain tumor, among which, glioblastoma remains a clinical challenge with limited treatment options and dismal prognosis. It has been shown that the dysregula...

    Authors: Fangling Cheng and Dongsheng Guo

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:270

    Content type: Review

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  16. Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this succes...

    Authors: Stephan Kruger, Matthias Ilmer, Sebastian Kobold, Bruno L. Cadilha, Stefan Endres, Steffen Ormanns, Gesa Schuebbe, Bernhard W. Renz, Jan G. D’Haese, Hans Schloesser, Volker Heinemann, Marion Subklewe, Stefan Boeck, Jens Werner and Michael von Bergwelt-Baildon

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:268

    Content type: Review

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  17. FAM83H was initially identified as a protein essential for dental enamel formation. Recent reports have shown that FAM83H is also involved in the progression of human cancers in conjunction with tumor-associat...

    Authors: Kyoung Min Kim, Usama Khamis Hussein, See-Hyoung Park, Mi Ae Kang, Young Jae Moon, Zhongkai Zhang, Yiping Song, Ho Sung Park, Jun Sang Bae, Byung-Hyun Park, Sang Hoon Ha, Woo Sung Moon, Jung Ryul Kim and Kyu Yun Jang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:267

    Content type: Research

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  18. Glioblastoma (GBM) is an aggressive brain tumor with universal recurrence and poor prognosis. The recurrence is largely driven by chemoradiation resistant cancer stem cells (CSCs). Epidermal growth factor rece...

    Authors: Raghupathy Vengoji, Muzafar A. Macha, Rama Krishna Nimmakayala, Satyanarayana Rachagani, Jawed A. Siddiqui, Kavita Mallya, Santhi Gorantla, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra and Nicole Shonka

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:266

    Content type: Research

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  19. Discovery and development of novel drugs that are capable of overcoming drug resistance in tumor cells are urgently needed clinically. In this study, we sought to explore whether ivermectin (IVM), a macrolide ...

    Authors: Lu Jiang, Pan Wang, Ying-Jian Sun and Yi-Jun Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:265

    Content type: Research

    Published on:

  20. Manganese superoxide dismutase (MnSOD) upregulating FoxM1 have previously been demonstrated promoting lung cancer stemness. Isovitexin exhibits antitumor activities in various cancers. This study aimed to asse...

    Authors: Xiaocheng Cao, Lihua Liu, Qing Yuan, Xiang Li, Yinghong Cui, Kaiqun Ren, Chang Zou, A. Chen, Chang Xu, Yebei Qiu, Meifang Quan, Jiansong Zhang, Jianguo Cao and Xiangding Chen

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:264

    Content type: Research

    Published on:

  21. Hepatocellular carcinoma (HCC) is the most common tumors in the worldwide, it develops resistance to radiotherapy during treatment, understanding the regulatory mechanisms of radioresistance generation is the ...

    Authors: Qing Yang, Binhui Xie, Hui Tang, Wei Meng, Changchang Jia, Xiaomei Zhang, Yi Zhang, Jianwen Zhang, Heping Li and Binsheng Fu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:263

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:387

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:336

  22. Autophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considere...

    Authors: Mara Cirone, Maria Saveria Gilardini Montani, Marisa Granato, Alessia Garufi, Alberto Faggioni and Gabriella D’Orazi

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:262

    Content type: Review

    Published on:

  23. Although the prognosis of patients with occult hepatitis B virus (HBV) infection (OBI) is usually benign, a small portion may undergo cirrhosis and subsequently hepatocellular carcinoma (HCC). We studied the m...

    Authors: Xiao-Ping Chen, Xin Long, Wen-long Jia, Han-Jie Wu, Jing Zhao, Hui-Fang Liang, Arian Laurence, Jun Zhu, Dong Dong, Yan Chen, Long Lin, Yu-Dong Xia, Wei-Yang Li, Gui-Bo Li, Zhi-Kun Zhao, Kui Wu…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:261

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:480

  24. Lung cancer is still the main cause of cancer death worldwide despite the availability of targeted therapies and immune-checkpoint inhibitors combined with chemotherapy. Cancer cell heterogeneity and primary o...

    Authors: Federica Giordano, Valentina Vaira, Diego Cortinovis, Sara Bonomo, Joyce Goedmakers, Federica Brena, Annamaria Cialdella, Leonarda Ianzano, Irene Forno, Maria Grazia Cerrito, Roberto Giovannoni, Gian Luca Ferri, Ennio Tasciotti, Silve Vicent, Francesco Damarco, Silvano Bosari…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:260

    Content type: Research

    Published on:

  25. USP13 has been reported to be involved in the tumorigenesis of human cancers, however, its functional role and regulatory mechanisms in bladder cancer (BC) remain unclear.

    Authors: Xiaojun Man, Chiyuan Piao, Xuyong Lin, Chuize Kong, Xiaolu Cui and Yuanjun Jiang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:259

    Content type: Research

    Published on:

  26. Pancreatic ductal adenocarcinoma (PDAC) is a stroma-rich carcinoma, and pancreatic stellate cells (PSCs) are a major component of this dense stroma. PSCs play significant roles in metastatic progression and ch...

    Authors: Hyun Ju Hwang, Min-Suk Oh, Dong Woo Lee and Hyo-Jeong Kuh

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:258

    Content type: Research

    Published on:

  27. We reported that horizontal transfer of malignant traits to target cells is a potential pathway to explain cancer dissemination. Although these results were encouraging, they were never corroborated by data sh...

    Authors: Mohamed Abdouh, Matteo Floris, Zu-Hua Gao, Vincenzo Arena, Manuel Arena and Goffredo Orazio Arena

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:257

    Content type: Research

    Published on:

  28. Long non-coding RNA PTENP1, the pseudogene of PTEN tumor suppressor, has been reported to exert its tumor suppressive function via modulation of PTEN expression in many malignancies, including breast cancer (B...

    Authors: Xue Gao, Tao Qin, Jun Mao, Jun Zhang, Shujun Fan, Ying Lu, Zhigang Sun, Qingqing Zhang, Bo Song and Lianhong Li

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:256

    Content type: Research

    Published on:

  29. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are being wildly used as target therapy in non-small-cell lung cancer (NSCLC). However, NSCLC patients with wild-type EGFR and KRAS mut...

    Authors: Ping Chen, Han-Peng Huang, Yi Wang, Jun Jin, Wei-Guo Long, Kan Chen, Xiao-Hui Zhao, Chen-Guo Chen and Jian Li

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:254

    Content type: Research

    Published on:

  30. Anti-PD-1/PD-L1 drugs are effective as monotherapy in a proportion of NSCLC patients and there is a strong rationale for combining them with targeted therapy. Inhibition of MAPK pathway may have pleiotropic ef...

    Authors: Carminia Maria Della Corte, Giusi Barra, Vincenza Ciaramella, Raimondo Di Liello, Giovanni Vicidomini, Silvia Zappavigna, Amalia Luce, Marianna Abate, Alfonso Fiorelli, Michele Caraglia, Mario Santini, Erika Martinelli, Teresa Troiani, Fortunato Ciardiello and Floriana Morgillo

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:253

    Content type: Research

    Published on:

  31. Optimal therapeutic strategies for hepatocellular carcinoma (HCC) patients are still challenging due to the high recurrence rate after surgical resection and chemotherapy resistance. Growing evidence shows tha...

    Authors: Jie Zhao, Ann Wozniak, Abby Adams, Josiah Cox, Anusha Vittal, Jordan Voss, Brian Bridges, Steven A. Weinman and Zhuan Li

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:252

    Content type: Research

    Published on:

  32. Cardiac glycosides are approved for the treatment of heart failure as Na+/K+ pump inhibitors. Their repurposing in oncology is currently investigated in preclinical and clinical studies. However, the identificati...

    Authors: Elodie M. Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gaël Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey R. Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert…

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:251

    Content type: Research

    Published on:

  33. Colorectal cancer (CRC) is the third most frequent cancer and the second leading cause of cancer-related death worldwide. Increasing evidence indicates that the deregulation of long noncoding RNAs (lncRNAs) co...

    Authors: Kaili Luo, Jingwen Geng, Qinkai Zhang, Yesha Xu, Xunzhu Zhou, Zheng Huang, Ke-Qing Shi, Chenwei Pan and Jianmin Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:249

    Content type: Research

    Published on:

  34. Glioma is the most common and lethal type of malignant brain tumor. Accumulating evidence has highlighted that RNA binding protein APOBEC1 complementation factor (A1CF) is involved in various cellular processe...

    Authors: Yichen Song, Lianqi Shao, Yixue Xue, Xuelei Ruan, Xiaobai Liu, Chunqing Yang, Jian Zheng, Shuyuan Shen, Jiajia Chen, Zhen Li and Yunhui Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:248

    Content type: Research

    Published on:

  35. Gallbladder cancer (GBC) is an extremely malignant tumor with a high mortality rate. Little is known about its invasion and metastasis mechanism so far.

    Authors: Hui Shen, Min He, Ruirong Lin, Ming Zhan, Sunwang Xu, Xince Huang, Chu Xu, Wei Chen, Yanhua Yao, Man Mohan and Jian Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:247

    Content type: Research

    Published on:

  36. Prostate cancer (PCa) is considered one of the most prevalent malignancy globally, and metastasis is a major cause of death. Apigenin (API) is a dietary flavonoid which exerts an antimetastatic effect in vario...

    Authors: Ming-Hsien Chien, Yung-Wei Lin, Yu-Ching Wen, Yi-Chieh Yang, Michael Hsiao, Junn-Liang Chang, Hsiang-Ching Huang and Wei-Jiunn Lee

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:246

    Content type: Research

    Published on:

  37. Cisplatin is the first-line chemotherapy used against most upper aerodigestive tract carcinomas. In head and neck cancer, sensitivity to cisplatin remains the key issue in treatment response and outcome. Genet...

    Authors: Wei-Min Chang, Yu-Chan Chang, Yi-Chieh Yang, Sze-Kwan Lin, Peter Mu-Hsin Chang and Michael Hsiao

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:245

    Content type: Research

    Published on:

  38. Gallbladder cancer (GBC) is the most malignant cancer occurring in the biliary tract cancer featured with undesirable prognosis, in which most patients die within a year of cholecystectomy. Long noncoding RNAs...

    Authors: Nan Lin, Zhicheng Yao, Mingxing Xu, Jingyao Chen, Yi Lu, Lin Yuan, Shuqin Zhou, Xiaoguang Zou and Ruiyun Xu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:244

    Content type: Research

    Published on:

  39. The chemotherapy-resistance of triple-negative breast cancer (TNBC) remains a major challenge. The Nek2B kinase and β-catenin serve as crucial regulators of mitotic processes. The aim of this study was to test...

    Authors: Honghong Shen, Wenpeng Yan, Jinyang Yuan, Ziyue Wang and Chen Wang

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:243

    Content type: Research

    Published on:

  40. Lung cancer remains the most common cause of cancer-related deaths, with a high incidence and mortality in both sexes worldwide. Chemoprevention has been the most effective strategy for lung cancer prevention....

    Authors: Yanmei Lou, Zhenzhen Guo, Yuanfeng Zhu, Muyan Kong, Rongrong Zhang, Linlin Lu, Feichi Wu, Zhongqiu Liu and Jinjun Wu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:242

    Content type: Research

    Published on:

  41. Primary brain tumors, in particular glioblastoma (GBM), remain among the most challenging cancers. Like most malignant tumors, GBM is characterized by hypoxic stress that triggers paracrine, adaptive responses...

    Authors: Svenja Offer, Julien A. Menard, Julio Enríquez Pérez, Kelin G. de Oliveira, Vineesh Indira Chandran, Maria C. Johansson, Anna Bång-Rudenstam, Peter Siesjö, Anna Ebbesson, Ingrid Hedenfalk, Pia C. Sundgren, Anna Darabi and Mattias Belting

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:241

    Content type: Research

    Published on:

  42. To determine whether the upregulation of basic leucine zipper ATF-like transcription factor 2 (BATF2) by calycosin suppresses the growth and epithelial-to-mesenchymal transition (EMT) in human colorectal cance...

    Authors: Qun Wang, Weijun Lu, Tao Yin and Li Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:240

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:288

  43. Temozolomide-perillyl alcohol conjugate (NEO212), a novel temozolomide (TMZ) analog, was previously reported to exert its anti-cancer effect in non-small cell lung cancer (NSCLC), and human nasopharyngeal carc...

    Authors: Xingguo Song, Lisheng Liu, Minghui Chang, Xinran Geng, Xingwu Wang, Weijun Wang, Thomas C. Chen, Li Xie and Xianrang Song

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:239

    Content type: Research

    Published on:

  44. Adherent junction associated protein 1 (AJAP1), a typical molecule of adherent junctions, has been found to be a tumor suppressor in many cancer types. Aberrant activation of β-catenin has been demonstrated to...

    Authors: Cong Xu, Fang Liu, Guomin Xiang, Lu Cao, Shuling Wang, Jing Liu, Qingxiang Meng, Danni Xu, Shuhua Lv, Jiao Jiao and Yun Niu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:238

    Content type: Research

    Published on:

  45. Liver cancer stem cells (LCSCs) are a small subset of cells characterized by unlimited self-renewal, cell differentiation, and uncontrollable cellular growth. LCSCs are also resistant to conventional therapies...

    Authors: Dong-Mei Wu, Zi-Hui Zheng, Ying-Bo Zhang, Shao-Hua Fan, Zi-Feng Zhang, Yong-Jian Wang, Yuan-Lin Zheng and Jun Lu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:237

    Content type: Research

    Published on:

  46. Targeting the epidermal growth factor receptor (EGFR) either alone or in combination with chemotherapy is an effective treatment for patients with RAS wild-type metastatic colorectal cancer (mCRC). However, only ...

    Authors: Valentina Belli, Nunzia Matrone, Stefania Napolitano, Giorgia Migliardi, Francesca Cottino, Andrea Bertotti, Livio Trusolino, Erika Martinelli, Floriana Morgillo, Davide Ciardiello, Vincenzo De Falco, Emilio Francesco Giunta, Umberto Bracale, Fortunato Ciardiello and Teresa Troiani

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:236

    Content type: Research

    Published on:

  47. Vascular maturity and functionality are closely associated with tumor progression and chemosensitivity. The antidiabetic agent metformin has shown its ability to inhibit tumor angiogenesis in metastatic breast...

    Authors: Ji-Chang Wang, Guang-Yue Li, Bo Wang, Su-Xia Han, Xin Sun, Yi-Na Jiang, Yan-Wei Shen, Can Zhou, Jun Feng, Shao-Ying Lu, Jian-Lin Liu, Mao-De Wang and Pei-Jun Liu

    Citation: Journal of Experimental & Clinical Cancer Research 2019 38:235

    Content type: Research

    Published on:

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