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  1. Prostate cancer(PCa) is the most commonly occurring male cancer in the USA. Abiraterone or Enzalutamide have been approved for the treatment of metastatic castration-resistant prostate cancer (CRPC). However, ...

    Authors: Linglong Yin, Yubing Ye, Ling Zou, Jinli Lin, Yi Dai, Yongming Fu, Youhong Liu, Yuchong Peng, Yingxue Gao, Yuxin Fu, Xuli Qi, Tanggang Deng, Songwei Zhang and Xiong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:204
  2. The pancreatic microenvironment has a defensive role against cancer but it can acquire tumor-promoting properties triggered by multiple mechanisms including alterations in the equilibrium between proteases and...

    Authors: Andrea Resovi, Perla Persichitti, Laura Brunelli, Lucia Minoli, Patrizia Borsotti, Giulia Garattini, Matteo Tironi, Erica Dugnani, Miriam Redegalli, Giulia De Simone, Roberta Pastorelli, Maria Rosa Bani, Lorenzo Piemonti, Deane F. Mosher, Raffaella Giavazzi, Giulia Taraboletti…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:201
  3. Advanced colorectal cancer (CRC) is difficult to treat. For that reason, the development of novel therapeutics is necessary. Here we describe a potentially actionable plasma membrane target, the amino acid tra...

    Authors: Juan Carlos Montero, Sofía del Carmen, Mar Abad, José M. Sayagués, Antonio Barbáchano, Asunción Fernández-Barral, Alberto Muñoz and Atanasio Pandiella
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:200
  4. Gemcitabine resistance (GR) is a significant clinical challenge in pancreatic adenocarcinoma (PAAD) treatment. Macrophages in the tumor immune-microenvironment are closely related to GR. Uncovering the macroph...

    Authors: Shengwei Jiang, Tingwei Deng, Huan Cheng, Weihan Liu, Dan Shi, Jiahui Yuan, Zhiwei He, Weiwei Wang, Boning Chen, Li Ma, Xianbin Zhang and Peng Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:199
  5. Aberrant somatic genomic alteration including copy number amplification is a hallmark of cancer genomes. We previously profiled genomic landscapes of prostate cancer (PCa), yet the underlying causal genes with...

    Authors: Xiayun Yang, Qin Zhang, Shuxuan Li, Raman Devarajan, Binjie Luo, Zenglai Tan, Zixian Wang, Nikolaos Giannareas, Tomasz Wenta, Wenlong Ma, Yuqing Li, Yuehong Yang, Aki Manninen, Song Wu and Gong-Hong Wei
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:198
  6. Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes wound repair following tissue damage. ATX...

    Authors: Matteo Centonze, Giusy Di Conza, Michael Lahn, Isabel Fabregat, Francesco Dituri, Isabella Gigante, Grazia Serino, Rosanna Scialpi, Livianna Carrieri, Roberto Negro, Elena Pizzuto and Gianluigi Giannelli
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:197

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:211

  7. Genetic and metabolic heterogeneity are well-known features of cancer and tumors can be viewed as an evolving mix of subclonal populations, subjected to selection driven by microenvironmental pressures or drug...

    Authors: Daniele Boso, Martina Tognon, Matteo Curtarello, Sonia Minuzzo, Ilaria Piga, Valentina Brillo, Elisabetta Lazzarini, Jessica Carlet, Ludovica Marra, Chiara Trento, Andrea Rasola, Ionica Masgras, Leonardo Caporali, Fabio Del Ben, Giulia Brisotto, Matteo Turetta…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:196
  8. Bone metastasis is a principal cause of mortality in patients with prostate cancer (PCa). Increasing evidence indicates that high expression of stromal interaction molecule 1 (STIM1)-mediated store-operated ca...

    Authors: Qianghua Zhou, Xu Chen, Kai Yao, Yangjie Zhang, Haixia He, Hao Huang, Hao Chen, Shengmeng Peng, Ming Huang, Liang Cheng, Qiang Zhang, Ruihui Xie, Kaiwen Li, Tianxin Lin and Hai Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:195
  9. RNA binding proteins (RBPs)—regulated gene expression play a vital role in various pathological processes, including the progression of cancer. However, the role of RBP in hepatocellular carcinoma (HCC) remain...

    Authors: Shuang Tao, Shu-Juan Xie, Li-Ting Diao, Guo Lv, Ya-Rui Hou, Yan-Xia Hu, Wan-Yi Xu, Bin Du and Zhen-Dong Xiao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:194
  10. Tissue-based biopsy is the present main tool to explore the molecular landscape of cancer, but it also has many limits to be frequently executed, being too invasive with the risk of side effects. These limits ...

    Authors: Daniele Santini, Andrea Botticelli, Antonio Galvano, Michele Iuliani, Lorena Incorvaia, Valerio Gristina, Chiara Taffon, Simone Foderaro, Elisa Paccagnella, Sonia Simonetti, Federico Fazio, Simone Scagnoli, Giulia Pomati, Francesco Pantano, Giuseppe Perrone, Elena De Falco…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:193
  11. Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical ...

    Authors: Jing Ma, Ruijuan Ma, Xueke Zeng, Liming Zhang, Jianing Liu, Wei Zhang, Tao Li, Hanjing Niu, Guochen Bao, Chaojie Wang, Peng George Wang, Jiajia Wang, Xia Li, Taotao Zou and Songqiang Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:192
  12. Circular RNAs (circRNAs) circularized by back-splicing of pre-mRNA are widely expressed and affected the proliferation, invasion and metastasis of bladder cancer (BCa). However, the mechanism underlying circRN...

    Authors: Yuanlong Li, Yao Kong, Mingjie An, Yuming Luo, Hanhao Zheng, Yan Lin, Jiancheng Chen, Jin Yang, Libo Liu, Baoming Luo, Jian Huang, Tianxin Lin and Changhao Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:191
  13. Drug resistance limits the treatment effect of cisplatin-based chemotherapy in head and neck squamous cell carcinoma (HNSCC), and the underlying mechanism is not fully understood. The aim of this study was to ...

    Authors: Teng Xu, Yuemei Yang, Zhihong Chen, Jinsong Wang, Xiaolei Wang, Yang Zheng, Chao Wang, Yachen Wang, Zaiou Zhu, Xu Ding, Junbo Zhou, Gang Li, Hongchuang Zhang, Wei Zhang, Yunong Wu and Xiaomeng Song
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:190
  14. The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World of RNA diagnostics and therapeut...

    Authors: Giovanni Blandino, Roberto Dinami, Marco Marcia, Eleni Anastasiadou, Brid M. Ryan, Alina Catalina Palcau, Luigi Fattore, Giulia Regazzo, Rosanna Sestito, Rossella Loria, Ana Belén Díaz Méndez, Maria Chiara Cappelletto, Claudio Pulito, Laura Monteonofrio, George A. Calin, Gabriella Sozzi…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:189
  15. Lung cancer is one of the most frequent causes of cancer-related deaths worldwide. Drug repurposing and nano-drug delivery systems are attracting considerable attention for improving anti-cancer therapy. Serta...

    Authors: Ruolan Liu, Qiong Li, Siyuan Qin, Ling Qiao, Mei Yang, Shanshan Liu, Edouard C. Nice, Wei Zhang, Canhua Huang, Shaojiang Zheng and Wei Gao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:188
  16. Prostate cancer is a major cause of cancer morbidity and mortality in men worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage androgen-sensitive disease, but prostate cancer gradu...

    Authors: Ioanna Mourkioti, Aikaterini Polyzou, Dimitris Veroutis, George Theocharous, Nefeli Lagopati, Emanuela Gentile, Vasiliki Stravokefalou, Dimitris-Foivos Thanos, Sophia Havaki, Dimitris Kletsas, Theocharis Panaretakis, Christopher J. Logothetis, Dimitris Stellas, Russell Petty, Giovanni Blandino, Angelos Papaspyropoulos…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:187
  17. The emergence of resistance to the highly successful BCL2-directed therapy is a major unmet need in acute myeloid leukemia (AML), an aggressive malignancy with poor survival rates. Towards identifying therapeu...

    Authors: Tarang Gaur, Ramulu Poddutoori, Leena Khare, Bhausaheb Bagal, Sonal Rashmi, Nikhil Patkar, Prashant Tembhare, Subramanian PG, Dhanlaxmi Shetty, Amit Dutt, Qi Zhang, Marina Konopleva, Uwe Platzbeckar, Sudeep Gupta, Susanta Samajdar, Murali Ramchandra…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:186
  18. Authors: Yonghao Zhan, Junhao Lin, Yuchen Liu, Mingwei Chen, Xiaoying Chen, Chengle Zhuang, Li Liu, Wen Xu, Zhicong Chen, Anbang He, Qiaoxia Zhang, Xiaojuan Sun, Guoping Zhao and Weiren Huang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:185

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:83

  19. Fructose is a very common sugar found in natural foods, while current studies demonstrate that high fructose intake is significantly associated with increased risk of multiple cancers and more aggressive tumor...

    Authors: Yanfen Cui, Hui Liu, Zhaosong Wang, He Zhang, Jianfei Tian, Zhiyong Wang, Weijie Song, Hui Guo, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Fei Zhang and Ruifang Niu
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:184
  20. Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote tumorigenesis and malignancy by a...

    Authors: MengTing Wang, QingYang Chen, ShuJie Wang, Han Xie, Jun Liu, RuiXiang Huang, YuFei Xiang, YanYi Jiang, DaSheng Tian and ErBao Bian
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:183
  21. Anaplastic thyroid carcinoma (ATC) was a rare and extremely malignant endocrine cancer with the distinct hallmark of high proportion of cancer stem cell-like characteristics. Therapies aiming to cancer stem-li...

    Authors: Tong Xu, Chaozhuang Zhu, Jinming Chen, Feifeng Song, Xinxin Ren, Shanshan Wang, Xiaofen Yi, Yiwen Zhang, Wanli Zhang, Qing Hu, Hui Qin, Yujia Liu, Song Zhang, Zhuo Tan, Zongfu Pan, Ping Huang…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:182
  22. Authors: Zhifei Ma, Hao Chen, Zhijun Xia, Jing You, Chencheng Han, Siwei Wang, Wenjia Xia, Yongkang Bai, Tongyan Liu, Lin Xu, Guoren Zhou, Youtao Xu and Rong Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:180

    The original article was published in Journal of Experimental & Clinical Cancer Research 2023 42:169

  23. Authors: Kai Li, Zi-Yang Peng, Shan Gao, Qing-Shi Wang, Rui Wang, Xiang Li, Guo-Dong Xiao, Jing Zhang, Hong Ren, Shou-Ching Tang and Xin Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:179

    The original article was published in Journal of Experimental & Clinical Cancer Research 2021 40:325

  24. Macrophages take center stage in the tumor microenvironment, a niche composed of extracellular matrix and a heterogeneous group of cells, including immune ones. They can evolve during tumor progression and acq...

    Authors: Anna Maria Lucianò, Marta Di Martile, Ana B. Pérez-Oliva, Marica Di Caprio, Maria Laura Foddai, Simonetta Buglioni, Victoriano Mulero and Donatella Del Bufalo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:178
  25. Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits ar...

    Authors: Yaxian Wang, Xinyang Zhong, Xuefeng He, Zijuan Hu, Huixia Huang, Jiayu Chen, Keji Chen, Senlin Zhao, Ping Wei and Dawei Li
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:177
  26. The mitogen-activated protein kinase (MAPK) signaling pathway is frequently hyperactivated in malignant melanoma and its inhibition has proved to be an efficient treatment option for cases harboring BRAFV600 muta...

    Authors: Corinna Kosnopfel, Simone Wendlinger, Heike Niessner, Johannes Siewert, Tobias Sinnberg, Angelika Hofmann, Jonas Wohlfarth, David Schrama, Marion Berthold, Claudia Siedel, Birgit Sauer, Aarthi Jayanthan, Georg Lenz, Sandra E. Dunn, Bastian Schilling and Birgit Schittek
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:175
  27. Cancer is the main cause of death worldwide and metastasis is a major cause of poor prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a multiplex process, including EMT throug...

    Authors: Mohammad Ahmad, Louis-Bastien Weiswald, Laurent Poulain, Christophe Denoyelle and Matthieu Meryet-Figuiere
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:173
  28. The interplay between gut microbiota and tumor microenvironment (TME) in the pathogenesis of colorectal cancer (CRC) is largely unknown. Here, we elucidated the functional role of B. adolescentis and its possible...

    Authors: Yifeng Lin, Lina Fan, Yadong Qi, Chaochao Xu, Dingjiacheng Jia, Yao Jiang, Shujie Chen and Liangjing Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:172

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:212

  29. Chemotherapy, radiotherapy, targeted therapy, and immunotherapy are established cancer treatment modalities that are widely used due to their demonstrated efficacy against tumors and favorable safety profiles ...

    Authors: Ting-Wan Kao, Geng-Hao Bai, Tian-Li Wang, Ie-Ming Shih, Chi-Mu Chuang, Chun-Liang Lo, Meng-Chen Tsai, Li-Yun Chiu, Chu-Chien Lin and Yao-An Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:171
  30. Approximately 20–50% of patients presenting with localized colorectal cancer progress to stage IV metastatic disease (mCRC) following initial treatment and this is a major prognostic determinant. Here, we have...

    Authors: Mario Cioce, Maria Rita Fumagalli, Sara Donzelli, Frauke Goeman, Valeria Canu, Daniela Rutigliano, Giulia Orlandi, Andrea Sacconi, Claudio Pulito, Alina Catalina Palcau, Maurizio Fanciulli, Aldo Morrone, Maria Grazia Diodoro, Marco Caricato, Anna Crescenzi, Martina Verri…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:170
  31. Circular RNAs (circRNAs) contribute to multiple biological functions and are also involved in pathological conditions such as cancer. However, the role of circRNAs in metabolic reprogramming, especially upon e...

    Authors: Zhifei Ma, Hao Chen, Zhijun Xia, Jing You, Chencheng Han, Siwei Wang, Wenjia Xia, Yongkang Bai, Tongyan Liu, Lin Xu, Guoren Zhou, Youtao Xu and Rong Yin
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:169

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2023 42:180

  32. Cutaneous squamous cell carcinoma (cSCC) is the second most prevalent form of skin cancer, showing a rapid increasing incidence worldwide. Although most cSCC can be cured by surgery, a sizeable number of cases...

    Authors: Marika Quadri, Natascia Tiso, Francesco Musmeci, Maria I. Morasso, Stephen R. Brooks, Luca Reggiani Bonetti, Rossana Panini, Roberta Lotti, Alessandra Marconi, Carlo Pincelli and Elisabetta Palazzo
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:167
  33. Increasing evidence suggests a vital role of the pre-metastatic niche in the formation of distant metastasis of many cancers. However, how the pre-metastatic niche is formed and promotes pulmonary metastasis o...

    Authors: Chong Zhang, Qing Li, Qi Xu, Wei Dong, Chunmei Li, Bin Deng, Jiao Gong, Li-Zhen Zhang and Junfei Jin
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:166
  34. The majority of women with epithelial ovarian cancer (OvCa) are diagnosed with metastatic disease, resulting in a poor 5-year survival of 31%. Obesity is a recognized non-infectious pandemic that increases OvC...

    Authors: Yueying Liu, Jing Yang, Tyvette S. Hilliard, Zhikun Wang, Jeff Johnson, Wanrui Wang, Elizabeth I. Harper, Connor Ott, Caitlin O’Brien, Leigh Campbell, Brian Crowley, Stephen Grisoli, Nicholas M. Stavrou, Anna Juncker-Jensen and M. Sharon Stack
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:165
  35. The receptor for advanced glycation-end products (RAGE) and its ligands have been implicated in obesity and associated inflammatory processes as well as in metabolic alterations like diabetes. In addition, RAG...

    Authors: Marianna Talia, Francesca Cirillo, Asia Spinelli, Azzurra Zicarelli, Domenica Scordamaglia, Lucia Muglia, Salvatore De Rosis, Damiano Cosimo Rigiracciolo, Gianfranco Filippelli, Ida Daniela Perrotta, Mariano Davoli, Rosanna De Rosa, Rachele Macirella, Elvira Brunelli, Anna Maria Miglietta, Bruno Nardo…
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:164
  36. Autologous tumor cell-based vaccines (ATVs) aim to prevent and treat tumor metastasis by activating patient-specific tumor antigens to induce immune memory. However, their clinical efficacy is limited. Mannan-...

    Authors: Juan Ye, Herui Wang, Rogelio Medina, Samik Chakraborty, Mitchell Sun, Alex Valenzuela, Xueyu Sang, Yaping Zhang, Ondrej Uher, Jan Zenka, Karel Pacak and Zhengping Zhuang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:163
  37. A growing body of research has revealed the connection of metabolism reprogramming and tumor progression, yet how metabolism reprogramming affects inter-patient heterogeneity and prognosis in head and neck squ...

    Authors: Jiezhong Guan, Xi Xu, Guo Qiu, Chong He, Xiaoyue Lu, Kang Wang, Xinyu Liu, Yuanyuan Li, Zihang Ling, Xuan Tang, Yujie Liang, Xiaoan Tao, Bin Cheng and Bo Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:162
  38. After diagnosis, glioblastoma (GBM) patients undertake tremendous psychological problems such as anxiety and depression, which may contribute to GBM progression. However, systematic study about the relationshi...

    Authors: Yan Wang, Xiang Wang, Kai Wang, Ji Qi, Yu Zhang, Xu Wang, Long Zhang, Yi Zhou, Linbo Gu, Rutong Yu and Xiuping Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:161
  39. Endothelial-mesenchymal transition (EndoMT) is an emerging adaptive process that modulates lymphatic endothelial function to drive aberrant lymphatic vascularization in the tumour microenvironment (TME); howev...

    Authors: Wen-Fei Wei, Hui-Ling Zhou, Pei-Yu Chen, Xiao-Lan Huang, Long Huang, Luo-Jiao Liang, Chu-Hong Guo, Chen-Fei Zhou, Lan Yu, Liang-Sheng Fan and Wei Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:160
  40. The management of advanced clear cell renal cell carcinoma (ccRCC) remains a major challenge in clinical practice, and the construction of more reliable prognostic prediction models and the further elucidation...

    Authors: Yawei Xu, Lei Li, Wuping Yang, Kenan Zhang, Zedan Zhang, Chaojian Yu, Jianhui Qiu, Lin Cai, Yanqing Gong, Zheng Zhang, Jingcheng Zhou and Kan Gong
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:159
  41. Authors: Boxuan Zhou, Jinhua Xue, Runxin Wu, Hongyu Meng, Ruixi Li, Zhaohong Mo, Hang Zhai, Xianyu Chen, Rongqiang Liu, Guie Lai, Xiaohong Chen, Taiyuan Li and Shiyang Zheng
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:158

    The original article was published in Journal of Experimental & Clinical Cancer Research 2023 42:138

  42. Pancreatic ductal adenocarcinoma (PDAC) tends to undergo distant metastasis, especially liver metastasis, leading to a poor prognosis. Metabolic remodelling and epigenetic reprogramming are two important hallm...

    Authors: Jinshou Yang, Bo Ren, Jie Ren, Gang Yang, Yuan Fang, Xing Wang, Feihan Zhou, Lei You and Yupei Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:155
  43. Osteosarcoma (OS) is the most common primary bone tumor in children and adolescent. Surgery and multidrug chemotherapy are the standard of treatment achieving 60–70% of event-free survival for localized diseas...

    Authors: Caterina Cascini, Chiara Ratti, Laura Botti, Beatrice Parma, Valeria Cancila, Adriana Salvaggio, Cristina Meazza, Claudio Tripodo, Mario P. Colombo and Claudia Chiodoni
    Citation: Journal of Experimental & Clinical Cancer Research 2023 42:154

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