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  1. Ferritin plays a central role in the intracellular iron metabolism; the molecule is a nanocage of 24 subunits of the heavy and light types. The heavy subunit (FHC) is provided of a ferroxidase activity and thu...

    Authors: I. Aversa, F. Zolea, C. Ieranò, S. Bulotta, A. M. Trotta, M. C. Faniello, C. De Marco, D. Malanga, F. Biamonte, G. Viglietto, G. Cuda, S. Scala and F. Costanzo
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:104
  2. Twist1 is involved in tumor initiation and progression, which especially contributes to tumor invasion and metastasis. Wogonoside is the main in-vivo metabolite of wogonin, and it is also a natural product wit...

    Authors: Yuyuan Yao, Kai Zhao, Zhou Yu, Haochuan Ren, Li Zhao, Zhiyu Li, Qinglong Guo and Na Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:103

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:444

  3. Epidermal growth factor receptor (EGFR) plays a pivotal role in the pathophysiology of esophageal squamous cell carcinoma (ESCC). However, the clinical effects of EGFR inhibitors on ESCC are controversial. Thi...

    Authors: Masahiro Yoshioka, Shinya Ohashi, Tomomi Ida, Yukie Nakai, Osamu Kikuchi, Yusuke Amanuma, Junichi Matsubara, Atsushi Yamada, Shin’ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa, Tsutomu Chiba, Hiroshi Seno and Manabu Muto
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:101
  4. MiRNAs are involved in aberrant DNA methylation through regulation of DNA methyltransferases (DNMTs) in the pathogenesis and progression of glioblastomas (GBM). MiR-152-3p was down-expressed in human malignanc...

    Authors: Jin Sun, Xinhua Tian, Junqing Zhang, Yanlin Huang, Xiaoning Lin, Luyue Chen and Shizhong Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:100
  5. miR-500a-3p has been demonstrated to be involved in the development, progression and metastasis in several human cancers. Constitutive activation of JAK/STAT3 signaling pathway has been reported to play an imp...

    Authors: Chunlin Jiang, Jianting Long, Baoxian Liu, Ming Xu, Wei Wang, Xiaoyan Xie, Xiaolin Wang and Ming Kuang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:99
  6. Worldwide breast cancer is the most common cancer in women. For many years clinicians and the researchers are examining and exploring various therapeutic modalities for breast cancer. Yet the disease has remai...

    Authors: Urmila Banik, Subramani Parasuraman, Arun Kumar Adhikary and Nor Hayati Othman
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:98
  7. Hepatocellular carcinoma (HCC) remains difficult to cure due to lack of effective treatment and the molecular mechanisms are complex and not completely understood. In this study, We investigated the role of CD...

    Authors: Yitao Wang, Xian Qin, Tao Guo, Pengpeng Liu, Ping Wu and Zhisu Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:97

    The Retraction Note to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:215

  8. Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor, is a novel anticancer drug used for treating several types of cancers....

    Authors: Jin Wang, Xiaoyang Liu, Yongzhi Hong, Songtao Wang, Pin Chen, Aihua Gu, Xiaoyuan Guo and Peng Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:96
  9. Recurrence is a common feature of craniopharyngiomas, benign tumors that origin from squamous epithelial remnants of Rathke’s pouch- arising at any segment of its whole course. There are two histotypes, showin...

    Authors: Elia Guadagno, Oreste de Divitiis, Domenico Solari, Giorgio Borrelli, Umberto Marcello Bracale, Alberto Di Somma, Paolo Cappabianca and Marialaura Del Basso De Caro
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:95
  10. Authors: Weilin Zhao, Ning Ma, Shumin Wang, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata and Kazuhiko Takeuchi
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:94

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:88

  11. Glioblastoma multiforme (GBM) is one of the most refractory and palindromic central nervous system (CNS) neoplasms, and current treatments have poor effects in GBM patients. Hence, the identification of novel ...

    Authors: Xun Wang, Zhenlong Yu, Chao Wang, Wei Cheng, Xiangge Tian, Xiaokui Huo, Yan Wang, Chengpeng Sun, Lei Feng, Jinshan Xing, Yulong Lan, Dongdong Sun, Qingjuan Hou, Baojing Zhang, Xiaochi Ma and Bo Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:93

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2020 39:199

  12. Collagen triple helix repeat containing-1 (CTHRC1), which was firstly identified overexpressed in the adventitia and neointima of injured rat arteries, could inhibit collagen expression and increase cell migra...

    Authors: Yuan-hui Lai, Jian Chen, Xiao-ping Wang, Yan-qing Wu, Hai-tao Peng, Xiao-hong Lin and Wen-jian Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:92
  13. Troglitazone (TGZ) is a peroxisome proliferator-activated receptor gamma (PPARγ) agonist that has been investigated as a potential chemopreventive and chemotherapeutic agent. However, the antitumor efficacy an...

    Authors: Megumi Fujita, Ai Hasegawa, Motohiro Yamamori and Noboru Okamura
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:91
  14. GPRC6A is implicated in the pathogenesis of prostate cancer, but its role remains uncertain because of a purported tolerant gene variant created by substitution of a K..Y polymorphism in the 3rd intracellular ...

    Authors: Ruisong Ye, Min Pi, John V. Cox, Satoru K. Nishimoto and L. Darryl Quarles
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:90
  15. Metastatic colorectal cancer (mCRC) is one of the major causes of cancer-related death. Despite the substantial progress in mCRC management, it remains important to identify new therapeutic options and biologi...

    Authors: S. Cherradi, A. Ayrolles-Torro, N. Vezzo-Vié, N. Gueguinou, V. Denis, E. Combes, F. Boissière, M. Busson, L. Canterel-Thouennon, C. Mollevi, M. Pugnière, F. Bibeau, M. Ychou, P. Martineau, C. Gongora and M. Del Rio
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:89
  16. Nasopharyngeal carcinoma (NPC) is a malignancy of the head and neck that is prevalent in Southeast Asia and southern China. Recent studies in epigenetics suggest that DNA methylation plays a pivotal role in th...

    Authors: Weilin Zhao, Ning Ma, Shumin Wang, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata and Kazuhiko Takeuchi
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:88

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:94

  17. Endoplasmic reticulum (ER) calcium storage and release play important roles in B lymphocyte maturation, survival, antigen-dependent cell activation and immunoglobulin synthesis. Calcium is accumulated in the e...

    Authors: Lamia Aït Ghezali, Atousa Arbabian, Hervé Roudot, Jean-Philippe Brouland, Fanny Baran-Marszak, Evelyn Salvaris, Andrew Boyd, Hans G. Drexler, Agnes Enyedi, Remi Letestu, Nadine Varin-Blank and Bela Papp
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:87
  18. Homeobox B7 (HOXB7) has been identified associated with poor prognosis of hepatocellular carcinoma (HCC). However, the specific mechanism by which HOXB7 promotes the malignant progression of HCC remains to be ...

    Authors: Hong-bo Huan, Da-peng Yang, Xu-dong Wen, Xue-jiao Chen, Liang Zhang, Li-li Wu, Ping Bie and Feng Xia
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:86
  19. PHF21B is newly identified to be involved in the tumor progression; however, its biological role and molecular mechanism in prostate cancer have not been defined. This study is aimed to study the role of PHF21...

    Authors: Qiji Li, Liping Ye, Wei Guo, Min Wang, Shuai Huang and Xinsheng Peng
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:85
  20. Oesophageal cancer is one of the most common malignancies worldwide,and oesophageal squamous cell carcinoma (ESCC) is the predominant histological type both globally and in China. Collagen triple helix repeat ...

    Authors: Chunni Wang, Zitong Li, Fei Shao, Xueying Yang, Xiaoli Feng, Susheng Shi, Yibo Gao and Jie He
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:84
  21. This study examined the ability of lipopolysaccharide (LPS) to affect glioma and glioma stem-like cells (GSCs) in vitro and to induce antitumor immunity in vivo and the role of TLR4 in these processes.

    Authors: Sheng Han, Chao Wang, Xiaofei Qin, Junzhe Xia and Anhua Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:83
  22. MicroRNAs (miRs) are involved in tumor progression by regulating tumor cells and tumor microenvironment. MiR21 is overexpressed in diffuse large B-cell lymphoma (DLBCL) and its biological impact on tumor micro...

    Authors: Zhong Zheng, Peng-Peng Xu, Li Wang, Hui-Jin Zhao, Xiang-Qin Weng, Hui-Juan Zhong, Bin Qu, Jie Xiong, Yan Zhao, Xue-Feng Wang, Anne Janin and Wei-Li Zhao
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:82
  23. 5-Fluorouracil (5-FU) is a widely used drug for the therapy of cancer. However, the chemoresistance of tumor cells to 5-FU usually limits its clinical effectiveness. In this study, we explored the role of NLRP...

    Authors: Xiaodong Feng, Qingqiong Luo, Han Zhang, Han Wang, Wantao Chen, Guangxun Meng and Fuxiang Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:81
  24. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic adaptable immune mechanism used by many bacteria and archaea to protect themselves from foreign nucleic acids. This complex s...

    Authors: A. Biagioni, A. Chillà, E. Andreucci, A. Laurenzana, F. Margheri, S. Peppicelli, M. Del Rosso and G. Fibbi
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:80
  25. Ovarian carcinoma is one of the most aggressive gynecological malignant neoplasms and makes up 25–30% of all cancer cases of the female genital tract. Currently, resistance to traditional chemotherapy is a gre...

    Authors: Hongbiao Huang, Ni Liu, Yuning Liao, Ningning Liu, Jianyu Cai, Xiaohong Xia, Zhiqiang Guo, Yanling Li, Qirong Wen, Qi Yin, Yan Liu, Qingxia Wu, Dhivya Rajakumar, Xiujie Sheng and Jinbao Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:79
  26. Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Nevertheless, its effects on colorectal cance...

    Authors: Haiyan Chen, Qian Xiao, Yeting Hu, Liubo Chen, Kai Jiang, Yang Tang, Yinuo Tan, Wangxiong Hu, Zhanhuai Wang, Jinjie He, Yue Liu, Yibo Cai, Qi Yang and Kefeng Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:78
  27. Bladder cancer (BCa) is the ninth most common form of cancer in the world. There is a continuing need not only for improving the accuracy of diagnostic markers but also for the development of new treatment str...

    Authors: Nana Pei, Yingying Mao, Pengfei Wan, Xinglu Chen, Andrew Li, Huiying Chen, Jinlong Li, Renqiang Wan, Yanling Zhang, Hongyan Du, Baihong Chen, Guangyu Jiang, Minghan Xia, Colin Sumners, Guixue Hu, Dongsheng Gu…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:77
  28. Epilepsy is a frequent symptom in patients with glioma. Although treatment with antiepileptic drugs is generally effective in controlling seizures, drug-resistant patients are not uncommon. Multidrug resistanc...

    Authors: Ambra Rizzo, Sara Donzelli, Vita Girgenti, Andrea Sacconi, Chiara Vasco, Andrea Salmaggi, Giovanni Blandino, Marta Maschio and Emilio Ciusani
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:76
  29. Increasing evidence has indicated an important role for estrogen receptor beta 1 (ERβ1) in breast cancer. However, the role of ERβ1 in the metastasis of androgen receptor (AR)-positive triple-negative breast c...

    Authors: Wei Song, Lin Tang, Yumei Xu, Qian Sun, Fang Yang and Xiaoxiang Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:75
  30. Multiple studies concluded that oncometabolites (e.g. D-2-hydroxyglutarate (2-HG) related to mutant isocitrate dehydrogenase 1/2 (IDH1/2) and lactate) have tumour promoting potential. Regulatory mechanisms implic...

    Authors: Zoltán Hujber, Gábor Petővári, Norbert Szoboszlai, Titanilla Dankó, Noémi Nagy, Csilla Kriston, Ildikó Krencz, Sándor Paku, Olivér Ozohanics, László Drahos, András Jeney and Anna Sebestyén
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:74
  31. Epidemiologic data in volcanic areas suggest that environmental factors might be involved in the increase of thyroid cancer (TC) incidence. Recent reports indicate that several heavy metals and metalloids are ...

    Authors: Emilia Luca, Laura Fici, Anna Ronchi, Ferdinando Marandino, Esther Diana Rossi, Maria Emiliana Caristo, Pasqualino Malandrino, Marco Russo, Alfredo Pontecorvi, Riccardo Vigneri and Fabiola Moretti
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:73
  32. Autophagy is a conserved catabolic process to degrade cellular organelles. The role of autophagy in cancer development is complex. Amplification of fibroblast growth factor receptor 1 (FGFR1) is one of the mos...

    Authors: Hong Yuan, Zi-Ming Li, Jiaxiang Shao, Wen-Xiang Ji, Weiliang Xia and Shun Lu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:72
  33. The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene i...

    Authors: Antonio Carlos de Freitas, Talita Helena Araújo de Oliveira, Marconi Rego Barros Jr. and Aldo Venuti
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:71
  34. Fibronectin (FN) is associated with tumorigenesis and progression in bladder cancer, however, the underlying mechanisms causing this remain largely unknown. Furthermore, cancerous inhibitor of protein phosphat...

    Authors: Fengbin Gao, Tianyuan Xu, Xianjin Wang, Shan Zhong, Shanwen Chen, Minguang Zhang, Xiaohua Zhang, Yifan Shen, Xiaojing Wang, Chen Xu and Zhoujun Shen
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:70
  35. Authors: Franco Di Filippo, Simona Di Filippo, Anna Maria Ferrari, Raffaele Antonetti, Alessandro Battaglia, Francesca Becherini, Laia Bernet, Renzo Boldorini, Catherine Bouteille, Simonetta Buglioni, Paolo Burelli, Rafael Cano, Vincenzo Canzonieri, Pierluigi Chiodera, Alfredo Cirilli, Luigi Coppola…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:69

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:193

  36. Patients with metastatic or relapsed gallbladder cancer generally have a poor prognosis. Therefore, targeting metastasis is one arm of therapeutic strategies to treat gallbladder cancer.

    Authors: Fei Zhang, Qiang Ma, Zihang Xu, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Yijian Zhang, Lin Jiang, Yunping Hu, Zheng Wang, Xuefeng Wang, Yong Zhang, Wei Gong and Yingbin Liu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:68

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:124

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2019 38:385

  37. Chemotherapy resistance is one of the major factors contributing to mortality from human epithelial ovarian cancer (EOC). Identifying drugs that can effectively kill chemotherapy-resistant EOC cells would be a...

    Authors: Amani I. Moraya, Jennifer L. Ali, Pranati Samadder, Lisa Liang, Ludivine Coudière Morrison, Tamra E. Werbowetski-Ogilvie, Makanjuola Ogunsina, Frank Schweizer, Gilbert Arthur and Mark W. Nachtigal
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:67
  38. The involvement of lipid metabolism in tumourigenesis and the progression of clear cell renal cell carcinoma (ccRCC) have been reported. However, the role of phospholipid profile alterations in ccRCC has not y...

    Authors: Yiqing Du, Qiang Wang, Xingzhong Zhang, Xiaofeng Wang, Caipeng Qin, Zhengzuo Sheng, Huaqi Yin, Changtao Jiang, Jing Li and Tao Xu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:66
  39. AHNAK, also known as desmoyokin, is a giant protein with the molecular size of approximately 700 kDa and exerts diverse functions in different types of cancer.

    Authors: Bo Chen, Jin Wang, Danian Dai, Qingyu Zhou, Xiaofang Guo, Zhi Tian, Xiaojia Huang, Lu Yang, Hailin Tang and Xiaoming Xie
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:65
  40. As a relatively conservative transcriptional regulator in biological evolution, heat shock factor 1 (HSF1) is activated by, and regulates the expression of heat shock proteins (HSPs) in response to a variety o...

    Authors: Wenjin Liang, Yong Liao, Jing Zhang, Qi Huang, Wei Luo, Jidong Yu, Jianhua Gong, Yi Zhou, Xuan Li, Bo Tang, Songqing He and Jinghong Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:64
  41. Epithelial ovarian cancer (EOC) is a spectrum of different diseases, which makes their treatment a challenge. Forkhead box M1 (FOXM1) is an oncogene aberrantly expressed in many solid cancers including serous ...

    Authors: Renata A. Tassi, Paola Todeschini, Eric R. Siegel, Stefano Calza, Paolo Cappella, Laura Ardighieri, Moris Cadei, Mattia Bugatti, Chiara Romani, Elisabetta Bandiera, Laura Zanotti, Laura Tassone, Donatella Guarino, Concetta Santonocito, Ettore D. Capoluongo, Luca Beltrame…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:63
  42. Multiple myeloma (MM) is a clonal plasma-cell neoplastic disorder arising from an indolent premalignant disease known as monoclonal gammopathy of undetermined significance (MGUS). MM is a biologically complex ...

    Authors: Anna Shvartsur, Kevin B. Givechian, Hermes Garban and Benjamin Bonavida
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:62
  43. The incidence and mortality rates of hepatocellular carcinoma (HCC) have steadily increased in recent years. A hypoxic microenvironment is one of the most important characteristics of solid tumors which has be...

    Authors: Meili Wang, Xiulan Zhao, Dongwang Zhu, Tieju Liu, Xiaohui Liang, Fang Liu, Yanhui Zhang, Xueyi Dong and Baocun Sun
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:60
  44. MicroRNAs are endogenously expressed, small non-coding RNAs that modulate gene expression by targeting specific mRNAs, resulting in translational repression or mRNA degradation. Although miR-584-5p has been re...

    Authors: Qing Li, Zheng Li, Song Wei, Weizhi Wang, Zheng Chen, Lei Zhang, Liang Chen, Bowen Li, Guangli Sun, Jianghao Xu, Qiang Li, Lu Wang, Zhipeng Xu, Yiwen Xia, Diancai Zhang, Hao Xu…
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:59
  45. Hexokinase (HK) is the rate-limiting enzyme in the first reaction of glycolysis. And Hexokinase 2 (HK2) is most closely related to malignant tumor which expresses at higher level compared with normal cells. HK...

    Authors: Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min, Weiguang Sun, Lixia Chen, Guangya Xiang and Hua Li
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:58
  46. BRCA1 mutated breast cancers are commonly diagnosed as negative for classical hormone receptors i.e. estrogen receptor, progesterone receptor and/or Her2. Due to these common targets b...

    Authors: Sabine Heublein, Doris Mayr, Alfons Meindl, Alexandra Kircher, Udo Jeschke and Nina Ditsch
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:57
  47. Grb2-associated binder 2 (Gab2) is a scaffolding protein that serves as a critical signaling amplifier downstream of tyrosine kinase receptors. Our previous study has shown that Gab2 induces epithelial-to-mese...

    Authors: Chenbo Ding, Junmin Luo, Xiaobo Fan, Longmei Li, Shanshan Li, Kunming Wen, Jihong Feng and Guoqiu Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:56
  48. Through high-throughput next-generation sequencing of promoters of solute carrier and ATP-binding cassette genes, which encode drug transporters, we aimed to identify SNPs associated with the response to imati...

    Authors: Monika Jaruskova, Nikola Curik, Rajna Hercog, Vaclava Polivkova, Eliska Motlova, Vladimir Benes, Hana Klamova, Pavla Pecherkova, Petra Belohlavkova, Filip Vrbacky and Katerina Machova Polakova
    Citation: Journal of Experimental & Clinical Cancer Research 2017 36:55

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